Pharmacy and Pharmaceutical Sciences Commons^™

G And P Genotyping Of Human Rotavirus Isolated In A University Hospital In Korea: Implications For Nosocomial Infections, Jung Oak Kang, Chang Ryul Kim, Paul E. Kilgore, Tae Yeal Choi

Department of Pharmacy Practice

To characterize rotavirus G and P genotypes circulating among infants and young children hospitalized with severe diarrhea in a university hospital in Gyeonggi province, Korea, and to examine any association of the genotypes and nosocomial infections, we genotyped 103 isolates of rotavirus by multiplex RT-PCR. In July 2001- June 2002, we found that globally common strains constituted 64.2% (G2P[4] 28.3%, G3P[8] 28.3%, G4P[8] 5.7%, and G1P[8] 1.9%), and the uncommon strain, G4P[6], constituted 26.4%. During July 2002-June 2003, the percentage of common strains decreased to 44.0% (G3P[8] 18.0%, G2P[4] 16.8%, and G1P[8] 10.0%), but G4P[6] increased to 36.0%. G9P[8] was …

Microemulsions As Precursors To Solid Nanoparticles, Russell John Mumper, Michael Jay

Pharmaceutical Sciences Faculty Patents

The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.

Pharmacy Newsletter : December 2006, Pharmacy Department

Pharmacy Newsletter

Content:

• Dengue Virus: DF and DHF
• Facts about Immuisation

Appl1 Associates With Trka And Gipc1 And Is Required For Nerve Growth Factor-Mediated Signal Transduction, D. C. Lin, C. Quevedo, N. E. Brewer, A. Bell, J. R. Testa, Mark L. Grimes, F. D. Miller, D. R. Kaplan

Biomedical and Pharmaceutical Sciences Faculty Publications

The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein. APPL1 and TrkA coirnmunoprecipitated in sympathetic neurons. We have identified two routes through which this association can occur. APPL1 was isolated as a binding partner for the TrkA-interacting protein GIPC1 from rat brain lysate by mass spectrometry. The PDZ domain of GIPC1 directly engaged the C-terminal sequence of APPL1. This interaction provides a means through which APPL1 may be recruited to TrkA. In addition, the APPL1 …

Organochlorine Levels In Seawater And Sediment From The Florida Gulf Coast, If Present, Are Low., Richard B. Philp

Richard B. Philp

Abstract Seawater and bottom sediment from two areas of the Gulf of Mexico near-shore waters along the Florida panhandle, one near Panacea (South of Tallahassee) and the other, St. Joseph Bay, about 100 km to the west, were analyzed for organochlorines (OCs). The first area is contiguous with the open water of Apalachee Bay and receives significant fresh water inflow. The second is a long, narrow bay with a north-facing mouth adjacent to the mainland and little fresh water inflow. Samples were analyzed for a panel of 28 OCs including several insecticides and metabolites as well as hexaxhlorobenzene and total …

Report Of The Aacp Criminal Background Check Advisory Panel, H. Anderson, M. A. Kirkpatrick, M. Mckenzie, W. M. Moore, K. Williams, W. Wuller, E. Anagnostiadis, L. Ross

Pharmacy Practice

No abstract provided.

Aluminum Bioavailability From The Approved Food Additive Leavening Agent Acidic Sodium Aluminum Phosphate, Incorporated Into A Baked Good, Is Lower Than From Water, Robert A. Yokel, Rebecca L. Florence

Pharmaceutical Sciences Faculty Publications

There are estimates of oral aluminum (Al) bioavailability from drinking water, but little information on Al bioavailability from foods. Foods contribute ∼95% and drinking water 1–2% of the typical human's daily Al intake. The objectives were to estimate oral Al bioavailability from a representative food containing the food additive acidic sodium aluminum phosphate (acidic SALP), a leavening agent in baked goods. Rats were acclimated to a special diet that resulted in no stomach contents 14 h after its withdrawal. They were trained to rapidly consume a biscuit containing 1.5% acidic SALP. Oral Al bioavailability was then determined from a biscuit …

2005 American Society For Parenteral And Enteral Nutrition (A.S.P.E.N.) Standards And Guidelines Survey, David Seres, Charlene Compher, Douglas Seidner, Laura Byham-Gray, Jane M. Gervasio, Stephen Mcclave, A.S.P.E.N. Standards And Guidelines Committees

Scholarship and Professional Work – COPHS

An online survey about the use and format of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Standards and Guidelines documents was conducted. The survey was sent to A.S.P.E.N. members, and an acceptable number of responses were received (470, or 9% of those surveyed). Most respondents indicated an overall satisfaction with the standards and guidelines and suggested format changes, many of which will be incorporated into future guidelines and standards. The results of this survey are presented here for general interest. Changes in the process with which A.S.P.E.N. produces standards and guidelines are discussed.

Current Controversies In Critical Care Pharmacotherapy: Incorporating Evidence Into Practice. How Can We Start Nutrition, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Nutrition In The Critically Ill Patient, Jane M. Gervasio

Scholarship and Professional Work – COPHS

Critical illness presents with the classic response to stress, including hypermetabolism and increased catabolism, resulting in a negative energy and nitrogen balance. These harmful events initiate the immunological response, starting with the systemic inflammatory response syndrome, which, if not resolved, may lead to multiple organ dysfunction syndrome (MODS). Furthermore, patients who do not develop early MODS manifest a compensation anti-inflammatory response syndrome, which suppresses immunity and predisposes the patient to sepsis, thereby ­increasing the risk of late MODS and ultimately death. The use of specialized nutrition support, including enteral nutrition (EN) and parenteral nutrition (PN), has been initiated in an …

Demographic Change And Response: Social Context And The Practice Of Birth Control In Six Countries, Sangeeta Parashar, Harriet B. Presser, Megan L. Klein Hattori, Sara Raley, Zhihong Sa

Department of Sociology Faculty Scholarship and Creative Works

This paper expands on Kingsley Davis’s demographic thesis of change and re- sponse. Specifically, we consider the social context that accounts for the primacy of particular birth control methods that bring about fertility change during specific time periods. We examine the relevance of state policy (including national family planning programs), the international population establishment, the medical profession, organized religion, and women’s groups using case studies from Japan, Russia, Puerto Rico, China, India, and Cameroon. Some of these countries are undergoing the second demographic transition, others the first. Despite variations in context, heavy reliance on sterilization and/or abortion as a means …

Exploiting The Enhanced Permeability And Retention Effect For Tumor Targeting., Arun Iyer

Arun Iyer

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.

Chain-Modified Pyridino-N Substituted Nicotine Compounds For Use In The Treatment Of Cns Pathologies, Peter A. Crooks, Linda Dwoshin, Rui Xu, Joshua T. Ayers

Pharmaceutical Sciences Faculty Patents

Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, addiction to opiates, addiction to alcohol, addiction to tobacco products, addiction to nicotine, schizophrenia and related diseases, depression and related conditions, Alzheimer's disease, Parkinson's disease, irritable bowel syndrome, and colitis. The compounds competitively inhibit central nervous system acting nicotinic receptor agonists and act at the putative α3β2* and α4β2 neuronal nicotinic receptors in the central nervous system.

Oy Canada! Trade's Non-Solution To "The Problem" Of U.S. Drug Prices, Daniel Gilman

Faculty Scholarship

Price disparities—price “differentiation” or “discrimination”—in pharmaceuticals markets have, in recent years, been the subject of much discussion. Price sensitivity should come as no surprise: Medicines play an increasingly important role in healthcare, while pharmaceuticals prices continue to rise. When prices vary greatly within markets or between neighboring markets, the pressure towards arbitrage is clear. This paper considers the question whether the re-importation of medicines from Canada or the EU is well advised and argues that it is not. First, we might reasonably question the extent to which we wish, as a matter of policy, to manage pharmaceuticals pricing; among other …

Pharmacy Newsletter : August 2006, Pharmacy Department

Pharmacy Newsletter

Content:

• Identification of ADRs through “Triggers”
• Drug Induced Fever

Nested Case-Control Study Of Autoimmune Disease In An Asbestos-Exposed Population, Curis W. Noonan, Jean C. Pfau, Theodore C. Larson, Michael R. Spence

Biomedical and Pharmaceutical Sciences Faculty Publications

OBJECTIVE: To explore the potential association between asbestos exposure and risk of autoimmmune disease, we conducted a case-control study among a cohort of 7,307 current and former residents of Libby, Montana, a community with historical occupational and environmental exposure to asbestos-contaminated vermiculite. METHODS: Cases were defined as those who reported having one of three systemic autoimmune diseases (SAIDs): systemic lupus erythematosus, scleroderma, or rheumatoid arthritis (RA). Controls were randomly selected at a 3:1 ratio from among the remaining 6,813 screening participants using frequency-matched age and sex groupings. RESULTS: The odds ratios (ORs) and 95% confidence intervals (CIs) for SAIDs among …

Antioxidant Effect Of Zinc And Zinc-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui

Edmund M. K. Lui

This study was concerned with the role of zinc (Zn) and zinc-metallothionein (Zn-MT) in oxidative stress. Hydrogen peroxide-induced oxidative injury was examined in Ehrlich ascites tumour cells isolated from control host mice, mice pretreated with 10 mg/kg ZnSO4 (i.p.) to increase cellular Zn/Zn-MT levels, and mice exposed to Zn-deficient diet to reduce the cellular Zn/Zn-MT levels. The results of the present study showed that Ehrlich cells with seven-fold differences in Zn-MT concentrations could be obtained by manipulating the Zn status of host mice and that high Zn and Zn-MT levels can make Ehrlich cells more resistant to H2O2-induced oxidative injury …

2006 Apothecary, Southwestern Oklahoma State University

Apothecary

This edition celebrates the golden anniversary of Apothecary. We would like to dedicate the 50th edition of Apothecary to all alumni and graduating seniors. Our cover includes a selection of our favorite Apothecary covers starting with the first in 1956 - 57 academic year. We have come a long way since 1956, and we can only hope that this edition will serve as a reminder to all alumni and seniors of the years spent at Southwestern Oklahoma State University College of Pharmacy.

Clinical Trials, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Camptothecin Intermediates And Prodrugs And Methods Of Preparation Thereof, Thomas G. Burke, Dennis P. Curran, Wu Du

Pharmaceutical Sciences Faculty Patents

The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs.

Research News: 2006, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Selective Parp-1 Targeting For Designing Chemo/Radio Sensitizing Agents, Marcos Oliveira

Pharmaceutical Sciences Faculty Patents

Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3 ligand domain have now been discovered on the PARP-1 protein. These domains are involved in PARP-1 activation. This discovery makes possible the use of bioinformatics tools for the design of new drugs and strategies for drug target selection, specifically targeting the PARP-1 enzyme.

Commencement Program 2006, Loma Linda University

Commencement Programs

CONTENTS

2 | 2006 Events of Commencement

3 | The Academic Procession

4 | Significance of Academic Regalia

5 | The Good Samaritan

6 | The Speakers

15 | The University Honorees

23 | The School Honorees

37 | The Program

• School of Medicine, 38
• School of Pharmacy, 47
• School of Dentistry, 52
• School of Science and Technology and Faculty of Religion, 63
• School of Nursing, 74
• School of Allied Health Professions - Physical Therapy, 80
• School of Allied Health Professions, 86
• School of Public Health, 95

Sampling And Analytical Strategies For Biomarker Discovery Using Mass Spectrometry, Thomas P. Conrads, Brian L. Hood, Timothy D. Veenstra

Pharmaceutical Sciences Faculty Publications

There is an often unspoken truth behind the course of scientific investigation that involves not what is necessarily academically worthy of study, but rather what is scientifically worthy in the eyes of funding agencies. The perception of worthy research is, as cost is driven in the simplest sense in economics, often driven by demand. Presently, the demand for novel diagnostic and therapeutic protein biomarkers that possess high sensitivity and specificity is placing major impact on the field of proteomics. The focal discovery technology that is being relied on is mass spectrometry (MS), whereas the challenge of biomarker discovery often lies …

Research, Precepting And The Irb, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Desulfovibrio Desulfuricans G20 Tetraheme Cytochrome Structure At 1.5 A˚ And Cytochrome Interaction With Metal Complexes, Mrunalini Pattarkine, J J. Tanner, C A. Bottoms, Y H. Lee, Judy D. Wall

Faculty Works

The structure of the type I tetraheme cytochrome c3 from Desulfovibrio desulfuricans G20 was determined to 1.5 A˚ by X-ray crystallography. In addition to the oxidized form, the structure of the molybdate-bound form of the protein was determined from oxidized crystals soaked in sodium molybdate. Only small structural shifts were obtained with metal binding, consistent with the remarkable structural stability of this protein. In vitro experiments with pure cytochrome showed that molybdate could oxidize the reduced cytochrome, although not as rapidly as U(VI) present as uranyl acetate. Alterations in the overall conformation and thermostability of the metal-oxidized protein were investigated …

In Vitro Expression And Purification Of Class I Mhc Molecules, Loi Cheng

Honors Scholar Theses

The major histocompatibility complex (MHC) is a gene family responsible for many critical functions of the immune system in most vertebrates. The MHC consists of three classes differentiated by their structure and function, and MHC class I encodes antigen binding proteins as well as chaperone and accessory proteins such as tapasin. The purpose of this project is to reconstitute several human MHC class I molecules in their peptide-filled and peptide-deficient forms, and to purify these proteins for biochemical study. The expressed proteins include wild type and mutant variants of the fusion protein human leukocyte antigen HLA-B*0801-fos, and human beta-2-microglobulin (β2m). …

Amankah Pengawet Makanan Bagi Manusia ?, Harmita Harmita

Majalah Ilmu Kefarmasian

No abstract provided.

Immunization Update, Karl M. Hess, Jeffery A. Goad

Pharmacy Faculty Articles and Research

"Immunization represents a very effective primary prevention strategy to curb the rate of vaccine preventable diseases...Pharmacists can play a leading role in vaccination by serving as an advocate, facilitator, and active immunizer. As an advocate, pharmacists provide vaccine education while motivating people to get immunized. As a facilitator, pharmacy’s can host other groups, such as the visiting nurses association, to come into the pharmacy and vaccinate. As an active immunizer, however, pharmacists serve their greatest role by giving immunizations to adolescents and adults."

Products With "Black Box" Warnings, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.