Medicine and Health Sciences Commons^™

Prospects For Rnai Therapy Of Covid-19, Hasan Uludağ, Kylie Parent, Hamidreza Montazeri Aliabadi, Azita Haddadi

Pharmacy Faculty Articles and Research

COVID-19 caused by the SARS-CoV-2 virus is a fast emerging disease with deadly consequences. The pulmonary system and lungs in particular are most prone to damage caused by the SARS-CoV-2 infection, which leaves a destructive footprint in the lung tissue, making it incapable of conducting its respiratory functions and resulting in severe acute respiratory disease and loss of life. There were no drug treatments or vaccines approved for SARS-CoV-2 at the onset of pandemic, necessitating an urgent need to develop effective therapeutics. To this end, the innate RNA interference (RNAi) mechanism can be employed to develop front line therapies against …

2020-07-30_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

México: Conocimientos, Actitudes Y Prácticas Relacionadas Con Covid-19, Population Council

Poverty, Gender, and Youth

Este informe presenta las respuestas de la primera ronda de recolección de información con personas adultas, adolescentes y autoridades comunitarios en las comunidades indígenas de Chiapas y Yucatán, México, del 1 al 30 de junio de 2020. En total, 295 personas originarias de 17 municipios fueron encuestados en Yucatán, y se encuestó a 83 personas de 15 municipios de Chiapas. Los adultos y adolescentes de ambos estados identificaron a los grupos en mayor riesgo de sufrir complicaciones. La inseguridad alimentaria puede ser una consecuencia de la pandemia Covid-19. En cuanto a los medios de vida, el 51% de las mujeres …

Improving The Detection Of Rheumatic Heart Disease In Children Residing In Samoa, Shay Harding

Student Works

Improving the Detection of Rheumatic Heart Disease in

Children Residing in Samoa

Shay Harding

College of Nursing, BYU

Master of Science

Rheumatic Heart disease (RHD) is the most common cause of heart related illness in individuals under 25 years of age and is a major health concern on the Pacific Islands of Samoa (Saxena et al., 2017). RHD related mortality among Samoan children is disproportionally high relative to the rest of the world; it is estimated to impact 10 out of every 1000 children there (Allen et al., 2017). The health care system in Samoa is limited in its resources, …

Heart Rate Variability And Direct Current Measurement Characteristics In Professional Mixed Martial Arts Athletes, Joseph O. C. Coyne, Aaron J. Coutts, Roman Fomin, Duncan N. French, Robert U. Newton, Greg Haff

Research outputs 2014 to 2021

This study’s purpose was to examine heart rate variability (HRV) and direct current potential (DC) measures’ sensitivity and correlations between changes in the acute recovery and stress scale (ARSS) and the previous day’s training load. Training load, HRV, DC and ARSS data were collected from fourteen professional mixed martial arts athletes (32.6 ± 5.3 years, 174.8 ± 8.8 cm, 79.2 ± 17.5 kg) the following morning after hard, easy and rest days. Sensitivity was expressed as a signal-to-noise ratio (SNR, inter-day typical error (TE) or coefficient of variation (%CV) divided by intra-day TE or %CV). Correlations between HRV, DC and …

A Novel Serpinb1 Single-Nucleotide Polymorphism Associated With Glycemic Control And Β-Cell Function In Egyptian Type 2 Diabetic Patients, Dina H. Kassem, Aya Adel, Ghada H. Sayed, Mohamed M. Kamal

Pharmacy

Aims: Serine protease inhibitor B1 (SerpinB1) is a neutrophil elastase inhibitor that has been proved to be associated with type 2 diabetes mellitus and pancreatic β-cell proliferation. In this study, we investigated 2 SERPINB1 SNPs, rs114597282 and rs15286, regarding their association with diabetes risk and various anthropometric and biochemical parameters in Egyptian type 2 diabetic patients.

Materials and Methods: A total of 160 subjects (62 control and 98 type 2 diabetic patients) participated in this study. Various anthropometric and biochemical parameters were assessed. Genotyping assay for the two SNPs was done using TaqMan genotyping assays. The association of rs15286 variants …

Paraventricular Hypothalamus Mediates Diurnal Rhythm Of Metabolism, Eun Ran Kim, Yuanzhong Xu, Ryan M Cassidy, Yungang Lu, Yongjie Yang, Jinbin Tian, De-Pei Li, Rachel Van Drunen, Aleix Ribas-Latre, Zhao-Lin Cai, Mingshan Xue, Benjamin R Arenkiel, Kristin Eckel-Mahan, Yong Xu, Qingchun Tong

Children’s Nutrition Research Center Staff Publications

Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism remains elusive. Here we show that deletion of BMAL1, a core clock gene, in paraventricular hypothalamic (PVH) neurons reduces diurnal rhythmicity in metabolism, causes obesity and diminishes PVH neuron activation in response to fast-refeeding. Animal models mimicking deficiency in PVH neuron responsiveness, achieved through clamping PVH neuron activity at high or low levels, both show obesity and reduced diurnal rhythmicity in metabolism. Interestingly, the PVH exhibits BMAL1-controlled rhythmic expression of GABA-A receptor γ2 subunit, and dampening …

Catholic Family Ties: Sustaining And Supporting Hiv-Positive Canadian Gay Men’S Faith, Mental Health, And Wellbeing, Renato M. Liboro

Psychology Faculty Research

Research has documented that sexual minorities and people living with HIV/AIDS have successfully used religious coping to help them overcome life challenges related to their sexual orientation and HIV status, including religious struggles surrounding their faith brought about by stigma and discrimination that have historically been promoted by organized religion. Research has also documented how sexual minorities and people living with HIV/AIDS have utilized family support as a vital resource for effectively coping with life challenges associated with homophobia, heterosexism, and HIV stigma, which have historically been perpetuated in certain family and faith dynamics. The aim of the community-engaged, qualitative …

You Don’T Have To Get Diabetes, Mitch Kaminski, Md, Mba, Nevaneva White, Dnp, Crnp, Cdces

Department of Family & Community Medicine Presentations and Grand Rounds

The goal is to streamline the steps required to make referrals to and enroll in the National Diabeties Prevention Program (DPP).

Cancer Prevention And Therapeutics For The Primary Care Clinician, Richard C. Wender, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Outline

•Basics of cancer screening •Recommended options for colorectal cancer screening •Trends in incidence and mortality •The 80% in Every Community initiative

محرمات الطعام والشراب في القرآن الكريم وأثرها في حفظ صحة الإنسان في الحضارة الإسلامية, Mohamed Abu Zeid

All Works

What was deprived of food and drink it was harmful to a person's health or himself. In this research, the researcher deals with the prohibitions of food and drink in the Holy Quran, as it explains how the ban of these beverages had a definite impact on the Islamic nation in the best conditions of physical and psychological health. This research will solve according to the inductive and descriptive approach, whereby the researcher will extrapolate the Quranic text and determine the prohibitions of foods and beverages in it, whether they are specific or outlined in the Quranic texts such as …

Using Think-Alouds To Uncover Expert-Novice Gaps In Aac Intervention Planning Skills, Allison M. Sauerwein, Jane R. Wegner

Teaching and Learning in Communication Sciences & Disorders

Because few studies have explored preservice speech-language pathologists’ (SLP’s) learning outcomes in augmentative and alternative communication (AAC) coursework and clinical practica, there is a need to investigate student learning in this area. This article represents a portion of a larger study that explored the expert-novice gap in planning for intervention with children who use AAC. The companion article reports clinical reasoning skills, whereas the present study revealed intervention planning skills. The methods are the consistent with those reported in the companion article. In summary, eight novice (i.e. preservice) SLPs and eight expert SLPs completed think-aloud tasks while they developed intervention …

2020 James B. Erdmann, Phd Award Recipients

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Jefferson Center for Interprofessional Practice and Education (JCIPE) congratulates this year's award winners and thanks them for all their efforts to support and advance this work on campus and beyond.

Health Mentors Reflection, Julie Distasi

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

My experience with the Health Mentors Program has been truly enjoyable.

Reflection: Enhancing Research And Training Through Interprofessional Collaboration And Mentorship, Kayla Askey, Pharmd Candidate 2020

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Throughout pharmacy school, I had the opportunity to take part in a variety of different interprofessional education events. Although all were valuable and worthwile, it wasn't untill I began collaborating with other professional disiciplines through research that I witnessed the real power of interprofesssional collaboration.

The Old Pine Community Center In Philadelphia Responds To Covid-19, April T. Jones, Med

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

I have always believed in the power of community. It is why I was compelled to serve as the CEO and Executive Director of the Old Pine Community Center and why I continue to stand at the helm.

Meet An Ipe Student Champion From Thomas Jefferson University

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Nick Safian, Sidney Kimmel Medical College, M2

1. Briefly describe your work with/related to JCIPE.
2. What excites you about this work?
3. What have you learned that was new?
4. Why is IPE/CP important to you?
5. How do you think you will apply your IPE/CP training to your future role

Prescribing For Pain: What Medical Students Learn And Where They Learn It, Chidinma Tiko-Okoye, Md Mph, Brian Mcanany, Mph, Sharon Larson, Phd:

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

• State of Issue/Problem Addressed
• Background
• Methodology
• Results
• Discussion
• Conclusion

Meet An Ipe Faculty Champion From Thomas Jefferson University

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Leigh Ann Hewston

1. Briefly describe your work with/related to JCIPE.
2. What excites you about this work?
3. Why is IPE/CP important to you?

Clinical Reasoning Skills In Aac Intervention Planning: Investigating The Expert-Novice Gap, Allison M. Sauerwein, Jane R. Wegner

Teaching and Learning in Communication Sciences & Disorders

Clinical reasoning skills underlie the decisions speech-language pathologists (SLPs) make during practice. Although clinical reasoning is included in speech-language pathology accreditation standards in the United States, there is limited research on preservice SLPs’ development or use of clinical reasoning skills. Because clinical reasoning skills specific to augmentative and alternative communication (AAC) service provision have not been identified or reported in depth, this qualitative study focused on two cases of children with developmental disabilities who used AAC systems. Eight novice (i.e. preservice) SLPs and eight expert SLPs completed think-aloud tasks while they developed intervention plans, which made their clinical reasoning skills …

Communication Sciences And Disorders Faculty Perceptions Of Interprofessional Education, Janine L. Schmedding-Bartley, Courtney Karasinski

Teaching and Learning in Communication Sciences & Disorders

Engagement in interprofessional collaborative practice is critical for communication disorders professionals to provide quality clinical services. Given limited research on implementation of interprofessional education (IPE) within communication disorders pre-professional training programs and research highlighting potential barriers to implementation of IPE, this investigation assessed communication sciences and disorders (CSD) faculty attitudes toward IPE. One hundred fifty-eight CSD faculty from accredited CSD graduate programs completed the Interprofessional Attitudes Scale (Norris, Carpenter, Eaton, Guo, Lassche, Pett, & Blumenthal, 2016). Collectively, the faculty supported CSD students learning from and with students from different disciplines and endorsed IPE as beneficial. Faculty with master’s degrees were …

The Impact Of Active Learning In A Speech-Language Pathology Swallowing And Dysphagia Course, Rebecca H. Affoo, Justin L. Bruner, Angela M. Dietsch, Ciara E. Nellenbach, Theresa M. Jones, Mark E. Lehman

Teaching and Learning in Communication Sciences & Disorders

The signature pedagogy in Speech-Language Pathology (SLP) higher education programs has been criticized for its instructor-centric lecture format and emphasis on the lower tiers of Bloom’s taxonomy (simply memorizing knowledge) at the expense of helping students develop the clinical problem-solving skills required for a lifetime of practice and learning. The purpose of this study was to examine the responses of a cohort of graduate speech-language pathology students to an active learning-oriented swallowing and dysphagia course design. A potential relationship between student perceptions of the active learning pedagogy and academic performance was also explored. The results suggest that active learning positively …

Guiding Students' Clinical Writing And Critical Thinking: Utilizing Scholarly Teaching To Develop And Implement A Clinical Writing Rubric, Bonnie Halvorson-Bourgeois, Mary Riotte, Susan Lambrecht Smith, Lesley Maxwell

Teaching and Learning in Communication Sciences & Disorders

The purpose of this paper is to describe the scholarly teaching approach used to develop, implement and refine a clinical writing rubric used to provide formative feedback to graduate students in an in-house Speech-Language Pathology graduate clinic. In addition to outlining the approach, details of the rubric and supporting documentation are provided.

Students' Perspectives Following Involvement In A Constraint Induced Aphasia Therapy Research Project, Bridget R. Dincher, Melissa Mcgrath, Julie Griffith

Teaching and Learning in Communication Sciences & Disorders

The purpose of this project was to provide a reflection on four students’ collaborative research experience implementing Constraint-Induced Aphasia Therapy and highlight the importance of student involvement in research opportunities. Guided reflections were completed and analyzed through a collaborative model to generate common themes of: 1) increased confidence in cuing and 2) adapting individualized treatment. Student engagement in clinical research enhances the quality of their educational experience by fostering clinical competence and confidence.

2020-07-29_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

2020-07-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …

Misuse Of Prescription Stimulants And Their Effect On Cognition, Zachary Friederichs

Theses and Graduate Projects

Prescription stimulants like Adderall and Ritalin are increasingly being diverted and misused by college students who fail to recognize the potential health risks in an effort to improve academic performance. The main aim of this literature review is to address the prevalence of their misuse, the effects they have on cognition, and adverse side effects that are typically associated with their use. Despite being frequently referred to as "cognitive enhancers" or "smart pills," results from studies on these m􏰗edications remain mixed/unclear as to whether cognitive domains such as memory, executive function, and processing speed are actually enhanced. However, not surprisingly, …

In Adults With Difficult Intubations, What Is A Gold Standard Method For Success?, Nathaniel Kitzmann

Theses and Graduate Projects

The objective of this thesis is to analyze existing literature and guidelines for difficult intubations and provide clinical recommendations. This paper is a retrospective analysis of human trials focusing on preparation, medication, and tools in the field of emergency airway management. Techniques will be described and discussed. A large portion of intubations are described as difficult and have the potential to fail. Articles retrieved from databases PubMed, Medline, and PLOS ONE and the search engine Google Scholar were reviewed. Websites for the institutions of the American Society of Anesthesiologists and Difficult Airway Society were used in guidance. Currently, many guidelines …

Neurological Symptoms Due To Coronavirus Disease 2019, Farage Ftiha, Moshe Shalom, Henry Jradeh

Publications and Research

In this review, we focus on summarizing everything that is known about the neurological effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). It has been shown that Coronavirus Disease 2019 (Covid-19) may result in neuromuscular disorders or damage to nerves outside of the brain and spinal cord, which may lead to weakness, numbness, and pain. Published literature has stated that SARS-COV-1 may infect the central nervous system and due to its similarities to SARS-COV-2, we suspect that SARS-COV-2 has the same potential. We conclude that Covid-19 has neurological manifestations. Further research should be done in this field to understand …

Management Of Failed Uka To Tka: Conventional Versus Robotic-Assisted Conversion Technique., Andrew G Yun, Marilena Qutami, Mary Chang-Hwa Chen, Kory B Dylan Pasko

Articles, Abstracts, and Reports

BACKGROUND: Failure of unicompartmental knee arthroplasty (UKA) is a distressing and technically challenging complication. Conventional conversion techniques (CCT) with rods and jigs have produced varying results. A robotic-assisted conversion technique (RCT) is an unexplored, though possibly advantageous, alternative. We compare our reconstructive outcomes between conventional and robotic methods in the management of failed UKA.

METHODS: Thirty-four patients with a failed UKA were retrospectively reviewed. Patients underwent conversion total knee arthroplasty (TKA) with either a CCT or RCT. Seventeen patients were included in each group. All procedures were done by a single surgeon at a single institution, with a mean time …