Medicine and Health Sciences Commons^™

Population Data-Driven Formulation Of A Covid-19 Therapeutic, Heather R. Campbell, Regan P. Cecil, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

This study is designed to utilize computer modeling of the US population through the ongoing CDC NHANES trial to reduce the need for preclinical formulation and toxicology studies of an Ebola antiviral (BSN389) being repurposed for COVID-19, and to thereby speed the candidate therapeutic to the clinic. BSN389 has poor solubility in water and that limits its bioavailability. BCD greatly increases the solubility of BSN389 and results in high bioavailability of BSN389 in animal studies. The goal of this study is to determine the current daily exposure of the population to beta cyclodextrin (BCD), and then keep the amount of …

A Case Of Systemic Sclerosis Sine Scleroderma, Adrian Lugo, Andrew Cappiello, Nemer Dabage, Guruswamy Ramamurthy

West Florida Division GME Research Day 2020

• Scleroderma and systemic sclerosis are autoimmune phenomena that can cause progressive and permanent damage to the organs of the human body.
• They can cause fibrosis of various internal organs, including the kidneys, lungs, GI tract, and heart
• Rarely, the only manifestation of systemic sclerosis is severe hypertension with renal failure, a subset known as systemic sclerosis sine scleroderma.

A Rare Case Of Leprosy In West Florida, Adrian Lugo, Taylor Studsrud, Nemer Dabage, James Demaio

West Florida Division GME Research Day 2020

• Leprosy is caused by acid-fast bacilli of the M. leprae complex, which includes M. leprae and M. lepromatosis.
• Transmission in the U.S. is rare, but has been documented in hunters who handle wild ninebanded armadillo.
• The origins of M. leprae infection among armadillos, the geographic range of the infected animals, and the potential risks infected armadillos present to people have been topics of concern.
• The infection originated amongst armadillos decades before they were ever used in leprosy research, and numerous surveys have confirmed that armadillos in the southern United States are a large natural reservoir for M. leprae; its prevalence …

Feasibility And Preliminary Outcomes Of A Brief Mindfulness-Based Intervention (Bmbi) To Decrease Stress And Improve Well-Being In Secondary School Teachers, Alex M. Roberts

Theses and Dissertations

Teachers often experience symptoms of stress and burnout due to the chronicity of their occupational demands. These symptoms can negatively impact teachers’ coping abilities and have implications for their physical and psychological health. Research indicates that mindfulness-based interventions (MBIs) have potential to help alleviate these symptoms of stress and burnout. Increasing numbers of MBIs for teachers have been implemented in the past five to ten years. However, few teacher-focused MBIs measure intervention feasibility and little data exist informing how to design and implement feasible MBIs in this context while simultaneously maximizing their potential positive effects. The current study examined the …

Can Children Catch Up From The Consequences Of Undernourishment? Evidence From Child Linear Growth, Developmental Epigenetics, And Brain And Neurocognitive Development, Jef L. Leroy, Edward A. Frongillo Jr., Pragya Dewan, Maureen M. Black, Robert A. Waterland

Faculty Publications

Recovery from nutritionally induced height deficits continues to garner attention. The current literature on catch-up growth, however, has 2 important limitations: wide-ranging definitions of catch-up growth are used, and it remains unclear whether children can recover from the broader consequences of undernutrition. We addressed these shortcomings by reviewing the literature on the criteria for catch-up in linear growth and on the potential to recover from undernutrition early in life in 3 domains: linear growth, developmental epigenetics, and child brain and neurocognitive development. Four criteria must be met to demonstrate catch-up growth in height: after a period in which a growth-inhibiting …

Clinical Decision-Making In A Patient With Cervical Radiculopathy And Cubital Tunnel Syndrome: Double Crush Syndrome, Taylor Nord

Physical Therapy Scholarly Projects

Background and Purpose: Double crush syndrome (DCS) is pathology involving the association between proximal and distal nerve lesions. It is often difficult to diagnose due to the variety of possible sources of tissue involvement and, therefore, is difficult to treat effectively. The purpose of this case report is to describe the physical therapy diagnosis and treatment of an older adult with DCS consisting of cervical radiculopathy (CR) and cubital tunnel syndrome (CuTS).

Case Description: 74-year-old female with a diagnosis of CR was referred to physical therapy. The physical examination confirmed this diagnosis. Due to the patient not responding well …

Ampk And Mtor Impose Dualistic Regulation Of Mitophagy And Autophagy In In Vitro Models Of Prostate Cancer, Brianne Richardson

PCOM Biomedical Studies Student Scholarship

Prostate cancer is the abnormal growth and proliferation of previously normal cells of the prostate and has the second highest incidence in men worldwide. Physiologic manipulation of AMP-activated protein kinase (AMPK), a highly conserved enzyme responsible for regulation of energy homeostasis during metabolic stress, is a potential treatment, especially for metastatic, castration-resistant prostate cancers. AMPK is a known inhibitor of the enzyme mTOR, the final enzyme in the PKT/AKT/mTOR pathway responsible for cell growth and proliferation signaling. The hypothesis of this project is that activation of AMPK leads to increased mTOR-dependent mitophagy and subsequent autophagy in prostate cancer cells. The …

Extreme Elevations Of Alkaline Phosphatase In Pregnancy: A Case Report, Zachary Stanley, Katherine Vignes, Miriam Marcum

Obstetrics and Gynecology Faculty Publications

Background: The normal serum concentration of alkaline phosphatase (ALP) in adults over the age of 18 ranges from 37 to 116 U/L, while in pregnant women levels of up to twice that upper limit can still be normal. There have been very few reports of extreme elevations in ALP, and here we present the case of a 29-year-old pregnant woman with an incidentally found 30-fold increase.

Case: The patient, G6P2-1-2-4, received routine prenatal care, though presented to obstetric triage at 36 weeks and 1 day of gestation for diagnosis and management of viral rhinosinusitis and was found to have an …

Conocimientos, Actitudes Y Prácticas Relacionadas A La Pandemia Del Covid-19 En Comunidades Indígenas De Yucatán Y Chiapas, Isabel Vieitez Martínez, Silvana Larrea, Fabiola Romero, Ludivine Cicolella

Poverty, Gender, and Youth

La Organización Mundial de la Salud ha recientemente indicado su preocupación sobre el mayor impacto que está teniendo y tendrá la pandemia por Covid-19 en la población indígena de América Latina. Aún cuando los resultados del presente estudio no sean representativos de toda la población indígena que vive en los municipios de Chiapas y Yucatán donde se realizó la encuesta, consideramos que los datos pueden identificar dimensiones que necesitan estudiarse a mayor detalle. También pueden guiar algunas de las acciones de las organizaciones locales que trabajan en estas comunidades, señalando áreas de oportunidad con respecto a conocimientos, actitudes y prácticas, …

Endovascular Treatment Of Cervical Myelopathy From Brachiocephalic Venous Stenosis., Craig Schreiber, Alex Anavim, Mark Kotapka, Paul Brady

Neurosurgery Resident Research

Central venous stenosis is a rare cause of neurologic pathology. Here we present a case of brachiocephalic vein stenosis causing cervical myelopathy through venous engorgement. Our patient was a 51-y/o male who presented with ambulatory dysfunction so he was evaluated for cervical myelopathy. Imaging revealed cord compression from venous engorgement and brachiocephalic vein stenosis. He was treated with angioplasty and vessel stenting which significantly improved flow on postintervention imaging. In conclusion, preoperative vascular imaging should be considered in myelopathic patients as it can detect this rare but dangerous etiology.

No Longer Expert: A Meta-Synthesis Describing The Transition From Clinician To Academic, Jane S. Grassley, Pamela K. Strohfus, Andrea C. Lambe

Nursing Faculty Publications and Presentations

Background: Recruitment of nurse clinicians into academic nursing has been important in addressing the faculty shortage. A description of their experiences as novice faculty could provide insights into easing their transition and improving faculty retention. Method: A systematic review of existing qualitative evidence was conducted to describe how nurses experience the transition from clinical practice to nursing academic. Criteria established by the Joanna Briggs Institute guided the review. Results: The meta-synthesis of the 12 selected qualitative studies yielded 11 themes and four meta-themes, which included: Unprepared, No Longer an Expert, In Search of Mentoring, and Beginning to Thrive. Conclusion: The …

Epstein Barr Virus-Immortalizedｂlymphocytes Exacerbate Experimental Autoimmune Encephalomyelitis In Xenograft Mice, Pascal Polepole, Alison Bartenslager, Yutong Liu, Thomas M. Petro, Samodha C. Fernando, Luwen Zhang

Nebraska Center for Virology: Faculty Publications

Multiple sclerosis (MS) is the most common autoimmune disorder affecting the central nervous system. Epstein-Barr virus (EBV) is a causative agent for infectious mononucleosis (IM) that is associated with MS pathogenesis. However, the exact mechanism by which EBV, specifically in IM, increases the risk for MS remains unknown. EBV immortalizes primary B lymphocytes in vitro and causes excessive B lymphocyte proliferation in IM in vivo. In asymptomatic carriers, EBV-infected B lymphocytes still proliferate to certain degrees, the process of which is tightly controlled by the host immune systems. Experimental autoimmune encephalomyelitis (EAE) mimics key features of MS in humans …

Dosimetric Comparison Of Hypofractionated Prostate Radiation With Simultaneous Integrated Boost And Conventional Fractionation With Sequential Boost, Kristina Sammon

Masters Projects

Introduction: Hypofractionated treatment delivery regimens are associated with better overall long-term disease control for prostate cancer. For patients with high-risk disease, there may be an indication for treatment of the surrounding pelvic lymph nodes for better over-all disease control. In order to achieve a hypofractionated regimen with treatment to the surrounding pelvic lymph nodes a simultaneous integrated boost technique is employed. There are concerns regarding achievability of target dose coverage and limitation of dose to the surrounding organs at risk with this fractionation.

Methods: This study is a retrospective dosimetric analysis of 7 randomly selected patients with high-risk prostate cancer. …

The Effectiveness Of Patient Education Utilizing The Teach-Back Method To Improve Patient Satisfaction, Gladys Cajucom Apuli

Doctoral Dissertations and Projects

The purpose of this Evidence-Based Project is to determine the effectiveness of using “teach-back” method in giving education to patients receiving chemotherapy and how this method can increase patient satisfaction with understanding of medication action and side effects. Teach-back method is a way of checking patient’s understanding by asking them to state in their own words the information about their health. It is a way to confirm that the explanations given by their provider is understood. Teach-back method can improve patient’s understanding and adherence, decrease call backs and cancelled appointments. This project was developed to improve the organization’s patient satisfaction …

Evaluating The Utilization Of A Combination Therapy To Improve Self-Efficacy And Glycemic Control In Patients With Type Two Diabetes Mellitus And Low Health Literacy, Crystal Manus Masling

Doctoral Dissertations and Projects

Type 2 diabetes mellitus is a significant health issue, as it requires patients to perform daily self-management activities. One in every three Americans with Type 2 diabetes has limited or low health literacy skills. Limited or low health literacy skills can impact a patient’s overall health outcome; therefore, a critical element for disease management and patient adherence is health literacy. The purpose of this three-month scholarly project was to determine if the utilization of an educational intervention specific to one’s level of health literacy, combined with a short message service reinforcement tool, could improve glycemic control and self-efficacy in Type …

Improving Newborn Outcomes Through Implementation Of Delayed Bathing: An Integrative Review, Tennille Ideen O'Connor

Doctoral Dissertations and Projects

Evidence-based practice is foundational to ensuring patient safety and quality of care. Implementing evidence-based practice is the responsibility of all care providers. The completion of an in-depth integrative review provides a project leader the opportunity to explore the benefits of delayed bathing of the newborn and impact of the practice on newborn outcomes. The goal of this integrative review is to identify the benefits of delayed bathing and ways to implement this practice in the clinical setting. This integrative review seeks to present care providers with the most recent research and guidelines as it relates to the practice of delayed …

Initial And Repeated Point Prevalence Surveys To Inform Sars-Cov-2 Infection Prevention In 26 Skilled Nursing Facilities - Detroit, Michigan, March-May 2020, Guillermo V. Sanchez, Caitlin Bierdon, Lauren R. Fink, Kelly M. Hatfield, Jordan Micah F. Polistico, Monica P. Meyers, Rebecca S. Noe, Casey E. Copen, Amanda K. Lyons, Gonzalo Gonzalez, Keith Kiama, Mark Lebednick, Bonnie K. Caander, Amen Agbonze, Aimee R. Surma, Avnish Sandhu, Valerie H. Mika, Tyler Prentiss, John Zervos, Donia A. Dalal, Amber M. Vasquez, Sujan C. Reddy, John Jernigan, Paul E. Kilgore, Marcus J. Zervos, Teena Chopra, Carla P. Bezold, Najibah K. Rehman

Department of Pharmacy Practice

No abstract provided.

Evaluating Public Posting, Goal Setting, And Rewards To Increase Physical Activity In Children, Bryon G. Miller

USF Tampa Graduate Theses and Dissertations

In Experiments 1 and 2 we evaluated a pedometer-based intervention consisting of public posting between two teams of students, with additional self-monitoring, goal setting, and reinforcement components, to increase physical activity during school recess. In the absence of self-monitoring, performance feedback alone did not increase physical activity levels above those observed during baseline. Additionally, higher levels of physical activity were observed when goal-setting was introduced, with the highest levels of activity observed when raffle tickets could be earned for exceeding a specified step-total goal. In Experiment 3 we removed the team component and evaluated similar intervention components across an entire …

Four Health Science Librarians’ Experiences: How They Responded To The Covid-19 Pandemic Crisis, Misa Mi, Yingting Zhang, Lin Wu, Wendy Wu

Library Scholarly Publications

In this article, four health sciences librarians from four academic libraries across the country will share their personal or library experiences in reaching out to faculty and students to meet their needs through their initiatives and continuous efforts using various technologies and tools. Three of the four academic libraries are located in two COVID-19 hard-hit states, Michigan and New Jersey. The article will describe their practice of health sciences librarianship during the unprecedented time and provide examples demonstrating how each of them strives to stay relevant, proactive, and become integral to their institutional efforts in support of students and employees …

Patient Personalized Fall Prevention, Olivia Mennig Bsn, Rn, Anne Kearns Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Sound Discrimination And Explicit Mapping Of Sounds To Meanings In Preschoolers With And Without Developmental Language Disorder, Carolyn Quam, Holly Cardinal, Celeste Gallegos, Todd Bodner

Speech and Hearing Sciences Faculty Publications and Presentations

Purpose: To investigate links between sound discrimination and explicit sound-meaning mapping by preschoolers with and without developmental language disorder (DLD).

Method: We tested 26 children with DLD and 26 age- and gender-matched peers with typical language development (TLD). Inclusion was determined via results of standardised assessments of language and cognitive skills and a hearing screening. Children completed two computerised tasks designed to assess pitch and duration discrimination and explicit mapping of pitch- and duration-contrasting sounds to objects.

Result: Children with TLD more successfully mapped pitch categories to meanings than children with DLD. Children with TLD also showed significantly better overall …

Challenges Of Doing Alzheimer’S Research In Costa Rica And Some Possible Solutions, Felipe Mejias

International Programs

Alzheimer's disease is a public health priority which has been researched for many years in the hope of finding a cure soon. Costa Rica has made significant progress in many areas of research; however, the research carried out in the country on Alzheimer's disease is very scarce. The present poster presents the challenges of developing scientific Alzheimer’s research in Costa Rica by reviewing current scientific research on Alzheimer's in Costa Rica and by conducting interviews with Costa Rican professionals who have conducted Alzheimer's research. The lack of investigative training of doctors, the difficulties in accessing patient data, and the lack …

Redefining The Meanings Of Daily-Occupations And Life Quality Amongst Mothers Living With Their Autistic Children, Eko Sumaryanto, Gandes Mutiara Aziz

International Programs

Raising children with autism is very challenging for mothers due to changes on how occupational performance and occupational roles are performed. This circumstance demands these mothers to redefine the meaning of doing occupations and how they perceive their well-being in general. This study empirically investigates how mothers redefine the meaning of daily activities and self-report their well-being. The study employs in-depth interviews and formulates specific themes of findings. The study uses the phenomenology approach to investigate the dynamics of meanings experienced by the respondents and how they construct the new version of well-being from raising the autistic children.

Household Tree Planting In Tigrai, Northern Ethiopia: Tree Species, Purposes, And Tenure Security, Zenebe Gebreegziabher, Alemu Mekonnen, Menale Kassie, Gunnar Köhlin

All Peer-Reviewed Publications

Trees on farms have multiple roles in rural livelihoods, providing significant economic and ecological benefits. Trees on farms also constitute vital components in mixed crop-livestock-tree systems. In this paper, we analyze household tree planting and tenure security and explore the most important determinants that enhance the propensity to plant trees, using a cross-sectional household-level dataset from a sample of 200 households in the highlands of Tigrai, northern Ethiopia. Specifically, we employ a sample selection model that simultaneously takes into account the two decisions of tree growers (whether or not to plant tree and how many) to analyze the effect of …

A Foldable Nonpenetrating Keratoprosthesis: Medium To Long-Term Clinical Results In Patients With Corneal Blindness Due To Noninflammatory Anterior Cornea Disease., Jose M Vargas, Eric Shiuey

Department of Medicine Faculty Papers

PURPOSE: To report the medium to long-term safety and performance outcomes of the KeraKlear nonpenetrating artificial cornea (KeraKlear) as the primary procedure in patients with corneal blindness due to noninflammatory anterior cornea disease.

METHODS: Fifteen patients with corneal blindness (preoperative visual acuity [VA] of ≥20/200) due to a non-inflammatory anterior corneal condition were included in this prospective, single-center study. Preoperative diagnoses included corneal scars, keratoconus, and corneal dystrophies. Diseased corneas were implanted with the KeraKlear (KeraMed Inc., Irvine, California, USA) by a single surgeon (JMV) using a femtosecond laser to create all incisions. Participants were followed up with for as …

Covid-19 Pandemic: Role Of Technology In Transforming Business To The New Normal, Fiona Fui-Hoon Nah, Keng Siau

Research Collection School Of Computing and Information Systems

COVID-19 has disrupted our lives and the economy. In this paper, we outline approaches in which information technology can be used to implement business strategies to enhance resilience by coping with, adapting to, and recovering from adversity resulting from the COVID-19 pandemic. We discuss how information technology such as digital supply chain, data analytics, artificial intelligence, machine learning, robotics, digital commerce, and Internet of Things can be used to enhance resilience and continuity of business.

Crisis (Pandemic) Management Playbook For Assisted Living, Daniel Haimowitz, Richard G. Stefanacci

College of Population Health Faculty Papers

No abstract provided.

A Health Care Comparison Of Areas In Ghana And In The United States, Lindsey Matsumoto

Honors Projects

The health care system is an important factor for the well-being of the human population all around the world, and yet, health care can differ greatly depending on a variety of factors including location and culture. When referring to health care, it is appropriate to include skilled physicians, hospitals, care clinics, and medical equipment. This article conducts a literature review that compares the health care systems of two countries, the Republic of Ghana and the United States of America. This information is relevant for not only expanding one’s knowledge, but also for travel purposes, as both countries have highly populated …

The Adult Public’S Perception Of The Utility Of Play Therapy, Margaret L. Hindman

Graduate Theses and Dissertations

Children communicate through symbolism and play as toys are children's words and play is their language (Landreth, 2012; Oaklander, 1988; Piaget, 1951; Ray, 2016). Play therapists facilitate developmentally appropriate support for children (Landreth, 2012). Often parents are unaware of the importance of play in children’s counseling (Brumfield & Christensen, 2011; Landreth, Bratton, Kellam, & Blackard, 2006).

Since adults often make decisions for children, it is important to know adults’ perceptions of play therapy utility. There is little research on parents’ knowledge of mental health services especially research specific to play therapy (Gallo, Comer, & Barlow, 2013; O’Connor & Langer, 2018). …

Availability-Resilient Control Of Uncertain Linear Stochastic Networked Control Systems, Chandreyee Bhowmick, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

The resilient output feedback control of linear networked control (NCS) system with uncertain dynamics in the presence of Gaussian noise is presented under the denial of service (DoS) attacks on communication networks. The DoS attacks on the sensor-to-controller (S-C) and controller-to-actuator (C-A) networks induce random packet losses. The NCS is viewed as a jump linear system, where the linear NCS matrices are a function of induced losses that are considered unknown. A set of novel correlation detectors is introduced to detect packet drops in the network channels using the property of Gaussian noise. By using an augmented system representation, the …