Medicine and Health Sciences Commons^™

Pitfalls Of Delirium Screening In Older Adults, Danya Khoujah, Debra Eagles

Journal of Geriatric Emergency Medicine

No abstract provided.

Clinical Evaluation Of An Auto-Segmentation Tool For Spine Sbrt Treatment, Yingxuan Chen, Yevgeniy Vinogradskiy, Yan Yu, Wenyin Shi, Haisong Lui

Department of Radiation Oncology Faculty Papers

Purpose: Spine SBRT target delineation is time-consuming due to the complex bone structure. Recently, Elements SmartBrush Spine (ESS) was developed by Brainlab to automatically generate a clinical target volume (CTV) based on gross tumor volume (GTV). The aim of this project is to evaluate the accuracy and efficiency of ESS auto-segmentation.

Methods: Twenty spine SBRT patients with 21 target sites treated at our institution were used for this retrospective comparison study. Planning CT/MRI images and physician-drawn GTVs were inputs for ESS. ESS can automatically segment the vertebra, split the vertebra into 6 sectors, and generate a CTV based on the …

Investigations Into The Improvement Of Angelman Syndrome Therapeutics, Austin W. Nenninger

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic neurodevelopmental disease caused by interruption of the function of the ubiquitin ligase UBE3A gene. Patients experience an early life onset of symptoms which include pronounced intellectual disability, drastic speech impairmentor inability to speak, severe movement disorders, seizures, aggression, disruptive sleep impairment, and unusual personality traits. Estimates of prevalence show that approximately 1:15000 births are affected.

The disease is severe, and the burden can be devastating to the patients and the caregivers that they require for the duration of their relatively normal lifespan. Current treatments for the disease are lacking. Many are expensive and …

Characterization Of Basal Ganglia Volume Changes In The Context Of Hiv And Polysubstance Use, Andrew J Monick, Michelle R Joyce, Natasha Chugh, Jason A Creighton, Owen P Morgan, Eric C Strain, Cherie L Marvel

Department of Medicine Faculty Papers

HIV and psychoactive substances can impact the integrity of the basal ganglia (BG), a neural substrate of cognition, motor control, and reward-seeking behaviors. This study assessed BG gray matter (GM) volume as a function of polysubstance (stimulant and opioid) use and HIV status. We hypothesized that comorbid polysubstance use and HIV seropositivity would alter BG GM volume differently than would polysubstance use or HIV status alone. We collected structural MRI scans, substance use history, and HIV diagnoses. Participants who had HIV (HIV +), a history of polysubstance dependence (POLY +), both, or neither completed assessments for cognition, motor function, and …

Impact Of Arginine Metabolism And Sensing In Mouse Models Of Alzheimer’S Disease, Chao Ma

USF Tampa Graduate Theses and Dissertations

Alzheimer’s disease (AD) remains the most common neurodegenerative disease in the central nervous system (CNS), with amyloidosis and tauopathy as their two main hallmarks. Typical AD pathologies include cerebral plaques deposited by amyloid-β, neurofibrillary tangles aggregated by tau, and neuroinflammation caused by activated brain myeloid cells. A critical theme is centered on impaired brain metabolism. Emerging evidence showed that impaired arginine metabolism was a novel biomarker pathway for AD. The manipulation of arginine metabolism by a critical enzyme arginase 1 (ARG1) in neurons indicated therapeutic benefits in alleviating tau pathology. Balanced cellular proteostasis was governed by the mechanistic target of …

Cardiovascular-Metabolic Responses And Oxygen Uptake Kinetics During Kayak Paddling In Normobaric Hypoxia In Young Flatwater Kayakers, Elvin Onarici Güngör, Celil Kaçoğlu, Ali Onur Cerrah, İlker Yılmaz

Baltic Journal of Health and Physical Activity

Background: The aim of the study was to evaluate response of cardiovascular, metabolic and oxygen consumption kinetics at kayak paddling exercise in the normoxic and normobaric environment. Material and Methods: Seven kayakers (age: 16±1.2 year; height: 165±8.3cm; body weight: 53±8kg; fat percentage: 17±4.4%; VO2max: 34.57±9.24 ml.kg-1.dk-1; Maximal La: 8.72±2.75 mM) with four years’ experience participated in the study. All subjects performed incremental maximal and sub-threshold constant load kayak paddling tests in normoxic and normobaric hypoxic conditions on different days. According to maximal tests results, the individual anaerobic threshold and VO2max values were determined. Results: VO2max, HRmax, peak power and maximal …

Investigation Of The Relationship Between Sit-And-Reach Flexibility And The Height, The Leg Length And The Trunk Length In Adolescent Athletes, Bihter Akınoğlu, Büşra Paköz, Adnan Hasanoğlu, Tuğba Kocahan

Baltic Journal of Health and Physical Activity

Background: Background: ‪‪The aim of this study is to investigate the relationship between the Sit-and-Reach (SR) test and the height, the leg length, and the trunk length of the male and female adolescent athletes, and to obtain relative SR test results using these anthropometric values. Material and methods: ‪‪Fifty-six adolescent athletes were included in the study. The athletes’ trunk, hip, and hamstring flexibility were evaluated with the SR test (traditional). The height-relative SR, leg length-relative SR and trunk length-relative SR test values were calculated by proportioning each data with the SR test values. Pearson/Spearman correlation analysis were used according to …

Detection Of Lung Carcinoma Arising From Ground Glass Opacities (Ggo) After 5 Years - A Retrospective Review, Elissa Herskovitz, Charalamobos Solomides, Julie Barta, Nathaniel R. Evans Iii, Gregory C. Kane

Department of Surgery Faculty Papers

Pure ground glass opacities (GGO) may indicate pre-invasive subtypes of lung carcinoma. These neoplasms typically demonstrate indolent patterns of growth; Fleischner Society guidelines recommend up to five years of serial imaging. Our aim was to determine the frequency of diagnosed carcinoma arising from GGO detected beyond 5 years of surveillance. We reviewed pathologic diagnoses of lung carcinoma (n = 442) between 2016 and 2018 of a tertiary academic hospital and National Cancer Institute-designated cancer center to identify all cancers that arose from ground glass opacities detected on CT scan. Of the 442 cases of lung carcinoma, 32 (7%) were found …

Durable Reduction Of Clostridioides Difficile Infection Recurrence And Microbiome Restoration After Treatment With Rbx2660: Results From An Open-Label Phase 2 Clinical Trial, Robert Orenstein, Erik R Dubberke, Sahil Khanna, Christine H Lee, David Yoho, Stuart Johnson, Gail Hecht, Herbert L Dupont, Dale N Gerding, Ken F Blount, Sarah Mische, Adam Harvey

Faculty, Staff and Student Publications

BACKGROUND: Effective treatment options for recurrent Clostridioides difficile infection (rCDI) are limited, with high recurrence rates associated with the current standard of care. Herein we report results from an open-label Phase 2 trial to evaluate the safety, efficacy, and durability of RBX2660-a standardized microbiota-based investigational live biotherapeutic-and a closely-matched historical control cohort.

METHODS: This prospective, multicenter, open-label Phase 2 study enrolled patients who had experienced either ≥ 2 recurrences of CDI, treated by standard-of-care antibiotic therapy, after a primary CDI episode, or ≥ 2 episodes of severe CDI requiring hospitalization. Participants received up to 2 doses of RBX2660 rectally administered …

Durable Reduction Of Clostridioides Difficile Infection Recurrence And Microbiome Restoration After Treatment With Rbx2660: Results From An Open-Label Phase 2 Clinical Trial, Robert Orenstein, Erik R Dubberke, Sahil Khanna, Christine H Lee, David Yoho, Stuart Johnson, Gail Hecht, Herbert L Dupont, Dale N Gerding, Ken F Blount, Sarah Mische, Adam Harvey

2020-Current year OA Pubs

BACKGROUND: Effective treatment options for recurrent Clostridioides difficile infection (rCDI) are limited, with high recurrence rates associated with the current standard of care. Herein we report results from an open-label Phase 2 trial to evaluate the safety, efficacy, and durability of RBX2660-a standardized microbiota-based investigational live biotherapeutic-and a closely-matched historical control cohort.

METHODS: This prospective, multicenter, open-label Phase 2 study enrolled patients who had experienced either ≥ 2 recurrences of CDI, treated by standard-of-care antibiotic therapy, after a primary CDI episode, or ≥ 2 episodes of severe CDI requiring hospitalization. Participants received up to 2 doses of RBX2660 rectally administered …

The Targeted Smac Mimetic Sw Iv-134 Augments Platinum-Based Chemotherapy In Pre-Clinical Models Of Ovarian Cancer, Pratibha S Binder, Yassar M Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G Mutch, William G Hawkins, Matthew A Powell, Dirk Spitzer

2020-Current year OA Pubs

BACKGROUND: Ovarian cancer is initially responsive to frontline chemotherapy. Unfortunately, it often recurs and becomes resistant to available therapies and the survival rate for advanced and recurrent ovarian cancer is unacceptably low. We thus hypothesized that it would be possible to achieve more durable treatment responses by combining cisplatin chemotherapy with SW IV-134, a cancer-targeted peptide mimetic and inducer of cell death. SW IV-134 is a recently developed small molecule conjugate linking a sigma-2 ligand with a peptide analog (mimetic) of the intrinsic death pathway activator SMAC (second-mitochondria activator of caspases). The sigma-2 receptor is overexpressed in ovarian cancer and …

Physical Activity And Gene Association With Human Obesity, Katarzyna Switala, Agata Leonska-Duniec

Baltic Journal of Health and Physical Activity

The obesity is a leading cause of health problems all over the world. It is a comlex health abnormality that is influenced by developmental, behavioural, environmental, and genetic factors. Although the role of physical activity and diet in regulation of body weight is well described, the genetic variants potentially influencing the characteristics and range of the body’s adaptive response to physical activity in healthy individuals still remains mostly unknown. The main aim of this study is to review current evidence, through a literature review and the results of our studies, on the influence of selected molecular markers on the development …

The Effect Of Core Strength Training On Flexibility And Balance In Sedentary Healthy Young Individuals, Hatice Yakut, Burcu Talu

Baltic Journal of Health and Physical Activity

Background: The aim of this study is to examine the effect of core strength training on the static and dynamic balance and flexibility of the sedentary young individuals. Material and methods: ‪‪41 healthy sedentary students participated in the study (age=21.56±1.05; height=171.90±8.18 cm; body weight=66.63±11.99 kg). Training was applied for 20–30 minutes a day, 2 days a week for 6 weeks. The sit-and-reach test, lateral bending test, hip flexion flexibility test, and the static and dynamic balance scores were used for outcome measures, which were calculated using the Balance System SD (Korebalance Premier-19 Systems Inc. USA). Results: Statistically significant increases were …

Identification Of Elite Performance Characteristics Specific To Anthropometric Characteristics, Athletic Skills And Motor Competencies Of Combat Athletes, Hilal Gürsoy, Umut Canli

Baltic Journal of Health and Physical Activity

Background: ‪‪Knowing all the features required for elite performance in sports disciplines under the name of combat sports is among the most important parameters for discipline-specific talent identification and selection. Material and methods: ‪‪The research group consists of male and female athletes within the age range of 12–17 who are licensed in taekwondo, karate, judo, and wrestling. A total of 70 athletes, 21 elite and 49 non-elite athletes, participated in the study voluntarily. Anthropometric, athletic and motor competency tests were applied to determine the elite performance elements of the groups. Results: Comparing the elite and non-elite athletes, statistically significant differences …

Evaluation Of Healthy Lifestyle Behaviors And The Level Of Knowledge Of Cardiovascular Risk Factors Of Individuals 60 Years Old And Older With A Chronic Disease, Nevzat Demirci, Ahmet Toptas

Baltic Journal of Health and Physical Activity

Background: This study aimed to evaluate healthy lifestyle behaviors and levels of knowledge of cardiovascular risk factors of individuals with chronic diseases aged 60 and over. Material and methods: The study was conducted with 362 participants over the age of 60 (female 67.12 ± 5.11 and male 69.38 ± 5.51). The Cardiovascular Disease Risk Factors Knowledge Level (CARRF-KL) Scale and the Healthy Lifestyle Behaviors Scale II (HLBS II) were used in the study. Results: The total mean scores of the participants in CARRF-KL and HLBS II were 16.99 ± 4.69 and 105.17 ± 22.88, respectively. The mean scores of the …

Differences Between Official And Non-Official Matches In Worst-Case Scenarios In Elite Futsal Players, Konstantinos Spyrou, Tomás T. Freitas, Elena Marín-Cascales, Rubén Herrero-Carrasco, Pedro E. Alcaraz

Baltic Journal of Health and Physical Activity

Background: ‪This study aimed to compare the worst-case scenarios (WCS) between official (OFF) and non-official (Non-OFF) matches, in different time-periods in an elite futsal team. Material and methods: Twenty-six games were divided into OFF (n = 13) and Non-OFF (n = 13). The WCS were calculated using: two methods, rolling averages (ROLL) and fixed-periods (FIX); four-length epochs (30-s, 1-, 3-, and 5-min); and player load per minute (PL·min-1). Results: Considering ROLL, significant and small differences were found in PL·min-1, with higher intensity in 30-s (p = 0.001; ES = -0.53) and 1-min (p = 0.001; ES = -0.47) in OFF …

The Effect Of Shoulder Injury Prevention Program On Glenohumeral Range Of Motion And Upper Extremity Performance In Adolescent Throwers: A Pilot Study, Gamze Cobanoglu, Hasan Aka, Nevin A. Guzel

Baltic Journal of Health and Physical Activity

Background: The Oslo Sports Trauma Research Center (OSTRC) Shoulder Injury Prevention Program is an exercise program developed to increase the internal rotation (IR) range of motion (ROM), external rotator muscle strength and scapular muscle strength and to improve kinetic chain involvement and thoracic mobility. The purpose of this study is to investigate the effect of this program on glenohumeral ROM and upper extremity functional performance in adolescent throwers. Material and Methods: Ten adolescent throwers (discus, shot put and javelin throwers) were involved in the study. The OSTRC Shoulder Injury Prevention Program was applied three times a week for 8 weeks …

Determination Of Energy Intake And Dietary Habits And Their Relationship With Physical Activity Levels And Healthy Lifestyle Behaviours Of Primary Education And Pre-Service Teachers, Arzu Özkan, Taner Bozkuş, Ali Özkan, Gürhan Kayihan

Baltic Journal of Health and Physical Activity

Background: Participation in physical activity (PA) from a young age helps to build the foundation for a healthy life in the future. The purpose of this study was to investigate the relationships between energy intake, dietary habits, PA levels, and healthy lifestyle behaviours (HLSBs) in primary education and pre-service teachers. Material and methods: A total of 105 primary education teachers (69 female, 36 male) and 95 pre-service teachers (64 female, 31 male) participated voluntarily in this study. To determine energy intake and dietary habits, participants completed a form detailing what they had consumed during the previous 24 hours. The short …

Methodology Of Physical Exercise: A Proposal And Reliability Of A Questionnaire For Fitness Professionals, Francys Paula Cantieri, Antonio Carlos Gomes, Gustavo Aires De Arruda, Diogo Henrique Constantino Coledam, Edineia Aparecida Gomes Ribeiro, Mauro Virgilio Gomes De Barros, Ágata Cristina Marques Aranha

Baltic Journal of Health and Physical Activity

Background: Several benefits of physical exercise for health are described in the literature and knowing the methodology adopted by professionals is relevant. Objective: Proposal and analysis of the psychometric properties of a questionnaire on the methodological practice of professionals working in the fitness area. Material and methods: Design: Reproducibility study. Method: The questionnaire was prepared following the steps: search for existing instruments, elaboration of the questions, pretesting (n = 30), face/content validity (n = 5), and reliability (n = 333). The internal consistency (Cronbach's Alpha), magnitude of the association between nominal questions (Cramer's V or Phi) and test-retest reliability (Kappa …

Profile Of Sport Competition Anxiety Trait And Psychological Coping Skills Among Secondary School Athletes In Enugu State, South East Nigeria, Tochi Emmanuel Iwuagwu, Joshua Emeka Umeifekwem, Samuel Ndubuisi Igwe, Okechukwu Kingsley Oforka, Oluchukwu Precious Udeh

Baltic Journal of Health and Physical Activity

Background: The study investigated the profile of sport competition anxiety trait and psychological coping skills (PCS) among secondary school athletes in Enugu State, South East Nigeria. Material/Methods: A total number of 420 secondary school athletes participated in a cross-sectional study. The profile of sport competition anxiety trait and psychological coping skills of the participants were measured using a 46-item questionnaire consisting of three socio-demographic factors as part I, a 15-item Sport Competition Anxiety Test (SCAT) as part II and a 28-item Athletic Coping Skills Inventory (ACSI) as part III. Mean, standard deviation and linear regressions were used for analyses. Results: …

Effects Of Social Isolation Caused By The Covid-19 Pandemic On Changes In Daily Activity: A Case Study Of Physical Education Students, Miroslaw Zalech

Baltic Journal of Health and Physical Activity

Background: The study sought to describe student time use and to analyse the effects of the COVID-19 pandemic (lockdown) on changes in the time use and their role within the context of health and social aspects. Material & Methods: The research was carried out every year from 2017 to 2020 in the same period of time. The study included 340 students of physical education. In their time budget diaries, the participants noted down the amount of time devoted to activities performed in a typical week. Results: The study showed that during the lockdown, students devoted less time to sports training, …

Physical Activity And Depression In Older Adults In Times Of The Covid-19 Pandemic, İnci Kesi̇Lmi̇Ş, Gülten Geçi̇Tli̇, Seda Kavak, Süleyman Kostal, Mehmet Melih Kesi̇Lmi̇Ş

Baltic Journal of Health and Physical Activity

Background: During the COVID-19 pandemic that affected the whole world, individuals aged 65 and over were in the group of “leaving home restriction” for a long time. Evaluation of physical activity and depression variables gains importance in the older adults who are physically exposed to inactivity. Methods: The research was conducted on 97 male and 78 female participants aged 65 and over with the “non-probabilistic sampling methods with convenience sampling” method. The Physical Activity Scale for Elderly (PASE), Geriatric Depression Scale (GDS) and Katz Activities of Daily Living Scale were used as data collection tools. Results: The difference between physical …

Factors Of Future Teachers’ Motivation Formation For The Physical Improvement, Anna Hakman, Olena Andrieieva, Vitalii Kashuba, Halyna Bezverkhnia, Viktoria Tsybulska, Mykola Maievskyi, Tetiana Osadchenko, Andrii Semenov, Olena Kljus, Oksana Tsiuniak, Nataliia Nikula, Oleksandr Tomenko

Baltic Journal of Health and Physical Activity

Background: The article uses factor analysis to obtain an insight into the peculiarities of the motivation for physical improvement of students from the Faculty of Primary Education with different modes of attendance. Material and methods: Analysis and synthesis of references, surveying, psychological testing, pedagogical experiment, and methods of mathematical statistics were applied. The study involved 173 female students (18–22 years of age) of pedagogical profile with full- and part-time attendance. Results: The survey highlighted the motivational factors that affect the involvement of female students of pedagogical profile in physical improvement. The motivational factors for second- and fourth-year female students with …

Effects Of Mental Fatigue On Psychophysiological, Cognitive Responses, And Technical Skills In Small-Sided Games In Amateur Soccer Players, Yusuf Soylu, Ersan Arslan

Baltic Journal of Health and Physical Activity

Background: The purpose of this study was to assess the effects of mental fatigue (MF) on the psychophysiological and cognitive responses and technical skills in small-sided games (SSGs) in amateur soccer players. Material and Methods: 18 soccer players played 2vs2, 3vs3, and 4vs4 SSGs under 2 different playing conditions: MF+SSGs and SSGs. The Feeling Scale (FS), Felt Arousal Scale (FAS), Visual Analogue Scale-Anxiety (VAS-A) and Motivation (MTV) were determined after each SSGs bout. A Trail-Making Test (TMT) was also determined in the beginning and at the end of each SSGs. Technical performance was continuously recorded with a camera during all …

The Relationship Between Perceived Freedom, Leisure Involvement, And Happiness Of Individuals Participating In Physical Activities, Emrah Serdar, Duygu Harmandar Demirel

Baltic Journal of Health and Physical Activity

Background: ‪‪This study is aimed to determine the relationship between the perceived freedom, involvement and happiness of individuals participating in physical activities. Material and Methods: The sample of the study consisted of 523 members. The Perceived Freedom in Leisure Scale, the Leisure Involvement Scale and the Oxford Happiness Questionnaire Short Form were used as data collection tools. In analysing the data, independent t-test, ANOVA, MANOVA and Pearson Correlation analysis were used. Results: Independent t-Test results determined a significant difference between OHQ-SF scores according to the participants’ gender. MANOVA analysis result showed that the main effect of the gender variable on …

Effect Of Mental Toughness On Sporting Performance: Review Of Studies, Monika Guszkowska, Katarzyna Wojcik

Baltic Journal of Health and Physical Activity

The aim of the present review was to establish the correlation between mental toughness and sporting performance based on the results of studies published in scientific journals between 2000 and 2020. The keywords mental toughness and performance/outcomes/results/ competition were used to identify the papers. The search included the EBSCO and PubMed databases. Eventually, the analysis covered 18 articles. The research results presented in 16 papers confirmed the positive correlations of mental toughness with sport results and performance level. No such relationship was found only in equestrian and Alpine skiing athletes. Although mental toughness in basketball players did not correlate with …

Methods Of Education Of High-Speed Qualities Of Children 14-15 Years Old (Teenagers), Norboev Komiljon, Eshberdiev Olim

Eurasian Journal of Sport Science

PurposeTo study the general state of involvement of schoolchildren in mass sports, to determine the effectiveness of a set of special exercises designed to develop the dexterity of a 14-15-year-old student in children's and youth sports schools (youth sports schools).

Methods: The level of children's need and interest in mass sports was determined by a pedagogical and psychological survey. Based on the specifics of the problems studied in the study, taking into account the availability of equipment and the level of professional training, the availability of scientific materials, the following pedagogical methods were used in the study. Analysis of scientific …

Medical School Watercooler Newsletter - March 11, 2022, Lindsey Lyle

Watercooler Newsletter

This is the March 11, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• USA Health researcher to present on breast cancer disparities at national conference
• Meet a Med Student: Sidney Bailey
• Bassam presents on diabetic neuropathy at annual meeting
• Poverty and public health: Arrieta works to reduce health disparities
• Gulf Coast Trauma Symposium set for March 24-25
• Nephrologist Abayomi Sanusi, M.D., joins internal medicine faculty
• Pathology seminar series set for March 17

Forward Together Update [Black Hawk County And Cdc Travel], March 11, 2022, University Of Northern Iowa

UNI Response to COVID-19

Shares information that Black Hawk County was reported to be in the low COVID-19 community level and what that means regarding prevention measures. Also reminds that CDC travel requirements have not changed. Reports that the Student Health Center would be closed over spring break and gives alternatives for the break.

2022-03-11_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …