Medicine and Health Sciences Commons^™

Factors Influencing Severity In Acute Ischemic Strokes, Inam E Khuda, Intisar Siddiqui, Saad Munzar, Rashid Nazir, Arsalan Ahmed

Pakistan Journal of Neurological Sciences (PJNS)

Background: Stroke severity is one of the factors that determines stroke related disability. We explored possible associations between stroke severity and commonly evaluated clinical parameters of stroke patients. Objective: To determine the relationships between clinical features including routine in- hospital investigations done in first 24 hours of admission and variations in the stroke severity. Patients and Methods: This was a retrospective, analytical study performed in the Department of Neurology at Shifa International Hospital, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Adult patients admitted with ischemic stroke, over a period of 39 months, with Middle Cerebral Artery infarctions, were included. National Institute of …

Knowledge And Use Of The International Classification Of Functioning, Disability And Health (Icf) Among Health Professionals In A Developing Country, Sidra K. Jafri, Olaf Kraus De Camargo

Pakistan Journal of Neurological Sciences (PJNS)

The World Health Organization’s (WHO) International Classification of Functioning, Disability, and Health (ICF) provides a biopsychosocial framework for understanding all the factors that should be considered while managing any health condition. The ICF has been employed for clinical, academic, research, and policymaking purposes in developed as well as developing countries. There is a great disparity in the representation in the literature regarding knowledge and potential application of the ICF in professional practice around the world especially from low middle-income countries like Pakistan. This study aims to evaluate the profile and knowledge of health professionals in Pakistan about the application of …

Concussion: A Review Of Epidemiology, Presentation And Treatment., Sidra Saleem, Arsalan Anwar, Fahham Asghar, Muhammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

A direct impact on the head can cause a Mild Traumatic Brain Injury or Concussion. It is a neuronal brain injury with or without loss of consciousness. Each year, approximately 69 million people are estimated to suffer from Concussion. Around 80-90% of these Concussion cases resolve within a week. The most commonly reported post-concussion symptoms include headache, cognitive changes, sleep disturbances, and depression. Essential in the approach to patients with concussion includes a detailed history taking and physical examination. Imaging modalities like Magnetic Resonance Images (MRI) of the brain may not show any significant changes; therefore more sensitive tests, like …

A Rare Presentation Of Pulmonary Sarcomatoid Carcinoma With Left Atrial Involvement And Spinal Metastasis Presenting With An Ischemic Infarct., Hina Imtiaz, Muhammad Dawood Amir Sheikh

Pakistan Journal of Neurological Sciences (PJNS)

Pulmonary Sarcomatoid Carcinoma is a rare, aggressive tumor comprising of both epithelial and mesenchymal cells. It is important to distinguish it from other lung tumors due to its poor prognosis and extensive metastasis. We present a case of a 36 year old female patient who initially presented with right sided weakness and slurred speech due to an ischemic infarct of the left basal ganglia. Further workup revealed a lung mass extending to the left atrium with spinal metastasis. Sarcomatoid Carcinoma remains a diagnostic challenge due to its early recurrence and atypical presentation.

Movement Disorder Associated With Celiac Disease And Thyroid Dysfunction:Case Report, Ramla Nayaib Hashmi, Ummul Kiram, Rabbia Tariq

Pakistan Journal of Neurological Sciences (PJNS)

Autoimmune movement disorders are uncommon yet likely treatable conditions. It is challenging to diagnose and manage these disorders, ultimately leading to a significant morbidity in terms of functional disability of patient. It is troublesome for practicing neurologists to identify whether the antibodies which are detected during the work up of these autoimmune movement disorders are merely incidental or have pathogenic role. This will help them to decide regarding whether to start immunotherapy or not. Here we have discussed two patients of movement disorder who were found to have positive work up for other autoimmune diseases. Available Literature on autoimmune movement …

Effects Of Intermittent Fasting On Taste Modulation And Perception, Sajid Hameed, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Postnatal Loss Of The Insulin Receptor In Osteoprogenitor Cells Does Not Impart A Metabolic Phenotype, John L. Fowlkes, R. Clay Bunn, Evangelia Kalaitzoglou, Phil Ray, Iuliana Popescu, Kathryn M. Thrailkill

Barnstable Brown Diabetes Center Faculty Publications

The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatally acquired, osteoblast-specific insulin deficiency on the pancreas-to-skeleton-to-pancreas circuit has not been studied. To explore this relationship, we created a model of postnatal elimination of insulin signaling in osteoprogenitors. Osteoprogenitor-selective ablation of the insulin receptor was induced after ~10 weeks of age in IR^l°^x/lox/Osx-Cre^+/− genotypic male and female mice (designated postnatal-OIRKO). At ~21 weeks of age, mice were then phenotypically and metabolically characterized. Postnatal-OIRKO mice demonstrated …

Bacterial Contamination Of Mobile Phones Among Health Care Workers: A Meta-Analysis Study, Azza Omran, Mohamed S. Taha

Journal of Medicine in Scientific Research

Background Mobile phones (MPs) are becoming commonplace in both community and hospital settings. There are studies that show that phones can be considered fomites in potential, ones that give organisms an environment conducive to their development, such as constant heat and moisture. Aim The present study aimed to do a meta-analysis to investigate the bacterial contamination of MPs among health care workers (HCWs). Materials and methods Using MEDLINE database (http://www.pubmed.com), we conducted a systematic literature search to identify relevant studies published within the past 20 years (from 2000 up to 2020). Appropriate articles were accessed in full text …

Bileaflet Augmentation For Repair Of Rheumatic Mitral Valve Disease In Egyptian Patients, Maged M. A. Kisho

Journal of Medicine in Scientific Research

Objectives Mitral valve (MV) repair in rheumatic patients is a challenging procedure and carries high incidence of early and late failure. We aimed in this study to evaluate the mid-term results of MV bileaflet augmentation to increase the depth of coaptation and achieve satisfactory results of repair. Patients and methods Between January 2015 and December 2018 at the National Heart Institute of Egypt, 24 rheumatic patients had leaflet augmentation with glutaraldehydetreated autologous pericardium as part of their mitral repair procedure. Their clinical and echocardiographic data were prospectively analyzed. Results The mean age of the rheumatic patients was 34.2 ± 14.7 …

Hospital Outcome And Predictors Of Mortality Of Primary Isolated On-Pump Coronary Artery Bypass Grafting In Acute Coronary Syndrome, Ahmed M. E. Abdelgawad

Journal of Medicine in Scientific Research

Background The effect of surgical treatment on patients with acute coronary syndrome (ACS) is disputable. The objective of the present study was to analyze the outcome, in-hospital mortality, and its predictors as well as major adverse cardiac and cerebrovascular events in patients referred to coronary artery bypass grafting (CABG) with ACS presentation. Patients and methods Hospital medical records of ACS presentation were retrieved from Madinah Cardiac Center database between November 2011 and August 2017. A total number of 630 patients who underwent primary isolated CABG for ACS presentation were identified. Of these, unstable angina (UA) pectoris was present in 277 …

Comparison Of Drug-Eluting And Bare-Metal Stents In Patients With Saphenous Vein Graft Stenosis, Ahmed Zayed, Ahmed Algebaly, Tamer El Banna

Journal of Medicine in Scientific Research

Background The use of drug-eluting stents (DES) during the percutaneous coronary intervention of patients with degenerated saphenous vein graft (SVG) is uncertain. Although previous studies showed that DES might decrease the rate of re-intervention in patients with SVG stenosis, randomized controlled trials comparing bare-metal stents (BMS) and DES in SVG lesions have been inconclusive. Objective The purpose of this study was to compare the outcomes in patients undergoing SVG stent implantation treated with DES or BMS. Patients and methods This was a retrospective observational study that included 60 patients who underwent percutaneous coronary intervention for SVG lesions, comprising 30 patients …

Effects Of Oral Sildenafil After Palliative Procedures To Increase Pulmonary Blood Flow In Cyanotic Heart Diseases, Ahmed Al-Gebaly, Ahmed Zayed, Amal Younan, Hanan Mohammed, Rania Aboushokka, Rasha Hossny, Yahia Mahmoud

Journal of Medicine in Scientific Research

Background Continuing efforts have been exerted to improve the outcome of palliative procedures for cyanotic congenital heart diseases. Sildenafil is known for the management of erectile dysfunction and pulmonary hypertension, but the cardiac benefits of this drug showed its impacts in the hemodynamic profile of cardiac patients. Aim To evaluate the effect of oral sildenafil on man-made shunts and vascular connection of cyanotic heart diseases. Patients and methods This comparative study was conducted from 2013 to 2017 on patients who had congenital cyanotic heart disease and who underwent acquired palliative procedure to increase the pulmonary blood flow. Procedures included: modified …

Evaluation Of Early Outcomes Of Modified Bentall Procedure As A Treatment Of Ascending Aortic Diseases, Ahmed S. Ali

Journal of Medicine in Scientific Research

Back ground Ascending aortic diseases are life-threatening conditions that have an increasing incidence. The modified Bentall procedure has become the technique of choice used to treat such diseases. Objectives This study evaluates early outcomes of patients who underwent modified Bentall procedure as a treatment of ascending aortic diseases. Patients and methods A total of 75 patients who underwent modified Bentall operation for ascending aortic diseases at the National Heart Institute during a 3-years period (July 2015 to August 2018) were studied prospectively. The included patients were divided according to the type of aortic disease into two groups: group A included …

Predictors Of Mortality In Valvular Infective Endocarditis: A Single-Center Study, Ahmed S. Ali

Journal of Medicine in Scientific Research

Background Valvular infective endocarditis (IE) may occur in association with either native or prosthetic valves, with great risk of mortality and morbidity. Surgical management is an essential part of the therapeutic process in these patients. Objectives This study aims at evaluation of early outcomes of surgically treated patients with native or prosthetic IE together with determining predictors of mortality. Patients and methods Outcomes of 60 patients who underwent surgery for native or prosthetic valve endocarditis at National Heart Institute during a 3-year period (April 2016 to March 2019) were studied prospectively. Preoperative, intraoperative, and postoperative data were tested as possible …

Rhinorrhea In Covid-19: Observation, Sora Yasri, Viroj Wiwanitkit

Journal of Medicine in Scientific Research

COVID‑19 is a new disease that started in China and spread to several countries[1]. After its first spread to Thailand, it has spread to more than 50 countries around the world [2]. In otolaryngology, otolarygeal presentation of this new infection is an interesting topic. As a respiratory infection, rhinorrhea is a possible clinical presentation in coronavirus infection. In previous new emerging coronavirus infection such as coronavirus 229E infection, rhinorrhea is observable [3]. Here, the authors share their observation on this specific issue.

From the data on 35 patients in our setting, Thailand, there is no patient with rhinorrhea. From summarizing …

The Rapid Covid Screening (Rcs) Tool, Muhammad Akbar Baig

Department of Emergency Medicine

As the covid-19 outbreak continues, there is a dire need to organise and allocate resources while optimising costs and time: identification of patients should be rapid and economical. with the current spectrum of clinical presentations of patients with covid-19, it is important to be thorough while determining symptoms involving the various organ systems including possible contact history. point-of-care (poc) lung ultrasound has already proven to be a reliable tool in diagnosing lung inflammatory processes: the results are immediate and the examination is safe, repeatable, and cheap. early use of poc lung ultrasound could prove invaluable in covid-19 patients, leading to …

Efficacy And Safety Of Intravenous 3% Hypertonic Saline Compared To Mannitol 20% For Lowering Intraocular Pressure In Patients With Glaucoma: A Prospective Randomized Double-Blind Study, Alaa A. Ibrham, Ashraf A. H. Mhmoud, Mohmed H. Mohamed, Wael A. E. Elhakeem

Journal of Medicine in Scientific Research

Objective The purpose of this study was to assess the efficacy and safety of intravenous 3% hypertonic saline (HTS) compared with mannitol 20% for lowering intraocular pressure (IOP) in patients with glaucoma. Patients and methods A total of 30 patients between age 35 and 60 years with American Society of Anesthesiologist status I–III with glaucoma (IOP=30 mmHg) were enrolled in a double-blind comparative study. Patients were randomized to one of two groups: group GH (n=15), where patients received HTS, and group GM (n=15), where patients received mannitol 20%. Results Regarding demographic data, no statistically significant difference was observed between the …

Homoeopathy In Epidemics: Bridging The Gap, Anil Khurana

Indian Journal of Research in Homoeopathy

No abstract provided.

Proposed Checklist For Standardising Homoeoprophylaxis Interventions, Isaac Golden

Indian Journal of Research in Homoeopathy

Background: Results from large homoeoprophylaxis (HP) interventions support the effectiveness of HP, but their variable methodology means that meaningful summaries of the combined data are difficult to produce. Objective: The aim of this article is to develop possible ways of standardising and improving the quality of data from HP interventions. Methods: Evidence collected from some large HP interventions is summarised. A previously suggested pre- and post-intervention checklist intended to help standardise the evidence from HP interventions is critically examined. Results: A summary of HP evidence from large interventions shows that there is a growing body of data suggesting a level …

An Online Cross-Sectional Survey On Knowledge, Attitudes, Practices And Perspectives Of Homoeopathic Practitioners Towards Covid-19, Divya Taneja, Anil Khurana

Indian Journal of Research in Homoeopathy

Background: In the light of pandemic of coronavirus disease (COVID-19), identification of level of epidemic preparedness and understanding of homoeopathic practitioners is required to utilise their services in mainstream healthcare effectively. Objective: The objective of this study was to identify knowledge, attitudes and practices of homoeopathic physicians about COVID-19. Methodology: An online cross-sectional survey was undertaken in the midst of the epidemic in India when services of homoeopathic doctors were under consideration. The ten knowledge questions were scored and analysed to identify differences with sociodemographic variables. Responses to the ten questions on attitudes and practices were analysed to identify differences …

A Review On The Role Of Homoeopathy In Epidemics With Some Reflections On Covid-19 (Sars-Cov-2), Anupriya Chaudhary, Anil Khurana

Indian Journal of Research in Homoeopathy

Background and Objectives: While the world is grappling with the current pandemic of COVID-19, medical fraternity and policy makers are still trying to find ways to control its spread in the absence of any definite treatment protocol. The escalating medical costs of infrastructural requirements in health care as well as development of vaccine are but a few challenges being faced. Alternative approaches to handle the situation require to be explored. This article reviews the role homoeopathy has played in controlling epidemics afflicting the mankind in the past while summarizing the scope of this approach in the current COVID-19 pandemic. Methods: …

A Review On Immunomodulatory Response Of Homoeopathic Medicines Through Cytokine Induction As Evidenced In In Vivo And In Vitro Studies, Mohit Mathur, Anu Kapoor

Indian Journal of Research in Homoeopathy

Background: This review discusses the importance of inter-individual variations in Homoeopathy and role of immune modulation through cytokine induction behind these variations in symptoms. Objectives: To analyse the effects of homoeopathic drugs in modulation of cytokine synthesis to find the individualised immunological mechanisms of these drugs. Methods: The PubMed database was searched for studies which analysed effects of homoeopathic medicines on cytokine synthesis. Full texts of shortlisted studies after scrutiny of abstracts, were analysed for study design, homoeopathic medicines used, cytokines analysed and results. Results: The PubMed search yielded 21 studies. After analysis of abstracts of 21 studies, 10 were …

Psychological Implications During The Outbreak Of Covid-19 And Its Homoeopathic Management, Sanjeevi Moorthi, P Radhika, K Muraleedharan

Indian Journal of Research in Homoeopathy

Background: Coronavirus disease 2019 (COVID-19) is rapidly spreading across the globe and is creating dread among all people irrespective of their socioeconomic status. To tackle the rapid spread of the disease, social distancing has been found to be the only measure. However, such distancing creates a lot of mental stress, as evident from previous studies. Objectives: The objective of the study was to assess the psychological implications during quarantine and isolation and to find the homoeopathic remedies that may be suitable. Methods: We have tried to collect the mental symptoms from the available literature and from the recent studies in …

Enabling Use Of Homoeopathy In India's Preparedness For Pandemic/Epidemic Situation Like Covid-19, Suhana Azis, Harleen Kaur

Indian Journal of Research in Homoeopathy

India reported its first positive case of COVID-19 on 30th January 2020. The alerts, the checks and the quarantines soon followed. As of 28th April 2020, India had crossed the 20,000 mark of positive cases and seen over 900 deaths. The nation is adapting and preparing fast for this rapidly spreading COVID outbreak, and new advisories superseding the previous ones as per the evolving needs are being issued by the concerned authorities on almost daily or weekly basis. The unprecedented spread of this pandemic was unforeseen, and therefore, many nations, including India, were caught off guard, and understandably so. The …

Homoeopathy In Pandemic Spanish Flu 1918, Vaishali Shinde

Indian Journal of Research in Homoeopathy

The mankind has been under the wrath of various H1N1 viruses tracing back to the Spanish flu (SF) in 1918 down to pandemics in 1957 H2N2, 1968 H3N2, 2009 H1N1 and COVID 19 in 2020. Despite a lot of advancements in genomic viral studies, laboratory techniques, medical advancement and treatment options in the form of antiviral and antibiotics, the threat of pandemics is hovering on mankind with a challenge at global and national level to fight against it. Homoeopathy has played a contributory role in the treatment and prevention in various epidemics in the past. In this overview, the role …

Multicenter Clinical Evaluation Of The Revogene Strep A Molecular Assay For Detection Of Streptococcus Pyogenes From Throat Swab Specimens, Dithi Banerjee, Jeff Michael, B. Schmitt, H. Salimnia, N. Mhaissen, D. M. Goldfarb, P. Lachance, M. L. Faron, T. Aufderheide, N. Ledeboer, A. Weissfeld, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

Copyright © 2020 Banerjee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license Group A streptococcus (GAS) species cause bacterial pharyngitis in both adults and children. Early and accurate diagnosis of GAS is important for appropriate antibiotic therapy to prevent GAS sequalae. The Revogene Strep A molecular assay (Meridian Bioscience Canada Inc, Quebec City, QC, Canada) is an automated real-time PCR assay for GAS detection from throat swab specimens within approximately 70 min. This multicenter prospective study evaluated the performance of the Revogene Strep A molecular assay compared to that …

Fecal Lactoferrin As A Parameter In Determining Invasive Causes Of Acute Diarrhea, Abeer E. S. Hamed, Gehan F. Oreby, Mohamed F. Alsoda, Sahar H. Quashwa

Journal of Medicine in Scientific Research

Introduction Diarrhea may be acute, which subsides by 7–14 days and is related to infections (bacterial or viral) or reaction to medications, or chronic, which lasts more than 2 weeks and is mainly caused by inflammatory bowel disease, functional bowel disorder, food allergies, or parasitic infestations. The infective etiologies may be noninvasive or invasive pathogens that have the capacity to invade intestinal mucosa and stimulate local inflammatory response [by activated neutrophils that secrete lactoferrin (LF)] and sometimes cause ulceration, hemorrhage, and systemic inflammatory response. Stool culture is the standard method for the diagnosis of invasive diarrhea; however, it is laborious …

Patent Ductus Arteriosus Treatment In Preterm Neonates, Which Is The Drug Of Choice Paracetamol Vs Ibuprofen?, Reham S. Abd Al Hamid

Journal of Medicine in Scientific Research

Background Patent ductus arteriosus (PDA) is one of the most prevalent problems in preterm infants. Although ibuprofen represents one of the choices for the closure of PDA, this treatment can cause severe gastrointestinal and adverse renal effects and worsen platelet function. Effective therapy for PDA had been suggested as paracetamol. Aim Our study is aiming to compare the efficacy and safety of paracetamol and ibuprofen. Patients and methods A prospective observational, single-center study was performed from December 2016 until August 2017, at ElGalaa Teaching Hospital in Cairo. In this study we included neonates with a gestational age of 28–36 weeks, …

Interleukin 33 In Premenopausal Women With Rheumatoid Arthritis: Is It Related To Generalized Bone Loss?, Eman R. Amer, Hala A. E. Tabl, Sahar H. Quashwa, Taghreed F. M. Mostafa

Journal of Medicine in Scientific Research

Aim The aim was to study the role of interleukin (IL)-33 in rheumatoid arthritis (RA)-induced generalized bone loss in premenopausal women and its relation to general disease activity and various laboratory markers. Patients and methods A total of 60 premenopausal women with RA were enrolled in this work as a study group and 30 age-matched healthy women as a control group. The participants were subjected to full clinical, radiological, and laboratory assessments. The following were assessed in patients and controls by enzyme-linked immunosorbent assay technique: serum level of IL-33, 25-hydroxyvitamin D3 [25(OH) D3], and bone turnover markers, osteocalcin and C-terminal …

Covid-19 And Blood Type: People With Which Group Are More Vulnerable?, Falah H. O. Al-Khikani

Journal of Medicine in Scientific Research

No abstract provided.