Effect Of Lifestyle-Based Lipid Lowering Interventions On The Relationship Between Circulating Levels Of Per-And Polyfluoroalkyl Substances And Serum Cholesterol,
2023
Wayne State University
Effect Of Lifestyle-Based Lipid Lowering Interventions On The Relationship Between Circulating Levels Of Per-And Polyfluoroalkyl Substances And Serum Cholesterol, Stephanie Morgan, M. Abdul Mottaleb, Maria P. Kraemer, Debra K. Moser, Jessica Worley, Andrew J. Morris, Michael C. Petriello
UK CARES Faculty Publications
Exposure to certain per-and polyfluoroalkyl substances (PFAS) has been shown to be positively associated with total and/or low-density lipoprotein cholesterol. Examining this association in lipid lowering interventions may provide additional evidence linking PFAS to cardiovascular risk. We examined the relationship of 6 PFAS with cholesterol in a 6-month lifestyle-based intervention. We quantitated PFAS in 350 individuals at baseline and post intervention and examined associations of PFAS with cholesterol before and after intervention. Food frequency questionnaires and GIS analyses were used to investigate PFAS hotspots and possible exposure routes. Cholesterol significantly decreased following intervention and in parallel, PFOS, PFOA, PFHxS, and …
Effects Of Occupationally Military-Relevant Particle Mixtures (Sio2, Cdo, Cr2O3) On A549 Human Pulmonary Epithelial Cells,
2023
Air Force Institute of Technology
Effects Of Occupationally Military-Relevant Particle Mixtures (Sio2, Cdo, Cr2O3) On A549 Human Pulmonary Epithelial Cells, Isabella M. Muffoletto
Theses and Dissertations
In the course of maintaining a safe, mission-ready aircraft fleet and operational runways, United States Airmen experience a range of occupational risks. These risks include inhalable hazards generated from oft-used maintenance practices, such as blasting which emits silica from the media abrasives as well as contaminants from the exterior coatings. Additional inhalation hazards range from engine and fuel emissions, chemical agents, radiation, and explosives, to naturally occurring and human-manufactured biopathogens. Of notable concern are emissions in forward-deployment areas, including urban pollution, particulates released from runway construction and maintenance activities, and combustion from burn pits containing hazardous and unknown combinations of …
Holistic Framework To Contextualize Dietary Quality Assessment: A Critical Review,
2023
Kansas State University
Holistic Framework To Contextualize Dietary Quality Assessment: A Critical Review, Jessica M. Phelan, Richard R. Rosenkranz, Connor J. Phelan, Sara K. Rosenkranz
Kinesiology and Nutrition Sciences Faculty Research
Numerous dietary quality indices exist to help quantify overall dietary intake and behaviors associated with positive health outcomes. Most indices focus solely on biomedical factors and nutrient or food intake, and exclude the influence of important social and environmental factors associated with dietary intake. Using the Diet Quality Index- International as one sample index to illustrate our proposed holistic conceptual framework, this critical review seeks to elucidate potential adaptations to dietary quality assessment by considering—in parallel—biomedical, environmental, and social factors. Considering these factors would add context to dietary quality assessment, influencing post-assessment recommendations for use across various populations and circumstances. …
Prevention Of Doxorubicin-Induced Cardiotoxicity By A Coumestan Analogue, Psoralidin,
2023
Noorda College of Osteopathic Medicine
Prevention Of Doxorubicin-Induced Cardiotoxicity By A Coumestan Analogue, Psoralidin, Mujtaba H. Shah, Myia Aiges, Kota V. Ramana
Annual Research Symposium
Natural phenolic compound Psoralidin limits cardiotoxicity associated with Doxorubicin
Development Of A Method For Identifying And Quantifying Epicatechin In Cinnamon Extract Supplement Capsules,
2023
Roseman University of Health Sciences
Development Of A Method For Identifying And Quantifying Epicatechin In Cinnamon Extract Supplement Capsules, Danielle Valls
Annual Research Symposium
No abstract provided.
Development Of An Lcms Method To Detect And Quantify Curcumin In A Novel Oral Formulation Of Turmeric,
2023
Roseman University of Health Sciences
Development Of An Lcms Method To Detect And Quantify Curcumin In A Novel Oral Formulation Of Turmeric, Brandon Renninger
Annual Research Symposium
No abstract provided.
Effects Of B4galnt1 Expression On Metastatic Phenotype And Response To Treatment In Osteosarcoma Cell Lines,
2023
Roseman University of Health Sciences
Effects Of B4galnt1 Expression On Metastatic Phenotype And Response To Treatment In Osteosarcoma Cell Lines, Fatemeh Zareihajiabadi
Annual Research Symposium
No abstract provided.
A Review On The Impact Of Cannabis In Society And The Analytical Methodologies For Cannabinoids,
2023
Lipscomb University
A Review On The Impact Of Cannabis In Society And The Analytical Methodologies For Cannabinoids, Matt J. Vergne, Lindsey K. Reynolds, Alexus Brown, Grayson Pullias, Anna Froemming
Faculty Works
The use of plant-based medicine dates back centuries, and cannabis (Cannabis sativa) is one such plant that has been used medicinally and illicitly. Although cannabis contains hundreds of cannabinoids and other natural products, its potential medicinal use was largely ignored by modern researchers due to the legal restrictions and heavy regulations introduced in the 1930s. As restrictions on cannabis access have eased since the 1990s there is renewed interest in the research of cannabinoids and the other components in the cannabis plant. The focus of this review article is an overview of cannabis and the analytical challenges in the quality …
Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury,
2023
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt
Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury, Ahmed F. Mohamed, Helmy M. Sayed, Hala F. Zaki, Marwa M. Safar
Bulletin of Faculty of Pharmacy Cairo University
Cilostazol was investigated as a protective agent against lipopolysaccharide (LPS)-associated acute kidney damage in mice. Cilostazol (50 mg/kg/day; p.o) administered for 7 consecutive days before a single LPS dose (2 mg/kg; i.p) hampered serum creatinine and cystatin C as well as renal KIM-1 and NGAL, repressed TLR4 and MYD88 transcription as well as NF-κB p65, IL-1β and MDA content, boosted Nrf-2 mRNA expression, HO-1 activity and GSH content. This was synchronous with an upregulation of p-PI3K and p-Akt expressions. Collectively, cilostazol prevented LPS renal injury which might correspond to modulation of TLR4/NF-κB, Nrf2/HO-1 and PI3K/Akt pathways.
Comparing The Toxicant Responses And Culturing Characteristics Of Long-Term Laboratory-Reared And Field Populations Of Ceriodaphnia Dubia,
2023
Arkansas State University
Comparing The Toxicant Responses And Culturing Characteristics Of Long-Term Laboratory-Reared And Field Populations Of Ceriodaphnia Dubia, Victoria Rose Lydy
Student Theses and Dissertations
Ceriodaphnia dubia is an EPA-recommended organism used in regulatory toxicity testing of surface waters and commercial chemicals. They are often cultured for extended periods in the laboratory with little knowledge of how it impacts subsequent generations. This thesis investigated if C. dubia cultured for an extended period were representative of three recently-collected field populations by comparing their culturing characteristics and sensitivities to toxicants. Comparative chronic toxicity tests with sodium chloride, the neonicotinoid insecticide thiamethoxam, and mixtures of the two toxicants measured differences in sensitivities among the laboratory and field cultures, specifically in the variability of responses. For culturing characteristics, the …
Tris(1,3-Dichloro-2-Propyl) Phosphate Is A Metabolism-Disrupting Chemical In Male Mice,
2023
University of Kentucky
Tris(1,3-Dichloro-2-Propyl) Phosphate Is A Metabolism-Disrupting Chemical In Male Mice, Sara Y. Ngo Tenlep, Megan L. Weaver, Jianzhong Chen, Olga A. Vsevolozhskaya, Andrew J. Morris, Cetewayo S. Rashid
Pharmacology and Nutritional Sciences Faculty Publications
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant. The primary TDCPP metabolite, bis(1,3-dichloro-2-propyl) phosphate (BDCPP), is detectable in the urine of over 90 % of Americans. Epidemiological studies show sex-specific associations between urinary BDCPP levels and metabolic syndrome, which is an established risk factor for type 2 diabetes, heart disease, and stroke. We used a mouse model to determine whether TDCPP exposure disrupts glucose homeostasis. Six-week old male and female C57BL/6J mice were given ad libitum access to diets containing vehicle (0.1 % DMSO) and TDCPP resulting in the following treatment groups: 0 mg/kg/day, 0.02 mg/kg/day, 1 mg/kg/day, or 100 …
Leveraging Bio-Inspired Molecules For Cancer Theranostics,
2023
CUNY Graduate Center
Leveraging Bio-Inspired Molecules For Cancer Theranostics, Douglas S. Macpherson
Dissertations, Theses, and Capstone Projects
A variety of molecules can be radiolabeled and delivered to a cancer site for the purposes of diagnostics and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the properties of those cells. Matrix metalloproteinase (MMP) enzymes are over-expressed by some metastatic cancers, in which they are responsible for the degradation and remodeling of the extracellular matrix. In recent years, MMPs have emerged as promising targets for enzyme-responsive diagnostic probes because oligopeptides can be designed to be selectively hydrolyzed …
Landscape And Site Factors Drive Invasive Phragmites Management And Native Plant Recovery Across Chesapeake Bay Wetlands,
2023
Utah State University
Landscape And Site Factors Drive Invasive Phragmites Management And Native Plant Recovery Across Chesapeake Bay Wetlands, Christine B. Rohal, Eric L. G. Hazelton, Eliza K. Mcfarland, Rebekah Downard, Melissa K. Mccormick, Dennis F. Whigham, Karin M. Kettenring
Watershed Sciences Student Research
Successful invasive plant management—where invaders are sufficiently reduced and diverse native plant communities recover—remains an elusive goal for land managers. The site- and landscape-scale drivers of variable management outcomes and vegetation recovery are poorly understood due to a lack of rigorous experiments that characterize longer term vegetation trends across contexts. We present the results of a five-year experiment across eight subestuaries of Chesapeake Bay, representing a gradient of watersheds with differing dominant land-use types and anthropogenic impacts, to evaluate invasive and native plant response to herbicide management. The focal invader, Phragmites australis (common reed), is one of the most aggressive …
Exploring Gaps In City Climate Planning In The Mountain West,
2023
University of Nevada, Las Vegas
Exploring Gaps In City Climate Planning In The Mountain West, Joshua Padilla, Caitlin J. Saladino, William E. Brown Jr.
Environment
This fact sheet explores data from the 2022 Brookings Institution report by Joseph W. Kane, Adie Tomer, Caroline George, and Jamal Russell Black called “Not according to plan: Exploring gaps in city climate planning and the need for regional action." The original report analyzes decarbonization plans for 50 of the largest U.S. cities and comparatively ranks each plan using a point system of 5 categories. This fact sheet focuses on Mountain West cities (Denver, CO; Phoenix, AZ; Las Vegas, NV; Salt Lake, UT; and Albuquerque, NM) included in the original study.
Bazedoxifene,
2023
University of Texas at Dallas
Romosozumab,
2023
Nova Southeastern University
Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo
HPD Articles
No abstract provided.
Abaloparatide,
2023
Nova Southeastern University
The Effects Of Salinity And Acetaminophen On The Aquatic Snail Physa Acuta,
2023
North Carolina Wesleyan University
The Effects Of Salinity And Acetaminophen On The Aquatic Snail Physa Acuta, Michelle Sackey-Ansah, Megan Mackey, Daniel Elias, Jason Doll, Alyssa Brookhart
Journal of the South Carolina Academy of Science
Pharmaceuticals are increasingly detected in water bodies, and their presence can negatively impact aquatic organisms. This effect can be amplified when combined with increasing salinity in freshwater ecosystems. Acetaminophen is a widely used analgesic that is commonly found in river, streams, and waters where it is discharged directly. Therefore, organisms present in these locations (e.g., insects, snails, amphibians, and fish) are likely to be affected by acetaminophen. In this study, we determined the effects of elevated salinity (0.68 g/L), acetaminophen (500 µg/L) and combined elevated salinity (0.68 g/L) and acetaminophen (500 µg/L), on the growth, reproduction, and movement of the …
Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus,
2023
University of Southern Mississippi
Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Amber M. Paul, Haiyan Sun, Dhiraj Acharya, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen
Publications
West Nile virus (WNV) causes annual outbreaks globally and is the leading cause of mosquito-borne disease in Unite States. In the absence of licensed therapeutics, there is an urgent need to develop effective and safe human vaccines against WNV. One of the major safety concerns for WNV vaccine development is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of infection (ADE). Herein, we report the development of a plant-based vaccine candidate that provides protective immunity against a lethal WNV challenge mice, while minimizes the risk of ADE for infection by Zika (ZIKV) and dengue …
Characterization Of Antiviral Immunity, Host Virus Interactions, And Toxicity Of Agrochemical Residues In The Western Honey Bee,
2023
Louisiana State University and Agricultural and Mechanical College
Characterization Of Antiviral Immunity, Host Virus Interactions, And Toxicity Of Agrochemical Residues In The Western Honey Bee, Christopher Fellows
LSU Doctoral Dissertations
Honey bee colonies have perished at an alarming rate for over 15 years. Among the multitude of threats to bee health, virus infections and agrochemical exposure appear to be major drivers of colony loss. As virus infection is among the most damaging influences on bee health, we first investigated a putative target for antiviral immunity, termed KATP channels. We previously demonstrated that pharmacologically activating KATP channels induces the production of reactive oxygen species and increases survival during infection with Israeli Acute Paralysis Virus. Here, we demonstrate that KATP modulation and ROS induction reduce virus replication and enhance …
