Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves,
2026
College of Food Science and Engineering , Inner Mongolia Agricultural University , Hohhot , Inner Mongolia 010018 , China
Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves, Dong Xiaoyue, Yun Xueyan, Zhang Lu, Dong Tongliga, Zhao Chenxi, Te Jinwei, Wang Xiukuan, Hao Qian, Miao Meishu, Su Ke
Food and Machinery
[Objective] To investigate the effects of probiotic fermentation conditions and drying methods on the quality of fermented sea buckthorn leaf products. [Methods] Lactiplantibacillus plantarum is used for fermentation. The fermentation process of sea buckthorn leaves is optimized through single-factor experiments combined with response surface methodology. Fermented sea buckthorn leaf extract is prepared under the optimal fermentation conditions and subsequently processed into freeze-dried powder by direct freeze-drying and spray freeze-drying, with or without low-voltage electrostatic field assistance. The effects of different treatments on viable cell counts, flavonoid and polyphenol retention rates, water activity, and in vitro digestion characteristics are evaluated. [Results] …
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage,
2026
College of Life Sciences , Linyi University , Linyi , Shandong 276000 , China
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo
Food and Machinery
[Objective] To improve the utilization rate of porcine blood and the safety of ham sausage. [Methods] Under specific conditions, hemoglobin in porcine blood is modified to produce glycosylated nitrosohemoglobin (GN-Hb). Different amounts of GN-Hb are added to replace sodium nitrite in heat-treated ham sausages. The quality characteristics of the sausages are evaluated through texture analysis, nutritional testing, color difference assessment, color acceptability, elasticity, chewiness, and overall acceptability. [Results] When the sodium nitrite dosage is 100 mg/kg and the GN-Hb dosage is 2.5 g/kg, high-temperature sterilized ham sausage containing the new pigment shows significant improvement in color and cohesion compared with …
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity,
2026
College of Food Science and Engineering , Xinyang Agriculture and Forestry University , Xinyang , Henan 464000 , China
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity, Tu Jianqiu, Xu Danhe, Chen Long, Wang Yaxin, Xu Jiahui, Jing Lixiang, Li Jianfang
Food and Machinery
[Objective] To optimize the extraction process of flavonoids from Xinyang Camellia sinensis and to compare the in vitro antioxidant activities of total flavonoids before and after purification. [Methods] Using Xinyang C. sinensis as raw material, a one-factor test is conducted to investigate the effects of ethanol volume fraction, ultrasonic time, ultrasonic power, and material–liquid ratio on the yield of flavonoids. Subsequently, a three-factor, three-level optimization model is established based on the Box–Behnken experimental design. Additionally, a macroporous adsorption resin is utilized for the purification of flavonoid crude extracts. Finally, the in vitro antioxidant activity of the total flavonoids is evaluated …
Advances In The Application Of Electroencephalography In Food Sensory Science,
2026
School of Food Science and Bioengineering , Changsha University of Science and Technology , Changsha , Hunan 410114 , China;Hunan Provincial Engineering Technology Research Center of Prepared Dishes , Changsha , Hunan 410114 , China
Advances In The Application Of Electroencephalography In Food Sensory Science, Li Wenbin, Hou Xiaoyi, Deng Na, Leng Tuo, Fu Haohua, Wang Jianhui
Food and Machinery
Traditional sensory evaluation of food is affected by subjectivity and other factors, resulting in significant limitations. Electroencephalography (EEG), owing to its advantages of high temporal resolution, non-invasiveness, and real-time dynamic monitoring, offers an objective neurophysiological perspective and analytical approach to address this issue, effectively advancing food science research from subjective descriptions to objective neural decoding. This paper systematically reviews the applications of EEG in food flavor recognition and prediction, objective evaluation of food quality, and analysis of food nutrition and consumer behavior. In light of the current state of technological development, it is proposed that multimodal technology integration and machine …
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata,
2026
School of Food and Pharmaceutical Engineering , Guizhou Institute of Technology , Guiyang , Guizhou 550025 , China
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata, Zhang Lunqing, Wang Xianxing, Li Qiaoqiao, Xu Cunbin, Wang Yu
Food and Machinery
Dictyophora rubrovalvata, a valuable edible fungus in China, is rich in active components such as polysaccharides, proteins, amino acids, and vitamins, exhibiting significant efficacy in antioxidant, anti-fatigue, antitumor, immunomodulatory, hepatoprotective, and anti-inflammatory activities. This paper systematically reviews recent research progress on the nutritional components, functional activities, and utilization status of D. rubrovalvata, both in China and elsewhere, with an outlook on its future development directions and application prospects.
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control,
2026
School of Health Management , Shanxi Technology and Business University , Taiyuan , Shanxi 030006 , China
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin
Food and Machinery
N-nitroso compounds, as one of the major food contaminants, are widely present in food and pose hazards such as carcinogenicity, teratogenicity, and mutagenicity, thus being a key focus in food safety monitoring. Although significant progress has been made in the research on N-nitroso compounds, studies on their metabolic mechanisms and reduction and control measures are still disconnected to a certain extent. Through a review of the classification, detection methods, and toxic effects of N-nitroso compounds, this article analyzes the intrinsic connection between their metabolic pathways in the body and strategies for external reduction and control, aiming to provide theoretical references …
Intelligent Detection Method For Food Packaging Defects Based On Improved U-Net And Machine Vision,
2026
Sias University , Zhengzhou , Henan 451100 , China
Intelligent Detection Method For Food Packaging Defects Based On Improved U-Net And Machine Vision, Qi Guohong, Zhang Jing, Li Lili
Food and Machinery
[Objective] To address the issues of weak generalization, insufficient accuracy, and poor anti-interference ability in existing intelligent detection methods for food packaging defects. [Methods] On the basis of the intelligent sorting system for food packaging defects, a method for intelligent detection of food packaging defects is proposed, which combines machine vision and an improved U-Net model. By introducing a multi-scale residual convolution module into the convolution module, the method reduces the computational complexity of the model and improves the training effect. By integrating channel attention, spatial attention, and multi-scale attention, a lightweight hybrid attention module is constructed to achieve the …
Sustainable Design Strategies For Regional Food Packaging Based On The Dual Circulation Of Matter And Culture,
2026
School of Arts , Baoding University of Technology , Baoding , Hebei 071000 , China
Sustainable Design Strategies For Regional Food Packaging Based On The Dual Circulation Of Matter And Culture, Jin Yuhan, Wang Chao, Hou Zhigang
Food and Machinery
In response to the current focus on material circulation in regional food packaging research and the lack of mechanisms for the dissemination of regional culture, this study explores a sustainable design pathway for the coordinated development of cultural and material circulation in the context of new retail. Taking a high-end apple gift box as a practice-based validation object, a dual-circulation packaging system integrating material and cultural circulation was constructed and validated from four aspects, i.e., material selection, structural innovation, visual narrative, and interactive experience, based on the triple bottom line (TBL) and cradle-to-cradle (C2C) theories. The use of locally sourced …
BYU
Data For Post-Retail Application Of Chitosan Coating And Uv-C Irradiation: Effects On Strawberry Shelf Life, Microbial Quality, And Consumer Acceptance, Jonathan Kershaw
ScholarsArchive Data
Food waste is a global issue with significant environmental, economic, and human health impacts. The largest share of household and retail food waste comes from fresh produce, much of which is still edible at the time of disposal. While previous work has investigated shelf-life extension technologies applied on freshly harvested produce, almost no studies have investigated the efficacy of these treatments when applied to post-retail produce. This study investigated the effect of UV-C exposure and chitosan coating on the quality, microbial load, and visual acceptance of post-retail strawberries. Strawberries were assigned to low dose UV-C, chitosan dip, or one of …
Advanced Hybrid-Green Ultrasound–Infrared–Microwave Trifolium Repens Essential Oil Isolation With Multi-Target Ethnomedicine Bioactivity Against Neuropathy, Inflammation And Multidrug-Resistant Infection,
2026
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon.
Advanced Hybrid-Green Ultrasound–Infrared–Microwave Trifolium Repens Essential Oil Isolation With Multi-Target Ethnomedicine Bioactivity Against Neuropathy, Inflammation And Multidrug-Resistant Infection, Sara Al Ayoubi, Ibrahim Abdelwahab, Maha Aboul-Ela, Abdalla El- Lakany, Karim Raafat
Journal of Food and Drug Analysis
Trifolium repens (white clover) is rich in bioactive volatiles with therapeutic potential. This study developed an advanced hybrid ultrasound–infrared–microwave hydro-distillation (UIMHD) method for efficient essential oil (EO) isolation and investigated its active sesquiterpene, pseudoionone, for multi-mechanistic neuroprotection in diabetic neuropathy (DN). The optimized UIMHD system synergistically combined ultrasound cavitation, infrared heating, and microwave hydro-distillation, enhancing yield and reducing time versus conventional extraction. Gas chromatography–mass spectrometry (GC–MS) profiling identified pseudoionone as the dominant constituent. Pharmacological evaluations were performed in alloxan-induced diabetic mice to assess antidiabetic, anti-inflammatory, neuroprotective, and anticonvulsant activities. Cytokine modulation (TNF-α, IL-6, IL-10), oxidative stress markers (CAT, GSH, TBARS), …
Can Semaglutide Influence Tumor Biomarkers? Insight From A Clinical Case,
2026
Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland
Can Semaglutide Influence Tumor Biomarkers? Insight From A Clinical Case, Alice Schianchi, Fabio Mauri, Christian Polli
Journal of Food and Drug Analysis
To our knowledge, this is the first case reported in literature, regarding an increase in tumoral biomarkers during a treatment with Semaglutide. A 61-year-old patient was referred to our gynecological consultation due to suspected adnexal cysts following an MRI performed for a functional defecation disorder. The patient was on Semaglutide treatment. Gynecological examination and transvaginal ultrasound were normal, with no evidence of adnexal cysts. Tumor biomarker testing revealed a significant increase in CA 19-9 and a mild elevation in CA-125. In an asymptomatic patient, these findings raised suspicion of a possible neoplastic origin involving the pancreas or biliary tract. However, …
Evaluating The Efficacy Of I-Fiber Pearl On Reducing Body Fat Accumulation In Obese Females: A Randomized, Double-Blind, And Placebo-Controlled Trial,
2026
Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
Evaluating The Efficacy Of I-Fiber Pearl On Reducing Body Fat Accumulation In Obese Females: A Randomized, Double-Blind, And Placebo-Controlled Trial, Hung-Hsuan Kuo, Chia-Chun Chen, Ching-Chang Cho, Chun-Tse Tsai, Shiuan-Chih Chen, Chin-Lin Hsu
Journal of Food and Drug Analysis
Obesity is a growing public health challenge worldwide, strongly linked to metabolic syndrome, type 2 diabetes, and cardiovascular disease. Inulin, a soluble, fermentable fiber derived mainly from Jerusalem artichoke and chicory, has been reported to improve weight management and metabolic health. This randomized, double-blind, placebo-controlled trial evaluated the effects of inulin-enriched tapioca pearls (I-fiber pearl) on body composition and lipid parameters in obese women. Methods: Fifty women (BMI ≥ 27 or waist > 80 cm; age 20–50 years) were randomized to receive either I-fiber pearl or placebo (2 packs/day, 100 g/pack) for 12 weeks. Anthropometric indices, body composition, and blood biochemistry …
Spatial Distribution: Effect Of Oxygen Availability On Gut Microbiota Adhesion And Colonization,
2026
Key Laboratory of Ecological Restoration of Regional Contaminated Environment, Ministry of Education, College of Environment, Shenyang University, Shenyang 110044, China
Spatial Distribution: Effect Of Oxygen Availability On Gut Microbiota Adhesion And Colonization, Ruixue Ding, Xiaotong Sun, Yinan Wang, Binbin Tu, Yue Liang, Qi Lin, Fuqiang Zhao
Journal of Food and Drug Analysis
The gut microbiota plays a crucial role in host digestion and immune regulation; however, most existing research relies on fecal sampling, leaving uncertainty regarding whether fecal microbiota can accurately reflect the symbiotic microbial components at distinct gut sites. To address this gap, this study employed 16S rRNA gene sequencing to systematically analyze the microbial composition of three spatial compartments in the rat colon: luminal contents, mucus layer, and epithelial tissue. The results revealed notable differences in microbial communities across the three compartments. The luminal contents, which were closely associated with the fecal microbiota, exhibited high microbial abundance, encompassing gram-positive bacteria, …
Novel Oral Delivery System Using Modified Inulin For Enhanced Liver Cancer Therapy,
2026
School of Pharmacy, National Defense Medical University, Taipei, Taiwan, ROC.
Novel Oral Delivery System Using Modified Inulin For Enhanced Liver Cancer Therapy, Sung-Ling Tang, Yu-Ju Lai, Wei-Cheng Lin, Meng-Yi Bai, Yu-Chi Wang
Journal of Food and Drug Analysis
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide. Although advanced oral anticancer drugs, such as sorafenib and lenvatinib, are available for treating HCC, their effectiveness is limited by significant side effects and the requirement for optimal liver function, restricting their broader use. Furthermore, these drugs cannot be used in combination, leading to suboptimal treatment outcomes. This study introduces a novel therapeutic approach by repurposing two existing drugs, niclosamide and disulfiram, as a combination therapy to treat HCC. Despite their known anticancer properties, these drugs face challenges such as high lipophilicity and a significant first-pass effect, resulting in …
Effect Of Cosmetic Whitening Ingredients’ Lipophilicity On Melanocyte Cytotoxicity: A Systematic Review,
2026
Department of Pharmacy, School of Health Care Professions, University of San Carlos, Nasipit, Talamban, Cebu, 6000, The Philippines
Effect Of Cosmetic Whitening Ingredients’ Lipophilicity On Melanocyte Cytotoxicity: A Systematic Review, Lord Sam B. Liston, Zach Uriel Cabije, Enrico John Belleza, Catherine Ortega, Mark Niño Melgo, Vanbeth Camson, Sabrina Dahlizar, Pajaree Sakdiset, Gea Abigail Ecoy, Gerard Lee See, Florencio Jr. Arce
Journal of Food and Drug Analysis
Tyrosinase is an enzyme involved in the early stages of melanin synthesis. Melanin, which gives skin its pigment, is the most targeted molecule in the development of skin-whitening cosmetic products. Consequential risks of chemically induced skin diseases are associated with the usage of skin-whitening products that contain tyrosinase-inhibiting compounds. Currently, products containing tyrosinase inhibitors on the market lack collective analysis of their toxicity on melanocytes. Moreover, national regulatory agencies (e.g., FDA) place the burden of ensuring the safety of whitening products on manufacturers, risking bias and selective reporting. In fact, the ASEAN Cosmetic Directive does not include more than half …
The Protective Potential Of Intestinal Bifidobacterium-Derived Extracellular Vesicles With Unique Lipid Composition Against Blue Light-Induced Damage In Retinal Cells,
2026
Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan, Taiwan
The Protective Potential Of Intestinal Bifidobacterium-Derived Extracellular Vesicles With Unique Lipid Composition Against Blue Light-Induced Damage In Retinal Cells, Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee
Journal of Food and Drug Analysis
Bifidobacterium longum is a probiotic that resides in the intestine, and extracellular vesicles (EVs) released by microorganisms have garnered attention in recent years for their role in regulating host health. This study found that triacylglycerol, cholesteryl esters, and free fatty acid (18:0 and 16:0) are primarily composed of lipids in B. longum-derived EVs by lipidomics assay. Such lipid composition facilitates the entry of EVs into ARPE-19 cells and protects the cells from oxidative death induced by blue light exposure. Transcriptomic analysis revealed that treatment with B. longum-derived EVs can regulate phosphoinositide 3-kinase and mTOR, thereby enhancing the survival …
Systematic Verification Of Saliva-Based Biosignatures For Oral Cancer Via Targeted Metabolomics,
2026
Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Systematic Verification Of Saliva-Based Biosignatures For Oral Cancer Via Targeted Metabolomics, Ya-Ju Hsieh, Yu Chang, Chi Yang, Nai Hsuan Teng, Jau-Song Yu, Kai-Ping Chang, Wen-Chen Chen, Lichieh Julie Chu, Yi-Ting Chen
Journal of Food and Drug Analysis
Oral squamous cell carcinoma (OSCC) remains a major global health challenge, and early detection is essential for improving patient outcomes. To identify reliable salivary biomarkers, we performed a targeted metabolomics study using 13C2/12C2-dansylation, integrating candidate metabolites from published OSCC metabolomics datasets and systematically verifying them through LC-MRM-MS. A panel of 26 metabolites was quantified in saliva samples from 299 subjects, including healthy controls (n = 98), oral potentially malignant disorders (OPMD I, n = 50; OPMD II, n = 53), and OSCC patients (n = 98). Among these, cadaverine, N-acetylcadaverine, choline, glycine, and …
Phthalate Exposure And Lipid Disruption In Taiwanese Children: Insights From Serum Lipidomic Approach,
2026
Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan
Phthalate Exposure And Lipid Disruption In Taiwanese Children: Insights From Serum Lipidomic Approach, Tzu-Hsin Yen, Wei-Chen Tseng, Sheng-Han Lee, Zhi-Yi Du, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Ching-Chun Lin, Hui-Ju Wen, Hao-Jan Liang, Yue-Leon Guo, Pau-Chung Chen, Ching-Yu Lin
Journal of Food and Drug Analysis
Phthalates are ubiquitous environmental contaminants that raise particular concern for children, who generally experience higher exposure levels and are more susceptible to environmental pollutants. To understand potential molecular mechanisms, we conducted a cross-sectional study of 256 Taiwanese children aged 8–10 years from two population-based cohorts: the Taiwan Birth Panel Study and the Taiwan Early-Life Cohort. Serum phosphocholine-containing lipids were profiled by liquid chromatography coupled with triple quadrupole mass spectrometry and associated with urinary levels of 12 phthalate metabolites. Multiple linear regression models, adjusted for demographic and socioeconomic factors, revealed that mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), an oxidative metabolite of di(2-ethylhexyl) phthalate (DEHP), …
Applications Of Nuclear Magnetic Resonance Spectroscopy In Pediatric Clinical Metabolomics: From Research To Future Perspectives,
2026
Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan, Taiwan
Applications Of Nuclear Magnetic Resonance Spectroscopy In Pediatric Clinical Metabolomics: From Research To Future Perspectives, Chieh-Ni Kuo, Meng-Han Chiang, Hsien-Ju Lee, Yu-Ying Yu, Eric Yi-Liang Shen, Chih-Yung Chiu
Journal of Food and Drug Analysis
Metabolomics studies small-molecule metabolites to provide insights into health and disease, supporting early diagnosis and personalized medicine. Advances in mass spectrometry and nuclear magnetic resonance (NMR) have expanded its use in metabolic, cancer, and cardiovascular diseases. In pediatrics, high-resolution NMR metabolomics has been instrumental in identifying age-related metabolic changes during early childhood and their associations with growth, nutrition, and disease risk. However, a comprehensive review of its clinical applications and future potential remains limited. This review highlights how utilizing specific NMR pulse sequences, such as CPMG and NOESY, allows for precise and non-destructive metabolic profiling of diverse biofluids, supported by …
The Evolution Of Desi-Msi: A Comprehensive Look At Preprocessing And Quantification Strategies For Metabolomics,
2026
Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan
The Evolution Of Desi-Msi: A Comprehensive Look At Preprocessing And Quantification Strategies For Metabolomics, Cheng-Hung Yang, Hung-Yao Ho, Chen-Yu Chang, Mei-Ling Cheng
Journal of Food and Drug Analysis
Mass spectrometry imaging (MSI) has become an indispensable tool in metabolomics for visualizing the spatial distribution of biomolecules within tissues. Due to its direct, ambient analysis capability, desorption electrospray ionization (DESI-MSI) has evolved from a rapid screening tool into a precise and reliable quantitative platform. We delve into its technical principles and particularly review the criticality of sample preprocessing, highlighting the paradigm shift from a "no-preprocessing" approach to one of "optimized preprocessing." The paper details how factors like sample preservation, choice of embedding agents, washing, drying, and on-tissue chemical derivatization all impact data quality. We also discuss how the addition …
