Pharmacology Commons^™

Acute Oral Toxicity Test Of Quercusinfectoria G. Olivier Extract In Rats, Tuanta Sematong, Sirinan Thubthimthed, Sareeya Reungpathanapong, Sarunya Laovitthayanggoon, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Synergy Effect Of Ceftazidime With Flavonoids Against Streptococcus Pyogenes, Supatcharee Siriwong, Pongrit Krubphachaya, Kanjana Thumanu, Griangsak Eumkeb

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Effects Of Red Kwao Krue (Butea Superba Roxb.) Extract On Sperm Quality And Testosterone Level In Mice, Griangsak Eumkeb, Wanatkamol Naknarong, Kittipot Sirichaiwetchakoon

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development And Validation Of Rp-Hplc Method For Quantitative Analysis Of Individual Y-Oryzanol In Cold Pressed Rice Bran Oil, Apirak Sakunpak, Jirapornchai Suksaeree, Laksana Charoenchai, Chaowalit Monton, Pathamapom Pathompak, Tossaton Charoonratana, Krisana Kraisintu

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Quantification And Validation Of Gallic Acid Content In Tri-Phala Extract And Effervescent Tablet By Hptlc, Beniapom Chainethvanich., Worawan Saingam, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development And Validation Of Rp-Hplc Method For Determination Of Piperine In Maha-Solos Tablet Formulation, Worawan Saingam, Chaowalit Monton, Jirapornchai Suksaeree, Natawat Chankana, Siriporn Kittiwisut, Laksana Charoenchai

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Shampoo Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limonella For Itchy Scalp, Buppachart Potduang, Itsara Keeta, Suchipha Wannaphatchaiyong, Wanlapha Saisin, Bundit Fungsin

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Jatu-Phalathika Formulation In Effervescent Tablet Dosage Form, Pongsak Awaivawanon, Anchana Sanrungmuang, Worawan Saingam, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Miscibility Study Of Benzocaine And Poly L-Lactide Using Solubility Parameter Calculation And Thermal Analysis, Yada Vattanagiivingyong, Narueporn Sutanthavibul, Jittima Chatchawalsaisin

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Lawsone Methyl Ether Loaded Chitosan-Dextran Sulfate Nanoparticles; Preliminary Study, Pattravee Niamprem, Pharkphoom Panichayupakaranant, Waree Tiyaboonchai

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fabrication And Evaluation Of Clotrimazole-Loaded Pvp/Hppcd Nanofiber Mats For Oral Candidiasis, Prasopchai Tonglairoum, Tanasait Ngawhirunpat, Theerasak Rojanarata, Ruchadaporn Kaomongkolgit, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard

USF Tampa Graduate Theses and Dissertations

Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma (MM) cell lines. Due to the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the parent linear peptide. These efforts led to the development of a cyclized peptidomimetic, MTI-101, with increased in vitro activity and robust in vivo activity as a single agent using two myeloma models that consider the bone marrow microenvironment. MTI-101 treatment resulted in mechanistically similar hallmarks of HYD1 induced cell death, namely the generation of …

Heavy Metal Content In Some Commonly Consumed Vegetables From Kariakoo Market, Dar Es Salaam, Tanzania, Eb Mubofu

Tanzania Journal of Science

This work reports on the levels of cadmium, lead, copper, manganese and zinc in 174 samples from eight varieties of green vegetables (amaranth, Chinese cabbage, cowpea leaves, green pepper, leafy cabbage, lettuce, okra and pumpkin leaf) commonly grown in Dar es Salaam and marketed at Kariakoo, Tanzania. The amount of cadmium and lead ranged between 3-42 and 11-60 μg/kg respectively. The amount of copper, manganese and zinc ranged between 0.35 - 2.12, 1.01 - 7.57, and 1.19 - 6.33 μg/kg respectively. On average consumption pattern, the contribution of these vegetables to the recommended daily intakes (RDI) for cadmium and lead …

Tremulous Jaw Movements Induced By The Vmat2 Inhibitor Tetrabenazine, Samantha J. Podurgiel

Master's Theses

Parkinsonism is a movement disorder characterized by several cardinal motor symptoms: resting tremor, akinesia, bradykinesia, rigidity, and postural instability. Parkinsonian resting tremor can be modeled in rodents using the tremulous jaw movement model. Tremulous jaw movements (TJMs) are defined as “rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus.” TJMs occur in a frequency range of 3-7 Hz and are induced by a number of pharmacological manipulations that parallel those seen in human Parkinsonism including dopamine (DA) depleting agents, DA antagonists, and cholinomimetic administration. Additionally, TJMs can be attenuated using antiparkinsonian …

Characterisation Of Pharmaceutical Grade Horse Chestnut Waste, Joanna Przyborska

Theses

Horse chestnut residue was made available by a local pharmaceutical company. The residue was subjected to compositional analysis and studied to determine potential for residual biological activity, including prebiotic, antimicrobial, anti-hyaluronidase and anti-elastase effects.

The residue had 52 % total solids, including 2.97% ash, 6.93% protein, 1.89% crude fat. Oleic acid (74.7%) was the main fatty acid components in the crude lipid component. The major ash components were potassium, phosphorus, calcium and magnesium.

Prebiotic potential of aqueous extract (HCE) from horse chestnut residue was confirmed. A new formula for calculation of prebiotic index (PI) was developed. PI for probiotics (Lactobacillus …

Cocaine-Induced Reinstatement Of A Conditioned Place Preference In Developing Rats: Involvement Of The D2 Receptor, Kimberly A. Badanich, Cheryl L. Kirstein

Psychology Faculty Publications

Reinstatement of conditioned place preferences have been used to investigate physiological mechanisms mediating drug-seeking behavior in adolescent and adult rodents; however, it is still unclear how psychostimulant exposure during adolescence affects neuron communication and whether these changes would elicit enhanced drug-seeking behavior later in adulthood. The present study determined whether the effects of intra-ventral tegmental area (VTA) or intra-nucleus accumbens septi (NAcc) dopamine (DA) D2 receptor antagonist infusions would block (or potentiate) cocaine-induced reinstatement of conditioned place preferences. Adolescent rats (postnatal day (PND 28–39)) were trained to express a cocaine place preference. The involvement of D2 receptors on cocaine-induced reinstatement …

Anti-Cancer Activity And Mutagenic Potential Of Novel Copper (Ii) Quinolinone Schiff Base Complexes In Hepatocarinoma Cells, Brian Duff, Venkat Reddy Thangella, Bernadette Creaven, Maureen Walsh, Denise Egan

Articles

This study determined the cytotoxic, cyto-selective and mutagenic potential of novel quinolinone Schiff base ligands and their corresponding copper(II) complexes in human-derived hepatic carcinoma cells (Hep-G2) and non-malignant human-derived hepatic cells (Chang). Results indicated that complexation of quinolinone Schiff bases with copper served to significantly enhance cytotoxicity. Here, the complex of (7E)-7-(3-ethoxy-2-hydroxybenzylideamino)-4-methylquinolin-2(1H)-one (TV117-FM) exhibited the lowest IC₅₀ value (17.9 μM) following 96 h continuous exposure, which was comparable to cisplatin (15.0 μM). However, results revealed that TV117-FM lacked cytoselectivity over non-malignant cells. Additionally, the complex was minimally effluxed from cells via Pglycoprotein (P-gp) and was shown to be non-mutagenic …

Physiologically-Based Pharmacokinetic Modeling Of Acetaminophen Metabolism And Toxicity, David M. Ng, Ali Navid

STAR Program Research Presentations

Acetaminophen is a common analgesic and antipyretic. Metabolism of acetaminophen and acetaminophen-induced liver necrosis are predicted using physiologically-based pharmacokinetic (PBPK) modeling. Pharmacokinetic means the model determines where the drug is distributed in the body over time. Physiologically-based means the anatomy and physiology of the human body is reflected in the structure and functioning of the model. Acetaminophen is usually safe and effective when taken as recommended, but consumption at higher levels may lead to liver damage. Additionally, other factors such as alcoholic liver disease, smoking, and malnutrition affect the maximum safe dose of acetaminophen.

Correlation Of In-Vitro Drug Dissolution And In-Vivo Drug Absorption Of Various Therapeutically Equivalent Pharmaceutical Solid Dosage Forms Of Simvastatin, Aphrodite Kotrotsios

PCOM Biomedical Studies Student Scholarship

Simvastatin is a well known anti-cholesterol drug that is commercially available in the United States in various strengths including Simvastatin Tablets, USP 80 mg, that are under the brand name Zocor (manufactured by Merck Pharmaceutical Co.) and various generic equivalent products for example those manufactured by Teva Pharmaceuticals, Inc. and Dr. Reddy’s Laboratories, Ltd. When generic products are tested in the United States, they must be found to be equivalent with their branded products by the FDA. Therefore, generic Simvastatin Tablets, USP 80 mg, have been tested and approved by the FDA as equivalents to, and substitutable with, the branded …

Localization And Expression Of Gfrα2 Receptors In Neonatal And Adolescent Mouse Heart., Bryan Gunter

Undergraduate Honors Theses

Neurturin (NRTN), a member of the glial cell-line derived neurotrophic factor(GDNF) family, is required in the development of parasympathetic cholinergic neurons. It signals through binding to a glycosyl-phophatidyl inositol (GPI)-linked receptor, GDNF family receptor α2 (GFRα2), which couples to Ret tyrosine kinase. Studies of NRTN knockout mice have shown that NRTN is essential for normal cholinergic innervation of the heart, but the precise role of NRTN remains unknown. For NRTN to evoke a biological response, GFRα2 must be localized to the surface of target neurons. The aim of this study was to determine the expression and localization of GFRα2 at …