Neuroscience and Neurobiology Commons^™

Evaluating The Brain-Enhancing Mitohormesis Of N-Propargylglycine, A Suicide Inhibitor Of Proline Dehydrogenase, To Offset The Proteotoxic Mechanisms Underlying Neurodegeneration In Huntington’S Disease And Evaluating The Phenotype Of A Mutant Pdia3 Knock-In Mouse Line As A Novel Genetic Model Of Neurological Disorders, Fadzai Teramayi

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Huntington’s Disease (HD) is characterized by atrophy of the striatal and cerebral cortical neurons producing a variety of severe, and life-shortening neurologic symptoms including motor dysfunction, cognitive decline, psychiatric disturbances, and weight loss. As with other life-threatening neurodegenerative disorders, HD has no effective treatment capable of preventing or mitigating its underlying hallmark, subcellular and pathogenetic mechanism, that is, proteotoxicity. While it has been suggested that inducing brain mitohormesis might offer a promising therapeutic strategy, to date, no brain-penetrating mitohormesis-inducing agent has yet been identified or tested in any neurodegenerative disease mouse model. Recently, N-propargylglycine (N-PPG) was shown …

Cognitive Task Enhancement Through Alpha Neurofeedback, Hannah L. Meyer, Douglas Peterson

Honors Thesis

Neurofeedback training has been a recent field of study in neuroscience, as a potential way to increase focus, and possibly boost cognitive performance. Most studies utilize a course of neurofeedback training sessions to find positive results in decreasing ADHD symptoms, depression symptoms, as well as further cognitive changes. In this study, we aim to determine the efficacy of a single session of neurofeedback training in increasing cognitive performance. To do so, we randomly separated 42 volunteers into either a control or experimental group. The experimental group participated in an n-back task both before and after an alpha neurofeedback training session, …

Danaher's "Jesus And The Bicameral Brain: Knowing And Being" (Book Review), Joseph Baumstarck Jr.

The Christian Librarian

No abstract provided.

The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review, Cheryl Ratliff

Expressive Therapies Capstone Theses

Empirically based therapies for posttraumatic stress disorder (PTSD) have been found to be less effective in treating more severe trauma presentations such as complex PTSD (CPTSD). Neurobiological investigation provides a framework for examining the physical and psychological effects of trauma on brain and nerve structures and provides insight into how to effectively treat CPTSD. This literature review examined symptomology of CPTSD resulting from complex trauma in childhood, neurobiological effects of trauma and their implications for treatment, and the efficacy of the current treatment models, primarily those of eye movement desensitization and reprocessing (EMDR), narrative exposure therapy (NET), and somatic psychotherapies. …

Sex-Specific Effects Of Chaperone And Glial Defenses On Experimental Lewy Body Disease, Tarun Bhatia

Electronic Theses and Dissertations

Lewy body disorders are a group of neurodegenerative conditions characterized by the pathological misfolding and aggregation of the abundant protein, α-synuclein. The most common Lewy body disorders are Parkinson’s disease and dementia with Lewy bodies. Apart from ageing, male sex is a major risk factor for Lewy body disorders, as men are at ~1.5-fold higher risk for these diseases than women. Yet, preclinical studies on Lewy body disorders rarely examine sex as a biological variable, and the mechanisms underlying sex-skewedness in disease risk remain undetermined.

Here, we developed a sex-stratified model of Lewy body disorders by exposing primary neurons harvested …

Mixed Mode Oscillations In Three-Timescale Coupled Morris-Lecar Neurons, Ngocanh Phan, Yangyang Wang

Biology and Medicine Through Mathematics Conference

No abstract provided.

Universality And Synchronization In Complex Quadratic Networks (Cqns), Anca R. Radulescu, Danae Evans

Biology and Medicine Through Mathematics Conference

No abstract provided.

Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s disease is the most common cause of dementia. None of the available drugs can cure the disease. Chimeric Antigen Receptor (CAR) macrophages, because of their phagocytic activity, have potential as a cellular treatment for amyloid aggregation. In this study, we generated an anti-amyloid CAR hematopoietic progenitor cell line. By inducing the progenitor cell line to differentiate into macrophages, we show that the anti-amyloid CAR-Macrophage has enhanced specific phagocytic activity towards amyloid in in vitro experiments. In addition, in ex vivo experiments, anti-amyloid CAR significantly reduces the plaque load on brain slice from APP/PS1 mice when compared to a non-targeted …

The Significance Of Sonic Branding To Strategically Stimulate Consumer Behavior: Content Analysis Of Four Interviews From Jeanna Isham’S “Sound In Marketing” Podcast, Ina Beilina

Student Theses and Dissertations

Purpose:
Sonic branding is not just about composing jingles like McDonald’s “I’m Lovin’ It.” Sonic branding is an industry that strategically designs a cohesive auditory component of a brand’s corporate identity. This paper examines the psychological impact of music and sound on consumer behavior reviewing studies from the past 40 years and investigates the significance of stimulating auditory perception by infusing sound in consumer experience in the modern 2020s.

Design/methodology/approach:
Qualitative content analysis of audio media was used to test two hypotheses. Four archival oral interview recordings from Jeanna Isham’s podcast “Sound in Marketing” featuring the sonic branding experts …

Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi

Biology and Medicine Through Mathematics Conference

No abstract provided.

Automated Fitting Of Allosteric Parameters In Receptor Oligomer Models, Spenser Wood

Biology and Medicine Through Mathematics Conference

No abstract provided.

Olfactory Bulb Processing Of Ortho Versus Retronasal Odors, Michelle F. Craft, Andrea Barreiro, Shree Gautam, Woodrow Shew, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Probability Distributions Of Active Sensing, Kathleen Hoffman

Biology and Medicine Through Mathematics Conference

No abstract provided.

Spanning The Auditory System: Subcortical And Cortical Auditory Processing Of Speech Sounds In Autistic And Typically Developing Children, Erin Stephanie Misato Matsuba

Theses - ALL

Autistic individuals often report atypical sensory processing, particularly in the auditory domain. However, the neural mechanisms that produce such symptoms are poorly understood. The Speech Auditory Brainstem Response (speech-ABR) and the Mismatch Negativity (MMN) are neurophysiological measures that capture different levels of auditory processing, such that the speech-ABR reflects processing at the subcortical level and the MMN measures cortical processing. The present study integrated both techniques in a multimethod approach, which spans both subcortical and cortical processing of speech sounds in a group of autistic children (n = 11) matched on chronological age and non-verbal IQ to their typically developing …

Antioxidant Synergy Of The Glutathione Pathway And Incidence Of Parkinson's Disease: A Systematic Review, Chelsea Clareann Yager

Theses - ALL

Background: The etiopathogenesis dopaminergic neuron dysfunction of Parkinson's Disease (PD) has not been clearly established. Oxidative stress is a commonly proposed causative mechanism for this dysfunction as variations in antioxidant intake have been observed between older adults with and without PD. The objective of this systematic review was to evaluate the synergistic relationship between antioxidant micronutrients of the glutathione pathway and the incidence of PD in older adults. Methods: This systematic review evaluated the relationship between the intake of vitamins C, D, and E, and selenium, riboflavin and niacin and incidence of PD according to PRISMA guidelines. Four electronic databases …

Closed-Loop Brain-Computer Interfaces For Memory Restoration Using Deep Brain Stimulation, David Xiaoliang Wang

Electrical Engineering Theses and Dissertations

The past two decades have witnessed the rapid growth of therapeutic brain-computer interfaces (BCI) targeting a diversity of brain dysfunctions. Among many neurosurgical procedures, deep brain stimulation (DBS) with neuromodulation technique has emerged as a fruitful treatment for neurodegenerative disorders such as epilepsy, Parkinson's disease, post-traumatic amnesia, and Alzheimer's disease, as well as neuropsychiatric disorders such as depression, obsessive-compulsive disorder, and schizophrenia. In parallel to the open-loop neuromodulation strategies for neuromotor disorders, recent investigations have demonstrated the superior performance of closed-loop neuromodulation systems for memory-relevant disorders due to the more sophisticated underlying brain circuitry during cognitive processes. Our efforts are …

Effects Of Neuronal Activation And Psychiatric Drug Treatment On Circhomer1 Biogenesis, Grigorios Papageorgiou

Biomedical Sciences ETDs

There are currently only very few efficacious drug treatments for SCZ and BD, none of which target and improve cognitive symptoms. Thus, there is an emerging need to develop novel therapeutics targeting molecular pathways linked to cognitive function and antipsychotic treatment. Circular RNAs (circRNAs) are stable non-coding RNAs, derived from the covalent back-splicing of precursor mRNA molecules. CircHomer1is a neuronal-enriched, activity-dependent circRNA, derived from the precursor of the long HOMER1B mRNA isoform, which is abundantly expressed in the adult frontal cortex and significantly downregulated in the prefrontal cortex of subjects with psychosis. Even though its relevance to psychiatric disorders …

Validity Of Neural Distance Measures In Representational Similarity Analysis, Fabian A. Soto, Emily R. Martin, Hyeonjeong Lee, Nafiz Ahmed, Juan Estepa, Kianoosh Hosseini, Olivia A. Stibolt, Valentina Roldan, Alycia Winters, Mohammadreza Bayat

MODVIS Workshop

No abstract provided.

Visual Expertise In An Anatomically-Inspired Model Of The Visual System, Garrison W. Cottrell, Martha Gahl, Shubham Kulkarni

MODVIS Workshop

We report on preliminary results of an anatomically-inspired deep learning model of the visual system and its role in explaining the face inversion effect. Contrary to the generally accepted wisdom, our hypothesis is that the face inversion effect can be accounted for by the representation in V1 combined with the reliance on the configuration of features due to face expertise. We take two features of the primate visual system into account: 1) The foveated retina; and 2) The log-polar mapping from retina to V1. We simulate acquisition of faces, etc., by gradually increasing the number of identities the network learns. …

Characterization Of Local And Global Statistics In Three Kinds Of Medical Images, And An Example Of Their Role In A Clinical Judgment, Jonathan Victor, Amanda Simon, Craig K. Abbey

MODVIS Workshop

No abstract provided.