Brushing Up On Antibiotic Stewardship: Pharmacy Students Survey And Educate Dentists On Antibiotic Prescribing Guidelines And Practices, Niyaz Pordel, Kamaladdin Saei, Feifei Jia, Kaitlin Meyer, Lisa M. Avery

Doctoral External Publications

To evaluate dentists’ knowledge of ABX stewardship tools and to determine the likelihood of incorporating various antibiotic stewardship principles into practice after receiving a pharmacy school generated newsletter.

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Among Novel Fda Approvals In 2023, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Many newly approved immediate-release (IR) solid oral drugs are accompanied by broad "do-not-crush" warnings, often without specific explanations. Building on our recent publication of crushability analysis of novel drugs approved between 2020 and 2022, this research extends the assessment to the approvals of 2023. Our goal is to provide healthcare providers with timely recommendations for the safe manipulation of immediate-release tablets and capsules for patients who cannot swallow them whole.

Winter 2024 Edition, Southwestern Oklahoma State University

The Sig

GREETINGS FROM THE DEAN’S OFFICE
Southwestern Opens Doors to Opportunities Beyond Imagination

Homecoming Saturday on October26th was a wonderful day, and we are grateful to all the alumni, family, and friends who attended. Coming back to the COP to rekindle with classmates and faculty is always a special time, especially after many years. As each 50-year and 40-year graduate was recognized and shared a story or special thought with everyone, I was impressed by the common themes.

Anticoagulation Strategies After Left Ventricular Thrombus., Corey Uetrecht Pharmd, Jennifer Sposito Pharmd, Bcps, Bcccp, Kassandra Foellinger Pharmd, Bcps, Jamie Gaul Pharmd, Bcps, Sarah Ferrell Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting,

This medication use evaluation found that prescribing practices of DOAC and warfarin did not change after AHA guidance publication. Patients with HFrEF were more often discharged on warfarin, while those with Afib were more often discharged on DOACs. Those discharged on a DOAC had the highest incidence of LV thrombus resolution up to 6 months post-discharge. Physicians within Parkview Health do not routinely utilize a loading dose when discharging a patient on a DOAC.

Stepping Back: Evaluating Antipseudomonal Antibiotic Use In Diabetic Foot Infection., Hannah Davis Pharmd, Michele Walters Pharmd, Bcps, Aq-Id, Sarah Ferrell Pharmd, Bcpps, Jui Patel Pharmd, Bcps, Tiffany O'Keefe Pharmd, Bcgp

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that anti-pseudomonal (PsA) coverage is overutilized in diabetic foot infection (DFI), even when broad qualifying criteria are applied. The proposed criteria were poor predictors of PsA growth, which was present in a small number of cases. Patients who did grow PsA were somewhat more likely to have severe DFI, history of DFI, and 90-day history of admission or anti-PsA antibiotic use, but many patients without PsA growth also met these criteria.

Comparing Cardiometabolic Monitoring And Side Effect Management In A Pharmacist-Led Ambulatory Clozapine Clinic Versus Standard Care., Nicholas Buttermore Pharmd, Jenna Gilbert Pharmd, Bcpp, Naana Boachie Pharmd, Bcacp, Kenneth Wiley Pharmd, Bcacp, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that cardiometabolic monitoring rates were significantly higher in the pharmacist group compared to standard care, and that clozapine-related side effects were screened more frequently.

Tenecteplase For Acute Ischemic Stroke: Insights From A Large Community Teaching Hospital, Ithar Alsarraf, Jennifer Pilotto, Rebecca E. Baker, Emily Reich

Posters

Acute Ischemic Stroke (AIS) is a leading cause of disability and death in the United States, requiring urgent treatment1,2; earlier treatment improves patient outcomes.

Fibrinolytic agents including alteplase and tenecteplase (TNK) reduce long-term disability in AIS but are associated with hemorrhagic risks3,4.

As of January 2024, Corewell Health East hospitals updated their guidelines that TNK would be the first line agent in the treatment of AIS.

Alteplase is the only approved agent for AIS, but TNK shows similar effectiveness along with shorter preparation and administration time which may ultimately improve door-to-needle time2 .

Careful consideration of patient characteristics is important …

October / November / December 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the October - November - December issue of Rural Rocks from the SWOSU College of Pharmacy.

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.

Dalbavancin Use At A Health System Network In Compliance With A Standard Plan Of Treatment For Infective Endocarditis And Osteomyelitis, Nicholas Lombardi, Anthoula Kritikos, Jacky Ye, Victor Cohen

Doctoral External Publications

Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and soft tissue infections caused by gram-positive microorganisms.

Used off-label in the management of infective endocarditis in IV drug users, as well as in osteomyelitis infections.

Extremely long half-life of greater than a week.

Potential cost-effective option for susceptible gram-positive infections and increased patient compliance.

Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani

Doctoral External Publications

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics.

Impact Of Order Set Implementation On Institutional Management Of Clostridioides Difficile In Adult Patients, Nicole Henry, Olivia Campbell, Heather Daly, Katelyn Quartuccio, Melanie Lintala

Doctoral External Publications

In February 2022, the University of Rochester Medical Center (URMC) updated their practice guidelines, in accordance with the Infectious Diseases Society of America, to include fidaxomicin as the preferred agent in patients with initial (non-fulminant) or first recurrence of C. difficile infection (CDI).

Health system protocols were updated to include polymerase chain reaction (PCR) testing for patients with suspected CDI followed by confirmation via toxin enzyme immunoassay (EIA).

In the appropriate clinical context, PCR+/EIA+ test confirms active CDI and warrants antibiotic treatment.

PCR+/EIA- test indicates likely colonization and may preclude the need for treatment.

A CDI order set was implemented …

Local Chapters Of Ashp And Apha Partner With The Monroe County Sheriff’S Department To Host A Drug Take-Back Event In The Rochester Community, Mackenzie Bermingham, Michael Currier, Bailey Walker, Laura Witt, Shawn E. Fellows, Angela Nagel

Doctoral External Publications

Objection/Study Goals:

To provide a safe, environmentally responsible way to dispose of unused or expired medications and to raise awareness about the risks of medication misuse in the community.

Students’ Performance And Perceptions Of Mock Trials As A Teaching And Assessment Activity Over Three Years At Two Institutions, Ettie Rosenberg, Shih-Ying H. Hsu, Hoai-An Truong, Reza Taheri

Pharmacy Faculty Articles and Research

Background: This study aimed to evaluate students’ performance and perception of a mock-trial teaching, learning, and assessment activity over three years at two institutions.

Methods: A mock trial (courtroom-style debate) implemented over three years (2017-2019) in a first professional year (P1) course at two institutions offered active learning in literature critique and evaluation, critical thinking, communication, teamwork, professionalism, and self-awareness. Student teams researched, prepared, and debated controversial topics as counsels, witnesses, or jurors for alternate mock trials. Descriptive analyses evaluated judge and juror trial scores and the 2019 Technology Acceptance Model (TAM) survey.

Results: The mock trials involved 319 student …

Anti-Inflammatory Potential Of Black Cumin Seed Oil And Its Nanoemulsion Formulation Against Lipopolysaccharide-Induced Liver Injury In Mice, Shady Swidan, Hesham Hafez, Rehab Hosni, Hatem Amin

Pharmacy

Original Article

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Haffez, Hesham^1,2,✉; Hosni, Rehab³; Swidan, Shady A.⁴; Amin, Hatem K.^1,5

Author Information

¹Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Helwan, 11795, Cairo, Egypt

²Center of Scientific Excellence “Helwan Structural Biology Research”, Helwan University, Helwan, 11795, Cairo, Egypt

³El Sisi Comprehensive Clinic, General Authority for Health Insurance-Giza, Haram, 12556, Giza, Egypt

⁴Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk, 11837, Cairo, …

Breast Cancer: Her2-Mutant P53 Cooperation And The Cell-Of-Origin Dependent Dynamics, Abie Williams-Villalobo

Dissertations (2016-Present)

Subtype. Specifically, NCP172 and NCP245 tumors grew faster and were predominantly triple- negative than NCP245. RNA sequencing identified many differentially expressed genes (DEGs) between tumor and mammary gland controls. Ingenuity Pathway Analysis (IPA) of the DEGs revealed that pathways like Deubiquitination, Cell Cycle Checkpoints, RHO GTPase cycle, and HIF1α Signaling were associated with aggressive tumor characteristics, with heightened pathway activity in NCP172 likely contributing to greater growth and invasiveness.

This study further examined how different cells-of-origin contribute to breast cancer heterogeneity by inducing mutant p53 in either mammary myoepithelial or luminal cells. Tumors originating from myoepithelial cells (Tk5) exhibited …

Evaluation Of Cardiometabolic Monitoring In Patients Taking Antipsychotic Agents Within A Community Health System., Kendra Yarian Pharmd, Jenna Gilbert Pharmd, Bcpp, Libby Stabler Pharmd, Bcacp, Quyen Nguyen Pharmd, Bcacp, Leia Gaddis Pharmd, Bcps, Dpla

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This evaluation found that the majority of patients on antipsychotic agents do not have all baseline monitoring completed, and that there are significant gaps especially in lipid panel and hemoglobin A1c. Other parameters (e.g., blood pressure, weight) were more likely to be gathered, likely as part of routine visit procedure.

Medication Use Evaluation Of Fecal Microbiota Spores (Live-Brpk) For The Prevention Of Recurrent Clostridioides Difficile Infection., Haley Michaud Pharmd, Trent Towne Pharmd, Bcps, Sarah Ferrell Pharmd, Bcpps, Bhavika Patel Pharmd, Noah Budi Pharmd

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This medication use evaluation found that infectious diseases providers were more likely to prescribe advanced treatments such as fidaxomicin or fecal microbiota compared to other specialties. Of the 93.1% of patients seen by Infectious Disease, 62.9% (n=17) of those patients were prescribed fecal microbiota spores (live-brpk) (VOWST). Of the 29 eligible patients, 41.4% (n=12) were identified as missed opportunities.

Optimization Of Beta-Lactam Dosing In Critically Ill Patients With Continuous Veno-Venous Hemofiltration Or Augmented Renal Clearance., Kristin Lytal Pharmd, Mspgx, Robert D. Beckett Pharmd, Bcps, Luke Keller Pharmd, Bcps, Bcccp, Michael Todt Pharmd, Bcccp

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This evaluation found that traditional dosing of beta-lactams found in practice is often (20 to 90%) suboptimal when compared to ideal evidence-based dosing, that optimizes efficacy while limiting adverse effects from drug toxicity.

Dofetilide Initiation In A Tertiary Medical Center: A Medication Use Evaluation., Zhixi Lui Pharmd, Kris Howard Pharm, Aacc, Megan Straub Pharmd, Bcps, Elizabeth Meisberger Pharmd, Bcps, Bccp, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This evaluation found that adherence to a pharmacist-managed protocol significantly increased dofetilide continuation rates at discharge and six months. Future implementation includes refining the current dofetilide order set, expanding the pharmacist’s role in dose selection, and standardizing documentation and intervention notes to improve protocol adherence.

Drop-It Like It’S Hot: A Droperidol Medication Use And Efficacy Evaluation In A Community Health System., Caleb Hoppe Pharmd, Sarah Meeks Pharmd, Allison Clemens Pharmd, Robert D. Beckett Pharm D

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that higher doses of droperidol for abdominal pain could provide more analgesic benefit without compromising patient safety. While droperidol appears effective at relieving nausea, other more cost-effective anti-emetics may be trialed first (without diphenhydramine). Droperidol appeared to provide light sedation, although most doses were low and used on patients without severe agitation (e.g. RASS ≥ 3).

Optimizing Serum Magnesium Monitoring And Replacement In A Community Hospital., Gabrielle O. Carreon Pharmd, Ms, Jesse Christman Pharmd, Bcop, Joshua Winebaugh Pharmd, Bcps, Robert D. Beckett Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

Findings highlight the need to revise our healthcare system’s standard hematology/oncology treatment plans to better align with appropriate magnesium monitoring, with up to 93% of magnesium lab draws potentially being unnecessary, and replacement, including better utilization of oral magnesium formulations instead of IV which can lower costs.

Discharge Antibiotic Use In Patients Hospitalized With Chronic Obstructive Pulmonary Disease (Copd) Exacerbations., Jennifer Mccarthy Pharmd, Ms, Sarah Pfaehler Pharmd, Mba, Bcps, Pacs, Ross Witte Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This medication use evaluation identified opportunities for improved prescribing in this population. The majority of patients receiving antibiotics had increased dyspnea only. Because of this, 90% of patients did not receive antibiotics appropriately; 94% received an excessive duration. The majority of patients had no prior to admission COPD maintenance therapy, potentially related to lack of baseline FEV1 data required for initiating therapy classification.

Pacific Rxtracts - December 2024, Pacific Rxtracts

Pacific RxTracts

Articles

• Attruby: A Promising Treatment for Transthyretin Amyloid Cardiomyopathy
• Triple Threat: GMRx2, An Emerging Low-Dose Triple Pill For Hypertension
• New Treatment for Hemophilia A or B
• Breaking the Placebo Barrier: FDA Review Challenges Effectiveness of Popular Decongestant
• Exploring Bempedoic Acid: Potential Benefits for Statin-Intolerant Patients and Liver Health
• The Flu Vaccine: Meeting You Where You Are
• Unique Application of Statins for Radiotherapy-Induced Cardiotoxicity
• One Shot, Two Solutions: How Semaglutide Combats Obesity and Knee Osteoarthritis

How Low Can We Go: Evaluation Of A Pharmacist-Led Weight Loss Management Program, Kelly Rubi, Elaina Rosario, Sara Panella, Jacqualine Igwe, Maria Pulido, Faaria Quadri

Nursing & Health Sciences Research Journal

Background: Obesity is a major health challenge that is associated with several health risks, including diabetes and hypertension. The purpose of this project was to evaluate the impact of clinical pharmacists on the therapy optimization of GLP-1 receptor agonists (GLP-1RAs) in a weight management program. Methods: This project evaluated a quality improvement initiative through a retrospective chart review that included patients who were treated with semaglutide or liraglutide between October 2022 and July 2023, with body mass indices (BMI) of 27 kg/m2 or greater with at least one weight-related comorbidity or a BMI greater than or equal to 30 kg/m2. …

Impact Of An Interdisciplinary Team On Patients Seen At A Heart Failure Clinic, Nilda Pelegrino, Faaria Quadri, Elaina Rosario, Jacqualine Igwe, Sandra Chaparro, Lourdes Labrada, Sara Panella, Maria Pulido, Stephen Breazeale, Zhenwei Zhang

Nursing & Health Sciences Research Journal

Background: Heart failure is a complex clinical syndrome that requires the involvement of interdisciplinary teams to address patient needs and optimize therapy. Interdisciplinary teams, including physicians, advanced practice practitioners, and pharmacists, play a crucial role in implementing guideline-directed medical therapy and addressing barriers to self-care that ultimately improve patients’ overall survival. This study assessed the impact of an interdisciplinary team on patients’ heart failure outcomes compared to patients solely managed by clinical cardiologists. Methods: This was a single-center retrospective chart review study of Baptist Health patients seen at the heart failure clinic. The study compared patients seen by an interdisciplinary …

Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don

Theses and Dissertations

In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.

For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …

Physicochemical Property Effects On Immune Modulating Polymeric Nanoparticles: Potential Applications In Spinal Cord Injury, Daniel J. Kolpek, Jaechang Kim, Hisham Mohammed, John C. Gensel, Jonghyuck Park

Markey Cancer Center Faculty Publications

Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability to reprogram innate immune cells. This reprogramming results in redirecting immune cells away from the injury site, downregulating pro-inflammatory signaling, and promoting a regenerative environment post-injury. However, to fully understand the mechanisms driving these effects and maximize therapeutic efficacy, it is crucial to assess NP interactions with innate immune cells. This review examines how the physicochemical properties of polymeric NPs influence their modulation of …

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …

Policies And Price Controls On The Research And Development Of Orphan Drugs In The United States And The European Union, Bena Pearl Filipczak Smith

Master's Theses

There is substantive literature surrounding the impact of price controls on the research and development (R&D) of new pharmaceutical products. The European Union (EU) and United States (US) are often studied in contrast to examine the influence of price controls as the US has fewer pharmaceutical price controls than the EU.

We find moderate evidence that the US spent more on annual domestic pharmaceutical R&D than the EU between 2004 and 2021, on average, before and after adjusting for GDP growth per capita and year. We find strong evidence that the US increased annual domestic R&D spending at a faster …