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Articles 721 - 750 of 9470
Full-Text Articles in Psychiatry and Psychology
Is Love A “Pathological Condition Of The Soul”? Joyce Carol Oates's Beasts And Rape: A Love Story, Nicolas P. Boileau
Is Love A “Pathological Condition Of The Soul”? Joyce Carol Oates's Beasts And Rape: A Love Story, Nicolas P. Boileau
Bearing Witness: Joyce Carol Oates Studies
This paper seeks to address the question of Oates’s relation to feminist and gender theories by looking at two novellas published consecutively, Beasts and Rape: A Love Story in the beginning of the 2000s. The short texts share a common storyline based on rape, which is far from uncommon in Oates’s fiction. However, I argue that there is something very specific in these two novellas in the way Oates chooses to handle the testimony of the rape, both overtly and covertly, both in graphic details and in repressed forms of expression, giving way to a reflection on women’s vulnerable position …
Neural Patterns Of Self-Efficacy And Resulting Changes After Cognitive Rehabilitation In Mild Traumatic Brain Injury, Emma N. Tribbey
Neural Patterns Of Self-Efficacy And Resulting Changes After Cognitive Rehabilitation In Mild Traumatic Brain Injury, Emma N. Tribbey
Theses
Mild traumatic brain injury (mTBI) often leads to cognitive impairments, which can significantly affect recovery outcomes. Although there are many different interventions available for individuals with mTBI, evidence-based research has indicated that cognitive rehabilitation programs can lead to significant improvement in psychological symptoms as well as psychosocial and vocational functioning in mTBI. Additionally, clinical research has identified a construct, self-efficacy, or the belief in one's capacity to achieve goals, that may play a critical role in further improving cognitive rehabilitation outcomes. Current research examining self-efficacy and cognitive rehabilitation in mTBI has found that higher self-efficacy is associated with greater treatment …
Ua12/2/1 College Heights Herald, Vol. 100, No. 3, Wku Student Affairs
Ua12/2/1 College Heights Herald, Vol. 100, No. 3, Wku Student Affairs
WKU Administration Documents
Magazine edition of the College Heights Herald for the period February 17 - April 20, 2025.
- Wilborn, Price. You Matter & You Are Not Alone
- Smith, Kane. Peggy Crowe Reflects on Counseling Center in Face of Staff Shortages
- Stafford, Hallie. Help with Horses – New Beginnings Therapeutic Horse Riding
- Hawkins, Kaylee. How a WKU Professor Helps Improve Student Mental Health – Jay Gabbard, National Alliance on Mental Illness Recovery Support Group
- McMahon, Jake. More Than a Coach – Brent Chumbley, Track & Field
- Simpson, Libby. WKU’s American Foundation for Suicide Prevention Brings Mental Health Into the Light
- Hardesty, Emma. Trans …
Psychopathy And The Media: A Dangerous False Perception, Ashton L. Brophy
Psychopathy And The Media: A Dangerous False Perception, Ashton L. Brophy
Harding Undergraduate Research Conference
Characterized by a lack of remorse or empathy, psychopaths– sufferers of Antisocial Personality Disorder– view the world far differently than the average person. This makes psychopathy an intriguing topic of study. However, many members of the general public lack understanding about the complexities of this disorder due to the false media depictions that make it difficult to accurately identify true psychopaths. By correcting the inaccurate narrative of psychopathy fed to the public through the media, it becomes possible to recognize the responsibility that is to be laid at the feet of the psychopathic offenders who chose violence.
The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson
The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the influence of military mindset on personal canine selection through the lived experiences of Tennessee military veterans to enhance military cultural competency and aid in development of complimentary and integrative approaches to veteran mental health. Insufficient research exists into understanding the specific needs of reintegrating veterans and into the benefits of canine-assisted therapies. The theories which guided this study were Albert Bandura’s Social Cognitive Theory of Learning and Abraham Maslow’s Theory of Motivation. This qualitative study was further guided by axiological philosophical assumptions. Fifteen participants were recruited via email and selected …
Agenda (Pdf), Department Of Psychiatry
Agenda (Pdf), Department Of Psychiatry
Dept. of Psychiatry Research Symposium
The abstract booklet for the 3rd Annual Department of Psychiatry Research Symposium held April 17, 2025.
Psychological Treatment Behind The Walls:Insights From The Inside, Rogelio Serrano
Psychological Treatment Behind The Walls:Insights From The Inside, Rogelio Serrano
Psychology Division Scholarship
Repeated eras of mass incarceration, criminalization of marginalized communities, and substance use policies have created a revolving door of justice involved populations. The ever-increasing prison population has repeatedly become the largest contingency of mental health clientele for an overburdened mental health system. Those who work with formerly incarcerated individuals in the community often don’t know the unique set of challenges faced by practitioners within the system. Increased understanding and coordination of care can offer opportunities for sustained recovery and reduced levels of recidivism. In this presentation participants will learn about the unique insights on mental health treatment that can be …
Gray Matter Morphology And Pain-Related Disability In Young Adults With Low Back Pain, Jo Armour Smith, Rongwen Tain, Isaac Chrisman, Kelli G. Sharp, Laura M. Glynn, Linda R. Van Dillen, Jesse V. Jacobs, Steven C. Cramer
Gray Matter Morphology And Pain-Related Disability In Young Adults With Low Back Pain, Jo Armour Smith, Rongwen Tain, Isaac Chrisman, Kelli G. Sharp, Laura M. Glynn, Linda R. Van Dillen, Jesse V. Jacobs, Steven C. Cramer
Physical Therapy Faculty Articles and Research
Structural neuroplasticity in the brain may contribute to the persistence of low back pain (LBP) symptoms and the disability associated with them. It is not known if structural adaptations are evident early in the lifespan in young adults with LBP. This study compared gray matter in cortical sensorimotor regions in young adults with and without persistent LBP and identified gray matter and clinical predictors of pain-related disability. Eighty-two individuals with and without a history of LBP participated. Peak and average gray matter density in cortical sensorimotor regions of interest was quantified using voxel-based morphometry. Pain-related disability, pain intensity, pain duration, …
Biopsychosocial-Based Exercise Model For Rheumatic Diseases Via Telerehabilitation: A Case Series With A One Year Follow Up, Nazlı Elif Nacar, Nur Banu Karaca, Zeynep Irem Bulut, Erkin Oguz Sarı, Senem Bulut, Yavuz Yakut, Sevim Oksüz, Sedat Kiraz, Edibe Unal
Biopsychosocial-Based Exercise Model For Rheumatic Diseases Via Telerehabilitation: A Case Series With A One Year Follow Up, Nazlı Elif Nacar, Nur Banu Karaca, Zeynep Irem Bulut, Erkin Oguz Sarı, Senem Bulut, Yavuz Yakut, Sevim Oksüz, Sedat Kiraz, Edibe Unal
Internet Journal of Allied Health Sciences and Practice
Purpose: This study aims to examine the sustainability of the biopsychosocial exercise performed by telerehabilitation on individuals with rheumatic disease, with and without supervision, and investigate the effect of the biopsychosocial-based exercise model on biopsychosocial status, general health status, and anxiety-depression levels of individuals. Method: Twenty patients with rheumatic diseases performed a biopsychosocial-based exercise model Cognitive Exercise Therapy Approach via telerehabilitation with physiotherapist-supervised and unsupervised exercises who continued for three sessions per week for 12 months. Outcome measures were Health Assessment Questionnaire, Hospital Anxiety and Depression Scale, and Cognitive Exercise Therapy Approach -Biopsychosocial Questionnaire. Patients were assessed at baseline, 3rd, …
Perinatal Mood And Anxiety Disorders (Pmads): A Scoping Review, Christina Willis Bsn, Rn, Nia Wells Bsn, Rn, Miranda Smith Bsn, Rn, Kate Fouquier Cnm, Phd, Facnm
Perinatal Mood And Anxiety Disorders (Pmads): A Scoping Review, Christina Willis Bsn, Rn, Nia Wells Bsn, Rn, Miranda Smith Bsn, Rn, Kate Fouquier Cnm, Phd, Facnm
Doctor of Nursing Practice Projects
Purpose/Background Perinatal Mood and Anxiety Disorders (PMADs), including postpartum depression, anxiety, and psychosis, significantly impact maternal and infant health. This scoping review consolidates current literature on PMADs, emphasizing prevalence, risk factors, screening, and treatment. The primary aim is to identify research gaps and inform clinical guidelines to enhance perinatal care.
Methods A literature search followed PRISMA guidelines from August 2022 to November 2024. Databases searched included PubMed, CINAHL, Scopus, and Google Scholar, using terms such as "perinatal mood disorders" and "maternal mental health." Inclusion criteria were English-language studies from the past decade addressing PMADs during pregnancy and up to one …
Behere Nevada: Partnership And Policy, Sara Hunt
Behere Nevada: Partnership And Policy, Sara Hunt
Community Engagement Expo Research Posters
Partnership: Nevada ranks 51st in the nation for mental illness prevalence and access to care (Mental Health America). Significant shortages in mental health professions, especially in rural areas. Other states using policy and funding to implement a “grow our own” model for behavioral health workforce development. Proposed a behavioral health workforce development center for Nevada.
Supporting Elementary Educators Through A Nervous System Regulation And Social-Emotional Learning Skills Workshop Intervention: An Musc Capstone Project, Lily Morgan
Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium
Teachers have a great influence on developing children’s emotional intelligence, regulatory capacity, and occupational engagement. These professionals also happen to report some of the highest rates of stress, mental health challenges (Agyapong, B. et al, 2022), and burnout (Xie, M., et al, 2022). Providing teachers with education and support on nervous system regulation, social-emotional learning skills, and related topics can improve their ability to manage job stress, enhance modeling and interactions with students, and improve their quality of life. This project aimed to enhance knowledge, provide access to resources, and serve to support elementary educators at an inner-city school in …
A New Paliperidone Palmitate Formulation: How Is It Different And Where Does It Fit In Our Array Of Choices For Long-Acting Formulations Of Risperidone And Paliperidone?, Justin Faden, Leslie Citrome
A New Paliperidone Palmitate Formulation: How Is It Different And Where Does It Fit In Our Array Of Choices For Long-Acting Formulations Of Risperidone And Paliperidone?, Justin Faden, Leslie Citrome
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Long-acting injectable (LAI) antipsychotics have been shown to enhance treatment adherence and outcomes in individuals with schizophrenia, schizoaffective disorder, and bipolar disorder. In recent years, the U.S. Food and Drug Administration (FDA) has approved several LAIs with differing amenities of care, such as mode of administration, duration of oral medication supplementation, dosing frequency, needle gauge and size, and injection volume, amongst others. Additionally, several LAIs are distinct formulations of risperidone and paliperidone, making it difficult to distinguish between formulations, and many providers are unfamiliar with these newer agents. In 2024, a once-monthly LAI formulation of paliperidone palmitate, manufactured by Luye …
Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz
Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz
ONU Student Research Colloquium
Fear-related disorders are often treated with exposure therapy, a technique based on the concept of extinction. However, this type of therapy is ineffective for many individuals, so finding a pharmacological adjunct that augments the extinction of fear could lead to better treatment outcomes. In recent preclinical work, investigators have shown that psychedelics can accelerate the extinction of fear, potentially through their impact on neurotrophic signaling. We previously found that psilocybin exerted sex-dependent effects on the extinction of conditioned fear to an isolated cue (i.e., a tone). Specifically, psilocybin enhanced the extinction of cue fear in male rats but impaired it …
A Narrative Review Of Military Reverse Triage., Daniel J Hurst
A Narrative Review Of Military Reverse Triage., Daniel J Hurst
Rowan-Virtua School of Osteopathic Medicine Departmental Research
INTRODUCTION: Military reverse triage has been described at several points in the literature. However, an extensive review of the concept and any gaps that may exist has not been conducted. This narrative review seeks to understand how reverse triage is used in the military literature and how it might be implemented in practice, as well as the documented historical applications of reverse triage.
MATERIALS AND METHODS: Four databases were searched manually for English-language articles: PubMed, SCOPUS, JSTOR, and Worldwide Political Science Abstracts. In addition, a manual search of references, U.S. DoD, and NATO doctrine, as well as other published works …
Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano
Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano
Institute of Emerging Health Professions Faculty Papers
IMPORTANCE: Driving under the influence of cannabis increases the risk of motor vehicle collisions. In some jurisdictions, deterrence rests on the ability to detect delta-9-tetrahydrocannabinol (THC) in blood. Recent evidence suggests that there may be a nuanced relationship of blood THC to driving.
OBJECTIVE: The purpose of this systematic review was to summarize all published papers investigating the presence of a linear relationship between blood THC and driving, primarily measured by simulated driving in the lab.
OUTCOMES: The main outcomes assessed included "weaving"/lateral control (eg, standard deviation of lateral position), speed, car following (following distance; coherence), reaction time, and overall …
Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood
Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood
MUSC Theses and Dissertations
Substance Use Disorder (SUD) is a relapsing disorder characterized by repeated seeking and use of psychoactive substances despite negative consequences to the individual. Epigenetic changes within the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are thought to underly the lasting propensity to relapse in SUD. The epigenetic enzyme histone deacetylase 5 (HDAC5) in NAc MSNs limits the formation of reward-cue associations in rodent models of drug seeking, but not sucrose seeking, leading to decreased relapse-like behavior. However, whether HDAC5 reduces drug seeking behavior through its own deacetylase activity or through the recruitment of co-repressors is unknown. Furthermore, these …
Cell Type-Specific Multi-Omics Analysis Of Cocaine Use Disorder In The Human Caudate Nucleus, Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P Völker, Svenja Müller, Anita C Hansson, Thomas D Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M M Oliveira, Consuelo Walss-Bass, Rick E Bernardi, Philipp Koch, Stephanie H Witt
Cell Type-Specific Multi-Omics Analysis Of Cocaine Use Disorder In The Human Caudate Nucleus, Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P Völker, Svenja Müller, Anita C Hansson, Thomas D Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M M Oliveira, Consuelo Walss-Bass, Rick E Bernardi, Philipp Koch, Stephanie H Witt
Faculty, Staff and Student Publications
Structural and functional alterations in the brain's reward circuitry are present in cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. To investigate these mechanisms, we performed single-nuclei multiome profiling on postmortem caudate nucleus tissue from six individuals with CocUD and eight controls. We profiled 30,030 nuclei, identifying 13 cell types including D1- and D2-medium spiny neurons (MSNs) and glial cells. We observed 1485 differentially regulated genes and 10,342 differentially accessible peaks, with alterations in MSNs and astrocytes related to neurotransmitter activity and synapse organization. Gene regulatory network analysis identified transcription factors including ZEB1 as exhibiting distinct CocUD-specific subclusters, …
Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva
Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva
Faculty Publications
We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …
52 - The Intersection Of Trauma Type And Alcohol Use In College Women: Examining Maladaptive Coping In A High-Risk Population, Mira I. Hopkins, Christopher T. Latourrette, Niya Richardson, Mellyssa G. Deoliveira, Sage E. Hawn
52 - The Intersection Of Trauma Type And Alcohol Use In College Women: Examining Maladaptive Coping In A High-Risk Population, Mira I. Hopkins, Christopher T. Latourrette, Niya Richardson, Mellyssa G. Deoliveira, Sage E. Hawn
Undergraduate Research Symposium
This study examines how different types of trauma exposure, interpersonal and non-interpersonal, relate to alcohol use as a coping mechanism in college women with trauma histories. Given the unique social and environmental pressures of college life, this research aims to highlight the ways in which trauma and substance use intersect in this high-risk population.
Impact Of Parental Adhd Status On Screen Time Allowance In Children: Insights From Nhis Data, Chase Moscovic
Impact Of Parental Adhd Status On Screen Time Allowance In Children: Insights From Nhis Data, Chase Moscovic
Medical Student Research Symposium
Title: Impact of Parental ADHD Status on Screen Time Allowance in Children: Insights from NHIS Data
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) affects both children and adults, with significant implications for daily functioning. While research has examined the impact of ADHD on children's screen time, less is known about how parental ADHD may influence screen time practices. This study explores the relationship between parental ADHD status and their regulation of children's screen time, a critical aspect of neurodevelopment in an increasingly digital world.
Methods: We analyzed data from the 2019–2023 National Health Interview Survey (NHIS), which includes U.S. household data on health …
The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta
The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta
Undergraduate Theses
Discrimination has profoundly shaped the lives of individuals within disadvantaged communities, but its impact on mental and physical health has often been overlooked. In this project, I review literature on perceived discrimination based on immigrant status and its effects on psychological and physical health and examine a potential mediator and moderator of these relationships. Specifically, the relationships between immigration-based discrimination and both mental health and physical health may be mediated by perceived stress, meaning that discrimination may lead to higher stress levels, which results in poorer health outcomes. Furthermore, these relationships may be moderated by psychological resilience; individuals with higher …
Protocol For A Multisite, Observational Clinical Study Of The Association Between Skin Colour And Pulse Oximeter Accuracy In Children Undergoing Cardiac Catheterisation (Pach Study), Halley Ruppel, Liming Huang, Christopher J Petit, Athar M Qureshi, Christopher P Bonafide, Elizabeth E Foglia, Jeffery Feldman, Meghan B Lane-Fall, Jennifer M Lynch, Anna Chien, Michelle Dunn, Michael L O'Byrne
Protocol For A Multisite, Observational Clinical Study Of The Association Between Skin Colour And Pulse Oximeter Accuracy In Children Undergoing Cardiac Catheterisation (Pach Study), Halley Ruppel, Liming Huang, Christopher J Petit, Athar M Qureshi, Christopher P Bonafide, Elizabeth E Foglia, Jeffery Feldman, Meghan B Lane-Fall, Jennifer M Lynch, Anna Chien, Michelle Dunn, Michael L O'Byrne
Faculty, Staff and Students Publications
Introduction: Prospective, real-world clinical studies of the association between skin color and pulse oximeter (SpO2) accuracy in children are needed to address the limitations of previous research. Such studies are essential for generating evidence for clinicians, regulators and industry. This is the protocol for a multisite study funded by the National Heart, Lung, and Blood Institute (R01HL171313; 1 January 2024-31 December 2028).
Methods and analysis: In this pragmatic, observational study conducted in three large paediatric cardiac catheterisation centres in the USA, children undergoing cardiac catheterisation with directly measured arterial oxygen saturation will be prospectively enrolled. The outcome variable (SpO2 bias) …
The Impact Of Covid-19 On Nurses' Feelings, Stress, Coping, And Motivation In Palestinian Treatment Centers Of Corona, † Wafaa Menawi, Shatha Mari, Ahmad Adel Hanani
The Impact Of Covid-19 On Nurses' Feelings, Stress, Coping, And Motivation In Palestinian Treatment Centers Of Corona, † Wafaa Menawi, Shatha Mari, Ahmad Adel Hanani
An-Najah University Journal for Research - B (Humanities)
Background: Frontline nurses of COVID-19 found themselves in an unfamiliar new disease work environment, fighting to adapt and control the stress while working at covid-19 centers in Palestine. Aim: To investigate the impact of COVID-19 on nurses' feelings, stress, coping, and motivation in COVID-19 Palestinian treatment Centers. Method: A descriptive cross-sectional design was conducted between Mid of July to the end of October 2021 by recruiting a purposive sample of 390 nurses who worked at the Ministry of Health during COVID-19 pandemic treatment centers. The nurses filled out the COVID-19 Health Personnel Questionnaire with Cronbach's Alpha > 0.9. Results: Palestinian frontline …
A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki
A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki
MUSC Theses and Dissertations
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4. We discovered that a conserved, long non-coding enhancer RNA (lnc-eRNA) transcribed from an activity-sensitive enhancer produces DNA-RNA hybrid R-loop structures that support 3D chromatin-looping of the enhancer and proximal promoter and stimulus-induced, rapid Npas4 gene induction. We also show that this Npas4 lnceRNA and its R-loops are required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, …
Safety And Efficacy Of 112 Mg Intranasal Esketamine In Patients With Treatment-Resistant Depression: A Retrospective Observational Study From Outpatient Community Clinics, Kirsten Brinkmeier, Michael Kritzer, Brandon Doan, Cecilia Li, Nicholas Mischel
Safety And Efficacy Of 112 Mg Intranasal Esketamine In Patients With Treatment-Resistant Depression: A Retrospective Observational Study From Outpatient Community Clinics, Kirsten Brinkmeier, Michael Kritzer, Brandon Doan, Cecilia Li, Nicholas Mischel
Medical Student Research Symposium
This retrospective study examined the safety and efficacy of 56, 84, and 112 mg intranasal (IN) esketamine via medical record review of 24 patients with treatment resistant depression (TRD). Doses ranged from 56 mg to 112 mg and were titrated across sessions to maximize individual response while considering tolerability. Treatment response was defined by reduction in average Patient Health Questionnaire-9 (PHQ-9) scores. Tolerability was defined by blood pressures at baseline, 40 minutes after, and 2 hours after drug administration. Patients ranged from 19 to 60 years old (average 38.87), and 15 (62.5%) were female. Patients received an average of 1 …
Externalizing Behavior Problems And Attentional Domains In A Community-Based Adolescent Sample, Kamakashi Sharma
Externalizing Behavior Problems And Attentional Domains In A Community-Based Adolescent Sample, Kamakashi Sharma
Medical Student Research Symposium
Externalizing behavior problems are characterized by maladaptive behavioral patterns directed toward the external environment, such as poor impulse control, aggression, and inattention. While existing literature suggests that attention may play a critical role in the cognitive profile of externalizing behaviors, the relationship between externalizing problem behaviors and specific attention domains in school-age youth remains understudied. This gap is particularly important as externalizing problems are prevalent during this developmental period and are predictive of adverse outcomes. In this study, we examined the association between externalizing problem behaviors and attentional performance in a community sample of 69 adolescents (M + SD = …
Opioid Vs. Money Choice Preference Patterns In Regular Heroin Users, Amolak S. Jhand, Mark Greenwald
Opioid Vs. Money Choice Preference Patterns In Regular Heroin Users, Amolak S. Jhand, Mark Greenwald
Medical Student Research Symposium
About two-thirds of people treated for opioid use disorder (OUD) return to opioid use within the first-year post-treatment, and about 10% report use while on agonist therapy. Understanding determinants of opioid-seeking is vital to reducing recurrence and its risks. We assessed individual differences in effortful choices between opioid and money amounts, modeling real-world choices.
Our lab conducted studies in which regular heroin-users were stabilized on buprenorphine to suppress withdrawal. Within experimental sessions, the participant could choose repeatedly across 12 trials between units of hydromorphone (HYD, 1 or 2 mg IM) vs. money ($2 or $4); HYD and money amounts differed …
Assessing Middle Eastern American Attitudes Towards Substance Use Disorders, Hazem Alata, Hussein Bazzi, Saleh Al-Juburi, Angie Achkar, Liam Browning, Nicole Oska, Adam Chaban, Arash Javanbakht
Assessing Middle Eastern American Attitudes Towards Substance Use Disorders, Hazem Alata, Hussein Bazzi, Saleh Al-Juburi, Angie Achkar, Liam Browning, Nicole Oska, Adam Chaban, Arash Javanbakht
Medical Student Research Symposium
Assessing Middle Eastern American Attitudes Towards Substance Use Disorders
Introduction:
Substance use disorders (SUD) among Middle Eastern and North African (MENA) populations remain largely understudied, despite evidence of high prevalence rates and lower rates of treatment engagement. Unique cultural conceptualizations and beliefs surrounding substance use disorders may perpetuate stigma, further contributing to disparities in access to and utilization of treatment services. This study aims to explore the attitudes and perspectives of individuals from MENA communities regarding substance use disorders, with the goal of identifying and addressing barriers to treatment.
Methods:
An anonymous bilingual Qualtrics survey was administered, gathering responses from …
Chronic Alcohol Withdrawal-Associated Increases In Vta Hcrtr1 Expression Are Associated With Heightened Nociception And Anxiety-Like Behavior In Female Rats, Shealan Cruise, Maria E. Secci, Leslie K. Kelley, Nathan M. Sharfman, Keishla Rodriguez-Graciani, Tiffany A. Wills, Nicholas W. Gilpin, Elizabeth M. Avegno
Chronic Alcohol Withdrawal-Associated Increases In Vta Hcrtr1 Expression Are Associated With Heightened Nociception And Anxiety-Like Behavior In Female Rats, Shealan Cruise, Maria E. Secci, Leslie K. Kelley, Nathan M. Sharfman, Keishla Rodriguez-Graciani, Tiffany A. Wills, Nicholas W. Gilpin, Elizabeth M. Avegno
School of Medicine Faculty Publications
Alcohol withdrawal is characterized by various symptoms that include pain and negative affect in the absence of the drug. The neural underpinnings of these behaviors are not entirely understood, but orexin has emerged as a candidate target for the treatment of substance use disorders. Here, we explored changes in orexin system-related gene expression in brain regions important for mediating reward and stress, including the ventral tegmental area (VTA) and extended amygdala (including the central amygdala, nucleus accumbens shell, and bed nucleus of the stria terminalis), in adolescent and adult female Wistar rats following chronic alcohol exposure. We observed higher numbers …