Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”,
2020
Taiwan Food and Drug Administration
Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”,
2020
Taiwan Food and Drug Administration
Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”,
2020
Taiwan Food and Drug Administration
Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”,
2020
Taiwan Food and Drug Administration
Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions,
2020
Chung-Shan Medical University Hospital, Taiwan
Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang
Journal of Food and Drug Analysis
Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were …
Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin,
2020
Konkuk University, Seoul, Republic of Korea
Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin
Journal of Food and Drug Analysis
Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in …
Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil,
2020
Alexandria University, Egypt
Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil, Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout, Hala M. Hammoda, Aly M. Metwally
Journal of Food and Drug Analysis
Hyperthyroidism is a common endocrine disorder associated with increased risk of cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved as first line option for many hyperthyroidism cases, including pregnancy and childhood, they exert significant toxic profile. Medicago sativa L. (alfalfa) also called “The father of all food” was among the diet consumed by mares that gave birth to foals with congenital hypothyroidism. Since, greenfeed was accused for the development of such condition, alfalfa may possess constituents with promising antithyroid potential that could be a valuable substitute for the conventional ATDs. The current work was designed to identify the …
Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis,
2020
Zhejiang University, China
Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis, Shuai Luo, Yanfei He, Hongxiang Sun
Journal of Food and Drug Analysis
Platycodin D (PD) has been used as the quality control marker of Radix Platycodonis for its high content and various pharmacological properties. In this study, a specific polyclonal antibody against PD (PD–pAb) was developed, and PD–pAb-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was established for the detection of PD in Radix Platycodonis. The 50% inhibition concentration (IC50) of PD was 2.70 μg/mL and the linearity range for PD was from 0.064 μg/mL to 100 μg/mL. No cross reactivity with PD–pAb was found in five PD analogs except for PD2 (0.93%). The average recovery of PD by icELISA was …
Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry,
2020
National Taiwan Normal University, Taipei, Taiwan
Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry, Wan-Rou Liao, Jen-Pang Huang, Sung-Fang Chen
Journal of Food and Drug Analysis
Nucleotides are composed of nitrogen bases, ribose units and phosphate groups. Adenine (Ade), adenosine monophosphate (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP) all play important roles in physiological metabolism. Royal jelly, a secretion produced by worker bees, contains a variety of natural ingredients and several studies have shown that royal jelly can serve as a source of nutrition for humans. In this study, a rapid and effective LC/MS method coupled with pre-processing methods was developed and validated for the accurate quantification of Ade, AMP, ADP and ATP in royal jelly. To achieve the best extraction efficiency, two pretreatment methods, …
Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission,
2020
Memorial University of Newfoundland, Canada
Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission, Priyatharini Ambigaipalan, Won Young Oh, Fereidoon Shahidi
Journal of Food and Drug Analysis
Tea epigallocatechin (EGC) was acylated with selected fatty acids, namely propionic acid [C3:0], caprylic acid [C8:0], lauric acid [C12:0], stearic acid [C18:0] and docosahexaenoic acid (DHA; C22:6 n-3). Antioxidant activity of EGC and its lipophilized derivatives were examined in various food (β-carotene–linoleate oil-in-water emulsion and bulk oil) and biological (supercoiled DNA and LDL) systems in vitro in order to evaluate the effect of increased lipophilicity on their antioxidant capacity. Lipophilized EGC derivatives were more effective in β-carotene–linoleate oil-in-water emulsion and bulk oil than their parent EGC molecule. Meanwhile, EGC and its derivatives showed more than 60 …
Next Generation Aryl Hydantoins As Antischistosomal Agents,
2020
University of Nebraska Medical Center
Next Generation Aryl Hydantoins As Antischistosomal Agents, Derek A. Leas
Theses & Dissertations
Schistosomiasis, also known as “snail fever,” is both an acute and chronic disease spread by trematode flukes from the tropical parasitic worm genus Schistosoma. The flukes are spread via diseased freshwater snails, which release the parasites into the water column where they find a new human host. According to the World Health Organization (WHO), 99 million people were treated for schistosomiasis in 2017. The primary treatment used to combat schistosomiasis is the drug praziquantel (PZQ), but due to high drug pressure and widespread administration, its effectiveness has eroded because of rising drug resistance. Furthermore, PZQ is active against adult but …
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria,
2020
Duquesne University
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon
Electronic Theses and Dissertations
This thesis describes the isolation, structure elucidation, and synthesis of natural products from marine cyanobacteria. A crude extract from a cyanobacterium collected in Curacao showed selective affinity for the dopamine D5 receptor in a screen against a panel of CNS receptors. Due to the high similarity of the D5 and D1 receptor, to date there are no known ligands that differentiate them. Attempts to purify the compound responsible for this affinity led to the isolation of the known compound caylobolide A. A second extract from a cyanobacterium collected in Panama underwent bioassay-guided fractionation and yielded the novel …
The Use Of Ultra-High Pressure Liquid Chromatography In High-Throughput Pharmaceutical Separations,
2020
Rowan University
The Use Of Ultra-High Pressure Liquid Chromatography In High-Throughput Pharmaceutical Separations, Glenn Anthony Kresge
Theses and Dissertations
The higher pressures and flow rates needed to increase throughput in ultra-high pressure liquid chromatography (UHPLC) can lead to thermal broadening due to viscous friction. The use of superficially porous particles and still-air thermal environments can help reduce this broadening, which is especially important in applications requiring high-throughput, isocratic separations, such as monograph methods for over-the-counter analgesics. In the first experiment discussed below, system suitability parameters (resolution and peak asymmetry) and temperature changes across the axial length of the column were monitored at conditions near column or system pressure limits. Results from this investigation indicated that shorter columns packed with …
Introduction To Dr. Jerzy Leszczynski,
2020
Taiwan Food and Drug Administration
Introduction To Dr. Jerzy Leszczynski, P. Fu
Journal of Food and Drug Analysis
[No abstract available]
Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats,
2020
Taiwan Food and Drug Administration
Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats, K.-N. Chen, W.-H. Peng, C.-W. Hou, C.-Y. Chen, H.-H. Chen, C.-H. Kuo, M. Korivi
Journal of Food and Drug Analysis
From ancient times, Dǎngshēn (Codonopsis javanica) has been used in Chinese traditional medicine. In this study we investigated the anti-hyperinsulinemia and antioxidant properties of C. javanica root extracts in a rat model of insulin resistance (IR), induced by chronic fructose feeding. Twenty-four Sprague–Dawley rats were randomized into control, fructose-treated (10%, w/v), and fructose then C. javanica (Fru + Cod)-treated groups. After 8 weeks fructose feeding, increased fasting serum insulin levels (2.6 ± 0.45 μg/L) and insulin area under the curve confirmed the IR (p < 0.001). However, C. javanica treatment to fructose-fed rats significantly attenuated the hyperinsulinemia with correspondingly improved glucose tolerance. Weight gain in Fru + Cod group was comparably (p < 0.01) lower than in the fructose-fed group. Furthermore, IR-induced increased hepatic lipid peroxidation, as demonstrated by elevated malondialdehyde levels, were significantly (p < 0.001) alleviated by C. javanica treatment. These findings reveal that chronic fructose intake may facilitate IR and oxidative damage, which could be eradicated by improved antioxidant status. Accordingly, we found that C. javanica treatment significantly improved the antioxidant enzyme activities, including superoxide dismutase, glutathione peroxidase and glutathione reductase in the liver. These findings that fructose-induced hyperinsulinemia and associated oxidative stress could be attenuated by C. javanica root extracts. © 2013
Evaluating The Urate-Lowering Effects Of Different Microbial Fermented Extracts In Hyperuricemic Models Accompanied With A Safety Study,
2020
Taiwan Food and Drug Administration
Evaluating The Urate-Lowering Effects Of Different Microbial Fermented Extracts In Hyperuricemic Models Accompanied With A Safety Study, R.-J. Chen, M.-H. Chen, Y.-L. Chen, C.-M. Hsiao, H.-M. Chen, S.-J. Chen, M.-D. Wu, Y.-J. Yech, G.-F. Yuan, Y.-J. Wang
Journal of Food and Drug Analysis
Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders. XOD inhibitors or uricase (catalyzes UA to the more soluble end product) can prevent these chronic diseases. However, currently available hypouricemic agents induce severe side effects. Therefore, we developed new microbial fermented extracts (MFEs) with substantial XOD inhibition activity from Lactobacillus (MFE-21) and Acetobacter (MFE-25), and MFE-120 with high uricase activity from Aspergillus. The urate-lowering effects and safety of these MFEs were evaluated. …
Lactobacillus Pentosus Gmnl-77 Inhibits Skin Lesions In Imiquimod-Induced Psoriasis-Like Mice,
2020
Taiwan Food and Drug Administration
Lactobacillus Pentosus Gmnl-77 Inhibits Skin Lesions In Imiquimod-Induced Psoriasis-Like Mice, Y.-H. Chen, C.-S. Wu, Y.-H. Chao, C.-C. Lin, H.-Y. Tsai, Y.-R. Li, Y.-Z. Chen, W.-H. Tsai, Y.-K. Chen
Journal of Food and Drug Analysis
Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L. pentosus GMNL-77 significantly decreased the mRNA levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and the IL-23/IL-17A axis-associated cytokines (IL-23, IL-17A/F, and IL-22) in the skin of …
Long-Term Feeding Of Red Algae (Gelidium Amansii) Ameliorates Glucose And Lipid Metabolism In A High Fructose Diet-Impaired Glucose Tolerance Rat Model,
2020
Taiwan Food and Drug Administration
Long-Term Feeding Of Red Algae (Gelidium Amansii) Ameliorates Glucose And Lipid Metabolism In A High Fructose Diet-Impaired Glucose Tolerance Rat Model, H.-C. Liu, C.-J. Chang, T.-H. Yang, M.-T. Chiang
Journal of Food and Drug Analysis
This study was designed to investigate the effect of Gelidium amansii (GA) on carbohydrate and lipid metabolism in rats with high fructose (HF) diet (57.1% w/w). Five-week-old male Sprague-Dawley rats were fed a HF diet to induce glucose intolerance and hyperlipidemia. The experiment was divided into three groups: (1) control diet group (Con); (2) HF diet group (HF); and (3) HF with GA diet group (HF + 5% GA). The rats were fed the experimental diets and drinking water ad libitum for 23 weeks. The results showed that GA significantly decreased retroperitoneal fat mass weight of HF diet-fed rats. Supplementation …
Determination Of Urea In Milk Based On N-Bromosuccinimide–Dichlorofluorescein Postchemiluminescence Method,
2020
Taiwan Food and Drug Administration
Determination Of Urea In Milk Based On N-Bromosuccinimide–Dichlorofluorescein Postchemiluminescence Method, F. Nie, N. Wang, P. Xu, J. Zheng
Journal of Food and Drug Analysis
A new postchemiluminescence (PCL) reaction was observed when urea was injected into the reaction mixture after the CL reaction of N-bromosuccinimide and dichlorofluorescein. A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics, CL spectra, fluorescence spectra, and other experiments. A new flow injection CL method for the determination of urea was established based on the PCL reaction. The relative standard deviation for the determination of urea was 1.3% (n = 11, c = 5.0 × 10−8 g/mL). The CL intensity responded linearly to the concentration of urea in the range 2.0 × 10−9–1.0 × …
Regulatory Aspects Of Living Biological Material,
2020
Taiwan Food and Drug Administration
Regulatory Aspects Of Living Biological Material, S.-C. Jong, J.M. Birmingham
Journal of Food and Drug Analysis
Any living biological material is, in effect, a biotechnology factory complete with sophisticated process designs and its own source of venture capital. Biotechnology is the application of living material and its process system to obtain useful products or services. It is not limited to the recent developments in recombinant DNA techniques, monoclonal antibodies, and related processes and products, aspects with which it is most often identified, but includes the manufacture of nonrecombinant biological material, such as microorganisms and plants and animals from traditional breeding methods; biologically active compounds; and a variety of foods and drugs. Due to complex economic, social, …
