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Full-Text Articles in Other Pharmacy and Pharmaceutical Sciences

Data For "Subtype-Selective Positive Modulation Of Sk Channels Depends On The Ha/Hb Helices", Miao Zhang, Meng Cui Mar 2021

Data For "Subtype-Selective Positive Modulation Of Sk Channels Depends On The Ha/Hb Helices", Miao Zhang, Meng Cui

Pharmacy Faculty Data Sets

In the activated state of small-conductance Ca2+-activated potassium (SK) channels, calmodulin interacts with the HA/HB helices and the S4-S5 linker. CyPPA potentiates SK2a and SK3 channel activity but not the SK1 and IK subtypes. Here, we report that the subtype-selectivity of CyPPA relies on the HA/HB helices. Mutating residues in the HA (V420) and HB (K467) helices of SK2a channels to their equivalent residues in IK channels diminished the potency of CyPPA. CyPPA elicited prominent responses on mutant IK channels with an arginine residue in the HB helix substituted for its equivalent lysine residue in the SK2a channels …


Augmenting The Access And Involvement Of Student Pharmacists In Research Opportunities Through Engaging Programming At An Academic Institution, Samantha Gruber Apr 2020

Augmenting The Access And Involvement Of Student Pharmacists In Research Opportunities Through Engaging Programming At An Academic Institution, Samantha Gruber

Honors Capstone Enhancement Presentations

A research study completed by Kritikos et al. investigated student pharmacists and their characteristics in order to find a relationship with their views of research and attitudes towards pharmacy practice research. The study also recognized perceived barriers to pursuing or completing pharmacy practice research and identified ways that pharmacy educators could promote research interest in pharmacy practice. The research study concluded that student pharmacists perceive a lack of awareness of the needs, benefits, and career opportunities associated with pharmacy practice research. In addition, the Accreditation Council for Pharmacy Education (ACPE) mentions in section 6.3 of the 2016 Standards that PharmD …