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Articles 15841 - 15870 of 23770
Full-Text Articles in Medicine and Health Sciences
2022-03-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2022-03-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.
Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …
2022-03-11_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2022-03-11_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …
2022-03-11_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
2022-03-11_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
Michigan COVID-19 Vaccine Data
The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.
First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.
Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.
This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).
The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, …
2022-03-11 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-03-11 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
John Lyman Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, John Lyman, Kristen Dilger
John Lyman Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, John Lyman, Kristen Dilger
Boonshoft 50th Anniversary Oral History Project
Kristen Dilger interviews John Lyman, a graduate of the Boonshoft School of Medicine. He worked in emergency medicine until his retirement where he works part-time doing occupational health. Part of the class of 1980, Lyman discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of Medicine assisted him in his early career.
Evaluation Of A Community-Based Performance Arts Programme For People Who Have Experienced Stroke In The Uk: Protocol For The Shaper-Stroke Odysseys Study, Carolina Estevao, Maria Baldellou Lopez, Rachel E. Davis, Lucinda Jarret, Tayana Soukup, Ioannis Bakolis, Andy Healey, Jean Harrington, Anthony Woods, Nikki Crane, Fiona Jones, Carmine Pariante, Daisy Fancourt, Nick Sevdalis
Evaluation Of A Community-Based Performance Arts Programme For People Who Have Experienced Stroke In The Uk: Protocol For The Shaper-Stroke Odysseys Study, Carolina Estevao, Maria Baldellou Lopez, Rachel E. Davis, Lucinda Jarret, Tayana Soukup, Ioannis Bakolis, Andy Healey, Jean Harrington, Anthony Woods, Nikki Crane, Fiona Jones, Carmine Pariante, Daisy Fancourt, Nick Sevdalis
Faculty Publications
INTRODUCTION: Stroke survivors, once in the community, face challenges with their long-term rehabilitation care and present higher levels of loneliness, depression and anxiety than the rest of the population. A community-based performance arts programme, Stroke Odysseys (SO), has been devised to tackle the challenges of living with stroke in the UK. In this study, we aim to evaluate the implementation, impact and experiences of SO for stroke survivors. METHODS AND ANALYSIS: Scaling-up Health Arts Programmes: Implementation and Effectiveness Research (SHAPER)-SO aims to scale-up SO to 75 participants and 47 stakeholders, while simultaneously evaluating the effectiveness and implementation of the programme. …
A Guide To Common Nutrition, Troy Scheer
A Guide To Common Nutrition, Troy Scheer
Honors Program: Senior Projects (Public)
The purpose of this project was to use the knowledge I have gained through my undergraduate courses and apply it in a format that would be beneficial for the average consumer. This project was researched, written, and designed to be accessible by someone without a background in science or nutrition with the goal of educating the reader of some basic nutrition principles. With this knowledge, it is my hope that the reader will be able to make better nutritional choices and liver a longer and healthier lifestyle by first learning how to choose the right foods. While putting this project …
Creation Of An Influenza A Virus Neuraminidase Consensus Vaccine In An Adenoviral Vector, Leigh Jahnke
Creation Of An Influenza A Virus Neuraminidase Consensus Vaccine In An Adenoviral Vector, Leigh Jahnke
Honors Program: Senior Projects (Public)
In the last decade, the estimated annual burden of the flu includes 12,000-52,000 deaths, 140,000-710,000 hospitalizations, and 9 million – 41 million illnesses (Centers for Disease Control and Prevention: Disease burden of the flu). Influenza A virus can mutate and infect a variety of different hosts, which results in frequent antigenic changes and even pandemics. This has led to increased attention on the creation of a universal Influenza A vaccine containing broader immunogenic coverage than current vaccines. Our research involved detailing the steps of the cloning process utilizing a consensus neuraminidase antigen. We utilized the pAdEasy Adenoviral Vector …
Predicting Autism From Infant Characteristics: A Systematic Review, Alysha Y. Henrichs, Cynthia Cress Ph.D.
Predicting Autism From Infant Characteristics: A Systematic Review, Alysha Y. Henrichs, Cynthia Cress Ph.D.
Honors Program: Senior Projects (Public)
A literature review was conducted of 73 articles to explore 12-month-old characteristics in infants that predicted later diagnosis with autism (ASD). Articles were reviewed if they discussed ASD, infants with siblings diagnosed with autism (high-risk) and/or infants later diagnosed with autism without known family history of ASD (low risk). Articles were not reviewed if the participants were 36 months or older at the start of the study. More factors were identified that discriminate characteristics associated with later ASD diagnosis in infants between 12-24 months compared to characteristics of infants below 12 months. Characteristics of infants under 12 months that were …
Mechanisms Of Organisational Learning In Hospitals: An Instrument Development Study, Bret Lyman, Emily L. Smith, Kaitlyn C. George
Mechanisms Of Organisational Learning In Hospitals: An Instrument Development Study, Bret Lyman, Emily L. Smith, Kaitlyn C. George
Faculty Publications
Aim: To develop a valid, reliable research instrument to measure mechanisms associated with organisational learning in hospitals.
Background: A valid, reliable instrument for measuring mechanisms of organisational learning would enable nurse leaders and researchers to improve health care through facilitation and study of organisational learning.
Methods: The Organizational Learning in Hospitals model was used as a framework to develop the Organizational Learning Instrument-Mechanisms. Cognitive interviews and expert reviews were used to refine and evaluate item-level and scale-level content validity. The instrument was distributed by email to a random sample of nurses working in inpatient hospitals in Utah (n = 1253). …
If Past Is Prologue, Then The Future Is Bleak: Contracts, Covid–19, And The Changed Circumstances Doctrines, Danielle K. Hart
If Past Is Prologue, Then The Future Is Bleak: Contracts, Covid–19, And The Changed Circumstances Doctrines, Danielle K. Hart
Texas A&M Law Review
At the heart of most of the systemic problems currently confronting individuals and businesses as a result of the COVID–19 pandemic is quite literally a contract. Housing. Insurance. Food. Health care. Child care. Employment. Manufacturing. Construction. Supply chains. You name it. Contracts are implicated everywhere. So make no mistake: How contract law addresses these ostensibly private contracts will have profound social consequences. If the past really is prologue, then the future is indeed bleak. The empirical study conducted for this Article establishes what the conventional wisdom has claimed for the last 70 years. More specifically, the empirical study here shows …
A High Precision Machine Learning-Enabled System For Predicting Idiopathic Ventricular Arrhythmia Origins, Jianwei Zheng, Guohua Fu, Daniele Struppa, Islam Abudayyeh, Tahmeed Contractor, Kyle Anderson, Huimin Chu, Cyril Rakovski
A High Precision Machine Learning-Enabled System For Predicting Idiopathic Ventricular Arrhythmia Origins, Jianwei Zheng, Guohua Fu, Daniele Struppa, Islam Abudayyeh, Tahmeed Contractor, Kyle Anderson, Huimin Chu, Cyril Rakovski
Mathematics, Physics, and Computer Science Faculty Articles and Research
Background: Radiofrequency catheter ablation (CA) is an efficient antiarrhythmic treatment with a class I indication for idiopathic ventricular arrhythmia (IVA), only when drugs are ineffective or have unacceptable side effects. The accurate prediction of the origins of IVA can significantly increase the operation success rate, reduce operation duration and decrease the risk of complications. The present work proposes an artificial intelligence-enabled ECG analysis algorithm to estimate possible origins of idiopathic ventricular arrhythmia at a clinical-grade level accuracy.
Method: A total of 18,612 ECG recordings extracted from 545 patients who underwent successful CA to treat IVA were proportionally sampled into training, …
Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums
Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums
School of Veterinary and Biomedical Sciences: Faculty Publications
The threat of bovine respiratory disease (BRD) for cattle operations is exacerbated by increasing prevalence of antimicrobial resistance (AMR) in Mannheimia haemolytica, a leading cause of BRD. Characterization of AMR in M. haemolytica by culture and susceptibility testing is complicated by uncertainty regarding the number of colonies that must be selected to accurately characterize AMR phenotypes (antibiograms) and genotypes in a culture. The study objective was to assess phenotypic and genotypic diversity of M. haemolytica isolates on nasopharyngeal swabs (NPS) from 28 cattle at risk for BRD or with BRD. NPS were swabbed onto five consecutive blood agar plates; …
Rare Occurrence Of Pseudomyxoma Peritonei (Pmp) Syndrome Arising From A Malignant Transformed Ovarian Primary Mature Cystic Teratoma Treated By Cytoreductive Surgery And Hipec: A Case Report, Francesca Ponzini, Luke Kowal, Mariam Ghafoor, Allison F Goldberg, Joanna Chan, Ryan Lamm, Shawnna Cannaday, Scott D. Richard, Avinoam Nevler, Harish Lavu, Wilbur Bowne, Norman G Rosenblum
Rare Occurrence Of Pseudomyxoma Peritonei (Pmp) Syndrome Arising From A Malignant Transformed Ovarian Primary Mature Cystic Teratoma Treated By Cytoreductive Surgery And Hipec: A Case Report, Francesca Ponzini, Luke Kowal, Mariam Ghafoor, Allison F Goldberg, Joanna Chan, Ryan Lamm, Shawnna Cannaday, Scott D. Richard, Avinoam Nevler, Harish Lavu, Wilbur Bowne, Norman G Rosenblum
Department of Surgery Faculty Papers
Background: Pseudomyxoma peritonei (PMP) syndrome is a disease process that typically occurs from ruptured appendiceal mucocele neoplasms. PMP syndrome arising from malignant transformation of an ovarian primary mature cystic teratoma (MCT) is a pathogenesis rarely encountered.
Case presentation: Herein, we report a 28-year-old patient evaluated and treated for a right ovarian mass and large volume symptomatic abdominopelvic mucinous ascites. Molecular profiling and genetic analysis revealed mutations in ATM, GNAS, and KRAS proteins while IHC demonstrated gastrointestinal-specific staining for CK20, CDX2, CK7, and SATB2. Peritoneal cytology showed paucicellular mucin. Diffuse peritoneal adenomucinosis (DPAM) variant of PMP arising from a ruptured ovarian …
Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen
Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen
Faculty, Staff and Student Publications
It is known that 8-chloro-adenosine (8-Cl-Ado) is a novel RNA-directed nucleoside analog that targets leukemic stem cells (LSCs). In a phase I clinical trial with 8-Cl-Ado in patients with refractory or relapsed (R/R) AML, we observed encouraging but short-lived clinical responses, likely due to intrinsic mechanisms of LSC resistance. LSC homeostasis depends on amino acid-driven and/or fatty acid oxidation (FAO)-driven oxidative phosphorylation (OXPHOS) for survival. We recently reported that 8-Cl-Ado and the BCL-2-selective inhibitor venetoclax (VEN) synergistically inhibit FAO and OXPHOS in LSCs, thereby suppressing acute myeloid leukemia (AML) growth in vitro and in vivo. Herein, we report that 8-Cl-Ado …
A Novel Proton-Integrating Radiography System Design Using A Monolithic Scintillator Detector: Experimental Studies, Chinmay D Darne, Daniel G Robertson, Fahed Alsanea, Charles-Antoine Collins-Fekete, Sam Beddar
A Novel Proton-Integrating Radiography System Design Using A Monolithic Scintillator Detector: Experimental Studies, Chinmay D Darne, Daniel G Robertson, Fahed Alsanea, Charles-Antoine Collins-Fekete, Sam Beddar
Faculty, Staff and Student Publications
Research on proton-based imaging systems aims to improve treatment planning, internal anatomy visualization, and patient alignment for proton radiotherapy. The purpose of this study was to demonstrate a new proton radiography system design consisting of a monolithic plastic scintillator volume and two optical cameras for use with scanning proton pencil beams. Unlike the thin scintillating plates currently used for proton radiography, the plastic scintillator volume (20 × 20 × 20 cm
Nurse Practitioner Role Perception, Job Satisfaction, And Anticipated Turnover In The Middle Atlantic States, Jenna R. Sabatino
Nurse Practitioner Role Perception, Job Satisfaction, And Anticipated Turnover In The Middle Atlantic States, Jenna R. Sabatino
Seton Hall University Dissertations and Theses (ETDs)
Background: The need for nurse practitioners (NPs) in the US has become very evident in recent years. However, the established significance of NPs in the healthcare system does not ensure that NPs are satisfied with their role. To date, no studies have examined NP job satisfaction in the Middle Atlantic States (MAS), which includes New York, New Jersey, and Pennsylvania. Only one study, thus far, has looked at NP role perception from the NPs own perspective, and was completed in the Midwest region of the US. Similarly, no studies have examined NP anticipated turnover the Mid-Atlantic region of the US. …
The Last Conversation, Muhammad Ismail Khalid Yousaf
The Last Conversation, Muhammad Ismail Khalid Yousaf
Journal of Wellness
The brain-death exam is one of the most sensitive undertakings for a physician, especially a neurologist, because of its social and legal implications. It is the vital examination establishing a clear lack of meaningful vitals, allowing a family to mark the end of a journey and a life finally complete. Physicians who perform and establish this death-decision must ensure they are au courant with the family's sentiments and concerns. It would behoove this obligated physician to bear in mind that it is a human being who will go through this invasive and rough exam. This comatose person is a father …
Ancestral Diversity Improves Discovery And Fine-Mapping Of Genetic Loci For Anthropometric Traits-The Hispanic/Latino Anthropometry Consortium, Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L . Buchanan, Anne E. Justice, Heather M. Highland, Xiuqing Guo, Wanying Zhu, John Blangero, Joanne E. Curran, Ravindranath Duggirala
Ancestral Diversity Improves Discovery And Fine-Mapping Of Genetic Loci For Anthropometric Traits-The Hispanic/Latino Anthropometry Consortium, Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L . Buchanan, Anne E. Justice, Heather M. Highland, Xiuqing Guo, Wanying Zhu, John Blangero, Joanne E. Curran, Ravindranath Duggirala
School of Medicine Publications
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS …
Fat As An Adjunct In Nerve Surgery, Allison Podsednik, Raysa Cabrejo, Joseph Rosen
Fat As An Adjunct In Nerve Surgery, Allison Podsednik, Raysa Cabrejo, Joseph Rosen
School of Medicine Publications
No abstract provided.
Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen
Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen
Faculty, Staff and Students Publications
AIMS: Despite statin and antihypertensive therapies, older Americans have high atherosclerotic cardiovascular disease (ASCVD) risk. Novel measures of triglyceride-rich lipoproteins, low-density lipoprotein triglycerides (LDL-TG), and remnant-like particle cholesterol (RLP-C), are associated with ASCVD in middle-aged adults. Polymorphisms in genes encoding angiopoietin-related protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III), two proteins involved in triglyceride catabolism, are associated with increased risk for hypertriglyceridaemia and ASCVD and are potential therapeutic targets. We examined associations of LDL-TG, RLP-C, apoC-III, and ANGPTL3 levels with ASCVD events in older adults in the Atherosclerosis Risk in Communities (ARIC) study.
METHODS AND RESULTS: In 6359 participants (mean age …
Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen
Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen
Faculty, Staff and Students Publications
AIMS: Despite statin and antihypertensive therapies, older Americans have high atherosclerotic cardiovascular disease (ASCVD) risk. Novel measures of triglyceride-rich lipoproteins, low-density lipoprotein triglycerides (LDL-TG), and remnant-like particle cholesterol (RLP-C), are associated with ASCVD in middle-aged adults. Polymorphisms in genes encoding angiopoietin-related protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III), two proteins involved in triglyceride catabolism, are associated with increased risk for hypertriglyceridaemia and ASCVD and are potential therapeutic targets. We examined associations of LDL-TG, RLP-C, apoC-III, and ANGPTL3 levels with ASCVD events in older adults in the Atherosclerosis Risk in Communities (ARIC) study.
METHODS AND RESULTS: In 6359 participants (mean age …
Genetic Variants Associated Mrna Stability In Lung, Jian-Rong Li, Mabel Tang, Yafang Li, Christopher I Amos, Chao Cheng
Genetic Variants Associated Mrna Stability In Lung, Jian-Rong Li, Mabel Tang, Yafang Li, Christopher I Amos, Chao Cheng
Faculty, Staff and Students Publications
BACKGROUND: Expression quantitative trait loci (eQTLs) analyses have been widely used to identify genetic variants associated with gene expression levels to understand what molecular mechanisms underlie genetic traits. The resultant eQTLs might affect the expression of associated genes through transcriptional or post-transcriptional regulation. In this study, we attempt to distinguish these two types of regulation by identifying genetic variants associated with mRNA stability of genes (stQTLs).
RESULTS: Here, we presented a computational framework that takes advantage of recently developed methods to infer the mRNA stability of genes based on RNA-seq data and performed association analysis to identify stQTLs. Using the …
Towards A Biological Definition Of Ards: Are Treatable Traits The Solution?, Lieuwe D J Bos, John G Laffey, Lorraine B Ware, Nanon F L Heijnen, Pratik Sinha, Brijesh Patel, Matthieu Jabaudon, Julie A Bastarache, Daniel F Mcauley, Charlotte Summers, Carolyn S Calfee, Manu Shankar-Hari
Towards A Biological Definition Of Ards: Are Treatable Traits The Solution?, Lieuwe D J Bos, John G Laffey, Lorraine B Ware, Nanon F L Heijnen, Pratik Sinha, Brijesh Patel, Matthieu Jabaudon, Julie A Bastarache, Daniel F Mcauley, Charlotte Summers, Carolyn S Calfee, Manu Shankar-Hari
2020-Current year OA Pubs
The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the lung, variable degrees of epithelial injury, variable degrees of endothelial barrier disruption, transmigration of leukocytes, alongside impaired fluid and ion clearance. These pathophysiological features are different between patients contributing to substantial biological heterogeneity. In this context, it is perhaps unsurprising that a wide range of pharmacological interventions targeting these pathophysiological processes have failed to improve patient outcomes. In this manuscript, our goal is to provide a narrative summary of the potential methods to capture the underlying …
Coronavirus Update 3-10-22, The Coronavirus Planning Team
Coronavirus Update 3-10-22, The Coronavirus Planning Team
University Briefings & Virtual Events
As you know, the deadline for employees to receive a booster shot was March 1, and the deadline for students is March 15. Anyone who has received an exemption or has not complied with the booster deadline will need to be tested weekly throughout the remainder of the semester. We also recommend that those who have not been vaccinated and/or received a booster wear a mask indoors.
Employment With The Northwest Territories Aquatics Program: A Significant Life Event?, Sebastien Denize, Audrey R. Giles
Employment With The Northwest Territories Aquatics Program: A Significant Life Event?, Sebastien Denize, Audrey R. Giles
International Journal of Aquatic Research and Education
For over 60 years, the Northwest Territories Aquatics Program (NWTAP) has employed university students from southern Canada with little to no exposure to northern Canada to run seasonal swimming pools and waterfronts in isolated northern communities. In this article, we examine the impact that working for this program had on nine former employees’ lives and whether or not working for the NWTAP could be categorized as a significant life experience. We used thematic analysis of the data from retrospective semi-structured interviews and open-ended questionnaires and identified four themes: (1) employment by the NWTAP enhanced the employees’ self-confidence, independence, and self-efficacy; …
Discovery And Preclinical Pharmacology Of Ine963, A Potent And Fast-Acting Blood-Stage Antimalarial With A High Barrier To Resistance And Potential For Single-Dose Cures In Uncomplicated Malaria., Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B Lakshminarayana, Jay Prakash Jain, Christopher Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Glaxosmithkline Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T Diagana, Christopher Sarko
Discovery And Preclinical Pharmacology Of Ine963, A Potent And Fast-Acting Blood-Stage Antimalarial With A High Barrier To Resistance And Potential For Single-Dose Cures In Uncomplicated Malaria., Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B Lakshminarayana, Jay Prakash Jain, Christopher Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Glaxosmithkline Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T Diagana, Christopher Sarko
Natural Sciences and Mathematics | Faculty Scholarship
A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency, selectivity against human kinases, and absorption, distribution, metabolism, excretion, and toxicity properties and extended pharmacological profiles culminated in the identification of INE963 (1), which demonstrates potent cellular activity against Pf 3D7 (EC50 = 0.006 μM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of/kg is fully curative in the Pf-humanized severe combined immunodeficient mouse model. INE963 (1) also exhibits a high barrier to resistance …
Content, Construct, And Criterion Validity, Reliability, And Objectivity For Aquatic Readiness Assessment For Brazilian Children, Nadia C. Valentini, Keila R G Pereira, Glauber C. Nobre
Content, Construct, And Criterion Validity, Reliability, And Objectivity For Aquatic Readiness Assessment For Brazilian Children, Nadia C. Valentini, Keila R G Pereira, Glauber C. Nobre
International Journal of Aquatic Research and Education
The Aquatic Readiness Assessment (ARA) is an assessment instrument for measuring children's aquatic readiness. The objective of the study was to translate the English version into Portuguese and to investigate the content, construct, and criterion validity as well as the reliability and rater objectivity of the ARA for Brazilian children. Twenty-three professionals and 464 children, newborn to 13 years-old participated in the study. We found strong content (94% to 100% of judges’ agreement) and criterion validity, internal consistency (α from .96 to .97), and inter-rater objectivity (ICC from .81 to .98), and test-retest reliability (ICC from .94 to .98). Appropriate …
Ability Of Lifeguards To Detect Submerged Manikins In Public Swimming Pool Environments, Élie Vignac, Pascal Lebihain, Brice Guignard, Natacha Heutte, Loic Le Minor, Bastien Soulé
Ability Of Lifeguards To Detect Submerged Manikins In Public Swimming Pool Environments, Élie Vignac, Pascal Lebihain, Brice Guignard, Natacha Heutte, Loic Le Minor, Bastien Soulé
International Journal of Aquatic Research and Education
To prevent drownings in public swimming pools (PSP), French legislation requires constant surveillance by state-certified lifeguards. While previous research showed that surveillance was not always effective, this article focuses on efficiency of surveillance when it is effective. We evaluated the ability of 4 volunteer professional lifeguards to detect a submerged manikin under controlled conditions. One hundred and eight (108) tests were carried out in 2 PSP. Four variables were controlled (i.e., distance, depth, surveillance station, attendance). Our results showed that rapid drowning detection was not exclusively linked to the individual detection capabilities of a lifeguard, but rather it emerged from …
The Covid-19 Pandemic: Exploring E-Learning Experience During Schools Closure In Tanzania, Fabian Gallus Mahundu
The Covid-19 Pandemic: Exploring E-Learning Experience During Schools Closure In Tanzania, Fabian Gallus Mahundu
Journal of Humanities and Social Sciences
of parents and guardians in supporting their children’s e-learning activities during the COVID-19 lockdown in Tanzania. The study adopted an exploratory qualitative research design. Data were collected using telephone interviews and open-ended questions (using google forms), which inquired parents’ and guardians’ experience in supporting home based e-learning activities among students during the COVID-19 lockdown. The paper argues that giving students free access to online learning materials during COVID-19 lockdowns is paramount. However, parents’ and guardians’ support through sharing one’s phones must be monitored to safeguard learners from accessing irrelevant materials. Findings show that parents and guardians had different experiences in …