Neuroscience and Neurobiology Commons^™

Animal Suffering Calls For More Than A Bigger Cage, Simon R. B. Leadbeater

Animal Sentience

Ng (2016) argues for incremental welfare biology partly because it would be impossible to demonstrate conclusively that animals are sentient. He argues that low cost changes in industrial practices and working collaboratively may be more effective in advancing animal welfare than more adversarial approaches. There is merit in some of Ng’s recommendations but a number of his arguments are, in my view, misdirected. The fact that nonhuman animals feel has already been adequately demonstrated. Cruelty to animals is intrinsic to some industries, so the only way to oppose it is to oppose the industry.

Considering Animals’ Feelings: Précis Of Sentience And Animal Welfare (Broom 2014), Donald M. Broom

Animal Sentience

The concept of sentience concerns the capacity to have feelings. There is evidence for sophisticated cognitive concepts and for both positive and negative feelings in a wide range of nonhuman animals. All vertebrates, including fish, as well as some molluscs and decapod crustaceans have pain systems. Most people today consider that their moral obligations extend to many animal species. Moral decisions about abortion, euthanasia, and the various ways we protect animals should take into account the research findings about sentience. In addition, all animal life should be respected and studies of the welfare of even the simplest invertebrate animals should …

Sentience And Animal Welfare: Affirming The Science And Addressing The Skepticism, Nancy Clarke

Animal Sentience

Broom’s (2014) book is a well-researched and thoroughly written exploration and evaluation of the journey from the origins of animal welfare science to what we can say we now know and need to consider in relation to animal sentience and welfare. This book will help to counter any skepticism among academics and policy makers.

Is Sentience Only A Nonessential Component Of Animal Welfare?, Ian J.H. Duncan

Animal Sentience

According to Broom (2014), animal welfare is a concept that can be applied to all animals, including single-celled organisms that are obviously not sentient. Such a stance makes it difficult to draw a connection between welfare and sentience, and that is the book’s downfall. Some excellent points are made about sentience and there are very good discussions on animal welfare. However, unless sentience is considered the essential component of welfare, any attempt to link the two phenomena will be unsuccessful — and that, indeed, is the case with this book.

Sentience And Animal Welfare: New Thoughts And Controversies, Donald M. Broom

Animal Sentience

Sentience involves having some degree of awareness but awareness of self is not as complex as some people believe. Fully functioning vertebrate animals, and some invertebrates, are sentient but neither humans nor non-humans are sentient early in development or if brain-damaged. Feelings are valuable adaptive mechanisms and an important part of welfare but are not all of welfare so the term welfare refers to all animals, not just to sentient animals. We have much to learn about what non-human animals want from us, the functioning of the more complex aspects of their brains and of our brains and how we …

Pain And Fish Welfare, Eliane Gonçalves-De-Freitas

Animal Sentience

The evolutionary approach of Key’s (2016) target article, generically comparing humans with fish of all kinds, is simplistic. The author ignores published research on structural and molecular aspects of pain in fish. The target article reads more like a selective polemic against fish welfare than an even-handed analysis.

Brain Processes For “Good” And “Bad” Feelings: How Far Back In Evolution?, Jaak Panksepp

Animal Sentience

The question of whether fish can experience pain or any other feelings can only be resolved by neurobiologically targeted experiments. This commentary summarizes why this is essential for resolving scientific debates about consciousness in other animals, and offers specific experiments that need to be done: (i) those that evaluate the rewarding and punishing effects of specific brain regions and systems (for instance, with deep-brain stimulation); (ii) those that evaluate the capacity of animals to regulate their affective states; and (iii) those that have direct implications for human affective feelings, with specific predictions — for instance, the development of new treatments …

Acculturation, Inflammation, And Depression Among Hispanic Adults In The United States, Kristin Marie Marano

Walden Dissertations and Doctoral Studies

Disparities exist in the recognition and treatment of depression among Hispanics in the United States, creating a social, ethical, economic, and public health burden. This study was designed to generate an improved understanding of the causes of and/or contributors to depression within this population. It was specifically designed to 1) assess the prevalence and severity of depression among Hispanic adults in the United States relative to adults of other race/ethnicities in the United States; 2) clarify the inconsistent results in the literature concerning the relationship between acculturation and depression among Hispanic adults in the United States; and 3) fill a …

Academic Success For The 21st Century Learner: Intrapersonal Intelligence And Resilience, Juanita Lynn Parker

Walden Dissertations and Doctoral Studies

Internal and personal strengths are associated with positive academic outcomes in the higher educational setting and are particularly relevant to the 21st century learner in the modern complex and global society. There is limited research addressing the connection between intrapersonal intelligence, resilience, and academic success. This information is important to better assist students in developing qualities that foster academic success and sustainability. The purpose of this study was to investigate the correlations between intrapersonal intelligence, as measured by the Multiple Intelligences Development Assessment Scales (MIDAS); resilience, as measured by the Connor-Davidson Resilience Scale (CD-RISC); and academic success, as measured by …

Short Term Memory Of Magnetic Resonance Imaging Technologists, Samuel Maldonado

Walden Dissertations and Doctoral Studies

This study examined the short term memory (STM) difference of magnetic resonance imaging (MRI) technologists versus non-MRI technologists. Human and animal studies have indicated that residual magnetic fields have caused changes within the cerebral structure. Research on residual magnetic fields and their effect on STM is still at its infancy. A quasi-experimental design was used to determine if any significant difference existed between the STM of MRI technologists (n = x) and a control population sample (n = x). The STM of both groups was assessed with the use of the Rivermead Behavioural Memory Test-Third Edition. Solicitation of the participants …

High Affinity Block Of Icl,Swell By Thiol-Reactive Small Molecules, Sung H. Park

Theses and Dissertations

Ebselen (Ebs) is considered as a glutathione peroxidase (GPx) mimetic and primarily thought to function by scavenging intracellular reactive oxygen species (ROS). Previous to our work, Deng et al. (2010a) demonstrated complete block of I_Cl,swell with 15 microM Ebs following endothelin-1 (ET-1) induced activation of the current in cardiomyocytes. This block was presumed to take effect mainly via the quenching of ROS. Nonetheless, our work with DI TNC1 astrocytes strongly emphasizes that Ebs might function by an alternative mechanism based on its kinetic profile in blocking I_Cl,swell. Our experiments showed that 45 nM Ebs can fully block …

Allosteric Effects Of G-Protein Coupled Receptor Heteromerization: Relevance To Psychosis, Jason W. Younkin

Theses and Dissertations

G-protein coupled receptors (GPCRs) implicated in disease are the predominant pharmaceutical targets. Growing evidence suggests that GPCRs form homo- and heteromeric complexes, resulting in allosteric functional changes. Ligands targeting one receptor can alter the function of the other receptor or receptors. Knowledge of these functional changes will provide unique opportunities to treat diseases. We examined two GPCR heteromers implicated in psychosis: mGlu2R-5HT2AR and D2R-5HT2AR. Using whole-cell patch clamp, we studied HEK-293 cells stably transfected with mGlu2R and 5HT2AR. Maximal heteromer formation allows inverse agonists to increase the G-protein activity of the opposite receptor, while sub-maximal heteromer formation does not. However, …

Acute And Chronic Effects Of Inhalants In Intracranial Self-Stimulation, Matthew Tracy

Theses and Dissertations

Inhalants are a loosely defined diverse group of volatile substances which people abuse. Despite widespread misuse of inhalants, there are limited preclinical methods available to study the reinforcement-like properties of inhalants. One procedure which has demonstrated substantial promise as a tool to investigate inhalant pharmacology is the intracranial self-stimulation (ICSS) procedure. ICSS utilizes pulses of electrical stimulation to the mesolimbic reward pathway to serve as a temporally defined and controlled operant reinforcer with a highly adjustable efficacy. The first aim of the project was to characterize the effects of commonly abused inhalants: including toluene, trichloroethane, nitrous oxide, isoflurane and R134a …

A Neural Circuit Of Appetite Control In C. Elegans, Kristen C. Davis

Theses and Dissertations

Feeding behavior and its associated neural circuitry is complex and intricate in mammalian systems, however, a simple model organism, such as C. elegans provides a more basic approach to understand factors and molecules involved. The fruit-dwelling nematode provides a unique set of resources; it only consists of 959 cells, 302 of which are neurons. In addition, each neuron’s connectivity and position within the worm is known and consistent between animals. Conservation of neurotransmitters and biochemical processes add to this impressive list. These resources provide an excellent background to address feeding behavior and the neural structures governing it.

Feeding behavior in …

Resolution Of Inflammation Rescues Axon Initial Segment Disruption, Nicholas M. George

Theses and Dissertations

Axonal domains are required for proper neuron function. These domains are unstable and degenerate concurrent with the inflammation in multiple sclerosis (MS) and the inflammatory disease models experimental autoimmune encephalomyelitis (EAE) and lipopolysaccharide (LPS) induced inflammation. Previous studies from our laboratory have shown that the axon initial segment (AIS) is maintained independently of the presence of myelin, but that AIS disruption is seen in MS as well as EAE and LPS-mediated inflammation. AIS loss can be interrupted in the early stage of EAE using the anti-inflammatory drug Didox. However, the potential for Didox directed repair of the AIS in later …

The Role Of Matrix Metalloproteinase 9 And Osteopontin In Synaptogenesis And Reinnervation Of The Olfactory Bulb Following Brain Injury, Melissa A. Powell

Theses and Dissertations

Traumatic brain injury (TBI) is a serious health concern, causing cognitive, motor, and sensory deficits, including olfactory dysfunction. This dissertation explores the effects of TBI on synaptic plasticity within the olfactory system, seeking to define mechanisms guiding postinjury sensory reinnervation. Physical forces induced by TBI can axotomize olfactory receptor neurons (ORNs), which innervate olfactory bulb (OB). These axons regenerate OB projections after injury, a process involving growth through a complex extracellular matrix (ECM). As such, we investigated a potential molecular mechanism capable of modifying local OB ECM to support postinjury synaptogenesis. Since matrix metalloproteinases (MMPs) and their ECM substrates are …

Special Muscles, Annamaria C. Scaccia

Capstones

Special Muscles is a documentary that explores living with Duchenne muscular dystrophy, a fatal degenerative disease that weakens the muscles at an aggressive rate. The film will give an uncensored look at how one family copes with inevitability of the disease and their journey chasing a promising experimental cure.

Special Muscles follows 7-year-old Pietro Scarso and his family as they face the challenges, complications and promise of treating Pietro’s progressive muscle disorder. The film travels from New York to Los Angeles to Philadelphia to document the Scarso family’s race against time as Pietro undergoes a 96-week clinical trial for Eteplirsen, …

Testing The Efficacy Of Lsn2463359, A Metabotropic Glutamate 5 Receptor Positive Allosteric Modulator, In Animal Models Of Schizophrenia, Dierdre M. Freamon

Seton Hall University Dissertations and Theses (ETDs)

For many years the dominant theory surrounding the cause of schizophrenia was focused on elevated dopamine levels found in critical areas of the brain. Recently a new theory has emerged pointing to elevated glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic cells in a tonic manner. Therefore, while traditional antipsychotics directly block dopamine receptors, some of the newly generated compounds are designed to modulate glutamate to normal levels.

I propose testing the efficacy of the metabotropic glutamate 5 receptor modulator LSN2463359, previously shown to act as an indirect agonist of the …

Reliability And Validity Of Neurobehavioral Function On The Psychology Experimental Building Language Test Battery In Young Adults, Brian J. Piper, Shane Mueller, Alexander R. Geerken, Kyle L. Dixon, Gregory Kroliczak, Reid H. Olsen, Jeremy K. Miller

Michigan Tech Publications, Part 1

Background. The Psychology Experiment Building Language (PEBL) software consists of over one-hundred computerized tests based on classic and novel cognitive neuropsychology and behavioral neurology measures. Although the PEBL tests are becoming more widely utilized, there is currently very limited information about the psychometric properties of these measures.

Methods. Study I examined inter-relationships among nine PEBL tests including indices of motor-function (Pursuit Rotor and Dexterity), attention (Test of Attentional Vigilance and Time-Wall), working memory (Digit Span Forward), and executive-function (PEBL Trail Making Test, Berg/Wisconsin Card Sorting Test, Iowa Gambling Test, and Mental Rotation) in a normative sample (N = 189, …

Rat Hind Limb Nociceptive Withdrawal Response Depends On Initial Paw Position But Not Stimulus Location, Kimberly Seamon

Senior Honors Projects, 2010-2019

There have been numerous studies in non-human animals on the effect of stimulus location on the NWR and at least a few studies that address the role of initial posture. However, all of these studies were conducted in anesthetized, decerebrated, or spinalized mammals. Since descending modulation and long loop reflexes may influence the NWR, the anesthetized spinalized/decerebrated animal may not be an adequate model of normal animals. Therefore, the primary aim of this study was to determine the effect of the stimulus location and initial paw position on the direction and magnitude of the nociceptive withdrawal response to heat stimulus …