Pharmacology Commons^™

Effects Of Partner Proteins On Bca2 Ring Ligase Activity, Stephanie Bacopulos, Yutaka Amemiya, Wenyi Yang, Judit Zubovits, Angelika Burger, Martin Yaffe, Arun K. Seth

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2.

Methods

Here, additional BCA2 binding proteins were found using yeast two-hybrid and bacterial-II-hybrid screening techniques with Human breast and HeLa cDNA libraries. Co-expression of these proteins was analyzed through IHC of TMAs. Investigation of the molecular interactions and effects were examined through a series of in vivo and in vitro assays.

Results

Ten unique …

Skin Irritation Study Of Two Patented Mix Extracts From Emblica, Ma-Khwaen And Khanun, Sareeya Reungpatthanaphong, Tuanta Sematong, Buppachart Potduang, Phanukit Kunhachan, Cholticha Niwaspragrit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Moisturizing Gel Formulation Containing Pueraria Mirifica Extracts As An Anti-Wrinkle Agent, Thanachod Thammachat, Sompoch Tubcharoen, Sitthiphong Soradech, Somnuk Promdang

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Valproic Acid-Induced Teratogenesis In Japanese Rice Fish (Oryzias Latipes) Embryogenesis, Mengmeng Wu

Electronic Theses and Dissertations

Valproic acid (VPA) was introduced as an antiepileptic in 1967 in France and it has become the most prescribed anticonvulsive drug therapy worldwide since then. In the clinic, valproic acid is selected to treat absence seizures, myoclonic seizures, generalized tonic-clonic seizures, atonic attacks and partial seizures. Epilepsy is the second most comneurologic disorder that affects pregnant women (0.5%–1%). Approximately 1 out of 250 pregnant women are taking antiepileptic drugs. Valproic acid is designated as a human teratogen, which induces major congenital anomalies, facial dysmorphic features, and autistic-like behaviors, which affect verbal, cognitive, communicative, and social abilities of affected children. We …

Mutation In The Plasmodium Falciparum Crt Protein Determines The Stereospecific Activity Of Antimalarial Cinchona Alkaloids, Carol E. Griffin, Jonathan M. Hoke, Upeka Samarakoon, Junhui Duan, Jianbing Mu, Michael T. Ferdig, David C. Warhurst, Roland A. Cooper

Biological Sciences Faculty Publications

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. They may act by the inhibition of heme crystallization within the parasite digestive vacuole in a manner similar to chloroquine. Earlier studies showed that a K76I mutation in the digestive vacuole-associated protein, PfCRT (P. falciparum chloroquine resistance transporter), reversed the normal potency order of quinine and quinidine toward P. falciparum. To further explore PfCRT-alkaloid interactions in the malaria parasite, we measured the in …

Quercetin And Derivatives As Butyrylcholinesterase Inhibitors, Siriluk Sontadsakul, Anchisa Prakongsantikul, Worawan Kitphati, Jaturong Pratuangdejkul, Veena Nukoolkam

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Biological Activities Of A Patented Mix Extract From Fruits Of Phyllanthus Emblica And Zanthoxylumlimonella, Buppachart Potduang, Bundit Fungsin, Isara Keeta, Natthachest Ketmanee, Anintitha Intharungsri, Sitthiphong Soradech, Cholticha Niwaspragrit, Sayan Tanpanich

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Anti-Periodontal Bacterial Activity Of Oxyresveratrol, Waranvoo Phoolcharoen, Sireerat Sooampon, Boonchoo Sritularak, Kittisak Likhitvitayawuid, Jintakom Kuvatanasuchati, Prasit Pavasant

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Microemulsion Formulation Of Angelica Sinensis Root Extract On Clove Oil /Nonionic Surfactant/ Water Mixture, Pichaya Ukosaramik, Prasan Tangyuenyongwatana, Rathapon Asasutjarit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Xanthones And Biphenyls From Garcinia Schomburgkiana Wood And Their Cytotoxicity, Chutichot Mungmee, Supotchana Sitthigool, Rutt Suttisri, Anumart Buakeaw

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Purification And Characterization Of Chemical Marker Compound From Azadirachta Indica Var. Siamensis Flowers, Noppunt Prakitboonyarit, Thitima Lhinhatrakool, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Determination Of Some Phenolic Compounds In Ethanolic Extract Of Elephantopus Scaber Linn. Leaves, Ubon Rerk-Am, Bantika Kongsombat, Sinn Tangsatirapakdee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Free Radical Scavenging Activity, Total Phenolic And Total Anthocyanin Contents Of Extracts From Mamao (Antidesma Ghaesembilla) Fruits, Paponpat Worasakungiat, Apirat Jamnonkoon, Wandee Gritsanapan, Pongtio Sithisam

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Anti-Inflammatory Activity Of Fruit Extracts From Phyllanthusemblica And Zanthoxylumlimenella, Amonrat Khayungamnawee, Sitthiphong Soradech, Buppachart Potduang, Tuanta Sematong, Sarunya Laovitthayanggoon, Isara Keeta, Cholticha Niwaspragrif, Arkachai Tantrawong

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Topical Anti-Inflammatory Activity Of Saponin Rich Extract From Sapindus Rarak, Amomrat Khayungamnawee, Siripen Jarikasem, Tuanta Sematong, Sarunya Laovithayanggoon, Jintara Khapang

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Phanukit Kunhachan, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cytotoxic Evaluation Of The Powder Of Spinacia Oleracea In Human Liver Hepatocarcinoma Cell Line Using Mtt Assay, Sarunva Laovitthavanggoon, Krittiya Thisayakorn, Pongsathorn Limsiriwong, Sawai Nakakaew, Kanjana Sriyam, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cytotoxicity Of Gold Nanoparticles In Human Imr-32 Neuroblastoma Cells, Pokchat Lohaphansomboon, Pithi Chanvorachote, Warangkana Warisnoicharoen

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Biological Activities Of Natural Phellinus Spp. Mushroom In Human Cancer Cells, Surapol Natakankitkul, Papawee Suabjakyong, Toshihiko Toida, Kyohei Higashi, Hiromi Sato, Koichi Ueno, Frankie Chan

The Thai Journal of Pharmaceutical Sciences

No abstract provided.