Neuroscience and Neurobiology Commons^™

Library Anxiety Of Law Students: A Study Utilizing The Multidimensional Library Anxiety Scale, Stacey L. Bowers

Sturm College of Law: Faculty Scholarship

The purpose of this study was to determine whether law students experienced library anxiety and, if so, which components contributed to that anxiety. The Multidimensional Library Anxiety Scale (mlas) developed by Dr. Doris Van Kampen was used to assess library anxiety levels of law students. The mlas is a 53 question Likert scale instrument that measures the construct of library anxiety. Participants in the study were law students enrolled in a private midwestern university during the 2009-2010 academic year who completed the survey instrument. Law students are a unique graduate school population who undergo an extremely rigorous and competitive course …

Basolateral Amygdala And Morphine-Induced Taste Avoidance In The Rat, Jamie Lovaglio, Jian-You Lin, Christopher T. Roman, Steve Reilly

Scholarship and Professional Work – COPHS

The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. Neurologically intact subjects rapidly learned to avoid drinking the taste conditioned stimulus (CS), an effect that was sustained throughout the experiment. Although the BLA-lesioned (BLAX) rats showed CS avoidance over the first few trials, the effect was not sustained. That is, by the end of the experiment, the BLAX rats were drinking the same amount of saccharin after seven saccharin-morphine trials as they did on the first trial (i.e., prior to the morphine injections). Potential interpretations of the results are discussed including …

Memory For Melodies, Andrea R. Halpern, James C. Bartlett

Faculty Contributions to Books

No abstract provided.

Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet

Wayne State University Dissertations

Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …

Virtual Environments And Sensory Integration: Effects Of Aging And Stroke, Nicoleta L. Bugnariu, Joyce Fung

All Faculty Scholarship

Research was carried out on the effects of aging and sensory motor defi cits following strokes with respect to the capacity of the central nervous system to resolve sensory confl icts created by Virtual Reality (VR). The results of this research demonstrate that VR can be a valuable tool for therapeutic interventions that require an adaptation to complex, multimodal environments. The rehabilitation protocols include balancing training in virtual environments.

Les études qui ont été menées sur les effets du vieillissement et des défi cits sensori-moteurs consé-cutivement aux accidents vasculaires cérébraux concernent la capacité du système nerveux cen-tral à résoudre les …

Do Athletes Respond Differently To Academic And Social Stress? An Examination Of Cortisol And Perceived Stress Throughout A Semester In College Athletes And Typical College Students, Rita Rose Holak

Behavioral Neuroscience Honors Papers

In order to be a successful athlete, you must be able to perform well under stressful situations. Are athletes also better at responding to stress under other circumstances such as social and academic stress? The present study investigated the impact of exercise on salivary cortisol and perceived stress in college students. Cortisol was sampled throughout a semester as well as before and after a laboratory‐based stress test during the final exam period. It was found that athletes had the largest increase in cortisol between baseline and the final exam period and the sedentary students had the smallest increase. Also, cortisol …

Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy

Psychology Faculty Publications

Most mammals play, but they do so in a dangerous world. The dynamic relationship between the stresses created by their world and the activity of play helps to explain the evolution of play in mammals, as the author demonstrates in evidence garnered from experiments that introduce elements of fear to rats at play. The author describes the resulting fearful behavior and quantifies the fluctuation in play that results, and then he investigates how these are modified by increased maternal care or the use of benzodiazepines. In conclusion, he discusses how such research can help shed light on the neurobiology underlying …

Dopamine D1 Receptor-Mediated Nmda Receptor Insertion Depends On Fyn But Not Src Kinase Pathway In Prefrontal Cortical Neurons, Jian-Li Hu, Gang Liu, Yan-Chun Li, Wen-Jun Gao, Yueqiao Huang

PCOM Scholarly Works

Background. Interactions between dopamine and glutamate in the prefrontal cortex are essential for cognitive functions such as working memory. Modulation of N-methyl-D-aspartic acid (NMDA) receptor functions by dopamine D1 receptor is believed to play a critical role in these functions. The aim of the work reported here is to explore the signaling pathway underlying D1 receptor-mediated trafficking of NMDA receptors in cultured rat prefrontal cortical neurons. Results. Activation of D1 receptor by selective agonist SKF-81297 significantly increased the expression of NR2B subunits. This effect was completely blocked by small interfering RNA knockdown of Fyn, but not Src. Under control conditions, …

Sleep Well To Stay Safe: Ready For Primetime?, Mihai C. Teodorescu, Mariana Szklo-Coxe

Community & Environmental Health Faculty Publications

Commentary on Kling et al. Sleep problems and workplace injuries in Canada. Sleep 2010;33:611-618.

Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors, Todd Brendon Francis

Wayne State University Dissertations

Introduction: Malignant glioma display a highly glycolytic phenotype where the tumors flux glucose to lactic acid independent of oxygen concentration ("aerobic glycolysis"). This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The end-product lactic acid is rapidly expelled from the cytosol by selective monocarboxylate transporters expressed on the plasma membrane. GATA response element islands are present on the promoter of glioma lactate transporter genes, and GATA-1 has been shown to be over-expressed in glioblastoma. Our long-term goal is to inhibit glioma proliferation by indirectly down-regulating GATA-1 to inhibit glycolysis. (Colen et al., 2006; …

Dopamine D1 Receptor-Mediated Enhancement Of Nmda Receptor Trafficking Requires Rapid Pkc-Dependent Synaptic Insertion In The Prefrontal Neurons, Yan-Chun Li, Gang Liu, Jian-Li Hu, Wen-Jun Gao, Yueqiao Huang

PCOM Scholarly Works

Understanding the interaction between dopamine and glutamate, particularly the interaction of dopamine and NMDA receptors, may enable a more rational approach to the treatment of schizophrenia, drug addiction, and other psychiatric disorders. We show that, in prefrontal cortical neurons, dopamine D1-induced enhancement of NMDA receptor function depends on rapid insertion of new NMDA receptor 2B subunits on the synaptic surface. Protein kinase A (PKA) inhibitor, but not protein kinase C (PKC) inhibitor, completely blocked dopamine D1 agonist SKF-81297-induced increase of the total expression of NMDA receptors. Furthermore, SKF-81297 failed to alter the surface expression and synaptic insertion of NMDA receptors …

Increased Dendrite Branching In Aβpp/Ps1 Mice And Elongation Of Dendrite Arbors By Fasudil Administration, Brian A. Couch, George J. Demarco, Shannon L. Gourley, Anthony J. Koleske

School of Biological Sciences: Faculty Publications

Amyloid-β (Aβ) overproduction and dendrite arbor atrophy are hallmarks of Alzheimer’s disease. The RhoA GTPase (Rho) signals through Rho kinase (ROCK) to control cytoskeletal dynamics and regulate neuron structure. Hyperactive Rho signaling destabilizes neurons leading to dendritic regression that can be rescued by genetic or pharmacological reduction of ROCK signaling. To understand what effect reduced ROCK signaling has on the dendrite arbors of mice that overproduce Aβ, we administered the ROCK inhibitor fasudil to AβPP/PS1 transgenic mice. We report that increased dendrite branching occurs in AβPP/PS1 mice and that fasudil promotes …

The Abl And Arg Non-Receptor Tyrosine Kinases Regulate Different Zones Of Stress Fiber, Focal Adhesion, And Contractile Network Localization In Spreading Fibroblasts, Justin G. Peacock, Brian A. Couch, Anthony J. Koleske

School of Biological Sciences: Faculty Publications

Directed cell migration requires precise spatial control of F-actin-based leading edge protrusion, focal adhesion (FA) dynamics, and actomyosin contractility. In spreading fibroblasts, the Abl family kinases, Abl and Arg, primarily localize to the nucleus and cell periphery, respectively. Here we provide evidence that Abl and Arg exert different spatial regulation on cellular contractile and adhesive structures. Loss of Abl function reduces FA, F-actin, and phosphorylated myosin light chain (pMLC) staining at the cell periphery, shifting the distribution of these elements more to the center of the cell than in wild-type (WT) and arg^—/— cells. Conversely, loss of Arg function …

Synaptic Clustering Of Psd-95 Is Regulated By C-Abl Through Tyrosine Phosphorylation, Karen Perez De Arce, Lorena Varela-Nallar, Olivia Farias, Alejandra Cifuentes, Paulina Bull, Brian A. Couch, Anthony J. Koleske, Nibaldo C. Inestrosa, Alejandra R. Alvarez

School of Biological Sciences: Faculty Publications

The c-Abl tyrosine kinase is present in mouse brain synapses, but its precise synaptic function is unknown. We found that c-Abl levels in the rat hippocampus increase postnatally, with expression peaking at the first postnatal week. In 14 d in vitro hippocampal neuron cultures, c-Abl localizes primarily to the postsynaptic compartment, in which it colocalizes with the postsynaptic scaffold protein postsynaptic density protein-95 (PSD-95) in apposition to presynaptic markers. c-Abl associates with PSD-95, and chemical or genetic inhibition of c-Abl kinase activity reduces PSD-95 tyrosine phosphorylation, leading to reduced PSD-95 clustering and reduced synapses in treated neurons. c-Abl can phosphorylate …

Mental Reversal Of Imagined Melodies: A Role For The Posterior Parietal Cortex, Robert J. Zatorre, Andrea R. Halpern, Marc Bouffard

Faculty Journal Articles

Two fMRI experiments explored the neural substrates of a musical imagery task that required manipulation of the imagined sounds: temporal reversal of a melody. Musicians were presented with the first few notes of a familiar tune (Experiment 1) or its title (Experiment 2), followed by a string of notes that was either an exact or an inexact reversal. The task was to judge whether the second string was correct or not by mentally reversing all its notes, thus requiring both maintenance and manipulation of the represented string. Both experiments showed considerable activation of the superior parietal lobe (intraparietal sulcus) during …

Perception Of Emotion In Sounded And Imagined Music, Brian L. Lucas, Emery Schubert, Andrea R. Halpern

Faculty Journal Articles

WE STUDIED THE EMOTIONAL RESPONSES BY MUSICIANS to familiar classical music excerpts both when the music was sounded, and when it was imagined.We used continuous response methodology to record response profiles for the dimensions of valence and arousal simultaneously and then on the single dimension of emotionality. The response profiles were compared using cross-correlation analysis, and an analysis of responses to musical feature turning points, which isolate instances of change in musical features thought to influence valence and arousal responses. We found strong similarity between the use of an emotionality arousal scale across the stimuli, regardless of condition (imagined …

Ganglioside-Cytokine Interaction In The Induction Of Primary Brain Cell Death, John Charles Gorbet

Open Access Theses & Dissertations

Gangliosides have been implicated in multiple pathologies affecting the central nervous system (CNS) and recent research has implicated them in playing an active role in the pathogenesis of multiple sclerosis. Empirical studies and theoretical considerations have suggested the possibility of interactions between gangliosides, like GD3, and pro-inflammatory cytokines present in the nervous system. This study sought to investigate the possibility that either individual gangliosides acting alone or complexed with other species interact with the known immune response factor TNF&alpha to initiate or facilitate cell death in the CNS. I examined the cellular viability and gene expression in primary brain cell …

Preliminary Archaeological Investigations At The Sierra Diablo Cave Site: Paleoindian And Archaic Occupations In Hudspeth County, Texas, Jose Javier Vasquez

Open Access Theses & Dissertations

It is generally rare to find archaeological sites in the Southwest that retain the type of contextual integrity that the Sierra Diablo Cave exhibits. Often times, cave sites such as the one currently studied offer excellent preservation of cultural materials due to the general lack of moisture and isolation from wind and water erosion. The research aimed to determine when the site was occupied as well as the types of activities that were occurring during those occupations. It exhibits an extensive stratigraphic sequence that contains a well pronounced Late Archaic Period assemblage (Strata A and B) and a Late Pleistocene/Early …

Safe Medication Use Among Hispanic College Students: Knowledge, Attitudes And Behaviors, Tania Guadalupe Quiroz

Open Access Theses & Dissertations

College students are at increased risk of medication errors. Research suggests that young adults are active users of over-the- counter (OTC) medications and other products that may increase the risk for negative health outcomes. Therefore, it is very important to analyze young adults' attitudes, beliefs, and behaviors about medication use among college students in order to provide them with the necessary information. Due to language and cultural factors, the issue is particularly relevant in U.S.-Mexico border communities. This casual-comparative study examined knowledge, attitudes, and behaviors regarding medication use among Hispanic college students. Data was collected through a survey developed by …

Involvement Of The Nmda Receptor In Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta In Vitro, Robert Matthew Mitchell

Dissertations

Alzheimer's disease (AD) is a progressive, mentally crippling, and eventually fatal form of dementia with growing prevalence in aging populations. In 2009 it was estimated that 5.3 million Americans have AD, with 5.1 million older than age 65 and 200,000 under 65. That accounts for 1 in 8 adults over 65. Furthermore, AD costs Americans 148 billion dollars in direct expenses, and is the leading cause of dementia and the 6th leading cause of death. Since improved medical care in general is increasing average life span and age is the primary risk factor for AD, there is need for basic …