A Pre-Clinical Assessment Of Minocycline For Treatment Of Chronic Neuropathic Pain After Spinal Cord Injury,
2012
The University of Texas Graduate School of Biomedical Sciences at Houston
A Pre-Clinical Assessment Of Minocycline For Treatment Of Chronic Neuropathic Pain After Spinal Cord Injury, Alissa R. Poteete
Dissertations and Theses (Open Access)
Patients living with a spinal cord injury (SCI) often develop chronic neuropathic pain (CNP). Unfortunately, the clinically approved, current standard of treatment, gabapentin, only provides temporary pain relief. This treatment can cause numerous adverse side effects that negatively affect the daily lives of SCI patients. There is a great need for alternative, effective treatments for SCI-dependent CNP.
Minocycline, an FDA-approved antibiotic, has been widely prescribed for the treatment of acne for several decades. However, recent studies demonstrate that minocycline has neuroprotective properties in several pre-clinical rodent models of CNS trauma and disease. Pre-clinical studies also show that short-term minocycline treatment …
Cosmetic Neurology: Enhancement Of The Mind And Attention Deficit Hyperactive Disorder Medication Abuse Among College Students,
2012
Liberty University
Cosmetic Neurology: Enhancement Of The Mind And Attention Deficit Hyperactive Disorder Medication Abuse Among College Students, Mary M. Huff
Senior Honors Theses
Cosmetic neurology is becoming increasingly popular, and it is not just sleep deprived, over worked college students who are interested. People are beginning to seek off-label prescriptions for medications that are typically used to treat disorders such as attention deficit hyperactive disorder (ADHD) or narcolepsy, while researchers are trying to create drugs used solely for mind enhancement purposes. Along with these drugs come many legal and ethical quandaries relating to the regulation of current use as well as the what ifs of future possibilities. A survey was conducted among college students regarding the diagnosis of ADHD, the abuse of ADHD …
Planarians In Pharmacology: Parthenolide Is A Specific Behavioral Antagonist Of Cocaine In The Planarian Girardia Tigrina,
2012
West Chester University of Pennsylvania
Planarians In Pharmacology: Parthenolide Is A Specific Behavioral Antagonist Of Cocaine In The Planarian Girardia Tigrina, Oné R. Pagán, Debra Baker, Sean Deats, Erica Montgomery, Matthew Tenaglia, Clinita Randolph, Dharini Kotturu, Christopher Tallarida, Daniel Bach, Galia Wilk, Scott Rawls, Robert B. Raffa
Biology Faculty Publications
Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic compounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide …
The Cyclin-Like Protein Spy1/Ringo Promotes Mammary Transformation And Is Elevated In Human Breast Cancer,
2012
Al Zyatoona Private University
The Cyclin-Like Protein Spy1/Ringo Promotes Mammary Transformation And Is Elevated In Human Breast Cancer, Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R. Fratiloiu, Bonnie F. Sloane, Lisa A. Porter
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary development and forced overexpression in mammary mouse models accelerates mammary tumorigenesis.
Methods
Using human tissue samples, cell culture models and in vivo analysis we study the implications of Spy1 as a mediator of mammary transformation and breast cancer proliferation.
Results
We demonstrate that this protein can facilitate transformation in a manner dependent upon the activation of the G2/M Cdk, Cdk1, and the subsequent inhibition of the anti-apoptotic regulator FOXO1. …
Analysis Of Gene Expression Alterations In Premalignant Progression From Normal Mammary Epithelium To Ductal Carcinoma In Situ By Multiple Orthogonal Tools,
2012
Wayne State University
Analysis Of Gene Expression Alterations In Premalignant Progression From Normal Mammary Epithelium To Ductal Carcinoma In Situ By Multiple Orthogonal Tools, Hitchintan Kaur
Wayne State University Dissertations
Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine gene expression changes in different DCIS models (MCF10.DCIS, SUM102 and SUM225) in comparison to normal breast epithelial cells (MCF10A) that may enable us to identify novel markers of disease progression and potential therapeutic targets. We cultured the cells in three dimensional reconstituted basement membrane (3D rBM) for RNA extraction and used the …
Xanthones And Biphenyls From Garcinia Schomburgkiana Wood And Their Cytotoxicity,
2012
Chulalongkorn University
Xanthones And Biphenyls From Garcinia Schomburgkiana Wood And Their Cytotoxicity, Chutichot Mungmee, Supotchana Sitthigool, Rutt Suttisri, Anumart Buakeaw
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Purification And Characterization Of Chemical Marker Compound From Azadirachta Indica Var. Siamensis Flowers,
2012
Chulalongkorn University
Purification And Characterization Of Chemical Marker Compound From Azadirachta Indica Var. Siamensis Flowers, Noppunt Prakitboonyarit, Thitima Lhinhatrakool, Prasan Tanguenyongwatana
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Determination Of Some Phenolic Compounds In Ethanolic Extract Of Elephantopus Scaber Linn. Leaves,
2012
Chulalongkorn University
Determination Of Some Phenolic Compounds In Ethanolic Extract Of Elephantopus Scaber Linn. Leaves, Ubon Rerk-Am, Bantika Kongsombat, Sinn Tangsatirapakdee, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Free Radical Scavenging Activity, Total Phenolic And Total Anthocyanin Contents Of Extracts From Mamao (Antidesma Ghaesembilla) Fruits,
2012
Chulalongkorn University
Free Radical Scavenging Activity, Total Phenolic And Total Anthocyanin Contents Of Extracts From Mamao (Antidesma Ghaesembilla) Fruits, Paponpat Worasakungiat, Apirat Jamnonkoon, Wandee Gritsanapan, Pongtio Sithisam
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Anti-Inflammatory Activity Of Fruit Extracts From Phyllanthusemblica And Zanthoxylumlimenella,
2012
Chulalongkorn University
Anti-Inflammatory Activity Of Fruit Extracts From Phyllanthusemblica And Zanthoxylumlimenella, Amonrat Khayungamnawee, Sitthiphong Soradech, Buppachart Potduang, Tuanta Sematong, Sarunya Laovitthayanggoon, Isara Keeta, Cholticha Niwaspragrif, Arkachai Tantrawong
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Topical Anti-Inflammatory Activity Of Saponin Rich Extract From Sapindus Rarak,
2012
Chulalongkorn University
Topical Anti-Inflammatory Activity Of Saponin Rich Extract From Sapindus Rarak, Amomrat Khayungamnawee, Siripen Jarikasem, Tuanta Sematong, Sarunya Laovithayanggoon, Jintara Khapang
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats,
2012
Chulalongkorn University
Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats,
2012
Chulalongkorn University
Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Phanukit Kunhachan, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Cytotoxic Evaluation Of The Powder Of Spinacia Oleracea In Human Liver Hepatocarcinoma Cell Line Using Mtt Assay,
2012
Chulalongkorn University
Cytotoxic Evaluation Of The Powder Of Spinacia Oleracea In Human Liver Hepatocarcinoma Cell Line Using Mtt Assay, Sarunva Laovitthavanggoon, Krittiya Thisayakorn, Pongsathorn Limsiriwong, Sawai Nakakaew, Kanjana Sriyam, Vicheon Kaeynok, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Cytotoxicity Of Gold Nanoparticles In Human Imr-32 Neuroblastoma Cells,
2012
Chulalongkorn University
Cytotoxicity Of Gold Nanoparticles In Human Imr-32 Neuroblastoma Cells, Pokchat Lohaphansomboon, Pithi Chanvorachote, Warangkana Warisnoicharoen
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Biological Activities Of Natural Phellinus Spp. Mushroom In Human Cancer Cells,
2012
Chulalongkorn University
Biological Activities Of Natural Phellinus Spp. Mushroom In Human Cancer Cells, Surapol Natakankitkul, Papawee Suabjakyong, Toshihiko Toida, Kyohei Higashi, Hiromi Sato, Koichi Ueno, Frankie Chan
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antiproliferative Effect Of Licorice Extract On Proliferation Of Keloid Fibroblasts,
2012
Chulalongkorn University
Antiproliferative Effect Of Licorice Extract On Proliferation Of Keloid Fibroblasts, Tanwarat Kaisongkram, Kwanchai Rattanamani, Saranya Laovitthayanggoon, Vilailux Chennangchee, Pongsatom Limsiriwong, Chuleeratana Bangchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Dna Protective Activity Against H2o2 And Uvc Of Momordica Cochinchinensis Fruit Extracts In Human Tk6 Cells,
2012
Chulalongkorn University
Dna Protective Activity Against H2o2 And Uvc Of Momordica Cochinchinensis Fruit Extracts In Human Tk6 Cells, Prapaipat Klungsupya, Janram Saenkhum, Thanchanok Muangman, Ubon Rerk-Am, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwatcharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Reduction Of Radiation-Induced Toxic Effects In Vivo By Apigenin,
2012
Chulalongkorn University
Reduction Of Radiation-Induced Toxic Effects In Vivo By Apigenin, Paiboon Reungpatthanaphong, Montree Tungjai, Louise Honikel, Kanokpom Noy Rithidech
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
The Characterization Of A Novel Bacteriocin With Antimrsa Activity Produced By Bacillus Sp. Strain Wary9-1m,
2012
Chulalongkorn University
The Characterization Of A Novel Bacteriocin With Antimrsa Activity Produced By Bacillus Sp. Strain Wary9-1m, Siripom Kaewklom, Ratchaneewan Aunpad
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
