Medicine and Health Sciences Commons^™

2020-07-29_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-07-29_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

Esrd And Endoavf: A Giant Leap Forward, Alison Tan, Md

Department of Family & Community Medicine Presentations and Grand Rounds

No abstract provided.

Hypergraph Analysis Of Structure Models, Cliff A. Joslyn, Teresa D. Schmidt, Martin Zwick

Complex Systems Faculty Publications and Presentations

Theoretical discussion on the analysis of hypergraph networks; application of analysis methods to hypergraph networks derived by applying Reconstructability Analysis to health care data (the PhD dissertation work of Teresa Schmidt).

Machine Learning Approaches For Fracture Risk Assessment: A Comparative Analysis Of Genomic And Phenotypic Data In 5130 Older Men, Qing Wu, Fatma Nasoz, Jongyun Jung, Bibek Bhattarai, Mira V. Han

School of Public Health Faculty Research

The study aims were to develop fracture prediction models by using machine learning approaches and genomic data, as well as to identify the best modeling approach for fracture prediction. The genomic data of Osteoporotic Fractures in Men, cohort Study (n = 5130), were analyzed. After a comprehensive genotype imputation, genetic risk score (GRS) was calculated from 1103 associated Single Nucleotide Polymorphisms for each participant. Data were normalized and split into a training set (80%) and a validation set (20%) for analysis. Random forest, gradient boosting, neural network, and logistic regression were used to develop prediction models for major osteoporotic fractures …

Graduate Commencement, Georgia (2020), Philadelphia College Of Osteopathic Medicine

Commencements

Georgia Campus Commencement program, Class of 2020. Degrees include Doctorate in Pharmacy, Master of Science in Biomedical Sciences, and Master of Science in Health Sciences - Physician Assistant Studies.

Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah

All Works

© Copyright © 2020 Ahmed, Khan, Kury and Shah. Background: Carveol is a natural drug product present in the essential oils of orange peel, dill, and caraway seeds. The seed oil of Carum Carvi has been reported to be antioxidant, anti-inflammatory, anti-hyperlipidemic, antidiabetic, and hepatoprotective. Methods: The antidiabetic potential of carveol was investigated by employing in-vitro, in-vivo, and in-silico approaches. Moreover, alpha-amylase inhibitory assay and an alloxan-induced diabetes model were used for in-vitro and in-vivo analysis, respectively. Results: Carveol showed its maximum energy values (≥ -7 Kcal/mol) against sodium-glucose co-transporter, aldose reductase, and sucrose-isomaltase intestinal, whereas it exhibited intermediate energy …

Implementation Of Family Psychosocial Risk Assessment In Pediatric Cancer With The Psychosocial Assessment Tool (Pat): Study Protocol For A Cluster-Randomized Comparative Effectiveness Trial, Anne E Kazak, Janet A Deatrick, Michele A Scialla, Eric Sandler, Rebecca E Madden, Lamia P Barakat

Department of Pediatrics Faculty Papers

BACKGROUND: Childhood cancer affects and is affected by multiple levels of the social ecology, including social and relational determinants of health (e.g., economic stability, housing, childcare, healthcare access, child and family problems). The 2015 Standards of Psychosocial Care in Pediatric Cancer outline optimal psychosocial care sensitive to these ecological factors, starting with assessment of psychosocial healthcare needs to promote medical and psychosocial outcomes across all children with cancer. To address the first standard of family psychosocial assessment, the Psychosocial Assessment Tool (PAT) is a validated screener ready for broad implementation.

METHOD: The PAT will be implemented across a national sample …

Environmental Surveillance As A Tool For Identifying High-Risk Settings For Typhoid Transmission, Jason R. Andrews, Alexander T. Yu, Senjuti Saha, Jivan Shakya, Kristen Aiemjoy, Lily Horng, Farah Qamar, Denise Garret, Stephen Baker, Samir Saha, Stephen P. Luby

Department of Paediatrics and Child Health

Enteric fever remains a major cause of morbidity in developing countries with poor sanitation conditions that enable fecal contamination of water distribution systems. Historical evidence has shown that contamination of water systems used for household consumption or agriculture are key transmission routes for Salmonella Typhi and Salmonella Paratyphi A. The World Health Organization now recommends that typhoid conjugate vaccines (TCV) be used in settings with high typhoid incidence; consequently, governments face a challenge regarding how to prioritize typhoid against other emerging diseases. A key issue is the lack of typhoid burden data in many low- and middle-income countries where TCV …

Structurally Vulnerable Neighbourhood Environments And Racial/Ethnic Covid-19 Inequities, Rachel L. Berkowitz, Xing Gao, Eli K. Michaels, Mahasin S. Mujahid

Faculty Research, Scholarly, and Creative Activity

Preliminary evidence indicates that the experience of the novel coronavirus is not shared equally across geographic areas. Findings in the United States suggest that the burden of COVID-19 morbidity and mortality may be hardest felt in disadvantaged and racially segregated places. Deprived neighbourhoods are disproportionately populated by people of colour, the same populations that are becoming sicker and dying more often from COVID-19. This commentary examines how structurally vulnerable neighbourhoods contribute to racial/ethnic inequities in SARS-COV-2 exposure and COVID-19 morbidity and mortality and considers opportunities to intervene through place-based initiatives and the implementation of a Health in All Policies strategy.

Whole Exome Sequencing In Patients With Williams-Beuren Syndrome Followed By Disease Modeling In Mice Points To Four Novel Pathways That May Modify Stenosis Risk, Phoebe C R Parrish, Delong Liu, Russell H Knutsen, Charles J Billington, Robert P Mecham, Yi-Ping Fu, Beth A Kozel

2020-Current year OA Pubs

Supravalvular aortic stenosis (SVAS) is a narrowing of the aorta caused by elastin (ELN) haploinsufficiency. SVAS severity varies among patients with Williams-Beuren syndrome (WBS), a rare disorder that removes one copy of ELN and 25-27 other genes. Twenty percent of children with WBS require one or more invasive and often risky procedures to correct the defect while 30% have no appreciable stenosis, despite sharing the same basic genetic lesion. There is no known medical therapy. Consequently, identifying genes that modify SVAS offers the potential for novel modifier-based therapeutics. To improve statistical power in our rare-disease cohort (N = 104 exomes), …

Self-Reflection And Screening Mental Health On Canadian Campuses: Validation Of The Mental Health Continuum Model, Shu-Ping Chen, Wen-Pin Chang, Heather Stuart

Occupational Therapy Faculty Publications

Background

This study describes the psychometric testing of the Mental Health Continuum (MHC) model the Canadian Department of National Defense developed initially, among undergraduates of three Canadian universities. The MHC is a tool that consists of 6 items to guide students the way to attend to, or monitor, signs and behavior indicators of their mental health status and suggest appropriate actions to improve their mental health.

Methods

Online survey data were collected from 4206 undergraduate students in three universities in two Canadian provinces during the spring of 2015 and winter of 2016. Participants completed an online survey questionnaire that consisted …

Interprofessional Continuous Professional Development In Qatar, Sara F. Mahoud, Pharmd, Bccp

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Hamad Medical Corporation (HMC) is the main governmental healthcare entity overseeing twelve hospitals which serve different specialties and geographical areas across the state of Qatar. At HMC, the pharmacy executive office oversees its Continuous Pharmacy Profeesional Development (CPPD) office. Since 2016, the CPPD office accomplished a lot of great achievements. Here is waht we learned so far about interprofessional education.

Jefferson Covid Stories, Danielle Snyderman, Md, Cmd, Nick Safian

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

The concept of Jefferson COVID stories was modeled after the Humans of New York photojournalism project. I approached Nick Safian, Sidney Kimmel Medical College, MS2, and together we started to create writing prompts to engage teh entire Jefferson community on a weekly basis.

From The Editors

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

As we write this Letter from the Editors, we are acutely aware that we are in a very different place than ever before. We know that this semester has been exceptionally challenging with the rapid transition to working, teaching and providing critical care in different formats and adapted settings to do our part to prevent the spread of a global pandemic, unprecidented in our lifetimes.

Collaborative Healthcare: Interprofessional Practice, Education And Evaluation (Jcipe), Volume 11, Number 1, Spring 2020/Summer 2020

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In this Issue

1- From the Editors

3- Jefferson Covid Stories

4- Interprofessional Continuous Professional Development in Qatar

5- Meet and IPE Faculty Champion from Thomas Jefferson University

6- Prescribing for Pain: What Medical Students Learn and Where They Learn It

7- Meet an IPE Student Champion from Thomas Jefferson University

8- The Old Pine Community Center in Philadelphia Responds to COVID-19

9- Reflection: Enchancing Research and Training Through Interprofessional Collaboration and Mentorship

10- Health Mentors Reflection

10- 2020 James B. Erdmann, PhD Award Recipients

Orthodontic Treatment Combined With Autotransplantation In Adults, I-Ting Chiang, Yi-Horng Chen, Rebecca Chen, Chien-Cheng Chen

Taiwanese Journal of Orthodontics

A 28-year-old female with mild skeletal Class II and dental Class I malocclusion had chief complaint of teeth crowding and poor esthetics. The patient presented with a convex facial profile, long face with a steep mandibular angle, bimaxillary dentoalveolar protrusion with 9 mm overjet, and dental crowding. She had severe caries on the maxillary right first and second molars, and the mandibular left second molar. The mandibular left first and second premolars had ill-fitting porcelain-fused-to-metal crowns. The maxillary right third molar and the mandibular left third molar were impacted. The orthodontic treatment included autotransplantation of the maxillary left first premolar …

Molar Protraction Through Downward Extension Of Maxillary Sinus In Patient With Central Diastema Caused By Small Lateral Incisors, Hsien-Fang Hung, Ming-Chu Huang, Ming-Jeaun Su

Taiwanese Journal of Orthodontics

A 32-year-old male patient presented with upper central diastema resulting from upper bilateral smallsized lateral incisors. The patient also had a deep bite of dental origin. A relatively simple mechanotherapy with pre-adjusted edgewise appliances was applied. A favorable and stable result of the ideal overbite and overjet after the correction of central diastema. Besides the above primary complaints, the prolonged retained roots of upper left first molar caused difficulty for proper space closure since the maxillary sinus wall was downward extended. The lower sinus floor may impede the orthodontic movement, but was very likely to be overlooked. The upper left …

Camouflage Orthodontic Treatment On Skeletal Class Ii Malocclusion With Idiopathic Condylar Resorption, Hsin-Yi Lo, Liang-Ru Chen, Kwong-Wa Li, Ming-Lun Hong

Taiwanese Journal of Orthodontics

Idiopathic condylar resorption (ICR), also known as idiopathic condylysis or condylar atrophy, and progressive condylar resorption (PCR), is a poorly understood progressive disease that affects the temporomandibular joint (TMJ) with multifactorial factors leading to severe mandibular retrognathism and anterior open bite. It is difficult to distinguish the exact causes for each individual. Different diagnostic methods and different treatment options can be chosen for different phases. In this report, we present a camouflage treatment with temporary anchorage devices (TADs) for a skeletal Class II open bite with ICR. The goal of improving facial profile and reconstructing of occlusion was achieved. Comprehensive …

Treatment Options For Obstructive Sleep Apnea, Shao-Chih Hsieh, Szu-Ting Chou, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) is sleep-disordered breathing caused by the collapse of the upper airway. Because anatomical abnormalities of the narrow upper airway are undoubtedly the most critical cause of OSA, the available treatment methods for OSA mostly focus on these anatomical problems. The collapse of the respiratory tract is associated with different levels of upper airway obstruction. The obstruction of the airway can be divided into three parts: the nasal cavity, retropalatal region, and retrolingual region. This article summarizes some common OSA treatment methods, their underlying theories, and their effect on the upper airway.

Effects Of Different Occlusion Setups With A Surgery-First Approach And Simulated Presurgical Orthodontics On The Mandibular Position In Skeletal Class Iii Malocclusion, Gloria Shih-Wen Fan, Yu-Chih Wang, Chiung Shing Huang, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Purpose: The purposes of this study were to compare the occlusion designs implemented for the surgery-first approach (SFA) and the resultant mandibular movements by different orthodontists, as well as to investigate whether presurgical dental alignment is associated with mandibular positioning.
Methods: This prospective study included 15 patients with skeletal Class III malocclusion who underwent orthognathic surgery through the SFA. Three orthodontists designed an occlusion setup for each case, which were assigned as SFA groups. The same group of patients, who received simulated presurgical orthodontics (SPO) through a virtual setup, composed the control group. The postoperative dental relationship and resultant mandibular …

2020-07-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

Role Of Lncrna Morrbid In Ptpn11(Shp2)E76k-Driven Juvenile Myelomonocytic Leukemia., Zhigang Cai, Chi Zhang, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Reuben Kapur

Faculty Research 2020

Mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, contribute to ∼35% of cases of juvenile myelomonocytic leukemia (JMML). A common clinical picture in children with JMML is that it presents as a constitutive hyperinflammatory syndrome, partially reminiscent of chronic myelomonocytic leukemia in adults. Thus, a component of JMML is associated with a hyperinflammatory state and abundant innate immune cells such as neutrophils and monocytes. Recently, we showed that the evolutionarily conserved mouse lncRNA Morrbid is specifically expressed in myeloid cells and uniquely represses the expression of the proapoptotic gene Bim to regulate the lifespan of myeloid cells. However, …

2020-07-28_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

Regulation Of Bmp4/Dpp Retrotranslocation And Signaling By Deglycosylation., Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad

Faculty Research 2020

During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported that NGLY1 regulates Drosophila BMP signaling in a tissue-specific manner (Galeone et al., 2017). Here, we establish the Drosophila Dpp and its mouse ortholog BMP4 as biologically relevant targets of NGLY1 and find, unexpectedly, that NGLY1-mediated deglycosylation of misfolded BMP4 is required for its retrotranslocation. Accumulation of misfolded BMP4 in the ER results in ER stress and prompts the ER recruitment of NGLY1. The ER-associated NGLY1 …

2020-07-28_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Longitudinal Changes Of Brain Microstructure And Function In Nonconcussed Female Rugby Players, Kathryn Y. Manning, Jeffrey S. Brooks, James P. Dickey, Alexandra Harriss, Lisa Fischer, Tatiana Jevremovic, Kevin Blackney, Christy Barreira, Arthur Brown, Robert Bartha, Tim Doherty, Douglas Fraser, Jeff Holmes, Gregory A. Dekaban, Ravi S. Menon

Brain and Mind Institute Researchers' Publications

ObjectiveTo longitudinally assess brain microstructure and function in female varsity athletes participating in contact and noncontact sports.MethodsConcussion-free female rugby players (n = 73) were compared to age-matched (ages 18-23) female swimmers and rowers (n = 31) during the in- and off-season. Diffusion and resting-state fMRI (rs-fMRI) measures were the primary outcomes. The Sports Concussion Assessment Tool and head impact accelerometers were used to monitor symptoms and impacts, respectively.ResultsWe found cross-sectional (contact vs noncontact) and longitudinal (in- vs off-season) changes in white matter diffusion measures and rs-fMRI network connectivity in concussion-free contact athletes relative to noncontact athletes. In particular, mean, axial, …

Computational Identification Of Gene Networks As A Biomarker Of Neuroblastoma Risk, Lidan Sun, Libo Jiang, Christa N Grant, Hong-Gang Wang, Claudia Gragnoli, Zhenqiu Liu, Rongling Wu

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Neuroblastoma is a common cancer in children, affected by a number of genes that interact with each other through intricate but coordinated networks. Traditional approaches can only reconstruct a single regulatory network that is topologically not informative enough to explain the complexity of neuroblastoma risk. We implemented and modified an advanced model for recovering informative, omnidirectional, dynamic, and personalized networks (idopNetworks) from static gene expression data for neuroblastoma risk. We analyzed 3439 immune genes of neuroblastoma for 217 high-risk patients and 30 low-risk patients by which to reconstruct large patient-specific idopNetworks. By converting these networks into risk-specific representations, we found …

Telemedicine In The Emergency Department In The Era Of Covid-19: Front-Line Experiences From 2 Institutions, Joel M. Hamm, Chris Greene, Michael T. Sweeney, Setareh Mohammadie, Linda B. Thompson, Eric Wallace, Walter Schrading

Emergency Medicine Faculty Publications

During the COVID-19 pandemic, one of the major changes that has occurred in emergency medicine is the evolution of telemedicine. With relaxation of regulatory and administrative barriers, the use of this already available technology has rapidly expanded. Telemedicine provides opportunity to markedly decrease personal protective equipment (PPE) and reduce healthcare worker exposures. Moreover, with the convenience and availability of access to medical care via telemedicine, a more fundamental change in healthcare delivery in the United States is likely. The implementation of telemedicine in the emergency department (ED) in particular has great potential to prevent the iatrogenic spread of COVID-19 and …

Neuroinvasion, Neurotropic, And Neuroinflammatory Events Of Sars-Cov-2: Understanding The Neurological Manifestations In Covid-19 Patients, Yassine Yachou, Abdeslem El Idrissi, Vladimir Belapasov, Said Ait Benali

Publications and Research

Respiratory viruses are opportunistic pathogens that infect the upper respiratory tract in humans and cause severe illnesses, especially in vulnerable populations. Some viruses have neuroinvasive properties and activate the immune response in the brain.These immune events may be neuroprotective or they may cause long-term damage similar to what is seen in some neurodegenerative diseases. The new “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV-2) is one of the Respiratory viruses causing highly acute lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical similarities to those reported in “Severe Acute Respiratory Syndrome Coronavirus” (SARS-CoV) and the “Middle East Respiratory SyndromeCoronavirus” (MERS-CoV) including neurological …