Psychiatry and Psychology Commons^™

From Trauma To Treatment: Chronic Neurobehavioral Consequences And Emerging Treatments, Moriah E. Mcguier

Dartmouth College Ph.D Dissertations

Severe trauma exposure related to traumatic brain injury (TBI) or psychiatric disorders like post-traumatic stress disorder (PTSD) leads to neurobehavioral and physiological impairments that reduce the quality of life of individuals and remain difficult to treat with current therapeutic options. Further, these conditions are highly comorbid, notably in PTSD with blast-traumatic brain injury (bTBI) commonly experienced by military members via explosive forces, leading to complex and heterogenous outcomes. To address this, preclinical models have been developed to recapitulate aspects of TBI and PTSD. This thesis utilizes two such models in rats, bTBI and the single prolonged stress (SPS) model for …

Eating Behavior Differences Across Dementia Diagnoses: The Roles Of Behavioral Symptoms And Anticipatory Physiological Responses, Charlie J. Lorkovic

Honors Program: Senior Projects (Public)

Objective: To determine how behavioral symptoms and impairment of the preparatory physiological response contribute to disordered eating behaviors in dementia, particularly frontotemporal dementia (FTD) and Alzheimer’s disease (AD).

Methods: This secondary analysis utilizes data from 242 patients (191 FTD, 51 AD) who took part in a collaborative study between the University of California, Berkeley, and the University of California, San Francisco. Preparatory physiological responses were measured as heart rate increases from a baseline to an instruction period, when participants were informed that they were about to watch an emotional film. Behavioral symptoms, including eating behaviors, were assessed using the Neuropsychiatric …

Examining The Mediating Effects Of Symptoms Of Depression, Anxiety, And Perceived Stress On The Association Between Bereavement And Inflammation, Kylee Faith Behringer

Master's Theses

Bereavement is a stressor that impacts the psychological well-being of an individual and their physical health. This study aimed to develop a more nuanced understanding of the association between bereavement and its psychological and biological consequences, and the potential mediating role of symptoms of depression, anxiety, and stress within the relationship between bereavement and inflammation. Data was collected through Midlife in the United States (MIDUS) Refresher 1, a longitudinal study that examines social, psychological, and biological vulnerabilities associated with potential health outcomes (Weinstein et al., 2019). The study consisted of 863 participants (bereaved=373, non-bereaved=490) who completed an in-person study visit …

Improving Brain Health: Exercise As A Tool For Enhancing Executive Function And Reducing Stress In Older African Americans, Destiny Ellise Ramos

Theses, Dissertations and Culminating Projects

Older African American (AA) adults face disproportionately higher risk of stress and Alzheimer's Disease and Related Dementias (ADRD) compared to other racial and ethnic groups, yet they remain underrepresented in intervention-based research. Previous research has suggested aerobic exercise may reduce stress and benefit executive functioning, which is among the first cognitive domains to be affected in ADRD; however, no studies to date have directly tested the impact of aerobic vs. non-aerobic exercise in older AAs at high risk for developing ADRD. The current study evaluated the effects of a group-based cardio dance fitness (CDF) exercise intervention versus a strength, flexibility, …

Reliability And Validity Of The Brief Emotional Experience Scale (Bees) As A Measure Of Emotional Well-Being, Shane L. Rogers, Nicole Brown, Matthew Goulding, Kathryn Campbell, Brennen Mills, Ross Hollett, Travis Cruickshank, Kazunori Nosaka

Research outputs 2022 to 2026

This study presents initial reliability and validity evidence for the Brief Emotional Experience Scale (BEES) as a measure of emotional well-being. Using ordinal confirmatory factor analysis across three cross-sectional samples, Australian university students (n = 1239), the general public (n = 5631), and school students from Australia and the UK (n = 767). A correlated two-factor structure was supported. In the university sample, the BEES demonstrated strong convergent validity with other well-being measures and was linked to the lowest levels of reported distress when completing the survey. Preliminary cut-offs for high emotional distress were developed via comparison with the Kessler …

To Heal A Mind: A Comparison Of Functional And Conventional Treatments In Major Depressive Disorder, Gillian Chambers

Senior Honors Theses

Incidence of major depressive disorder is increasing year over year, with little able to be done to halt the spread of the condition. However, there are many treatment possibilities considered unconventional by the healthcare system. This thesis examines the respective benefits and risks, in comparison to one another, between conventional pharmacological treatment and functional, holistic treatment of depression. This was done via integrative review of available clinical literature, synthesizing evidence on both conventional and functional treatments for depression, as dictated by Whittemore and Knafl (2005). Exploratory search methods revealed 758 records fulfilling inclusion criteria, which were screened and narrowed down …

The Effects Of Loving-Kindness Meditation (Lkm) On Relationship Satisfaction In Couple Therapy, Ruimeng Gao

Electronic Theses and Dissertations

This thesis explores the integration of loving-kindness meditation (LKM) into couple therapy sessions and its impact on relationship satisfaction. Meditation, historically rooted in religious practices, has increasingly been adopted in Western therapeutic contexts due to its demonstrated benefits for mental health and interpersonal well-being. Although mindfulness-based interventions have gained popularity in psychotherapy, research specifically examining the use of LKM in couple therapy remains limited. This study investigates whether incorporating LKM into therapy sessions enhances relationship satisfaction compared to standard therapy alone. Couples were randomly assigned to either a control group, which received standard therapy, or an experimental group, which practiced …

Measuring The Strategies To Cope With Shift Work Among Healthcare Workers, Khushi Mehta, Lindsay Ham

Psychological Science Undergraduate Honors Theses

It is known that lack of sleep, no matter what career a person is in, is detrimental to the overall longevity and health of an individual. Balance of sleep can be easy to attain, especially if one’s work life is able to facilitate it. Healthcare workers, however, often do not have that luxury. Healthcare professionals work a variety of shifts ranging from night shifts, 12-16-hour shifts, regular daytime hours, and being on call during the night. These irregular working schedules can have a detrimental effect on their sleep quality and quantity. If healthcare workers don’t get enough sleep, it can …

Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave

Dissertations and Theses (Open Access)

Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …

Exploring The Biasing Effects Of Gender On Personality Disorder Diagnoses Formulated By Artificial Intelligence, Zoe Colclough

Student Theses

Gender bias is prevalent in personality disorder assessments, and while artificial intelligence has been posited as a solution to improve diagnostic objectivity and accuracy, the potential for such technologies to propagate human gender bias in mental health contexts remains underexplored. This study investigated the influences of gender bias on the diagnostic performance of ChatGPT-4o for personality disorders using three factorial research designs, which involved experimentally manipulating patient gender in a combined sample of 360 vignettes and case studies. Vignettes were synthesized through a novel artificial intelligence-assisted methodology established for this research, and case studies were identified from the literature. Significant …

Exercise As An Intervention For Postpartum Depression (Ppd), Kylie P. Mistretta

Honors Scholar Theses

Objective: To illustrate the applications of exercise for preventing the development of postpartum depression (PPD) and addressing associated risk factors identified in the literature. Data Sources: PubMed and EBSCO: Academic Search Premier were accessed using the search terms exercise OR physical activity OR yoga AND postpartum depression OR postnatal depression. A secondary search of PubMed was conducted using the search terms exercise AND pregnancy AND depression OR gestational diabetes OR weight gain OR sleep quality.

Study Selection: Studies selected for inclusion were peer-reviewed, published after January 2012, written in English, and relevant to the PPD risk factors examined. Only clinical …

Maternal Dysbiosis Produces Long-Lasting Behavioral Changes In Offspring, Jacob Hudobenko, Claudia M Di Gesù, Patrick R Mooz, Joseph Petrosino, Nagireddy Putluri, Bhanu P Ganesh, Kristen Rebeles, Frank W Blixt, Venugopal R Venna, Louise D Mccullough

Faculty, Staff and Student Publications

Advanced maternal age (AMA) is defined as a pregnancy in a woman older than 35 years of age. AMA increases the risk for both maternal and neonatal complications, including miscarriage and stillbirth. AMA has also been linked to neurodevelopmental and neuropsychiatric disorders in the offspring. Recent studies have found that age-associated compositional shifts in the gut microbiota contribute to altered microbial metabolism and enhanced inflammation in the host. We investigated the specific contribution of the maternal microbiome on pregnancy outcomes and offspring behavior by recolonizing young female mice with aged female microbiome prior to pregnancy. We discovered that pre-pregnancy colonization …

Neuroimaging-Based Variability In Subtyping Biomarkers For Psychiatric Heterogeneity, Zhenfu Wen, Mira Z Hammoud, Carole E Siegel, Eugene M Laska, Duna Abu-Amara, Amit Etkin, Mohammed R Milad, Charles R Marmar

Faculty, Staff and Student Publications

Neuroimaging-based subtyping is increasingly used to explain heterogeneity in psychiatric disorders. However, the clinical utility of these subtyping efforts remains unclear, and replication has been challenging. Here we examined how the choice of neuroimaging measures influences the derivation of neuro-subtypes and the consequences for clinical delineation. On a clinically heterogeneous dataset (total n = 566) that included controls (n = 268) and cases (n = 298) of psychiatric conditions, including individuals diagnosed with post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), and comorbidity of both (PTSD&TBI), we identified neuro-subtypes among the cases using either structural, resting-state, or task-based measures. The …

Azetukalner, A Novel Kv7 Potassium Channel Opener, In Adults With Major Depressive Disorder: A Randomized Clinical Trial, Noam N Butterfield, Constanza Luzon Rosenblut, Maurizio Fava, Christoph U Correll, Anthony J Rothschild, James W Murrough, Sanjay J Mathew, Gregory N Beatch, Celene Grayson, Cynthia Harden, Jenny Qian, Joe Mcintosh, Rostam Namdari, Christopher Kenney

Staff and Researcher Publications

Importance: Available antidepressants provide inadequate therapeutic responses in many patients with major depressive disorder (MDD), highlighting a substantial unmet need.

Objective: To evaluate the efficacy and safety of azetukalner, a novel, potent KV7 potassium channel opener, in participants with MDD.

Design, setting, and participants: X-NOVA was a multicenter, proof-of-concept, phase 2, randomized, double-blind, parallel-group, placebo-controlled clinical trial that evaluated azetukalner in participants (adults aged ≥18 to ≤65 years) with moderate to severe MDD in a current depressive episode. Participants were enrolled between April 2022 and October 2023, and data analysis occurred from January 2023 to January 2024.

Intervention: Participants were …

Navacaprant, A Novel And Highly Selective Kappa Opioid Receptor Antagonist, In Adults With Major Depressive Disorder: A Randomized, Double-Blind Phase 2 Clinical Trial, Sanjay J Mathew, Andrew J Cutler, Nicole C Visitacion, Michael Gold, Jason Yuan, Bill Aurora

Staff and Researcher Publications

PURPOSE/BACKGROUND: This phase 2a randomized, double-blind, placebo-controlled, 8-week trial assessed the efficacy and safety of navacaprant, a highly selective kappa opioid receptor antagonist, in adults with major depressive disorder (MDD).

METHODS/PROCEDURES: Participants with 17-Item Hamilton Depression Rating Scale (HAMD-17) scores of 14 to 30 were randomized 1:1 to once-daily navacaprant 80 mg or placebo (n = 102 each). The primary endpoint was HAMD-17 change from baseline (CFB) to week 8. Secondary endpoints included CFB in Snaith-Hamilton Pleasure Scale (SHAPS). No adjustment for multiple comparisons was made.

FINDINGS/RESULTS: At week 8, HAMD-17 CFB was not statistically significantly improved with navacaprant vs …

Does Institutional Response Matter? A Qualitative Study Of Child Sexual Abuse Within Southern Baptist Convention-Affiliated Churches, Bonnie Colleen Wetzel

Doctoral Dissertations and Projects

Child sexual abuse (CSA) affects approximately one in four girls and one in 20 boys in the US, with 91% of perpetrators being known to the child (Centers for Disease Control and Prevention, 2022). This instrumental case study explored how adult female CSA survivors (N=9) perceive their experiences and institutional responses within Southern Baptist Convention (SBC)- affiliated churches. Data collection involved Zoom interviews, journal prompts, and focus groups. Two research questions guided the study: How do adult survivors perceive their experiences of abuse within SBC-affiliated churches? And how do they perceive the church's response following disclosure? Betrayal Trauma Theory (Freyd, …

A Psychometric Evaluation Of The Intentionality Bias Task, David Willard

Graduate Theses and Dissertations (2019 - present)

Intentionality Bias Task (IBT) provides quick and easy assessment of the tendency to overattribute intentionality to the behaviors of others. The IBT has been used repeatedly in research that has attempted to connect intentionality bias to a wide range of disorders and socio-emotional abilities, including schizophrenia spectrum disorder, autism spectrum disorder, and cognitive empathy. To date, however, there has been no systematic examination of the IBT’s psychometric properties. The present study attempts to fill this gap by testing whether the IBT possesses a reliable factor structure. Specifically, the 34 items of the IBT were written to reflect two types of …

“Re-Storying” Anne Shirley And The Adhd Child: A Crip Genealogy Of Anne Of Green Gables, Darian Aleyna Wilson

Department of English: Dissertations, Theses, and Student Research

This thesis explores the contested nature of Attention Deficit Hyperactivity Disorder (ADHD), focusing on its cultural and historical constructions. While ADHD has been included in the Diagnostic and Statistical Manual of Mental Disorders since 1980, its legitimacy remains a subject of debate across medical, disability studies, and historical scholarship. Using Eli Clare’s critique of diagnosis as a tool rather than a fact, this project examines how ADHD is both pathologized and re-storied within societal and medical discourses. It highlights the tension between medical classifications and lived experiences of those diagnosed with ADHD, particularly in the context of girlhood.

The central …

Investigating Mental Health Outcomes Of National Collegiate Athletic Association (Ncaa) Division I Student-Athletes At The University Of Louisville, 2019-2023., Paul Harvey

Electronic Theses and Dissertations

Mental health outcomes among collegiate student-athletes, has become a broader concern in the 21^st century. This study examines prevalence and incidence of anxiety and depression amongst student-athletes at the University of Louisville from 2019-2023 across different Sports Groups. The prevalence of anxiety was found to be 20.22% and risk of anxiety was 15.65%. The prevalence of depression was found to be 13.11% and risk of depression was 18.75%. Logistic regression was used to estimate the association between sports groups and anxiety/depression. There was a borderline association between sports groups and prevalence of anxiety after confounder adjustment (OR=1.86, 95% CI: …

Useful Measures Of Adult Attachment And Object Relations In Psychotherapy, Matilde A. Torallas Huerta

Dissertations

This is a literature review of objective and projective measures of attachment and object relations in adults, with the objective of reviewing outstanding research to identify the key factors for adult attachment assessment considered within attachment and object relations theories, what measures of adult attachment styles and dysfunction work best, and to provide key themes of assistance in the measurement of attachment and object relations in adult clients in psychotherapy. Theoretical foundations of attachment and object relations theory are reviewed as well as objective and projective instruments grouped by format. The 10 themes found to be useful in the assessment …

Mechanisms Of Behavioral Change In Hosts Of Toxoplasma Gondii: A Review, Olivia Grimsley

Senior Honors Theses

The parasite Toxoplasma gondii is a highly ubiquitous parasite that latently infects an estimated 33% percent of the global population. Toxoplasmosis is of obvious clinical significance due to the extremely high risks to the unborn who contract it congenitally. Less attention has been given to a more subtle aspect of latent infection, which is the behavioral alterations that are commonly experienced by those who contract the parasite. Infected individuals commonly display a variety of altered behaviors, such as increased aggression and risk-seeking behaviors, depression, higher tendency towards suicide and self-directed violence, a loss of fear response, and a greatly increased …

The Role Of Endogenous Estrogen In Effects Of Non-Invasive Brain Stimulation On Cognitive Performance, Samantha Walsh

Theses, Dissertations and Culminating Projects

High-definition transcranial direct current stimulation (HD-tDCS) directly modulates brain activity, allowing the study of brain-behavior relationships in cognitive processes. However, cognitive effects of tDCS vary widely, partly due to individual differences in baseline brain activity. Estrogen levels, which fluctuate during the menstrual cycle, are known to affect cortical excitability and impact neural response to tDCS, but no research to date has examined the potential moderating role of endogenous estrogen in tDCS effects on cognition. In this study, N = 16 healthy female adults completed four sessions of a working memory (WM) task while receiving tDCS (two active sessions, two sham) …

Hands-On Healing: The Role Of Creative Art And Clay In Happiness And Stress Reduction, Aria Mokhtari, Mahdi Ghasemi, Melika Eshaghian, Kat Bishop, Brittany Turner, Ryan Golshir, Ana De Faria Lima, Kaylee Stone, Soojin Lee, Jennifer Cooper

Symposium of Student Scholars

Stress and mental health concerns are increasing among students at Kennesaw State University. Creativity has gained recognition for their therapeutic benefits. This research investigated the impact of clay sculpting on stress reduction and emotional well-being. Through qualitative and quantitative assessments, we analyzed participants' self-reported stress levels before and after participating in clay sculpting. A pre-and post-event survey measured the impact of engagement in these activities. After evaluating feedback and statistical trends, this study can provide evidence supporting clay sculpting as an effective tool for enhancing mental well-being among students. Stress levels were assessed using numerical rating scales (a form of …

Evaluating Referral Rates For Positive Postpartum Depression Screenings At Telehealth And Well-Child Visits: A Scoping Review, Rachel Macklin Barber, Mph, Bsn, Rn, Damaris Amber Brooks, Bsn, Rn, Ashli-Emeria Gary, Bsn, Rn, Margaret Harvey, Phd, Acnp-Bc, Chfn, Kate Fouquier Phd, Aprn, Cnm, Pmh-C, Facnm

Doctor of Nursing Practice Projects

Purpose/Background

Postpartum depression (PPD) affects one in nine women. It has distressing impacts, including behavioral and attachment issues and toveruse of healthcare services. PPD occurs within 4 weeks to 12 months postpartum. A scoping review was conducted to compare referral rates to mental health providers after PPD screenings were conducted via telehealth versus those completed at well-child visits.

Methods

Peer-reviewed articles published within five years before the initial search, beginning September 2022 and ending November 2024, were selected. Articles were sourced from several publications using an online library database with various MeSH terms and Boolean operators. Search results were narrowed …

Assessing Healthcare Students’ Self-Efficacy In Disaster Response: A Cross-Sectional Analysis, Aydın Şenol, Abdülkerim Adıyaman, Canan Birimoglu Okuyan

Makara Journal of Health Research

Background: Assessing healthcare students’ self-efficacy in disaster response is crucial for preparing them to effectively manage real-world disaster situations. This study aimed to assess the self-efficacy status of healthcare students in disaster response.

Methods: The data for this cross-sectional analysis were gathered from 498 healthcare students between November 18, 2023, and February 14, 2024, using an individual diagnostic form and the disaster-response self-efficacy (DRSE) scale. This scale is used to assess an individual’s self-efficacy in responding effectively to disasters, including on-site rescue competency, disaster psychological nursing competency, disaster role quality, and adaptation competency.

Results: The mean age …

Expediting Tool-Use Learning: Effects Of Non-Invasive Neurostimulation Of The Left Anterior Supramarginal Gyrus, Kamila Haliru

Honors Thesis

The left anterior supramarginal gyrus (aSMG) has been implicated as an important brain region in tool use. While anodal transcranial Direct Current Stimulation (atDCS) over the primary motor cortex (M1) has been shown to facilitate skilled tool use, the effects of aSMG stimulation remain largely unexplored. Using a chopstick-marble paradigm, this thesis examined whether atDCS to the left aSMG would enhance tool-use learning. Electroencephalography (EEG) was concurrently recorded to assess atDCS-dependent changes to the beta and gamma frequency bands. Our results demonstrated that atDCS over the left aSMG significantly expedited tool-use learning and was associated with increased gamma band activity …

Evaluation Of Depression Screening Tools For Utilization In Adolescents: A Scoping Review, Helen Whitaker Bsn, Rn, Jade Bray Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C, Jacqueline Sharp Dnp, Aprn, Pmhp-Bc, Sharon Little Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Anxiety and depression are prevalent mood disorders among the adolescent population with significant impacts on academic performance, social interactions, and mental well-being. With depression rates continuing to rise and suicide among the leading causes of death in adolescents, there is an urgent need for effective screening and intervention. While depression screening is recommended in the primary care setting, many adolescents do not have regular access to healthcare, complicating early identification and treatment. The purpose of this scoping review is to compare the effectiveness of two depression screening tools, the Patient Health Questionnaire (PHQ-9) and the Beck Depression Inventory (BDI), …

The Dialogue Dilemma: The Role Of Patient-Clinician Communication For Low-Income People Who Smoke And Manage Multiple Conditions, Monique T. Cano, Michael R. Lindstrom, Ricardo F. Muñoz

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: Adults from low-income backgrounds who smoke face significant health disparities related to tobacco use, often at disproportionately high rates. These individuals are more likely to endure multiple mental and physical (MP) health conditions, which can negatively influence their self-rated health (SRH). The quality and effectiveness of patient-clinician communication (PCC) can influence how patients perceive their own health. Understanding how PCC influences SRH among low-income adults who smoke and suffer from multiple MP conditions is essential for clinical care as multimorbidity is on the rise. This study examines how PCC may influence the health perceptions of low-income adults who smoke …

Factors Influence Homeless People’S Psychological Well-Being And Suicidal Ideation, Pi-Ming Yeh

Epsilon Sigma at-Large Research Conference

Introduction/Significance: About 582,462 individuals are experiencing homelessness in America. Homelessness is devastating, regardless of age. But for children, it can have serious physical, emotional, and psychological implications.

Purpose: The purpose of this study was to examine the influences of spiritual well-being, coping strategies, family interaction, and personality on psychological well-being, and suicidal ideation among people with homelessness.

Methods: Sixty people with homelessness were recruited in the Eastern Tennessee Downtown Day Center, USA. IRB was approved. This was a cross-sectional descriptive research design. Questionnaires were used to do data collection. SPSS 28.0 was used to do the data analysis. Descriptive …

The Use Of Person-Centered Language In Scientific Research Articles Focused On Psychosis, Zach Monahan, Tanner Stone, Vinay Swami, Kelly Dunn, Micah Hartwell

Journal of Patient-Centered Research and Reviews

Purpose: Societal stigma of psychosis leads to delayed treatment for individuals experiencing early symptoms, for fear of being labeled “crazy” or “psychotic.” Delayed treatment can worsen the prognosis of individuals with psychosis. Proper adherence to person-centered language (PCL) guidelines can curb the widely held stigmatized preconceptions about psychotic conditions.

Methods: Our meta-epidemiological analysis began with a systematic search of literature in PubMed discussing psychosis from 2020-2022. From the 14,522 results, we randomly selected 500 articles in journals with at least 20 articles on psychosis (n = 9,775), of which 241 articles met the inclusion criteria. These papers were screened for …