Medicine and Health Sciences Commons^™

Antibacterial And Anti-Hiv-1 Gp120 Activities Of Selected Medicinal Plants, Rose J. Masalu, Cyprian B. Mpinda

Journal of Humanities and Social Sciences

Medicinal plants play an important role in traditional medicine and drug development research because of their numerous bioactivities. However, some concerns have risen on the inefficiencies of such products due to improper use of medicinal plant products, notably when mixed with other traditional remedies. This study evaluates the antibacterial and anti-human immunodeficiency virus 1 glycoprotein 120/CD4 (anti-HIV-1 GP120/CD4) activities of medicinal plants species Sapium ellipticum, Pseudospondias microcarpa, and Capparis erythrocarpos; and their respective combinations effects. Results revealed that aqueous and ethyl acetate extracts of S. ellipticum and P. microcarpa had antimicrobial activities against S. aureus (ATCC 25923), E. coli (ATCC …

Re-Joining Formal Schooling After A Postpartum Hiatus: Experiences Of Teenage Mothers Of Zanzibar, Elliott P. Niboye

Journal of Humanities and Social Sciences

The lack of nuanced understanding of how teens undertake their triple roles as mothers, parents and student is prevalent in Tanzania. This article highlights the plight of teenage mothers who are readmitted back to formal schooling in Zanzibar. Four objectives guided this study. The first was to determine the age at which most teenage girls fall pregnant,; second, how long do teen mothers take to return to school after delivery; third, the challenges that teenage mothers encounters when they re-join schooling; and lastly, the coping strategies used by teen mothers to overcome challenges encountered after re joining school. Public rapid …

Contamination Of Aflatoxins And Selected Heavy Metals In Commercially Available Traditional Herbal Medicines In Dar Es Salaam, Tanzania, Frank P. Fovo, Esther F. Mvung

Journal of Humanities and Social Sciences

This study assesses the contamination of mycoflora, aflatoxins and selected heavy metals (Iron (Fe), Copper (Cu), Zinc (Zn) and Lead) (Pb) in traditional herbal medicines commercially available in Dar es Salaam. Samples were collected from registered traditional healers in three districts: Ilala, Kinondoni and Temeke. Fungal load were assessed using the pour plate technique, whereas aflatoxins and heavy metals were analysed using High Pressure Liquid Chromatography (HPLC) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS), respectively. The toxin levels obtained were high compared to the permissible levels reported in the Codex Alimentarius Commission. The fungal load in the sampled herbal materials …

An Atypical Case Of Extreme Polypharmacy, Michael A. Veronin

Pharmacy Faculty Publications and Presentations

A commonly reported definition of polypharmacy is the numerical definition of 5 or more medications daily, and definitions have ranged from 2 or more to 11 or more medications. In this case report, an extreme case of polypharmacy is presented, highlighted by the inordinate number of drugs used over time throughout the patient’s care. A 48-year-old African American female with multiple comorbidities experienced a serious adverse drug event (ADE) prompting reporting to MedWatch, the US Food and Drug Administration’s adverse drug event reporting system. The patient’s concomitant medications included 146 drug entities, across 82 therapeutic drug categories. It is apparent …

Examining Newcomer Women’S Experiences With Perinatal Care In Ontario, Canada: An Application Of Carspecken’S Critical Ethnographic Method, Jessica Pimienta, Oona St-Amant, Sepali Guruge, Corinne Hart, Cristina Catallo

The Qualitative Report

This article provides a practical description of Carspecken’s (1996) five-stage critical ethnographic approach entitled “Critical Qualitative Research (CQR).” Situated epistemologically and ontologically in the critical paradigm, this article is an exploration of critical ethnography as an important methodology for shedding light on the discursive culture of perinatal care for newcomer women during the three-month health insurance waiting period in Ontario, Canada. We argue that Carspecken’s approach to critical ethnography is especially instrumental in illuminating the social structures that contribute to health inequities.

Cytokines In The Pathogenesis Of Large Granular Lymphocytic Leukemia, Colleen Isabelle, Amy Boles, Nitin Chakravarti, Pierluigi Porcu, Jonathan Brammer, Anjali Mishra

Department of Medical Oncology Faculty Papers

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro-survival signaling. In recent years, it has become clear that cytokines and their receptors are aberrantly expressed in LGLL cells. The exact initiation process of LGLL is unknown, although several cytokine-driven mechanisms have emerged. Elevated levels of several cytokines, including interleukin-15 (IL-15) and platelet-derived growth factor (PDGF), have been described in LGLL patients. Evidence from humans and animal models has shown that cytokines may also contribute to the co-occurrence of a wide range of autoimmune …

Spatial Deconcentration Of Tourism Concentrations: A Visitors’ Galaxy Impact Model Of The Covid-19 Crisis, Jaewon Lim, Karima Kourtit, Peter Nijkamp, Christopher Stream

Public Policy and Leadership Faculty Research

This paper analyzes the impact of COVID-19 on mass tourism concentrations, such as Las Vegas. It argues that health risks and perceptions may induce a more deconcentrated pattern of mass tourism, with more geographical dispersion to rural and natural areas. The analytical framework is modeled and applied to extensive data on Las Vegas tourism. The proposition on deconcentrated tourism concentrations is confirmed. Pre-pandemic outer-inner city complementary relations between “Outdoor Activities” in 11 surrounding national parks and the “Gaming Industry” in Las Vegas have transformed into outer-inner city substitution relations in the COVID-19 pandemic. This represents the evolving deconcentration of tourism …

Complementary Feeding Practices And The Associated Risk Of Childhood Obesity Among Ethnic Minority Groups Living In High-Income Countries: Protocol For A Systematic Review And Meta-Analysis, Maido Tsenoli, Moien A.B. Khan, Linda Östlundh, Teresa Arora, Omar Omar

All Works

INTRODUCTION: Complementary feeding (CF) is defined as the period from when exclusive breast milk and formula are no longer sufficient for meeting the infant's nutritional needs. The CF period occurs from birth to 23 months of age. Though the recommended guidelines for introducing CF is from around 6 months of age, data indicates that some infants are introduced to food earlier than 6 months which can predispose children to obesity and overweight. Obesity in ethnic minority groups (EMG) is higher than their native counterparts and often tracks into adulthood. Hence, our aim was to conduct a systematic review and meta-analysis …

Moving The Needle Toward Fair Compensation In Pediatric Nephrology., Darcy K. Weidemann, I A Ashoor, D E Soranno, R Sheth, C Carter, P D Brophy

Manuscripts, Articles, Book Chapters and Other Papers

Remuneration issues are a substantial threat to the long-term stability of the pediatric nephrology workforce. It is uncertain whether the pediatric nephrology workforce will meet the growing needs of children with kidney disease without a substantial overhaul of the current reimbursement policies. In contrast to adult nephrology, the majority of pediatric nephrologists practice in an academic setting affiliated with a university and/or children's hospital. The pediatric nephrology service line is crucial to maintaining the financial health and wellness of a comprehensive children's hospital. However, in the current fee-for-service system, the clinical care for children with kidney disease is neither sufficiently …

Blood-Based Biomarker Panel For Personalized Lung Cancer Risk Assessment, Johannes F Fahrmann, Tracey Marsh, Ehsan Irajizad, Nikul Patel, Eunice Murage, Jody Vykoukal, Jennifer B Dennison, Kim-Anh Do, Edwin Ostrin, Margaret R Spitz, Stephen Lam, Sanjay Shete, Rafael Meza, Martin C Tammemägi, Ziding Feng, Samir M Hanash

Faculty, Staff and Student Publications

Purpose: To investigate whether a panel of circulating protein biomarkers would improve risk assessment for lung cancer screening in combination with a risk model on the basis of participant characteristics.

Methods: A blinded validation study was performed using prostate lung colorectal ovarian (PLCO) Cancer Screening Trial data and biospecimens to evaluate the performance of a four-marker protein panel (4MP) consisting of the precursor form of surfactant protein B, cancer antigen 125, carcinoembryonic antigen, and cytokeratin-19 fragment in combination with a lung cancer risk prediction model (PLCOm2012) compared with current US Preventive Services Task Force (USPSTF) screening criteria. The 4MP was …

Measurable Residual Disease Response And Prognosis In Treatment-Naïve Acute Myeloid Leukemia With Venetoclax And Azacitidine, Keith W Pratz, Brian A Jonas, Vinod Pullarkat, Christian Recher, Andre C Schuh, Michael J Thirman, Jacqueline S Garcia, Courtney D Dinardo, Vladimir Vorobyev, Nicola S Fracchiolla, Su-Peng Yeh, Jun Ho Jang, Muhit Ozcan, Kazuhito Yamamoto, Arpad Illes, Ying Zhou, Monique Dail, Brenda Chyla, Jalaja Potluri, Hartmut Döhner

Faculty, Staff and Student Publications

PURPOSE: There is limited evidence on the clinical utility of monitoring measurable residual disease (MRD) in patients with acute myeloid leukemia treated with lower-intensity therapy. Herein, we explored the outcomes of patients treated with venetoclax and azacitidine who achieved composite complete remission (CRc; complete remission + complete remission with incomplete hematologic recovery) and MRD < 10

METHODS: The patients included in this report were treated with venetoclax and azacitidine. Bone marrow aspirate samples for multiparametric flow cytometry assessments were collected for central analysis at baseline, end of cycle 1, and every three cycles thereafter. MRD-negative response was defined as < 1 residual blast per 1,000 leukocytes (< 10

RESULTS: One hundred …

Covid-19 And Social Determinants Of Health: Medicaid Managed Care Organizations’ Experiences With Addressing Member Social Needs, Samuel T. Opoku, Bettye Apenteng, Linda Kimsey, Angela H. Peden, Charles F. Owens

Health Policy & Community Health: Faculty Publications

Background

The significant adverse social and economic impact of the COVID-19 pandemic has cast broader light on the importance of addressing social determinants of health (SDOH). Medicaid Managed Care Organizations (MMCOs) have increasingly taken on a leadership role in integrating medical and social services for Medicaid members. However, the experiences of MMCOs in addressing member social needs during the pandemic has not yet been examined.

Aim

The purpose of this study was to describe MMCOs’ experiences with addressing the social needs of Medicaid members during the COVID-19 pandemic.

Methods

The study was a qualitative study using data from 28 semi-structured …

Role Of Bmi1 In Acute Lung Injury, María Helena Hernández-Cuervo

USF Tampa Graduate Theses and Dissertations

Acute Lung Injury (ALI) is a set of signs and symptoms that lead to acute hypoxemic respiratory failure characterized by bilateral pulmonary infiltrates not attributed to cardiogenic origin. It is caused by a massive innate immune response, with the migration of white blood cells (neutrophils and macrophages principally) and a cytokine storm, followed by alterations in mitochondrial function, increase in reactive oxygen species production, and oxidative stress that in turn induces more mitochondrial damage. Several studies have shown that mitochondrial alterations are key events in the mechanism of ALI and reducing mitochondrial dysfunction could be a possible target in the …

Atomic Structure Of The Predominant Gii4 Human Norovirus Capsid Reveals Novel Stability And Plasticity, Liya Hu, Wilhelm Salmen, Rong Chen, Yi Zhou, Frederick Neill, James E Crowe, Robert L Atmar, Mary K Estes, B V Venkataram Prasad

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) cause sporadic and epidemic viral gastroenteritis worldwide. The GII.4 variants are responsible for most HuNoV infections, and GII.4 virus-like particles (VLPs) are being used in vaccine development. The atomic structure of the GII.4 capsid in the native T = 3 state has not been determined. Here we present the GII.4 VLP structure with T = 3 symmetry determined using X-ray crystallography and cryo-EM at 3.0 Å and 3.8 Å resolution, respectively, which reveals unanticipated novel features. A novel aspect in the crystal structure determined without imposing icosahedral symmetry is the remarkable adaptability of the capsid protein VP1 …

Cross-Sectional Evaluation Of Chronic Medication Use Across Age Categories, Alecia N. Muwonge, Nedra Geddes-Mccarthy

NSU REACH and IPE Day

Purpose: The objective of this study was to estimate the use of chronic medications for hypertension, hyperlipidemia, hyperglycemia, and depression in adults over 18 years old. Background: Aging is associated with increased multimorbid conditions. Management of multimorbid conditions can be complex, making polypharmacy a prevalent problem in the adult population. Previous studies investigated the prevalence of chronic medication use in older adults, but none have evaluated the trends in use with increasing age. Methods: This retrospective cross-sectional study used general population data from NHANES during the 2011-2018 cohort years for a population of all adults 18 years of age and …

The Potential Role Of Virtual Reality Simulation To Meet Core Competencies In Non-Technical Skills In Physician Assistant Education, Jonathan D. Caplan

NSU REACH and IPE Day

please see poster presentation

2022-03-09 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-03-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2022-03-09_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Astrocyte-Secreted Chordin-Like 1 Regulates Spine Density After Ischemic Injury, Elena Blanco-Suarez, Nicola J Allen

Department of Neuroscience Faculty Papers

Ischemic injury occurs when the brain is deprived of blood flow, preventing cells from receiving essential nutrients. The injury core is the brain region directly deprived and is surrounded by the peri-infarct area, the region with recovery potential. In the peri-infarct area neurons undergo acute loss of dendritic spines, which modifies synaptic plasticity and determines neuronal survival. Astrocytes can be protective or detrimental to the ischemic injury response depending on the specific stage, yet we lack clear understanding of the underlying mechanisms. Chordin-like 1 (Chrdl1) is an astrocyte-secreted protein that promotes synaptic maturation and limits experience-dependent plasticity in the mouse …

Implementation Of Mindfulness-Based Movement For Sheltered Women, Rhea Rughani, Oliver Armand, Ashley Murrieta Ortega, Erin Murphy, Jordan Greenshield, Alorea Mae Domingo

Nursing Leadership in Community Engagement Projects

Introduction

In 1894, Angeline’s Day Center for Women was established through the Young Women’s Christian Association (YWCA) to serve the evolving needs of homeless women in Seattle by addressing existing racial and socioeconomic health disparities (Schafranek, 2021). Angeline’s provides overnight and day services to address the COVID-19 related heightened community need, including healthcare, meals, and hygiene services to 40 women (Schafranek, 2021). In 2022, the Seattle Pacific University (SPU) Lydia Green Nursing Program partnered with Angeline's to analyze and address the needs of the population they serve. The undergraduate nursing students performed a windshield survey and developed a community diagnosis …

Covid-19 Testing And Education At The Allen Family Center, Zoe Beck, Elijah Chong-Gum, Josselyn Gonzalez Perea, Sydnie Gould, Emily Planck, Kamila Tracey

Nursing Leadership in Community Engagement Projects

COVID-19 Testing and Education at the Allen Family Center

COVID-19 Testing and Education at the Allen Family Center The Mount Baker community is home to many families experiencing homelessness and housing instability. According to the Department of Community and Health Services, there is an estimate of 40,800 people in King County who experienced homelessness in 2020 (King County Department of Community, 2021). The Allen Family Center (AFC) is an inviting community resource, partnered with Mary’s Place and Mercy Housing Northwest, that serves families by providing assistance with housing, medical care, and childcare; recently, the AFC began providing COVID-19 testing available …

Key Factors For Improving Rigor And Reproducibility: Guidelines, Peer Reviews, And Journal Technical Reviews, Hong S. Lu, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing detailed prospective experimental designs and providing raw data are essential premises of rigor and reproducibility. Standard peer reviews and journal-specific technical and statistical reviews are critical factors for enhancing rigor and reproducibility. This brief review also shares some experience from Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal, that has implemented several mechanisms to enhance rigor and reproducibility for preclinical research.

Brief Report: Cause Of Death Among People Discharged From Infective Endocarditis Related Hospitalization—West Virginia, 2016–2019, Zheng Dai, Gordon S. Smith, Brian Hendricks, Ruchi Bhandari

Faculty & Staff Scholarship

Background and Objectives

Compare proportion of all-cause and cause-specific mortality among West Virginia Medicaid enrollees who were discharged from infective endocarditis (IE) hospitalization with and without opioid use disorder (OUD) diagnosis.

Methods

The proportions of cause-specific deaths among those who were discharged from IE-related hospitalizations were compared by OUD diagnosis.

Results

The top three underlying causes of death discharged from IE hospitalization were accidental drug poisoning, mental and behavioral disorders due to polysubstance use, and cardiovascular diseases. Of the total deaths occurring among patients discharged after IE-related hospitalization, the proportion has increased seven times from 2016 to 2019 among the …

T-Cell Responses To Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses To The Colorectal Cancer Antigen, Guanylyl Cyclase C, John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D Carlson, Joshua Barton, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical, colorectal, and pancreatic. Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C-specific CD8+ T-cell responses towards the dominant H-2Kd-restricted epitope, GUCY2C254-262. However, Lm-GUCY2C produced robust CD8+ T-cell responses towards Lm-derived peptides suggesting that GUCY2C254-262 peptide may be subdominant to Lm-derived peptides. Indeed, incorporating immunogenic Lm peptides into an adenovirus-based GUCY2C …

Contraceptive Counseling During The Covid-19 Pandemic (2020) At Choose Well Participating Clinical Partners In South Carolina, Center For Applied Reasearch And Evaluation In Women's Health, East Tennessee State University

Center for Applied Research and Evaluation (CARE) in Women's Health Issue Briefs

In January-August 2021, staff at Choose Well participating clinical partners were asked about their experiences with Choose Well in 2020, including perceptions about access to contraceptive counseling and facilitators and barriers to contraceptive counseling. Interviews were conducted over the phone, audio recorded with permission, and transcribed. The aim of this issue brief is to examine access to contraceptive counseling across three sectors, hospitals, health departments, and Federally Qualified Health Centers (FQHCs), that provided contraceptive counseling and partnered with Choose Well during the COVID-19 pandemic (2020). Findings from each sectors’ perceptions of contraceptive counseling are presented.

Understanding Queer Women’S Satisfaction With Healthcare Providers: The Role Of Positive Lgb Identity And Communication, Maddie Luebe

Honors Program: Senior Projects (Public)

Much research has explored the negative effects of having a queer identity in healthcare, such as stigmatization and discrimination, but little research examined the potential benefits of a positive LGBTQ identity in healthcare. This study investigated the relationship between having a positive LGBTQ identity and provider satisfaction through comfort communicating with a provider. This study also considered the potential effect of participants’ fear of provider heterosexism in this relationship. Survey data were collected from 506 queer-identified women in the United States. Using moderated mediation, results found that more positive feelings associated with one’s queer identity was associated with increased comfort …

Zoom In To Fitness: A Novel Way Of Bringing Fitness Experts To Seniors, Tessa Wells, Jenna Boyd, Gabriel Fisher, Victoria Kranz, Mckenzi Petricko

Posters and Presentations: Physical Therapy

Participants will discover a how a local educational institution was able to think creatively and bring much-needed programming to local seniors during the height of the COVID-19 pandemic restrictions. Participants will also experience first-hand how a virtual physical activity session can be delivered safely and effectively in the comfort of the senior’s own living environment or a group fitness room environment. Participants will be asked to think creatively of possible community partners, as well as possible barriers and facilitators to implementing this innovative wellness strategy. Information will be presented regarding additional activities that could be presented in this format such …

Use Of Machine Learning Approaches And Statistical Techniques To Adjust For Nonadherence In Randomized Clinical Trials., Andrew G Chapple

School of Public Health Faculty Publications

No abstract provided.

Chronic Relapsing Neutrophilic Meningitis As The Sole Manifestation Of Nocardiosis In A Patient With Mixed Connective Tissue Disease., M Anthony Albornoz, Erin K Threlfall, Michael Baldassari, Lawrence J Livornese

Department of Neurosurgery Faculty Papers

We describe a rare case of a patient with mixed connective tissue disease maintained on chronic oral corticosteroids, who was hospitalized on five occasions over five consecutive months due to persistent relapsing neutrophilic meningitis caused by Nocardia asteroides. Immunosuppression due to the chronic use of corticosteroids was identified as the underlying mechanism of susceptibility. Our report highlights the challenges associated with systemic Nocardiosis, particularly in the immunocompromised host.