Pharmacy and Pharmaceutical Sciences Commons^™

Pharmacy Team Leads Efforts For Covid-19 Vaccine Clinic For Underserved, Kyle Mcmillan, Christine R. Birnie Phd

Pharmacy Faculty/Staff Publications

Completing Advanced Practice Placement Experience (APPE) rotations in the midst of a pandemic such as COVID-19 left many pharmacy students across the state and country with frequent changes and cancellations to their schedules. As stressful and anxiety- producing as that can be, it also creates some unique opportunities. During one of my last rotations, I had the opportunity to participate in a Service-Learning Elective at St. Joseph’s Neighborhood Center in Rochester, N.Y., where we were able to design and execute the Center’s first COVID-19 vaccine clinic.

Introduction To Leadership Development Using The "Five Practices" Framework In A Co-Curricular Pharmacy Student-Development Program, Sumyya Wase, Melinda E. Lull

Pharmacy Faculty/Staff Publications

Introduction and leadership framework: With the increased expectation that pharmacy education should prepare students to become pharmacy leaders, schools of pharmacy are struggling to find ways to incorporate leadership topics. One way to incorporate content is to build co-curricular programs that introduce and practice leadership frameworks. The co-curricular program described in this study introduces leadership content using Kouzes and Posner's Student Leadership Challenge. Educational context and methods: Students were offered three workshops developed around the Five Practices framework. Each workshop provided background knowledge before engaging in self-reflection, discussion, and application activities. Students participated in a pre−/post-series assessment of leadership practices, …

Wastewater Surveillance For Sars-Cov-2 On College Campuses: Initial Efforts, Lessons Learned, And Research Needs, Sasha Harris-Lovett, Kara L. Nelson, Paloma Beamer, Heather N. Bischel, Aaron Bivins, Andrea Bruder, Caitlyn Butler, Todd D. Camenisch, Susan K. De Long, Smruthi Karthikeyan, David A. Larsen, Katherine Meiediercks, Paula J. Mouser, Sheree Pagsuyoin, Sarah M. Prasek, Tyler S. Radniecki, Jeffrey L. Ram, D. Keith Roper, Hannah Safford, Samendra P. Sherchan, William Shuster, Thibault Stalder, Robert T. Wheeler, Katrina Smith Korfmacher

Pharmacy Faculty/Staff Publications

Wastewater surveillance for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging approach to help identify the risk of a coronavirus disease (COVID-19) outbreak. This tool can contribute to public health surveillance at both community (wastewater treatment system) and institutional (e.g., colleges, prisons, and nursing homes) scales. This paper explores the successes, challenges, and lessons learned from initial wastewater surveillance efforts at colleges and university systems to inform future research, development and implementation. We present the experiences of 25 college and university systems in the United States that monitored campus wastewater for SARS-CoV-2 during the fall 2020 academic …

Effects Of Compaction Pressure, Speed And Punch Head Profile On The Ultrasonically-Extracted Physical Properties Of Pharmaceutical Compacts, Xiaochi Xu, Yigitcan Coskunturk, Vivek S. Dave, Justin V. Kuriyilel, Murray F. Wright, Rutesh H. Dave, Centin Cetinkaya

Pharmacy Faculty/Staff Publications

Despite a well-established manufacturing-process understanding, tablet quality issues are frequently encountered during various stages of drug-product development. Compact breaking force (tensile strength), capping and friability are among the commonly observed characteristics that determine the integrity, quality and manufacturability of tablets. In current study, a design space of the compaction pressure, compaction speed and head flat types is introduced for solid dosage compacts prepared from pure silicified microcrystalline cellulose, a popular tableting excipient. In the reported experiments, five types of head flat types at six compaction pressure levels and two compaction speeds were employed and their effects on compact mechanical properties …

Physical And Chemical Stability Of Dexamethasone Sodium Phosphate In Intravenous Admixtures Used To Prevent Chemotherapy-Induced Nausea And Vomiting, Ina Buga, Joy Uzoma, Kristin Reindel, Kateryna Rashid, Tuong Diep, Pamela Mccartan, Fang Zhao

Pharmacy Faculty/Staff Publications

Purpose: Dilute intravenous (IV) admixtures of dexamethasone sodium phosphate (DSP) are becoming increasingly used in antiemetic regimens to prevent chemotherapy-induced nausea and vomiting (CINV). Based on its chemical structure and previous studies, DSP is known to be susceptible to hydrolysis and oxidation under certain conditions. There are limited data to directly support the selection of IV diluents, storage conditions, and beyond-use dates for the dilute IV solutions of DSP used in the antiemetic regimens. This study was designed to investigate these parameters. Methods: A stability-indicating high-performance liquid chromatography (HPLC) method was first developed for the analysis of DSP. Commercially available …

Prevalence, Determinants, And Characteristics Of Extemporaneous Compounding In Jordanian Pharmacies, Hatim S. Alkhatib, Sara Jalouqa, Nour Maraqa, Anna Ratka, Eman Elayeh, Suha Al Muhaissen

Pharmacy Faculty/Staff Publications

Background:

Pharmaceutical compounding is an essential component in pharmacy practice allowing pharmacists to provide dosage forms or strengths that are commercially unavailable. Medications compounded for patient-specific needs contribute to personalized medicine. Extemporaneous compounding provided by pharmacies overcomes the market shortage of these therapeutic products. The aim of this study is to investigate and characterize the prevalence, characteristics, and determinants of extemporaneous compounding in Jordanian pharmacies.

Methods:

This study was based on a cross-sectional questionnaire and included 431 randomly selected pharmacies in the twelve governorates of the country. Data were collected via face to face interviews of pharmacists who voluntarily and …

A Review Of The Food And Drug Administration Adverse Event Reporting System For Tramadol-Related Hypoglycemia, Katherine Juba, Robbert Van Manen, Shawn E. Fellows

Pharmacy Faculty/Staff Publications

Background: Hypoglycemia is a rare adverse effect of tramadol that is described in the medical literature and package insert. Objective: The purpose of this study was to review reports of tramadol and hypoglycemia in the Food and Drug Administration Adverse Event Reporting System (FAERS) database to determine a potential association. Methods: Disproportionality analysis with Bayesian correction was used to compare tramadol and hypoglycemia with other medications in FAERS. The results were considered significant if the fifth percentile of the Empirical Bayesian geometric mean distribution (EB05) >2. Logistic regression odds ratios was used to determine if age, diabetes medications, and renal …

172. Risk Factors For 30-Day Mortality In Patients With Staphylococcus Aureus Bacteremia At A Community Hospital: A Prospective Case–Control Study, Charles Hoffmann, Gordon Watkins, Patrick Desimone, Peter Hallisey, David Hutchinson, Stephen Colodny, Jeffrey Burkey, Amanda Michael, Jo-Anne Klein, Christina Welc

Pharmacy Faculty/Staff Publications

Background:

Staphylococcus aureus bacteremia (SAB) is associated with 30-day all-cause mortality rates approaching 20–30%. The purpose of this case–control study was to evaluate risk factors for 30-day mortality in patients with SAB at a community hospital.

Methods:

As part of an antimicrobial stewardship program (ASP) initiative mandating Infectious Diseases consultation for episodes of SAB, our ASP prospectively monitored all cases of SAB at a 341-bed community hospital in Jefferson Hills, PA from April 2017–February 2019. Cases included patients with 30-day mortality from the initial positive blood culture. Only the first episode of SAB was included; patients were excluded if a …

2103. Emergency Department (Ed) Stewardship: Stratifying Ed Sepsis Order Sets By Penicillin (Pcn) Allergy Severity, Mary L. Staicu, Maryrose Laguio-Vila, Allison Ramsey, Kelly Conn, Kristin Woodring

Pharmacy Faculty/Staff Publications

Background:

The Surviving Sepsis Campaign Guidelines recommends administration of broad-spectrum antibiotics within 1 hour of sepsis diagnosis; electronic order sets drive antibiotic selection with pre-populated regimens based on the suspected infectious indication. Given the low rate of cephalosporin cross-reactivity in patients with a PCN allergy, we modified our ED sepsis order set (Images 1 and 2) to include cephalosporin options in patients with reported mild-to-moderate PCN reaction histories. This was a single-center, retrospective analysis evaluating the impact of this change on antibiotic prescribing and associated outcomes.

Methods:

An electronic medical record (EMR) report identified patients ≥18 years of age with …

Glucosamine Hcl-Based Solid Dispersions To Enhance The Biopharmaceutical Properties Of Acyclovir, Darshan R. Telange, Snehal B. Bhagat, Arun T. Patil, Milind J. Umekar, Anil M. Pethe, Nishikant Raut, Vivek S. Dave

Pharmacy Faculty/Staff Publications

The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir and glucosamine HCl were prepared by an ethanol-based solvent evaporation method. The prepared formulations characterized by photomicroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transforms infrared spectrophotometry (FTIR), powder x-ray diffractometry (PXRD) and drug content analysis. The functional characterization of ACV-SD was performed by aqueous solubility evaluation, dissolution studies, fasted versus fed state dissolution comparison, ex vivo permeability, and stability …

Penicillin Allergy Assessment And Skin Testing In The Outpatient Setting, Wesley D. Kufel, Julie Ann Justo, P. Brandon Bookstaver, Lisa M. Avery

Pharmacy Faculty/Staff Publications

Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians. Thus, allergy assessment and penicillin skin testing (PST) are important management strategies to reconcile and clarify labeled penicillin allergies. While PST is more common in the inpatient setting where the results will immediately impact antibiotic management, this process is becoming of increasing importance in the outpatient setting. PST in the outpatient setting allows clinicians to proactively de-label and educate patients accordingly so beta-lactam antibiotics may …

Penicillin Allergy Skin Testing In The Inpatient Setting, Julie Ann Justo, Wesley D. Kufel, Lisa M. Avery, P. Brandon Bookstaver

Pharmacy Faculty/Staff Publications

The consequences of a documented penicillin allergy in the medical record are especially troublesome in acutely ill, hospitalized patients. A penicillin allergy label may lead to alternative or second line therapies resulting in adverse drug events, negative clinical outcomes and increased costs. Reconciling penicillin allergies is a necessity to facilitate early, optimal therapy and is a shared responsibility among the healthcare team. Penicillin skin testing (PST) has been utilized successfully in hospitalized patients to de-label erroneous penicillin allergies and optimize antibiotic therapy. This targeted review aims to discuss the practical development and implementation of PST in the inpatient setting. This …

A Systematic Review Of The Evidence Behind Use Of Reduced Doses Of Acetaminophen In Chronic Liver Disease, Anne Schweighardt, Katherine Juba

Pharmacy Faculty/Staff Publications

Acetaminophen is among the most commonly used nonopioid analgesics, but significant variation exists in its prescribing practices for cirrhosis patients. Our primary objective was to describe the quality of evidence supporting or refuting the use of acetaminophen in patients with hepatic dysfunction. A comprehensive literature review of PubMed, Cochrane Library, Web of Science, and International Pharmaceutical Abstracts using the search terms “acetaminophen,” “paracetamol,” “chronic liver disease,” “cirrhosis,” and “hepatic disease” for studies describing changes in acetaminophen metabolism in patients with hepatic dysfunction was conducted. Twelve studies and four abstracts were included. Ten studies and three abstracts were pharmacokinetic studies. Two …

Pharmacy Students’ Attitudes And Perceptions Toward Pharmacogenomics Education, Shanice Coriolan, Nimota Arikawe, Arden Moscati, Lisheng Zhou, Stephanie Dym, Seda Donmez, Adinoyi Garba, Sahsa Falbaum, Zvi Loewy, Melinda E. Lull, Maha Saad, Jane Shtaynberg, Aniwaa Owusu Obeng

Pharmacy Faculty/Staff Publications

Purpose

To evaluate final-year pharmacy students’ perceptions toward pharmacogenomics education, their attitudes on its clinical relevance, and their readiness to use such knowledge in practice.

Methods

A 19-question survey was developed and modified from prior studies and was pretested on a small group of pharmacogenomics faculty and pharmacy students. The final survey was administered to 978 final-year pharmacy students in 8 school/colleges of pharmacy in New York and New Jersey between January and May 2017. The survey targeted 3 main themes: perceptions toward pharmacogenomics education, attitudes toward the clinical relevance of this education, and the students’ readiness to use knowledge …

The Use Of Aerosolized Ribavirin In Respiratory Syncytial Virus Lower Respiratory Tract Infections In Adult Immunocompromised Patients: A Systematic Review, Lisa M. Avery, Charles Hoffmann, Karen M. Whalen

Pharmacy Faculty/Staff Publications

Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug costs remain a challenge for patient management. The purpose of this systematic review is to summarize the efficacy and adverse event profile of RBV AER for the treatment of hospitalized RSV LRTI in immunocompromised adult patients. Methods: A Medline/PubMed, Embase, Google Scholar, Clinicaltrials.gov, and Cochrane Library database search was conducted from 1966 to January 2019 for the use of RBV AER. Search strategy: [(ribavirin OR ICN1229) AND …

Physical Properties And Solubility Studies Of Nifedipine-Peg 1450/Hpmcas-Hf Solid Dispersions, Rahul V. Haware, Bhavani Prasad Vinjamuri, Monika Gavireddi, Vivek S. Dave, Deepak Gupta, Mahavir B. Chougule, William C. Stagner

Pharmacy Faculty/Staff Publications

Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with polyethylene glycol (PEG) 1450 and hypromellose acetate succinate (HPMCAS-HF) to increase NIF solubility while achieving acceptable physical stability. HPMCAS-HF was used as a crystallization inhibitor. Individual formulation components, their physical mixtures (PMs), and SDs were characterized by differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy (FTIR). NIF solubility and percent crystallinity (PC) were determined at the initial time and after 5 days stored at 25 °C and 60% RH. FTIR indicated that hydrogen bonding was involved with the amorphization process. FTIR showed that …

Assessment Of The Use Of Non-Pharmacological Methods For Managing Depression In Patients With Myotonic Dystrophy (Dm) And Facioscapulohumeral Muscular Dystrophy (Fshd), Mackenzie Roberts, Amy L. Parkhill, Deidre Skalla, Kimberly Miller

Pharmacy Faculty/Staff Publications

Background: Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are two types of muscular dystrophies with multi-system manifestations.

Purpose: The purpose of this study was to determine 1: the prevalence of depression in patients with myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) and 2: which non-pharmacological methods DM and FSHD patients are using to manage their depression.

Methods: A survey was conducted using the online system, Qualtrics. The voluntary and anonymous survey was emailed to 1,205 eligible patients from the National Registry for DM and FSHD Patients and Family Members at the University of Rochester. Participants were at least …

Empathy And The Development Of Affective Skills, Anna Ratka

Pharmacy Faculty/Staff Publications

Empathy, the most important human attribute that matters in every aspect of life, is essential in health care. Provision of patient-centered care requires empathic health care practitioners. The correlation between empathy of health care providers and improved patient adherence, satisfaction, and treatment outcomes is well-established. Scholarly evidence shows positive correlations between empathy and affective domains and confirms that soft skills are grounded in empathy. Empathic students have stronger affective skills and are capable to acquire, develop, reinforce, and display strong affective behaviors, abilities, and attitudes. As an innate quality, empathy is malleable. The level of empathy can be influenced by …

Antimicrobial Susceptibility Trends Observed In Urinary Pathogens Obtained From New York State, Elliot L. Rank, Thomas Lodise, Lisa M. Avery, Eve Bankert, Erica Dobson, Ghinwa Dumyati, Stephen Hassett, Marina Keller, Matthew Pearsall, Theresa Lubowski, Joseph J. Carreno

Pharmacy Faculty/Staff Publications

International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones had higher prevalences. This study highlights the need for local outpatient antimicrobial stewardship programs.

Basics Of Compounding: Vehicles For Compounded Oral Liquid Medications: A Review, Kara Cutaia, Lipika Chablani, Fang Zhao

Pharmacy Faculty/Staff Publications

Compounded oral liquid medications play an important role in addressing the unmet needs of special patient populations, including pediatric, geriatric, and tube fed patients. The use of manufactured vehicles can streamline the compounding activities for pharmacists. In recent years, there is an increase in the availability of manufactured vehicles with various promotional features. This article uses the general formulation principles as a guide to compare and contrast the manufactured vehicles regarding their physicochemical properties, presence of preservatives and dyes, organoleptic properties, and ease of use. A summary table is provided as a reference tool to assist pharmacists in selecting the …

Early Detection Of Capping Risk In Pharmaceutical Compacts, Xiaochi Xu, Chaitanya Krishna Prasad Vallabh, Stephen W. Hoag, Vivek S. Dave, Centin Cetinkaya

Pharmacy Faculty/Staff Publications

Capping is a common mechanical defect in tablet manufacturing, exhibited during or after the compression process. Predicting tablet capping in terms of process variables (e.g. compaction pressure and speed) and formulation properties is essential in pharmaceutical industry. In current work, a non-destructive contact ultrasonic approach for detecting capping risk in the pharmaceutical compacts prepared under various compression forces and speeds is presented. It is shown that the extracted mechanical properties can be used as early indicators for invisible capping (prior to visible damage). Based on the analysis of X-ray cross-section images and a large set of waveform data, it is …

Formulation And Stability Study Of Eslicarbazepine Acetate Oral Suspensions For Extemporaneous Compounding, Fang Zhao, Vivek S. Dave, Mazin Z. Mar, Jonathan R. Perri

Pharmacy Faculty/Staff Publications

Eslicarbazepine acetate is an anticonvulsant drug with a recent U.S. Food and Drug Administration approval for expanded use in children and adolescents. Currently, eslicarbazepine acetate is only available in the U.S. as 200-mg to 800-mg strength tablets (Aptiom), which are not easy to administer for pediatric patients. This study was initiated to develop an oral suspension formulation for extemporaneous compounding by pharmacists and to generate stability data for storage recommendations. Nine suspension formulations of eslicarbazepine acetate were prepared from Aptiom tablets and commercially available liquid vehicles using the standard mortar/pestle method. The vehicles varied mainly in their solvents, viscosities, and …

Salts Of Therapeutic Agents: Chemical, Physicochemical, And Biological Considerations, Deepak Gupta, Deepak Bhatia, Vivek S. Dave, Vijaykumar B. Sutariya, Sheeba Varghese Gupta

Pharmacy Faculty/Staff Publications

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a …

Drug-Phospholipid Complex-Loaded Matrix Film Formulation For The Enhanced Transdermal Delivery Of Quercetin, Darshan R. Telange, Kuldeep D. Wavare, Arun T. Patil, Milind J. Umekar, Sridhar Anand, Vivek S. Dave

Pharmacy Faculty/Staff Publications

A novel quercetin-phospholipid-complex(QPLC)-loaded matrix film for improved transdermal delivery of quercetin was developed. The QPLC formulation, prepared using a solvent-evaporation method, was optimized using a central-composite design. The optimized QPLC formulation was characterized by particle size and zeta potential analysis, thermal analysis, Fourier transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance spectroscopy (1H-NMR). QPLC formulation was functionally evaluated for solubility and in vitro dissolution of quercetin. Matrix films of pure quercetin (Q-MF)or QPLC QPLC-MF) were prepared using a solvent casting method. The prepared Q-MF and QPLC-MF were characterized for weight uniformity, folding endurance, moisture content, and moisture uptake. The …

Herpes Zoster Subunit Vaccine For The Prevention Of Herpes Zoster, Melanie Symoniak, Pejman Farrokh, Mona A. Gandhi, Judianne Slish

Pharmacy Faculty/Staff Publications

Purpose Published literature on the efficacy and safety of the herpes zoster (HZ) subunit vaccine (HZ/su vaccine) in reducing the risks of HZ and postherpetic neuralgia (PHN) in adults 50 years of age and older, as well as the vaccine’s properties and efficacy relative to live attenuated vaccine, is reviewed.

Summary HZ/su vaccine (Shingrix, GlaxoSmithKline) is a recently Food and Drug Administration (FDA)–approved vaccine indicated for the prevention of HZ in adults 50 years of age and older. Based on several Phase III trials, the Advisory Committee on Immunization Practices has preferentially recommended HZ/su vaccine over a live attenuated vaccine …

Impact Of Outpatient Vs Inpatient Absssi Treatment On Outcomes: A Retrospective Observational Analysis Of Medical Charts Across Us Emergency Departments, P. Brandon Bookstaver, Timothy C. Jenkins, Edward Stenehjem, Shira Doron, Jack Brown, Shannon H. Goldwater, Carlos Lopes, Angela Haynes, Chuka Udeze, Yifan Mo, Patrick Gllard, Yan Liu, Katelyn Keyloun

Pharmacy Faculty/Staff Publications

Background

The objective of this study was to characterize treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) and describe the association between hospital admission and emergency department (ED) visits or readmissions within 30 days after initial episode of care (IEC).

Methods

This was a retrospective, observational, cohort study of adults with ABSSSI who presented to an ED between July 1, 2012, and June 30, 2013. Patient, health care facility, and treatment characteristics, including unplanned ED visits or readmissions, were obtained through manual chart review and abstraction. Adjusted logistic regression analysis examined likelihood of all-cause unplanned ED …

The Relationship Between Prior Experiences In Mathematics And Pharmacy School Success, Kelly M. Conn, Christine R. Birnie, David Mccaffrey, Jack Brown

Pharmacy Faculty/Staff Publications

Objective. To assess students’ pre-pharmacy math experiences, confidence in math ability, and relationship between experiences, confidence, and grades in math-based pharmacy courses.

Methods. A cross-sectional survey of first year to third year pharmacy students was conducted. Students reported type of pre-pharmacy math courses taken, when they were taken [high school (HS) vs. college] and year of HS and college graduation. Students rated their confidence in math ability using the previously validated 11-item Fogerty Math Confidence Scale (Cronbach alpha=0.92). Math grade point average (GPA), Pharmacy College Admission Test quantitative (PCAT quant) scores, and grades (calculations and kinetics) were obtained from transcripts …

Administration Of Long-Acting Injections, Christopher Noel, Karl Williams

Pharmacy Faculty/Staff Publications

Expanding the scope of pharmacy practice demonstrates that the profession has been successful at improving public health. Despite being a late adopter, New York's limited experience with vaccines has improved immunization rates and lowered rates of disease. During emergencies, the 2017-2018 flu season for example, the state has turned to pharmacists to go beyond what the pharmacy practice law permits, in this case enabling immunizations in pediatric patients.¹ This illustrates recognition of untapped potential within the profession to contribute to the public health. Another opportunity for pharmacists to enhance the public health is embodied in a Bill introduced in …

Variation Between Point-Of-Care And Laboratory Hba1ctesting In Clinical Practice, Shawn E. Fellows, Gabriela Cipriano

Pharmacy Faculty/Staff Publications

Aims: The aim of this study was to identify potential disparities between Point-Of-Care Testing (POCT) and laboratory hemoglobinH bA1c reporting at a Federally Qualified Health Center (FQHC).
Methods: The electronic medical record was reviewed to identify POCT HbA1c done at a FQHC and centralized laboratory HbA1c performed on the same day. Manual data extraction was used to identify potential variables that could account for disparities between POCT and laboratory testing.
Results: A total of 42 samples in 40 patients were identified. The median HbA1c difference was 1.5mmol/mol (0.15%) and ranged from -26-52 mmol/mol (-2.4 to 4.8%). Of the patients in …

Ciprofloxacin For The Treatment Of Cardiobacterium Hominis Prosthetic Valve Endocarditis, Lisa M. Avery, Catherine B. Felberbaum, Muhammad Hasan

Pharmacy Faculty/Staff Publications

Prosthetic valve endocarditis due to Cardiobacterium hominis is rare and recommended therapy includes a third generation cephalosporin. We report a case of Cardiobacterium hominis endocarditis post transcatheter aortic valve replacement in a patient with significant beta-lactam antimicrobial sensitivities who was successfully treated with ciprofloxacin monotherapy in conjunction with surgery.