Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety,
2023
The British University in Egypt
Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer
Pharmacy
Anxiety is one of the most prevalent forms of psychopathology that afects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/beneft ratio resulting in a shift toward active ingredients with better safety profle such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best …
Soil Properties And Potassium Availability In Pullen Farm Murray, Kentucky,
2023
Murray State University
Soil Properties And Potassium Availability In Pullen Farm Murray, Kentucky, Ava Isaacs, Gracey Moffitt, Whitney Sides
Posters-at-the-Capitol
One of the most important factors regarding soil and plant health is nutrient availability and fertility. Of these two factors that were mentioned available potassium is a key component. With that being said we decided that it would be beneficial to see how potassium can be traced within the soil in various locations after fertilizer is applied. There were two parts to this experiment. Part one was taking soil core samples in order to obtain various soil properties such as soil organic matter, soil water holding capacity and bulk density and observe if these properties have any effect on the …
Phase 1a Clinical Study For Q-Griffithsin Intranasal Spray For Prevention Of Coronavirus,
2023
University of Louisville
Phase 1a Clinical Study For Q-Griffithsin Intranasal Spray For Prevention Of Coronavirus, Megan Bezold, Kenneth Palmer, Nobuyuki Matoba, Elizabeth Cash
Posters-at-the-Capitol
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible virus that causes acute respiratory disease with possible long-term complications, known as coronavirus disease 2019 (COVID-19). Griffithsin (GRFT; including the oxidation-resistant variant Q-GRFT used in this study) is an algal carbohydrate-binding protein exhibiting antiviral effects against many enveloped viruses, including all major variants of SARS- CoV-2 reported to date. Q-GRFT has been recombinantly manufactured in Nicotiana benthamiana plants, thoroughly purified, and formulated as an intranasal spray designed to be developed as a non-vaccine broad-spectrum prophylactic product for acute use. This is the first-in-human, randomized, double-blind, placebo-controlled study. The …
Access To And Utilization Of Primary Care: A Synthesis,
2023
Eastern Kentucky University
Access To And Utilization Of Primary Care: A Synthesis, Klaire M. Johnson
Kentucky Journal of Undergraduate Scholarship
Barriers to access and utilization of primary care affect nearly 9% of the nation’s population (USDHHS, n.d.a). These barriers are important to evaluate for members of the aging population due to increased need for health care as a result of chronic conditions and falls. Research indicates that access for the aging population is affected by a variety of factors, including: transportation, non-financial barriers, and internal factors. Issues surrounding current delivery of care, such as a workforce shortage of primary care physicians, have compounded the problem even further. While this issue has begun to be addressed through the Affordable Care Act, …
What Is The Optimal Timing Of Embryo Biopsy For Diagnosing Genetic Abnormalities?,
2023
Touro College and University System
What Is The Optimal Timing Of Embryo Biopsy For Diagnosing Genetic Abnormalities?, Nekhama Riznyk
The Science Journal of the Lander College of Arts and Sciences
Introduction and Purpose: This paper examines current trends in assisted reproductive technology, specifically the use of preimplantation genetic diagnosis (PGD to help in the preimplantation detection of genetic abnormalities such as monogenetic diseases and aneuploidy. PGD can be carried out in different stages, and the timing of the procedure has become one of the major issues in implementation. Three major stages of biopsy have been applied when carrying out PGD: Polar body biopsy (pre-conception), cleavage stage biopsy (3 days after conception), and blastocyst stage biopsy (6 days after conception). The purpose of the paper was to explore these stages and …
Improving The Prediction And Management Of Intrauterine Growth Restriction,
2023
Touro College and University System
Improving The Prediction And Management Of Intrauterine Growth Restriction, Shulamis Sadowsky
The Science Journal of the Lander College of Arts and Sciences
Intrauterine growth restriction (IUGR) is a potentially fatal and often missed obstetric complication. The fetus is deprived of vital blood, oxygen, and nutrients due to faulty maternofetal circulation, leading to a severe lack of fetal growth. Since current prenatal testing is highly ineffective at diagnosing the condition, many babies with IUGR are negatively impacted before, during, and after birth. This paper assesses alternative and innovative detection and management methods of IUGR. Current routine prenatal care includes simple fundal height measurements to screen for IUGR. This analysis finds that other testing may increase the rate of detection of the disease. Maternal …
Is Nanotechnology An Effective Treatment For Diabetic Wounds?,
2023
Touro College and University System
Is Nanotechnology An Effective Treatment For Diabetic Wounds?, Esther Auerbach
The Science Journal of the Lander College of Arts and Sciences
Diabetes Mellitus is increasingly impacting millions of adults worldwide. Multiple complications are associated with the disease, including non-healing chronic wounds. Treatment of diabetic wounds and foot ulcers is a complex challenge, as standard treatment options are ineffective. This review focuses on the use of nanotechnology as a treatment option. Nanomaterials include inorganic and organic nanoparticles as well as nanofilms and fibers. Analysis of the benefits of these nanoparticles will be discussed which include their antimicrobial, anti-inflammatory, antioxidant, and wound healing capabilities. A critical overview of the possible bene- fits will be assessed from in vitro and in vivo studies. Overall, …
Can Physicians Transfer Bacteria Onto Patients Through Their Neckties?,
2023
Touro College and University System
Can Physicians Transfer Bacteria Onto Patients Through Their Neckties?, Alexandra Pinkhas
The Science Journal of the Lander College of Arts and Sciences
Hospital-acquired infections are exacerbated by the presence of transmission agents such as bacteria on neckties. Physicians can put patients at risk of infections if bacteria contaminate their ties during their normal hospital routines. In the hospital setting, some of the most common bacteria include Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus, Streptococcus pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridioides difficile. Studies have shown that neckties can act as transmission agents, especially when they come into contact with patients. Additionally, the type of material used to make a necktie determines the viability of bacteria. Wearing neckties increases risk for …
Intraoral Appliance Therapy - A Better Alternative For Apnea Than Cpap?,
2023
Touro College and University System
Intraoral Appliance Therapy - A Better Alternative For Apnea Than Cpap?, Bryan Teigman
The Science Journal of the Lander College of Arts and Sciences
Obstructive sleep apnea (OSA) is a condition where there is a physiologic hindrance of airflow to the lungs, triggering the brain to interfere with the sleep cycle and awaken an individual to provide sufficient oxygen flow. For years, the continuous positive airway pressure (CPAP) machine has been the gold standard of care for patients suffering from OSA. Nonetheless, the machine has its flaws of being bulky, noisy, and other side effects, causing a low adherence rate and thus a lower relief rate of OSA symptoms. Accordingly, there have been many researchers seeking a more effective way to treat OSA, such …
Is Intermittent Fasting A Better Option Than Continuous Calorie Restriction?,
2023
Touro College and University System
Is Intermittent Fasting A Better Option Than Continuous Calorie Restriction?, Joseph J Cynamon
The Science Journal of the Lander College of Arts and Sciences
Intermittent fasting has become an increasingly popular diet for weight loss in the United States in the past ten years. Proponents of intermittent fasting claim that restricting calories via a fasting period yields more significant weight loss and better improvements in biomarkers for longevity than restricting calories continuously. The goal of this paper is to determine whether intermittent fasting leads to weight loss and is more beneficial than continuous calorie restriction. The paper first details the physiological processes which can occur during fasting that are theorized to render fasting advantageous. It then reviews the limited available research that experimentally compares …
How Can We Eliminate Peanut Allergies?,
2023
Touro College and University System
How Can We Eliminate Peanut Allergies?, Ari Weingarten
The Science Journal of the Lander College of Arts and Sciences
For a long time, people with peanut allergies have had to carefully read labels, carry around emergency epinephrine injections, and live in fear of accidentally consuming an otherwise benign food that could potentially kill them. Thankfully, researchers have been working on ways to alleviate the harmful effects of these allergies and perhaps even find a cure. In the Learning Early About Peanut allergy (LEAP) study performed in 2015, researchers examined whether the early introduction of peanut consumption could be used to prevent peanut allergies. According to the study, peanuts can be introduced orally to high-risk infants who are sensitized, as …
Singer’S Voice Quality - Genetic Or Environmental Influences?,
2023
Touro College and University System
Singer’S Voice Quality - Genetic Or Environmental Influences?, Dobra Baum
The Science Journal of the Lander College of Arts and Sciences
This paper explores the singing voice in terms of the vocal mechanism’s key anatomical features and the physiology of the vocal function. It focuses on phonation and resonation and examines the anatomy and physiology of the vocal tract and the respiratory system. The aim is to determine whether the singer’s voice is only the product of genetics or due to environmental influences. It conducts a procedure to evaluate how singers use their voices to modify breathing, pitch, volume, and timbre through resonance shaping. It also investigates the hereditary transmission of a good singing voice, on chromosome 12q, between relatives, and …
Full Issue: Volume 16, Number 2, Spring 2023,
2023
Touro College and University System
Full Issue: Volume 16, Number 2, Spring 2023
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 16, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2023.
Rheumatoid Arthritis: Traditional Drugs Vs. Alternative Medicine,
2023
Touro College and University System
Rheumatoid Arthritis: Traditional Drugs Vs. Alternative Medicine, Menachem Rubenstein
The Science Journal of the Lander College of Arts and Sciences
Rheumatoid arthritis is a systemic autoimmune disease which is inflammatory and chronic. This disease affects the joint linings of those with this condition, which causes painful swelling. Complications of this disease can cause problems in the patients’ eyes, skin, heart, lungs, and other organs. Being that there is no cure for Rheumatoid Arthritis, different treatment approaches are aimed to reduce the current pain and to slow further damage. In this paper, we will present a summary of past and present treatments to address the best possible treatment options for Rheumatoid arthritis. We will place an added emphasis on the use …
Alcohol Consumption And Its Effects On The Liver,
2023
Touro College and University System
Alcohol Consumption And Its Effects On The Liver, Eveline Weinreb
The Science Journal of the Lander College of Arts and Sciences
Thousands of people die each year in the United States from alcohol related deaths. Why does the metabolism of alcohol cause severe damage to the body? Ethanol enters the body in the form of wine, and other alcoholic beverages and travels through the digestive system and then to the liver where it is metabolized. There are a series of steps involved in the breakdown of ethanol, and toxic byproducts are formed such as reactive oxygen species (ROS). These oxygen radicals can lead to damaged deoxyribonucleic acid (DNA) and to the formation of adducts. Chronic alcohol consumption can lead to liver …
Overexpression Of Abcc1 And Abcg2 Confers Resistance To Bmn-673, A Poly (Adp-Ribose) Polymerase (Parp) Inhibitors,
2023
Saint John's University, Jamaica New York
Overexpression Of Abcc1 And Abcg2 Confers Resistance To Bmn-673, A Poly (Adp-Ribose) Polymerase (Parp) Inhibitors, Qiuxu Teng
Theses and Dissertations
Cancer remains a growing public health challenge worldwide. Although the development of chemotherapies has effectively reduced the cancer death rate and improved patients’ prognosis, the frequent occurrence of multi-drug resistance (MDR) in cancer has caused impairments on the efficacy of many structure-unrelated anticancer agents, leading to treatment failure and recurrence. One of the most common causes of MDR is the overexpression of ATP-binding cassette (ABC) transporters on cancer cell membranes, which transport anticancer drugs out of cancer cells, thereby reducing the intracellular drug concentration. BMN-673 (talazoparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor that is approved for BRCA-mutated HER2-negative …
Mancozeb Exposure Results In Oxidative Stress And Disruption Of Mitochondrial Complexes Iii & Iv In Transformed Human Colon Cells,
2023
Saint John's University, Jamaica New York
Mancozeb Exposure Results In Oxidative Stress And Disruption Of Mitochondrial Complexes Iii & Iv In Transformed Human Colon Cells, Amanda Dhaneshwar
Theses and Dissertations
The ethylene bisdithiocarbamate pesticides, a subclass of the dithiocarbamate pesticides, are broad spectrum organometallic fungicides used on a variety of crops. The fungicide Mancozeb is comprised of an ethylene bisdithiocarbamate backbone complexed to the metals manganese and zinc. Ingestion of food containing pesticide residue and occupational exposure are common routes of Mancozeb exposure. Previous work demonstrated that Mancozeb exposure to HT-29 colon cancer cells resulted in cytotoxicity, apoptosis, and disruption of mitochondrial complex I, II, and V activity. The current study investigated the effect of Mancozeb exposure on mitochondrial complex III and IV activity and oxidative stress parameters in the …
Cytotoxicity Of Copper (Ii) Octanoate On Mouse Hippocampal Astrocytes,
2023
Saint John's University, Jamaica New York
Cytotoxicity Of Copper (Ii) Octanoate On Mouse Hippocampal Astrocytes, Ali A. Shohatee
Theses and Dissertations
Copper, as an essential trace element, is crucial for various biological processes but has also been utilized as a constituent of various pesticides for decades. Copper (II) octanoate is a pesticide utilized as a fungicide and is approved for use in the production of certified organic foods. Previous studies have implicated copper as an inducer of oxidative stress and activator of the Nrf2-ARE pathway. Nrf2 is essential in regulating the transcription of various genes to alleviate toxicity such as those involved in glutathione synthesis and detoxification. Due to the limited toxicological data, this study into the potential induction of oxidative …
Growth And Survival Of Amphibians Exposed To Road Salt And Glyphosate-Based Herbicide,
2023
Western Kentucky University
Growth And Survival Of Amphibians Exposed To Road Salt And Glyphosate-Based Herbicide, Jerica Eaton
Mahurin Honors College Capstone Experience/Thesis Projects
Amphibian populations are threatened by increasing levels of environmental pollution resulting from human activities. Areas with mixed land use that include agriculture and urban development experience increased contamination from surface herbicide and road deicer application. Upon entering water sources, these chemicals have the capacity to disrupt the natural dynamics of aquatic ecosystems. This study aimed to evaluate the effects of these contaminants on amphibian populations. I used the spotted salamander (Ambystoma maculatum) as a model, rearing larvae from hatching to metamorphosis. I subjected larvae in each of the treatment groups to varying levels of herbicide and salt concentrations. …
Sanfilippo Syndrome: Symptoms, Therapies And The Search For A Cure,
2023
Touro College and University System
Sanfilippo Syndrome: Symptoms, Therapies And The Search For A Cure, Elisheva Garfinkel
The Science Journal of the Lander College of Arts and Sciences
Sanfilippo syndrome, also named Mucopolysaccharidosis III (MPS) is an uncommon disorder that develops due to abnormalities in the nervous system and brain. Aspects of this condition include losing motor and mental function beginning at just a few months old. Four different proteins are involved in the breakdown of Heparin Sulfate (HS) in the extracellular matrix. “When one of these proteins is missing or inadequate, Mucopolysaccharidosis III (MPS), can result (“Sanfilippo Syndrome”, 2019) The specific protein that is insufficient will determine which of the four corresponding forms of Sanfilippo syndrome is present. “All variations of Sanfilippo Syndrome are easily identified by …
