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Articles 4081 - 4110 of 63015
Full-Text Articles in Computer Sciences
Development Of Fuzzy Ontology For Explainable Artificial Intelligence For Decision-Making In Fuzzy Environment, Pavel Kosov
Development Of Fuzzy Ontology For Explainable Artificial Intelligence For Decision-Making In Fuzzy Environment, Pavel Kosov
Chemical Technology, Control and Management
In modern artificial intelligence systems, there is an acute need to understand the decision-making logic of "black box" algorithms. Our research proposes an innovative method for increasing the transparency of such systems through the formalization of fuzzy explanatory mechanisms. We have developed an extension of existing ontological approaches by introducing the concept of fuzziness into the structure of explanatory properties, which allows overcoming the fundamental limitations of traditional XAI methods. The proposed formalization is based on the theory of collective mental models and principles of fuzzy logic, providing a more accurate reflection of uncertainty and subjectivity in expert knowledge. Our …
A Critical Realist Erp Implementation In Zimbabwean Mining Industry Organisations, Jairos Mukwenha
A Critical Realist Erp Implementation In Zimbabwean Mining Industry Organisations, Jairos Mukwenha
Tanzania Journal of Engineering and Technology (TJET)
This research uses a critical realist framework to examine the factors influencing the success of enterprise resource planning (ERP) system implementation in Zimbabwean mining industry organisations. From the perspective of critical realism, the mining industry in Zimbabwe faces a complex interplay of opportunities and obstacles while implementing ERP systems. The deployment of ERP in mining firms is critically examined in this paper, emphasising how these systems might improve operational efficiency while considering Zimbabwe's particular socioeconomic circumstances. By exploring underlying structures, mechanisms, and outcomes, the research aims to identify critical challenges and opportunities and develop practical recommendations for improving ERP adoption …
Development Of A Microcontroller-Based Intelligent Traffic Light Control System For Vehicular Movement In T-Junctions, Frederick O. Ehiagwina
Development Of A Microcontroller-Based Intelligent Traffic Light Control System For Vehicular Movement In T-Junctions, Frederick O. Ehiagwina
Tanzania Journal of Engineering and Technology (TJET)
This research is devoted to the issue of regulating traffic congestion in major cities using light-dependent resistors coupled with the PIC16F877A microcontroller. This study proposes an intelligent traffic control system for T-Junctions, utilizing sensing and control to optimize traffic flow through dynamic phase adjustments and congestion reduction, enabled by a microcontroller-based decision-making system. The proposed system reduces traffic congestion, automates control, and enhances safety, minimizing accidents and lowering infrastructure costs. Under simulated environment, it demonstrates an average response time of 50 ms and achieves 99% accuracy in displaying the correct countdown. Finally, the number of state transitions handled per minute …
An Efficient Blockchain-Based Privacy Preservation Scheme For Smart Grids, Mohamad Badra, Rouba Borghol
An Efficient Blockchain-Based Privacy Preservation Scheme For Smart Grids, Mohamad Badra, Rouba Borghol
All Works
Smart grids have revolutionized electricity management and distribution, but they also generate and transmit vast amounts of consumer data, raising privacy concerns. In this paper, we propose a blockchain-based solution to preserve user's privacy in smart grids and to mitigates data forgery, profiling, and man-in-the-middle attacks. Moreover, our solution provides security services such as authentication and non-repudiation to prevent unauthorized access to sensitive data and ensure accountability and traceability. We validate our approach through testing and show that it is a simple, scalable, cost-effective solution with minimal computational processing overhead.
Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B.
Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B.
Tanzania Journal of Engineering and Technology (TJET)
The Fiber Bragg Grating (FBG) sensor has become a widespread sensing device because of its small size, passive design, immunity to electromagnetic interference, and direct ability to measure physical properties like temperature and strain. Recently, femtosecond infrared laser processing and regeneration techniques have resulted in the development of stable high-temperature gratings, which are a powerful tool in smart factories, an aspect of the fourth Industrial Revolution (4IR), and show promise for application in harsh environments like high pressure, high temperature, or ionizing radiation. The development of stable high-temperature gratings that can withstand harsh environmental factors like high temperatures, pressures, and …
Application Of Artificial Neural Network Models For Predicting Diesel And Petrol Prices In The Geographically Sparsed Regions In Tanzania, John M. Kafuku
Application Of Artificial Neural Network Models For Predicting Diesel And Petrol Prices In The Geographically Sparsed Regions In Tanzania, John M. Kafuku
Tanzania Journal of Engineering and Technology (TJET)
Fuel consumption in Tanzania, mainly diesel and petrol, accounts for 82 percent of the energy consumption in the country, with significant price volatility affecting market stability, availability of fuel, and investment decisions. This study uses an artificial neural network (ANN) with a backpropagating algorithm to predict fuel prices in four regions of Tanzania. Key input parameters include the currency inflation rate (CIR), the petrol fuel inventory (PFI), the diesel fuel inventory (DFI), and the fuel transport costs (FTC). The study selected the 6-10-10-2 ANN structures for Sumbawanga-Rukwa, Mpanda-Katavi, and Mbeya-Mbeya as well as 6-10-9-2 for the Songea-Ruvuma region. The results …
A Fuzzy Based Framework For Sustainable Technology Selection In Small-Scale Gold Mining Operations, John M. Kafuku
A Fuzzy Based Framework For Sustainable Technology Selection In Small-Scale Gold Mining Operations, John M. Kafuku
Tanzania Journal of Engineering and Technology (TJET)
Small-scale gold mining (SSGM) operations in Tanzania has been operating inefficiently due to inadequate mining processing technologies, poor working tools, lack of enough capital, and insufficient electricity. Despite the efforts made by different stakeholders in boosting the sustainability of SSGM yet the sector has not reached the expected goal. This paper proposes a framework for appropriate technology selection to help small scale gold miners in evaluating various gold mineral processing technologies. The framework utilizes the fuzzy logic set theory for technology evaluation and selection. The developed framework for technology selection upon validation provided results that technology adequacy of more than …
Synthetic Inertia Provision For Load Frequency Control In Networks With High Penetration Of Renewable Energy Sources, Paulina Mkoi
Synthetic Inertia Provision For Load Frequency Control In Networks With High Penetration Of Renewable Energy Sources, Paulina Mkoi
Tanzania Journal of Engineering and Technology (TJET)
The integration of renewable energy sources (RESs) such as solar photovoltaic (PV) and wind energy has become a promising solution as the world shifts toward clean energy. Solar PV and wind resources are increasingly replacing conventional synchronous generators, leading to reduced system inertia and increased vulnerability to frequency instability during disturbances. To address this challenge, this study proposes a novel synthetic inertia provision strategy using a battery energy storage system (BESS) integrated alongside solar PV. The proposed method dynamically compensates for the loss of inertia by considering the variability of solar PV output due to changes in irradiance and temperature. …
College Market, Krysta L. Ray, Sijan Panday, Janniebeth Melendez, Gavin Kent
College Market, Krysta L. Ray, Sijan Panday, Janniebeth Melendez, Gavin Kent
ATU Scholars Symposium
Each year, according to planetaid.org, college students generate 640 million pounds of waste with items like clothes, furniture, books, and other belongings to avoid the hassle of moving them, contributing to unnecessary waste. Current marketplace applications are overloaded with listings, making it difficult for students to buy and sell items efficiently. For example, 250 million sellers worldwide user Facebook Marketplace. To address this, College Market offers a solution that reduces waste while facilitating seamless connections between students selling unwanted goods and those seeking affordable, local items. College Market is a secure, campus-centered application designed to address both environmental and economic …
Generating More Equitable Fair Use, Jacqueline Kessel
Generating More Equitable Fair Use, Jacqueline Kessel
Pepperdine Law Review
From advancing healthcare and education to threatening democratic systems, generative artificial intelligence (AI) has demonstrated a capacity to positively and negatively impact society. And these benefits and consequences are not shared equitably. Copyright law, however, stands as a powerful mechanism in monitoring AI system development. Several complaints have charged generative AI system developers with copyright infringement, alleging that (1) ingesting copyrighted works as training data infringes the copyright owner’s exclusive right to reproduce works in copies and (2) generating AI outputs infringes the exclusive right to prepare derivative works because the outputs are based upon the works on which the …
Meet Atu Intro, Caleb Urbani, Darlene Matamoros, Dena Paw, Jean Caballero
Meet Atu Intro, Caleb Urbani, Darlene Matamoros, Dena Paw, Jean Caballero
ATU Scholars Symposium
Meet ATU is our app designed to improve a student’s network and campus experience. Specifically made for students at Arkansas Tech University, Meet ATU allows students to connect and engage with their classmates easily. Students can add classes to their profiles using a course reference number. Students can also personalize their profiles to help them find other students to connect with within their enrolled classes. Meet ATU encourages students to communicate and collaborate with others through the messaging page. This would help students grow their network. The app will also include a leaderboard page that tracks points earned through various …
Self-Supervised Learning And Its Applications In Medical Image Analysis, Siladittya Manna
Self-Supervised Learning And Its Applications In Medical Image Analysis, Siladittya Manna
Doctoral Theses
Self-supervised learning (SSL) enables learning robust representations from unlabeled data and it consists of two stages: pretext and downstream. The representations learnt in the pretext task are transferred to the downstream task. Self-supervised learning has appli- cations in various domains, such as computer vision tasks, natural language processing, speech and audio processing, etc. In transfer learning scenarios, due to differences in the data distribution of the source and the target data, the hierarchical co-adaptation of the representations is destroyed, and hence proper fine-tuning is required to achieve satisfactory performance. With self-supervised pre-training, it is possible to learn repre- sentations aligned …
Analysis And Monitoring Of A Robotics Curriculum: Are Simnow Modules Valuable?, Jacob Applegarth, Ibrahim Baida, Anthony Iacco, Ngan Nguyen, Nathan Novotny
Analysis And Monitoring Of A Robotics Curriculum: Are Simnow Modules Valuable?, Jacob Applegarth, Ibrahim Baida, Anthony Iacco, Ngan Nguyen, Nathan Novotny
Posters
No abstract provided.
One Size Doesn’T Fit All: Towards Design And Evaluation Of Developmentally Appropriate Parental Control Tool, Prakriti Dumaru, Mahdi Nasrullah Al-Ameen
One Size Doesn’T Fit All: Towards Design And Evaluation Of Developmentally Appropriate Parental Control Tool, Prakriti Dumaru, Mahdi Nasrullah Al-Ameen
Computer Science Student Research
As children progress through developmental stages, they undergo substantial biological, cognitive, and social changes, creating unique needs for online safety across different age groups (e.g., young children, tweens, teens). The existing parental control tools fail to account for these differences, leaving a notable gap in the literature on parental mediation. To this end, we conducted 10 focus group sessions with a total of 20 parents to understand their preferences for age-appropriate design components that promote self-regulation and open communication, followed by an ideation workshop with four UX design experts to translate these preferences into customized features. We then evaluated these …
Exploring The Impacts Of An Adaptive Haptic Heartbeat Within A Socially Assistive Robot, Jade Thompson
Exploring The Impacts Of An Adaptive Haptic Heartbeat Within A Socially Assistive Robot, Jade Thompson
Honors Theses
This research investigates the therapeutic effects of an adaptive haptic heartbeat within Therabot, a stuffed robotic dog. A simulated haptic heartbeat that adjusts its own speed based on user heart rate was developed for integration within Therabot. A user study evaluated the effects of various heartbeat behaviors on user experiences with Therabot, with respect to improvements in self-reported state anxiety, physiological improvements, and perceptions of the robot. A relationship was found between improvements in self-reported state anxiety and positive opinions of Therabot, regardless of condition. Additionally, differences were found between conditions with respect to improved aspects of state anxiety, with …
Autonomous Intelligence In Fashion: A Comprehensive Analysis Of Agentic Ai Across The Fashion Ecosystem, Andrew Burnstine
Autonomous Intelligence In Fashion: A Comprehensive Analysis Of Agentic Ai Across The Fashion Ecosystem, Andrew Burnstine
Faculty and Staff Publications & Presentations
The fashion industry is undergoing a paradigm shift with the emergence of agentic artificial intelligence (AI), a sophisticated class of intelligent systems exhibiting autonomous decision-making, continuous learning, and adaptive action with minimal human intervention. Moving beyond traditional AI applications in fashion focused on predictive analytics, generative tools, and supervised automation, agentic AI introduces a transformative paradigm wherein intelligent agents proactively navigate the complexities inherent in design, manufacturing, supply chain optimization, and consumer personalization. This paper presents a comprehensive exploration of the evolving role of agentic AI across the multifaceted fashion ecosystem, offering an in-depth analysis of its technological underpinnings, operational …
Fact-Based Counter Narrative Generation To Combat Hate Speech, Brian Wilk, Homaira Huda Shomee, Suman Kalyan Maity, Sourav Medya
Fact-Based Counter Narrative Generation To Combat Hate Speech, Brian Wilk, Homaira Huda Shomee, Suman Kalyan Maity, Sourav Medya
Computer Science Faculty Research & Creative Works
Online hatred has become an increasingly pervasive issue, affecting individuals and communities across various digital platforms. To combat hate speech in such platforms, counter narratives (CNs) are regarded as an effective method. In recent years, there has been growing interest in using generative AI tools to construct CNs. However, most of the generative models produce generic responses to hate speech and can hallucinate, reducing their effectiveness. To address the above limitations, we propose a counter narrative generation method that enhances CNs by providing non-aggressive, fact-based narratives with relevant background knowledge from two distinct sources, including a web search module. Furthermore, …
The Attitudes And Perspectives Of Laboratory Professionals On The Use Of Machine Learning Combined With Maldi For Viral Identification: A Qualitative Study, Grace Johnson
Honors Projects
The use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with machine learning (ML) has been proposed by numerous studies as a novel approach for viral identification. However, the development and implementation of this instrumentation is still in its early stages, and laboratory professionals' perspectives on its feasibility, accuracy, implementation, and effect on current laboratory operating procedures remain underexplored.
This study aimed to investigate laboratory professionals’ attitudes and opinions regarding the use of MALDI-TOF-MS coupled with machine learning for viral identification, focusing on perceived benefits, barriers, and factors that would affect participants’ opinions on implementation.
A qualitative descriptive research …
Cascading Effects: Analyzing Project Failure Impact In The Maven Central Ecosystem, Mina Shehata
Cascading Effects: Analyzing Project Failure Impact In The Maven Central Ecosystem, Mina Shehata
SPARK Symposium Presentations
Abstract—This study examines failure propagation patterns within the Maven Central ecosystem, a critical software de- pendency repository, through comprehensive analysis of dependency networks using the Goblin framework. Our dual-sampling methodology, investigating both top dependencies and random libraries, revealed two distinct failure propagation patterns that pose significant risks to ecosystem stability. Core infrastructure failures, particularly evident in cases like the AWS SDK family with 429,800 total dependencies, create immediate and widespread disruption, affecting an average of 20,402 dependent projects and propagating through dependency chains averaging 90.80 levels deep.
Our analysis of peripheral projects reveals their significant cascading effects, with higher average …
Real-Time Active-Learning Method For Audio-Based Anomalous Event Identification And Rare Events Classification For Audio Events Detection, Farkhund Iqbal, Ahmed Abbasi, Ahmad Almadhor, Shtwai Alsubai, Michal Gregus
Real-Time Active-Learning Method For Audio-Based Anomalous Event Identification And Rare Events Classification For Audio Events Detection, Farkhund Iqbal, Ahmed Abbasi, Ahmad Almadhor, Shtwai Alsubai, Michal Gregus
All Works
Introduction: Audio event detection, the application of scientific methods to analyze audio recordings, can be helpful in examining and analyzing audio recordings to preserve, analyze, and interpret sound evidence. Furthermore, it can be helpful in safety and compliance, security, surveillance, maintenance, and predictive analysis. Audio event detection aims to recover meaningful information from audio recordings, such as determining the authenticity of the recording, identifying the speakers, and reconstructing conversations. However, filtering out noise for better accuracy in audio event detection is a major challenge. A greater sense of public security can be achieved by developing automated event detection systems that …
Cyber Safety: Protecting Yourself Online, Laxima Niure Kandel, Kayla D. Taylor, Bhawana Poudel, Helen Hernandez
Cyber Safety: Protecting Yourself Online, Laxima Niure Kandel, Kayla D. Taylor, Bhawana Poudel, Helen Hernandez
Graduate Student Works
The IEEE Women in Engineering (WIE) Affinity Group of Daytona hosted a cybersecurity awareness event on Saturday, April 26, 2025, at the Port Orange Regional Library. The session was designed specifically to help seniors in Volusia County learn how to protect themselves online, avoid scams, create strong passwords, and safely navigate the digital world.
Autoradai: A Versatile Artificial Intelligence Framework Validated For Detecting Extracapsular Extension In Prostate Cancer, Pegah Khosravi, Shady Saikali, Abolfazl Alipour, Saber Mohammadi, Maxwell Boger, Dalanda M. Diallo, Christopher J. Smith, Marcio C. Moschovas, Iman Hajirasouliha, Andrew J. Hung, Srirama S. Venkataraman, Vipul Patel
Autoradai: A Versatile Artificial Intelligence Framework Validated For Detecting Extracapsular Extension In Prostate Cancer, Pegah Khosravi, Shady Saikali, Abolfazl Alipour, Saber Mohammadi, Maxwell Boger, Dalanda M. Diallo, Christopher J. Smith, Marcio C. Moschovas, Iman Hajirasouliha, Andrew J. Hung, Srirama S. Venkataraman, Vipul Patel
Publications and Research
Preoperative identification of extracapsular extension (ECE) in prostate cancer (PCa) is crucial for effective treatment planning, as ECE presence significantly increases the risk of positive surgical margins and early biochemical recurrence following radical prostatectomy. AutoRadAI, an innovative artificial intelligence (AI) framework, was developed to address this clinical challenge while demonstrating broader potential for diverse medical imaging applications. The framework integrates T2-weighted MRI data with histopathology annotations, leveraging a dual convolutional neural network (multi-CNN) architecture. AutoRadAI comprises two key components: ProSliceFinder, which isolates prostate-relevant MRI slices, and ExCapNet, which evaluates ECE likelihood at the patient level. The system was trained and …
Systemization Of Knowledge (Sok): Goals, Coverage, And Evaluation In Cybersecurity And Privacy Games, Yue Huang, Marthie Grobler, Lauren S. Ferro, Georgia Psaroulis, Sanchari Das, Jing Wei, Helge Janicke
Systemization Of Knowledge (Sok): Goals, Coverage, And Evaluation In Cybersecurity And Privacy Games, Yue Huang, Marthie Grobler, Lauren S. Ferro, Georgia Psaroulis, Sanchari Das, Jing Wei, Helge Janicke
Research outputs 2022 to 2026
This paper systematized existing knowledge on cybersecurity and privacy game-based approaches, exploring their goals, scope, and evaluation methods. Our review of 93 academic papers revealed that these approaches serve multiple purposes and target diverse player types. We identified 11 key aspects of cybersecurity and privacy that these approaches addressed, such as threats, defensive strategies, and data privacy. Additionally, we analyzed the effectiveness evaluation methods of these approaches, emphasizing the connections between evaluation techniques, types of data used, and their alignment with the approaches' goals. We also summarized the aspects of user experience evaluated in the literature and the types of …
The Role Of Ai In Risk Management: Benefits, Challenges, And Adoption Strategies, Lukas Ludwig
The Role Of Ai In Risk Management: Benefits, Challenges, And Adoption Strategies, Lukas Ludwig
Honors Projects in Information Systems and Analytics
This study explores the role of artificial intelligence (AI) in risk management, focusing on its integration within business operations. The primary objective of this research is to examine both the potential benefits and associated risks of adopting AI technologies, with a specific emphasis on data security, ethical concerns, and governance. A mixed methodology was employed, combining a comprehensive literature review on AI's applications and limitations with qualitative interviews conducted with professionals from various industries, including risk management, higher education, and IT development. The findings highlight key challenges in AI adoption, such as data privacy issues, bias in AI algorithms, and …
"Exploring The Training Data Landscape For Ai Based Threathunting For Protecting Intellectual Property", Manzi Siibo, Christopher Kreider
"Exploring The Training Data Landscape For Ai Based Threathunting For Protecting Intellectual Property", Manzi Siibo, Christopher Kreider
Cybersecurity Undergraduate Research Showcase
This study provides a comprehensive evaluation of the effectiveness that would result in the integration of AI into traditional threat hunting systems. To do so, 10-15 scholarly articles and data sets were evaluated to see the results of AI and machine learning threat hunting versus traditional systems. With so many proven benefits of this integration, this paper also explores how it impacts the protection of Intellectual property which is some of the most important forms of information that threat hunting systems aim to protect.
Fictional Failures And Real-World Lessons: Ethical Speculation Through Design Fiction On Emotional Support Conversational Ai, Fayle Kollig, Jessica Pater, Fayika Farhat Nova, Casey Fiesler
Fictional Failures And Real-World Lessons: Ethical Speculation Through Design Fiction On Emotional Support Conversational Ai, Fayle Kollig, Jessica Pater, Fayika Farhat Nova, Casey Fiesler
Health Services and Informatics Research
Conversational artificial intelligence (CAI), which replicates human-to-human interaction as human-to-machine, is increasingly developed to address insufficient access to healthcare. In this paper, we use design fiction methods to speculate on ethical consequences of CAI that offers emotional support to complement or replace mental healthcare. Through a near-future news article about a fictional, failed CAI, we explore safety and privacy concerns associated with mismatches between what an emotional support CAI is advertised to do, what it technically can do, and how it is likely to be used. We pose the following questions to researchers, regulators, and developers: How might we jointly …
The Role Of Natural Language Processing In Abstract Dataset To Improve Virtual Assistant Devices, Reem Alshahoomi, Salma Alameri, Sanaa Alfalasi, Feras Al-Obeidat
The Role Of Natural Language Processing In Abstract Dataset To Improve Virtual Assistant Devices, Reem Alshahoomi, Salma Alameri, Sanaa Alfalasi, Feras Al-Obeidat
All Works
Natural Language Processing (NLP) has transformed human-computer interaction, especially in the realm of virtual assistants. NLP enables machines to understand, interpret, and generate human language, driving innovations in applications ranging from virtual assistants to customer service chatbots. This paper delves into the intersection of NLP and virtual assistants, examining advanced models like BERT and RoBERTa, which enhance contextual understanding and user intent recognition. Through a comprehensive evaluation using the dataset of research abstracts to explore new methods and improve response for virtual assistant devices, it explores methods to improve model efficiency, precision, and scalability. By leveraging machine learning techniques and …
Navigating Ethical Dimensions In The Metaverse: Challenges, Frameworks, And Solutions, Mousa Al-Kfairy, Saed Alrabaee, Omar Alfandi, Amr Taha Mohamed, Souheil Khaddaj
Navigating Ethical Dimensions In The Metaverse: Challenges, Frameworks, And Solutions, Mousa Al-Kfairy, Saed Alrabaee, Omar Alfandi, Amr Taha Mohamed, Souheil Khaddaj
All Works
The Metaverse is rapidly evolving into a transformative digital ecosystem, bringing with it unprecedented opportunities and a complex array of ethical challenges. This narrative review, based on an in-depth analysis of 105 full publications, explores the key ethical themes associated with the Metaverse, including privacy and data security, identity and behavior, digital inclusivity, mental and physical health, ethical AI, content moderation, intellectual property, governance, environmental sustainability, harassment, cultural representation, and economic implications. Proposed solutions for these challenges encompass privacy-by-design frameworks, robust identity verification systems, equitable access initiatives, explainable AI, and blockchain-based intellectual property protections. Additionally, the review examines governance and …
Using Keystroke Dynamics Behavioral Biometrics To Identify Users, Bradley F. Budach
Using Keystroke Dynamics Behavioral Biometrics To Identify Users, Bradley F. Budach
Research & Creative Achievement Day
This study explores the use of keystroke dynamics as a behavioral biometric for user identification. Unlike physiological biometrics, such as fingerprints or facial recognition, keystroke dynamics leverages the unique typing patterns of individuals to create a distinctive signature. This research was to develop a machine learning-based system that utilizes keystroke dynamics for continuous and unobtrusive user authentication. By collecting and analyzing keystroke data from multiple users, relevant features were extracted and used to train a machine learning model to identify user keystroke signatures with an equal error rate of 0.11. This model allows for reliable and scalable authentication that can …
Plasma Profiling Reveals Proteins Specific To Primary Disease Origin Of Retroperitoneal Fibrosis, Thomas J. Pelowitz, Benjamin Hurr, Matthew Koster, Jaeyun Sung
Plasma Profiling Reveals Proteins Specific To Primary Disease Origin Of Retroperitoneal Fibrosis, Thomas J. Pelowitz, Benjamin Hurr, Matthew Koster, Jaeyun Sung
Research & Creative Achievement Day
Retroperitoneal fibrosis (RPF) is a rare inflammatory disease characterized by the formation of scar-like tissue in the retroperitoneum, which can lead to life-threatening obstructive nephropathy. RPF is typically a secondary disease, arising from various underlying conditions. Currently, no objective and highly accurate diagnostic methods exist. Identifying blood protein biomarkers specific to RPF could facilitate the development of objective minimally invasive diagnostic tests.
In this study, blood plasma samples were collected from 45 participants spanning 5 different primary causes of RPF, including idiopathic cases where no underlying condition was identified. Six participants without significant diseases at the time of sample collection …