Pharmacy and Pharmaceutical Sciences Commons^™

Folic Acid–Carbon Dot–Gemcitabine Nanoparticles For Targeted Cancer Drug Delivery, Irfan Huda, Hua Mei

SPARK Symposium Presentations

This project aims to develop a folic acid-attached carbon dot nanoparticle system (FA-CDs-GEM) for the targeted delivery of gemcitabine to cancer cells. While gemcitabine is widely used, its effectiveness is limited because a short in vivo half life and lack of selectivity, which lead to severe side effects. Carbon dots offer a simple and modifiable platform as the drug delivery and bioimaging agent. Conjugation of folic acid to the carbon dots enables selective targeting of cancer cells that overexpress folate receptors. In this study, we synthesized and characterized FA-CD-GEM nanoparticles and developed an HPLC calibration curve of GEM to accurately …

The Standardization Of Protocols For Lines And Drips In Complex Cases, Allee A. Rudolph

Scholars Week

Medication errors occur far too often, yet many can be prevented through simple measures such as intravenous line labeling. Clear, highly visible labels enable quick identification reducing the response time in critical situations. The incorporation of color-coding and icons can only enhance the ability to distinguish between the lines with confidence.

From Fog To Function: An Occupational Therapist's Guide To Evaluating And Treating Cancer-Related Cognitive Impairments, Lauren E. Toner

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Cancer – related cognitive impairment (CRCI) is a common side effect of cancer treatment that interferes with cancer survivors’ occupational performance, independence, and quality of life. Despite its high prevalence, CRCI remains under recognized and inconsistently addressed within oncology care. About 70% of individuals diagnosed with cancer report cognitive changes during or after treatment, yet many do not receive treatment. Occupational therapists are clinically trained to evaluate and treat functional cognition, activities of daily activities, instrumental activities of daily living, and client centered goals, positioning them as key providers in addressing CRCI. However, limited occupational therapy specific resources have hindered …

Acoustic Filter For Biopharmacy, Nicholas Rivet

Three Minute Thesis (3MT)

The design and development of a novel flow induced acoustically tuned “filterless” filter is proposed. The proposed research is on developing two or more prototypes that function as a cell retention device for perfusion cell cultures used in continuous manufacturing of monoclonal antibodies and recombinant proteins. This research will provide a non-invasive, cost-effective, flexible, and robust cell retention device for sustainable manufacturing of biologics.

Evaluation Of A Pharmacist-Driven Electrolyte Replacement Protocol In A Community Health System, Corey Uetrecht Pharmd Candidate

Pharmacy Residency

This evaluation found a higher rate of pharmacist consults for electrolyte management, though these were not always indicated. Repletion via oral route was not optimized and there were opportunities for improvement in protocol alignment.

Presented at Great Lakes PRC

Implementation Of An Evidence Based Skin And Soft Tissue Infection Algorithm At A Large Community Health System, Jennifer Mccarthy Pharmd, Ms

Pharmacy Residency

This study found a continued need for an updated skin and soft tissue infection algorithm. Ongoing reliance on IV antibiotics suggests underutilization of oral options. Promoting oral antibiotic use may reduce inpatient admissions and length of stay.

Presented at OHIO PRC

Silent Pressure: Outcomes Of As-Needed Antihypertensives In Hospitalized Adults*, Corey Uetrecht Pharmd Candidate

Pharmacy Residency

Presented at ACCP

This study found that PRN antihypertensives are frequently used for AEBP in hospitalized patients, despite limited benefit and potential risk of hypotension-related adverse events.

Development And Implementation Of An Analgesia, Sedation, And Paralysis Order Panel For Mechanically Ventilated Pediatric Patients At A Large Community Health System, Kristin Lytal Pharmd, Mspgx

Pharmacy Residency

This project describes best practices and steps taken in development of a protocol for analgesia, sedation, and paralysis in pediatric patients.

This was presented at OHIO PRC.

“Pinkalicious": Outer Membrane Vesicles Isolated From Pseudoalteromonas Rubra Carry Prodigiosin Antibiotics As Cargo, Margaret Hill

Senior Honors Projects

Astrangia poculata, the state coral of Rhode Island, is susceptible to infection by Vibrio coralliilyticus RE22, which is a common marine pathogen affecting various invertebrate species. The settlement of coral larvae prior to the establishment of colonies is mediated by crustose coralline algae (CCA). This process may be induced by CCA-associated protective bacteria that colonize corals in early metamorphosis; furthermore, such bacteria potentially have downstream effects in the susceptibility of corals to pathogens. Strains of Pseudoalteromonas rubra isolated from CCA have been shown to induce larval settlement of tropical corals. We hypothesize that P. rubra induces the settlement of …

Adverse Infusion-Related Event Severity In Oncology Patients Receiving Chemotherapy Agents Vs. Immunotherapy Agents, Tayler Hutto

Annual Research Symposium

In recent years, immunotherapy investigational drugs in cancer research has been underway in treating multiple forms of cancer due to a lower side effect profile and decreased severe infusion-reaction risk compared to conventional chemotherapy agents. The purpose of this study was to determine the infusion reaction severity among patients receiving either chemotherapy treatment or immunotherapy agents based on the CTCAE (Common Terminology Criteria for Adverse Events) scale to improve patient care outcomes.

In this intent-to-treat, retrospective observational study, a survey of patients throughout 10 Intermountain Healthcare infusion clinics was conducted to obtain documentation on patients who had received chemotherapy and/or …

Pharmacy Law: Pharmacists Awareness Of Licensure Regulations, The Mpje And Nabp - A State-Wide Study, Andrew Holick

Annual Research Symposium

No abstract provided.

Implementation Of A Clinical Journal Club To Improve Student Knowledge, Christian J. Stang

ONU Student Research Colloquium

Evidence-based medicine is a crucial component of pharmacy practice that is utilized to ensure the best possible outcomes for patients. It is a concept that ensures clinical guidelines are constantly analyzed for quality improvement with therapeutic practices enhanced for the highest standards for patient care. At the heart of incorporating evidence-based medicine is literature review and analysis, a practice conducted not only by healthcare professionals but also students in healthcare programs. The implementation of literature review into these healthcare programs better prepares students to critically evaluate and review medical literature with the ultimate purpose to improve patient care in their …

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached …

Epi-Pens: Honors Capstone Enhancement, Chelsey Boecker

Honors Capstone Enhancement Presentations

No abstract provided.

Pharmacist-Prescribed Birth Control: A Policy Analysis, Brianna Full

UNO Student Research and Creative Activity Fair

Although unintended pregnancy in the United States has steadily decreased from 2008, rates are still unacceptably high as almost half (42%) of all pregnancies are not wanted or timed correctly (Finer & Zolna). In 2011, 2.8 million of the 6.1 million pregnancies in the United States each year were unintended. Public health professionals are worried about unintended pregnancy because research shows that unwanted or mistimed pregnancies come with associations to adverse maternal and child health outcomes, such as delayed prenatal care, premature birth, and negative physical and mental health effects for children (Frost, Frohwirth & Zolna, 2016). Also, two-thirds (68%) …

Efficacy Of Cpap Compared To Standard Pharmacotherapy In Reducing Cognitive Impairment Symptoms In Patients With Alzheimer's Disease, Nicholas Moylan

Capstone Showcase

This review analyzed the following question: In adults age 65 years old or older diagnosed with Alzheimer’s Disease (P), is nightly use of CPAP (I) more effective in reducing cognitive impairment symptoms (O) than standard pharmacotherapy options (C)? A literature search conducted through Google Scholar and PubMed granted six relevant articles that provided data for this review. No current studies compared CPAP treatment with pharmacotherapy, and each study used unique measures of cognitive function, making direct comparison of the two therapies difficult. Results demonstrated that first line pharmacotherapy can improve cognitive function, but only in limited way and only in …

Expanded Access (Compassionate Use) For Investigational Drugs Or Biologics, Lukas Gilmore

Parkview Pharmacy Department

A presentation given at the Parkview Cancer Institute (PCI) Oncology Research Committee meeting in October 22, 2019.

Investigational Drug Service Department of Parkview Health

Building A Rotation Syllabus Using Legos: Learning Experience Goals & Objectives, Radhan Gopalani

All Publications

No abstract provided.

Case Presentation On Congestive Heart Failure And Pulmonary Edema, Tetiana Soloviova, Denise Aris

Publications and Research

No abstract provided.

An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey

UNO Student Research and Creative Activity Fair

Stimulants are a class of drugs that have a variety of effects on the brain, including changes in receptor activity in the brain areas responsible for- memory, attention, emotion, motor control, and the reward pathway. Stimulants may be generally classified by their availability. For example, prescription stimulants, which include drugs such as methylphenidate (Concerta™, Ritalin™) and mixed amphetamine salts (Adderall™), must be prescribed by medical professionals. Another regulated stimulant, albeit one available without a prescription, is nicotine; a highly addictive chemical that is age-restricted by the U.S. federal government. Nicotine is found in tobacco products, and in tobacco-free alternatives including …

Effects Of Naltrexone On Alcohol And Nicotine Use In Female P Rats, Usman Z. Hamid, Michael T. Bardo Ph.D.

Posters-at-the-Capitol

Title: Effects of Naltrexone on Alcohol and Nicotine Use in Female P Rats

Author: Usman Z. Hamid, Department of Psychology, University of Kentucky

Faculty Mentor: Michael T. Bardo, Ph.D., Department of Psychology, University of Kentucky

Alcohol is the most commonly abused substance worldwide. It is often co-abused with nicotine, which increases the difficulty of cessation of both alcohol and nicotine. Despite having similar mechanisms of action, there is no single medication to treat the co-abuse. The objective of the current study is to analyze the effects of the opiate antagonist naltrexone on alcohol consumption and the co-use of alcohol and …

Do Paraben Derivatives Alter T Cell Immunity?, Hailey Kintz

Spring Presentation of Undergraduate Research

T cells immunity is linked to a complex system of cytokines that determine differentiation of naïve T cells into Th1, Th2, Th17, and Treg cells. Estrogen production or periods of elevated production have been correlated with an anti-inflammatory state in which Th2 and Treg cells are up-regulated. Such responses in the immune system are capable of supporting pre-cancerous activity. We are investigating the tie between the xenoestrogen compounds found in cosmetics, parabens, and their ability to regulate T cell immunity. Testing parabens and paraben derivatives with weaker estrogen receptor association will allow for a better understanding of the interplay between …

We Are The Medicine, Madalynn Wendland, Toni Speed

Interprofessional Education

We are all healers— to ourselves, each other and the world around us. Whether you are on the path of becoming a health professional, or have been in practice for a long time, this half-day workshop will help you to view healing from a holistic perspective that draws from the ancient traditions while respecting contemporary science.

Challenges And Solutions In Library And Information Sciences: Formulating A Pharmacy Collection Without A Prescription, Kristin Laughtin-Dunker

Library Presentations, Posters, and Audiovisual Materials

Librarians, pharmacists, and scientists encounter diverse challenges relating to knowledge management, the creation, organization, and retrieval of information. This session will highlight current challenges faced in this area by colleagues from across the Academy. Participants will have the opportunity to engage in two roundtable discussions. By the end of the session, participants will be able to describe current challenges faced in Library and Information Science, and bring solutions back to their academic program.

These slides include the "Formulating a Pharmacy Collection Without a Prescription" portion of the panel, which discussed the collection development process for a group of non-health science …

Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing

Andrews Research Conference

Streptococcus mutans JH1140 is a strain of bacteria which produces a lantibiotic product, named mutacin 1140. Mutacin 1140 has been shown to be effective at inhibiting Gram-positive bacterial infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Mutacin 1140 is a ribosomally synthesized peptide antibiotic that undergoes extensive posttranslational modifications (PTM). We have found that Mutacin 1140 and an aminoglycoside, Kanamycin, when combined together, act synergistically against Staphylococcus aureus. This was determined by performing serial kill curve dilution overlays on solid media, followed up with kill curve by microdilution plate, and most recently confirmed with kill curve CFU count plates …

Evaluating The Safety And Efficacy Of Classical Greek And Roman Treatments Compared To Modern Treatment, Morgan A. Wynes

Senior Honors Projects

Classical Greek and Roman civilizations survived for centuries and have greatly influenced the civilizations that have succeeded them. The treatments of diseases of both civilizations changed over time as physicians and philosophers such as Hippocrates and Galen developed a better understanding of the human body. Some of the treatments for disease used in ancient Greece and Rome remain in use today.

This project was designed to assess the safety and efficacy of classical Greek and Roman medicinal treatments and compare them to modern day treatments. The first step of the project was to identify classical diseases with telltale symptoms that …

Pharmacy Research On Medication Disposal Practices Using Service-Learning, Patricia L. Darbishire, Anne Packard, Maryam Noureldin, Sumaya Bahrami

Engagement & Service-Learning Summit

Abstract

The purpose was to engage students in local communities to determine what types of medications commonly go unused, discover common medication disposal practices, gauge the public’s opinion on medication disposal, and collect unwanted medications.

Student pharmacists and a faculty mentor hosted 15 medication take-back events in conjunction with community partners, and administered a survey to participants exploring disposal practices, opinions and returned medication(s). Educational brochures on safe disposal methods were distributed to participants.

Four hundred and seventy-eight surveys were collected and 4,993 medications were identified and analyzed. The top three reasons for bringing medications to collection events included: medication …

Student And Community Perceptions On Reasons For Medication Non-Adherence, Patricia L. Darbishire, Daraoun Mashrah

Engagement & Service-Learning Summit

Abstract

The purpose of this research was to improve medication adherence by exploring and reflecting on differences in the perceptions of pharmacy students and the public regarding factors contributing to medication non-adherence.

Two hundred eighty six pharmacy students and 310 patients participated in this study. Patients were recruited by pharmacy students from Midwest community pharmacies, while the students completed an experiential rotation. Students identified their patients based on evidence of non-adherence from medication profiles and asked patients to participate in the assignment. Data was collected over a four-year period, resulting in two years of information on patient perceptions and two …

Standardized Pediatric Vancomycin Dosing And Influence On Target Concentrations, Tibisay Villalobos Md, Jenny Boucher Pharmd, Jd, Bcps

Department of Pediatrics

No abstract provided.