Other Pharmacy and Pharmaceutical Sciences Commons^™

Puer Tea, Dry, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Yogurt, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Cephalopods (Cuttlefish, Octopus, And Squid), Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Vinegar, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Grapefruit And Grapefruit Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Grape Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Table F: Fluoride Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Coffee Beverage, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Harnessing The Potential Of Several Local Indonesian Tuber-Derived Starches As Pharmaceutical Excipients, Ronald Horison, Silvia Surini

Pharmaceutical Sciences and Research

Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations with distinct functional properties influenced by the natural starch granules’ properties and amylose-amylopectin ratio. Previous research utilizing natural and modified starches from these tubers has demonstrated their potential in pharmaceutical formulation. These starch tubers have been studied and provided promising results in tablet formulation and film development. Additionally, they could be involved in developing more advanced dosage forms, such as starch …

Identification Of New Leads Against Ubiquitin Specific Protease-7 (Usp7): A Step Towards The Potential Treatment Of Cancers, Sumaira Javaid, Seema Zadi, Muhammad Awais, Atai-Tul Wahab, Humaira Zafar, Innokentiy Maslennikov, M. Iqbal Choudhary

Pharmacy Faculty Articles and Research

Ubiquitin-specific protease-7 (USP7) is an important drug target as it regulates multiple proteins and genes (such as MDM2 and p53) with roles in cancer progression. Its inhibition can hinder the function of oncogenes, increase tumor suppression, and enhance immune response. The current study was designed to express USP7 in a prokaryotic system, followed by screening of small molecules against it using biophysical methods, primarily STD-NMR technique. Among them, 12 compounds showed interaction with USP7 as inferred from NMR-based screening. These compounds further caused destabilization of USP7 by reducing its melting temperature (T_m) up to 6 °C in …

The Role Of Peptides In Combatting Hiv Infection: Applications And Insights, Naiera M. Helmy, Keykavous Parang

Pharmacy Faculty Articles and Research

Peptide-based inhibitors represent a promising approach for the treatment of HIV-1, offering a range of potential advantages, including specificity, low toxicity, and the ability to target various stages of the viral lifecycle. This review outlines the current state of research on peptide-based anti-HIV therapies, highlighting key advancements and identifying future research directions. Over the past few years, there has been significant progress in developing synthetic peptide-based drugs that target various stages of the viral life cycle, including entry and replication. These approaches aim to create effective anti-HIV therapies. Additionally, peptides have proven valuable in the development of anti-HIV vaccines. In …

A Review Of 3d Printing Technology In Drug Design Applications, Hasanain Shakir Mahmood, Jinan M. Al-Mousawy, Jamal Ali Ashoor, Ashti M.H. Saeed, Alaa Abdul Razzaq Al-Nuaimi, Pegah Khosravian

Maaen Journal for Medical Sciences

Sustainable technologies such as Additive manufacturing or three-dimensional printing (3D printing) have resulted in drastic changes in a number of industries including healthcare and pharmaceuticals. The current review focuses on the achievements accomplished on the effectiveness of three-dimensional printing in the field of drug designing and development. This technology is very precise and can be customized and that gives a way of developing complicated drug delivery systems and individualized medications. Promising areas of focus are the development of particular formulations of medicinal preparations, identification of new approaches to the drug release and potential creation of specific drug production for specific …

Predisposing, Enabling, And Need Factors Influencing Health-Related Quality Of Life Among People With Metabolic Syndrome, Olajide Adekunle, Yun Wang, Ismaeel Yunusa, Marc L. Fleming, Enrique Seoane-Vazquez, Lawrence M. Brown

Pharmacy Faculty Articles and Research

Background

Objective

Methods

How Allied Health Programs Can Integrate Pharmacists Into Didactic Education Medication Curriculum: Benefits, Challenges, And Implementation, Dawn M. Battise, Susan M. Smith

Internet Journal of Allied Health Sciences and Practice

Many allied health professionals are required to receive medication-related education. As the “medication experts,” pharmacists are uniquely qualified to provide such training. Although pharmacy involvement in interprofessional education is frequently described, there is limited data about the pharmacist's role in the allied health didactic setting. This paper describes how two allied health programs leveraged the medication knowledge of pharmacy educators to enhance delivery of medication related content. Strategies are provided for pharmacy and allied health educators who are considering implementing a similar interprofessional model.

Perceptions Of Virtual Reality In Cardiac Pharmacy Education, Morgan E. Mendes

Senior Theses

Background: The reformation of how educational content is portrayed is not a new phenomenon. However, the world of pharmacy has been slow to adapt, particularly considering higher education’s declining attendance rates and less engaging lectures. XR can be a great addition to learners’ curriculum, particularly VR, with various applications including adjunctive pharmacotherapy, patient counseling, pharmacist training, and pharmacological modeling. Despite the various barriers VR integration faces, the benefits of VR necessitate its future implementation into our COP curriculum as an augmentative form of learning.

Methods: An independent study of 11 students at the UofSC COP was conducted in the Spring …

A Mixed Methods Evaluation Of Pharmacists' Readiness To Provide Long-Acting Injectable Hiv Pre-Exposure Prophylaxis In California, Raiza Beltran, Lauren A. Hunter, Laura J. Packel, Loriann De Martini, Ian W. Holloway, Betty J. Dong, Jerika Lam, Sandra I. Mccoy, Ayako Miyashita Ochoa

Pharmacy Faculty Articles and Research

Background:

Pre-exposure prophylaxis (PrEP) uptake remains low among people who could benefit, some of whom may prefer alternatives to oral PrEP, such as long-acting injectable pre-exposure prophylaxis (LAI-PrEP). We evaluated the potential for LAI-PrEP provision in pharmacies through a mixed methods study of pharmacists in California, where Senate Bill 159 enables pharmacists to independently provide oral PrEP.

Methods:

In 2022–2023, we conducted an online cross-sectional survey of California pharmacists and pharmacy students (n = 919) and in-depth interviews with pharmacists (n = 30), both of which included modules assessing attitudes about PrEP provision. Using log-binomial regression, we estimated prevalence ratios …

Molecular Targets For Breast Cancer Therapy, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

"Breast cancer is by far the most common cancer in women, and for a while, it surpassed lung cancer as the most diagnosed cancer, regardless of gender, in 2020 [1]. Chemotherapy and hormone therapy are still the first line of treatment, despite extensive research in molecularly targeted drugs. Therefore, triple negative breast cancer (TNBC) is still known as the most challenging type for treatment due to the limited identified targets. Inherent and acquired resistance are still major hurdles in breast cancer therapy, which further highlights the importance of identifying new molecular targets in this battle. The inherent resistance of unresponsive …

At A Crossroads: The Crucial Role Of Pharmacists In Healthcare Teams To End The Hiv Epidemic, Jerika Lam, Jennifer M. Cocohoba

Pharmacy Faculty Articles and Research

"Therapeutic advances in treatment and prevention have slowed the human immunodeficiency virus (HIV) epidemic, yet the virus and complications related to it still claim an alarming 630,000 lives globally every year.^1,2 The United States’ goals for the Ending the HIV Epidemic (EHE) initiative include reducing new infections by 90% by the year 2030 and advancing health equity through key treatment and prevention initiatives.³ Multiple agencies, professions, and patient groups are working diligently to achieve the EHE goals. Pharmacists have long recognized that our profession is a key resource in ending the HIV epidemic. We demonstrate this in the …

Taste Masked Of Eplerenone Using Egg Box Method, Asmaa Mohammed Rashid

Maaen Journal for Medical Sciences

Eplerenone is a selective mineralocorticoid receptor antagonist employed to manage hypertension, central serous retinopathy, and chronic heart failure. It has a highly bitter taste, which reduces patient compliance with the drug.

The aim of this study was masking the very bitter taste of the eplerenone to improve patient compliance especially for geriatric patient.

The medication was encapsulated utilizing the ionic gelation process, in which a 1% w/w sodium alginate solution was utilized to form egg box structures.Two different concentrations of CaCl2 (0.5.1%w/v) were used as cross-linkers, and different drug: polymer ratios were tested. The formulas were evaluated based on their …

Exploring The Use Of An Interprofessional Education Session For Speech-Language Pathology And Pharmacy Students, Sophia Werden Abrams, Heather Macphee, Linnea Hodge, Justine Hamilton, Ashwini Namasivayam-Macdonald

Teaching and Learning in Communication Sciences & Disorders

Interprofessional education (IPE) occurs when students are provided the opportunity to learn with and from others of related professions to improve the potential for future collaboration. The aim of this study was to explore the perceptions of students about working with professionals from different disciplines before and after their engagement in an interprofessional learning activity and determine any changes in their willingness to work in interprofessional teams.

Doctor of Pharmacy students from the University of Manitoba and Master’s speech-language pathology students from McMaster University participated in an online inter-university and inter-provincial education module. Students were invited to complete the Interprofessional …

Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri

Pharmaceutical Sciences and Research

Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. …

Application Of Pvp Va 64 And Poloxamer 188/407 In Solid Dispersion Technology For Improving Solubility Of Valsartan, Sulastari Cahyani, Teuku Nanda Saifullah Sulaiman, Marlyn Dian Laksitorini

Pharmaceutical Sciences and Research

Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve the solubility of valsartan using a solid dispersion system. Polyvinylpyrrolidone/vinyl acetate 64 (PVP VA 64), a hydrophilic polymer, was incorporated to inhibit the recrystallization of valsartan, while poloxamer 188 and poloxamer 407, used as surfactants, aimed to enhance valsartan’s solubility and intrinsic dissolution rate. Valsartan solid dispersions were prepared using the spray drying method, and the optimal formulation …

Recent Updates On Dried Blood Spot And Volumetric Absorptive Microsampling As Microsampling Technique For Antiepileptic Drug Determination: A Systematic Review, Asmiladita Pridilla, Yahdiana Harahap, Denni Joko Purwanto, Baitha Palanggatan Maggadani

Pharmaceutical Sciences and Research

Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose …

Biosynthesis Of Agnps Mediated By Equisetum Debile Roxb. Herb Water Extract And Its Potency As An Antioxidant, Yuni Retnaningtyas, Alviani Dwi Karmilasari, Endah Puspitasari

Pharmaceutical Sciences and Research

Silver nanoparticles (AgNPs) are metal nanoparticles currently under development. AgNPs are recognized for their remarkable stability, low reactivity, and advantageous biological properties, including antioxidant activity. Phenolic compounds derived from the Equisetum debile Roxb. (Ed-R) herb have the potential to be explored as bio-reduction and capping agents in the synthesis of silver nanoparticles. The primary objective of this study is to synthesize AgNPs using a water extract from Ed-R herb and to assess their antioxidant activity. The optimal composition for the biosynthesis of AgNPs comprises 10% Ed-R water extract, 8.0 mM AgNO₃, and deionized water in a ratio of …

Global Perspective Of The Risks Of Falsified And Counterfeit Medicines: A Critical Review Of The Literature, Aonghus J. Feeney, Jeffery A. Goad, Gerard T. Flaherty

Pharmacy Faculty Articles and Research

Background

Methods

Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi, Ayan K. Barui, Ashraf M. Mohieldin, Ankan Gupta, Ramani Ramachandran, Surya M. Nauli

Pharmacy Faculty Articles and Research

Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, underlining its potential role in cancer. However, the correlation between primary cilia and miR-17 has yet to be fully elucidated. The present study examines the presence of miR-17 in primary cilia. The miR-17 expression is studied in selected ciliary protein knockdown cells. Using in situ hybridization (ISH), we identified the subcellular localization of miR-17 in both cilium and cell body. We confirmed the importance …

Tirzepatide Protects Against Hepatic Oxidative Stress In High-Fat Induced Obesity In Male Rats, Ashraf Jameel Alathary, Zahraa Jawad Kadhim

Maaen Journal for Medical Sciences

Background

Obesity is a prevalent health issue that affects people of all ages at a high rate. Tirzepatide (TZP) is a hypoglycemic medication that acts as a dual antagonist for both the GIP-1 and GIP receptors. Previous reports have shown that TZP treatment demonstrated substantial weight reduction as well as lipid-modulating effects in obese and overweight individuals.

Objective

The aim from this study is to examine the potential protective effect of TZP on oxidative stress status and HFD induced obesity in male rats.

Methods

This research employed a total of 28 adult male Sprague-Dawley rats. Normal control group involved seven …

One More Negative Regulator Of Ac6: S-Nitrosylation, Isabella Cattani-Cavalieri, Rennolds S. Ostrom

Pharmacy Faculty Articles and Research

"In this issue of the Journal, Maghsoudi and colleagues (pp. 82–96) report a series of studies that delineate the biochemical and pharmacological mechanism of this resistance (4). The study focuses on adenylyl cyclase (AC), an enzyme crucial for pulmonary vasodilation through its action of synthesizing cAMP. There are nine isoforms of AC (AC1–AC9) that are all stimulated by Gs but otherwise are distinct in their regulatory qualities, subcellular localization, and expression profiles throughout the body (5). AC6 plays a significant role in fetal and neonatal lung, especially in pulmonary artery smooth muscle cells, where …

Central Nervous System Antiviral Pharmacology, Sean N. Avedissian

Theses & Dissertations

Soon after viral infection, viruses like Human Immunodeficiency Virus (HIV) and SARS-CoV-2 can disseminate throughout the body and establish reservoirs in the central nervous system (CNS). The persistence of viruses in cells of these reservoirs is a major obstacle to virus eradication. This is due to the abundance of cells/receptors that these viruses utilize to gain entry into cells found at these various reservoir sites. Consequently, these same anatomical sites also may be pharmacologic sanctuaries, as evidenced by concentrations of antiretroviral drugs (ARVs) and antivirals (AVs) that are lower in reservoirs than those in peripheral blood; in some cases, these …

Characterization Of Population Pharmacokinetics And Associated Interindividual Variability Of Drugs Used In Mass Drug Administration Against Lymphatic Filariasis, Abdullah Alshehri

Theses & Dissertations

Lymphatic filariasis (LF) is a mosquito-borne filarial infection that affects the lymphatic system. The progression of the disease is associated with severe comorbidities and social stigma among patients. The World Health Organization has categorized the disease as a public health problem, and it has been targeted by mass drug administration (MDA) campaigns over the past two decades. Several preventive chemotherapies have been used in MDA campaigns against LF, including a combination of three anti-filarial drugs (IDA therapy): albendazole (ALB), diethylcarbamazine (DEC), and ivermectin (IVM). Other antiparasitic drugs, such as moxidectin (MOX), are still under investigation for their activity against LF. …