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Articles 1 - 5 of 5
Full-Text Articles in Other Pharmacy and Pharmaceutical Sciences
Longitudinal Assessment Of Pharmacy Student Attitudes Towards Mental Illness, Jessica Dillon
Longitudinal Assessment Of Pharmacy Student Attitudes Towards Mental Illness, Jessica Dillon
Honors Scholar Theses
Background: Mental health stigma in providers is one of the greatest barriers in effective care in psychiatric patients. When patients feel stigma towards them, they have lower levels of self-esteem and lower medication adherence. When training healthcare providers, specifically pharmacists, it is important to assess the effectiveness of training at reducing stigma levels. Previous studies have shown that didactic teaching does not significantly decrease stigma in pharmacy students. However, other studies have shown that students who participated in psychiatric rotations have less stigma surrounding mental health following the rotation. Currently there are no studies that assess the same students’ stigma …
The Potential Of Intrinsically Disordered Proteins As Drug Targets, Matt Staid
The Potential Of Intrinsically Disordered Proteins As Drug Targets, Matt Staid
Honors Scholar Theses
Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a negative regulator of inflammatory signaling in several diseases. TNIP1 is also an intrinsically disordered protein (IDP), which makes it difficult for current drugs to affect it. More research on IDPs could lead to novel drugs targeting TNIP1, leading to improved therapies for patients with acute and chronic inflammatory diseases. The main difference between IDPs and the more common ordered proteins is that IDPs are flexible, a characteristic of TNIP1 which was demonstrated in this study via protease sensitivity. Ordered proteins are rigid, which means that they only have one …
Assessing The Effect Of Chronic Dopamine Receptor 2 Blockade As A Potential Model Of Secondary Negative Symptoms In Rats Using The Fr5/Chow Feeding Choice Task, Cyrene Nicholas
Honors Scholar Theses
Haloperidol, a dopamine (DA) D2 receptor antagonist, is an antipsychotic drug which is commonly used to treat schizophrenia and other psychiatric disorders. These disorders are often characterized by elevated striatal dopamine, which is speculated to have a role in producing positive symptoms such as hallucinations, delusions, and paranoia, as well as symptoms related to motivational salience and reward prediction. Individuals with schizophrenia also exhibit negative symptoms, such as amotivation, anergia, fatigue, and apathy among others. While some negative symptoms of schizophrenia are inherent to the pathophysiology, other negative symptoms are hypothesized to be partially induced by chronic exposure to antipsychotic …
Effects Of Lisdexamfetamine And Haloperidol On A Binge-Like Eating Model & Preliminary Investigations Of The Dopaminergic Mechanism Underlying Binge Eating Disorder (Bed), Maxime Braun
Honors Scholar Theses
Binge eating disorder (BED) is a psychophysiological disorder defined as the excessive intake of high-caloric, palatable foods within a short span of time, accompanied by feelings of distress. Animal models of binge-like eating behavior have been developed that give intermittent, limited access to a highly palatable food. Presby et al. (2020) used chocolate as the highly palatable food to induce binge-like eating behavior in rats. Lisdexamfetamine (LDX), a d-amphetamine prodrug and dopamine (DA) uptake inhibitor, is currently used to treat BED in humand. In rats, binge-like eating of chocolate was induced by exposure to unpredictable and limited chocolate access over …
Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino
Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino
Honors Scholar Theses
The following series of studies investigates the elimination and uptake trends of halothane, acetone, and ethanol vapors in the airways of C57BL/6J mice. These vapors were chosen because they span a wide range of solubilities, as indicated by their blood-air partition coefficients, and are not associated with any significant airway metabolism or reactivity with tissue substrates in vivo. Mice were exposed to a homogeneous vapor mixture containing a 1:1:1 ratio of halothane, acetone, and ethanol at relative concentrations of approximately 10 ppm. Exposure studies were performed with mice in two states, conscious and deceased, in order to provide control …