Medicine and Health Sciences Commons^™

Arthropathy In Hereditary Haemochromatosis Segregates With Elevated Erythrocyte Mean Corpuscular Volume, A. Rehman, G. J. Carroll, L. W. Powell, L. E. Ramm, G. A. Ramm, John K. Olynyk

Research outputs 2014 to 2021

Objective: To evaluate the relationship between erythrocyte parameters and the presence or absence of arthritis in HFE C282Y homozygous hereditary haemochromatosis (HH) subjects compared to control groups of non-HH subjects with arthritis.

Method: Erythrocyte and arthritis parameters [mean corpuscular volume (MCV) and mean cell haemoglobin (MCH)] were obtained from consecutive HH subjects (n = 119) who were referred for initial evaluation and management. For comparison, MCV and MCH values were collected from randomly selected non-HH subjects with rheumatoid arthritis (n = 100) and osteoarthritis (n = 100), consisting of equal numbers of men and women. Two other comparison groups comprised …

A Pilot Evaluation Of Simulation-Based Interprofessional Education For Occupational Therapy, Speech Pathology And Dietetic Students: Improvements In Attitudes And Confidence, Brennen Mills, Sara Hansen, Charn Nang, Helen Mcdonald, Philippa Lyons-Wall, Jacqui Hunt, Therese O’Sullivan

Research outputs 2014 to 2021

Many higher education institutions struggle to provide interprofessional practice opportunities for their pre-licensure students due to demanding workloads, difficulties with timetabling, and problems with sourcing suitable placements that provide appropriate practice opportunities. A series of complex unfolding video-based simulation scenarios involving a patient who had experienced a stroke was utilized as a case study for a three-hour interprofessional practice workshop. 69 occupational therapy (OT), speech pathology (SP) and dietetics (DT) students participated in a mixed-methods study comparing interprofessional attitudes before and after the workshop. Attitudes toward interprofessional practice improved pre- vs. post-workshop and overall. Students were highly satisfied with the …

Cbf-1 Promotes The Establishment And Maintenance Of Hiv Latency By Recruiting Polycomb Repressive Complexes, Prc1 And Prc2, At Hiv Ltr., Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Shilpa Sonti, Sonia Zicari, Lin Sun, Aseel Alqatawni, Michael Bukrinsky, Gary Simon, Ashok Chauhan, René Daniel, Mudit Tyagi

Center for Translational Medicine Faculty Papers

The C-promoter binding factor-1 (CBF-1) is a potent and specific inhibitor of the human immunodeficiency virus (HIV)-1 LTR promoter. Here, we demonstrate that the knockdown of endogenous CBF-1 in latently infected primary CD4+ T cells, using specific small hairpin RNAs (shRNA), resulted in the reactivation of latent HIV proviruses. Chromatin immunoprecipitation (ChIP) assays using latently infected primary T cells and Jurkat T-cell lines demonstrated that CBF-1 induces the establishment and maintenance of HIV latency by recruiting polycomb group (PcG/PRC) corepressor complexes or polycomb repressive complexes 1 and 2 (PRC1 and PRC2). Knockdown of CBF-1 resulted in the dissociation of PRCs …

Erratum: Increased Risk Of Tinnitus Following A Trigeminal Neuralgia Diagnosis: A One-Year Follow-Up Study (J Headache Pain (2020) 21 (46) Doi: 10.1186/S10194-020-01121-6), Yen Fu Cheng, Sudha Xirasagar Mbbs., Ph.D, Tzong Han Yang, Chuan Song Wu, Yi Wei Kao, Ben Chang Shia, Herng Ching Lin

Publications

Following publication of the original article [1], we were notified that the following affiliations need to be added for the first author Yen-Fu Cheng: Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.

Elementary Classroom Teachers’ Self-Reported Use Of Movement Integration Products And Perceived Facilitators And Barriers Related To Product Use, Roddrick Dugger, Aaron Rafferty, Ethan Hunt, Michael W. Beets, Collin Andrew Webster, Brian Chen, Jeffrey Michael Rehling, Robert Glenn Weaver

Faculty Publications

Movement integration (MI) products are designed to provide children with physical activity during general education classroom time. The purpose of this study was to examine elementary classroom teachers’ self-reported use of MI products and subsequent perceptions of the facilitators of and barriers to MI product use. This study utilized a mixed-methods design. Elementary classroom teachers (n = 40) at four schools each tested four of six common MI products in their classroom for one week. Teachers completed a daily diary, documenting duration and frequency of product use. Following each product test, focus groups were conducted with teachers to assess facilitators …

Surface Modification Of Biomaterials To Reduce Polyethylene Wear In Metal-Polymer Contact / Tan Mean Yee, Tan Mean Yee

Student Works (2020-2029)

This research focus on studying different surface modification (Texturing and DLC coating) on the metal part of TKR (Total knee replacement) in improving UHMWPE (Ultra-high molecular weight polyethylene) wear. TKR was widely being used to relieve knee pain due to osteoarthritis and further restore knee function of patients. Generally, TKR consists of metal femoral component, metal tibial component, and UHMWPE tibial insert. TKR will fail due to various factors over time, however, this study will be focusing on failure cause by loosening. Loosening failure of TKR was mainly caused by wear debris generated during articulation motion, where UHMWPE wear was …

Linguistic Analysis Of Empathy In Medical School Admission Essays, Mary Yaden, David Yaden, Anneke Buffone, Johannes Eichstaedt, Patrick Crutchley, Laura Smith, Jonathan Cass, Clara Callahan, Susan Rosenthal, Lyle Ungar, Andrew Schwartz, Mohammadreza Hojat

Department of Psychiatry and Human Behavior Faculty Papers

Objectives: This study aimed to determine whether words used in medical school admissions essays can predict physician empathy.

Methods: A computational form of linguistic analysis was used for the content analysis of medical school admissions essays. Words in medical school admissions essays were computationally grouped into 20 'topics' which were then correlated with scores on the Jefferson Scale of Empathy. The study sample included 1,805 matriculants (between 2008-2015) at a single medical college in the North East of the United States who wrote an admissions essay and completed the Jefferson Scale of Empathy at matriculation.

Results: After correcting for multiple …

Educational Case: A Case Of Transfusion-Transmitted Babesiosis: Diagnostic Perspectives Across The Clinical Laboratory., Kaitlyn Dykes, Alexis R. Peedin

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology.

Cross-Sectional Associations Between The Neighborhood Built Environment And Physical Activity In A Rural Setting: The Bogalusa Heart Study., Jeanette Gustat, Christopher E Anderson, Queendaleen C Chukwurah, Maeve E Wallace, Stephanie T Broyles, Lydia A Bazzano

School of Public Health Faculty Publications

Background: Insufficient physical activity (PA) is a common health risk and more prevalent in rural populations. Few studies have assessed relationships between the built environment and PA in rural settings, and community policy guidance to promote PA through built environment interventions is primarily based on evidence from urban studies.Methods: Participants in the Bogalusa Heart Study, a longitudinal study in rural Louisiana, with International Physical Activity Questionnaire data from 2012 to 2013 and a valid residential address (N = 1245) were included. PA was summarized as the number of weekly metabolic equivalent (MET)-minutes of total, transportation, and leisure time PA. The …

Pain In The Prehospital Setting In Rwanda: Results Of A Mixed-Methods Quality Improvement Project., A Rosenberg, E Uwitonze, M Dworkin, J P D Guidry, T Cyuzuzo, D Banerjee, K Mcintyre, K Carlyle, J M Uwitonze, I Kabagema, T Dushime, S Jayaraman

Student Papers, Posters & Projects

Introduction: Pain is a universal human experience tied to an individual's health but difficult to understand. It is especially important in health emergencies. We performed a two-step quality improvement project to assess pain management by the SAMU ambulance service in Kigali, Rwanda, examining how pain is assessed and treated by ambulance staff to facilitate development of standardized guidelines of pain management in the prehospital setting, which did not exist at the time of the study.

Materials and Methods: Deidentified ambulance service records from December 2012 to May 2016 were analyzed descriptively for patient demographics, emergency conditions, pain assessment, and medications …

Intratumoral Translocation Positive Heterogeneity In Pediatric Alveolar Rhabdomyosarcoma Tumors Correlates To Patient Survival Prognosis, Katrina Gleditsch, Jorge Peñas, Danielle Mercer, Ayesha Umrigar, James Briscoe, Matthew Stark, Fern Tsien, Andrew D. Hollenbach

School of Medicine Faculty Publications

Alveolar rhabdomyosarcoma (ARMS) is characterized by one of three translocation states: t(2;13) (q35;q14) producing PAX3-FOXO1, t(1;13) (p36;q14) producing PAX7-FOXO1, or translocation-negative. Tumors with t(2;13) are associated with greater disease severity and mortality than t(1;13) positive or translocation negative patients. Consistent with this fact, previous work concluded that a molecular analysis of RMS translocation status is essential for the accurate determination of prognosis and diagnosis. However, despite this knowledge, most diagnoses rely on histology and in some cases utilize fluorescence in situ hybridization (FISH) probes unable to differentiate between translocation products. Along these same lines, diagnostic RT-PCR analysis, which can differentiate …

An Analysis Of A New Shoe Technology In The Gait Patterns Of A Child With A Neurological Disability, Emma Madonna, Jeff Bauer

The SUNY Journal of the Scholarship of Engagement: JoSE

This study focused on the application of a unique technology originally designed to supply biofeedback to dancers, but in this case was used to assist a child learning to walk while battling the effects of Cerebral Palsy. The musical shoes, called Electroskip^TM, utilize a biofeedback system that generates variable sounds/beats/songs when an individual is walking and placing pressure on their heel or toe. The study lasted six weeks with two sessions per week. Each session started with shoes fitted with Electroskip^TM technology placed on the child’s feet. When instructed by the researcher the child would proceed to …

Association Of Body Shape Index (Absi) With Hand Grip Strength, Nir Y. Krakauer, Jesse C. Krakauer

Publications and Research

Hand grip is a leading measure of muscle strength and general health, yet its association with body shape is not well characterized. Here, we examine correlations between grip strength, a body shape index (ABSI), and body mass index (BMI) in the 2011–2014 United States National Health and Nutrition Examination Survey cohorts. Grip strength was found to correlate negatively with ABSI (though positively with BMI), suggesting that those with a more central body profile tend to be weaker than others with the same weight. Individuals with low grip strength, as well as those with high ABSI, were more likely to die …

2020-09-17_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Characterization Of The Intraarticular Cytokine Response In Children With Septic Arthritis, Walter Dehority, Kathryn Helmig, Scott Plaster, Nathan Huff, Andrew Parsons, Selina Silva

2020 Pediatric Research Forum Session

Background:

Acute septic arthritis (ASA) is the most common pediatric orthopaedic infection, and may be associated with severe sequelae. An improved understanding of the intra-articular inflammatory response in ASA may facilitate the use of immunomodulatory agents to attenuate the deleterious effects of the host immunological response on synovial tissue, help monitor disease progression and differentiate ASA from non-infectious arthritides. To our knowledge, no study has characterized the intra-articular cytokine response in children with ASA in detail. Given this, we attempted to validate a multi-plex cytokine assay for use in the blood and synovial fluid of children with ASA.

Methods:

Twelve …

Effects Of Race/Ethnicity On Appendicitis Pain Management, Alfonso Belmonte, Christal Chow, Maria Heubeck, Deirdre Hill, Harry Snow

2020 Pediatric Research Forum Session

Background:

Race is a well-researched factor that contributes to variation in care of multiple diagnoses such as asthma, antibiotic prescribing, and pain control. This is also true for appendicitis. As the 6th most common cause for inpatient stay, it costs on average of $7,800 per patient. Despite efforts to standardize care, race and ethnicity continue to play a role in treatment and outcomes on pediatric appendicitis.

We hope to further explore the effects that race/ethnicity have in medical care, diagnosis and complications of acute pediatric appendicitis. We hope that identifying these effects will help providers to actively address race/ethnic health …

E. Behavioral Evaluation And Addiction Management (Beam) Team, Deanne Niedziela

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

D. Improved Management Of Patients Experiencing Alcohol Withdrawal, Arianna Barnes

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

Cinematic Portrayal Of Infectious Disease Outbreaks, Walter Dehority

2020 Pediatric Research Forum Session

Background:

Movies are a shared cultural experience. Films likely reflect societal fears, and may provide insight into how the public perceives infectious disease outbreaks.

Methods:

A search of IMDb.com was conducted in February/March 2020 (updating a 2017 search) using 163 infection-related search terms to identify films with an emphasis on infectious diseases (as assessed by review of plot synopses on IMDb, the American Film Institute database, or Wikipedia) through December 31, 2019. Films featuring an outbreak or pandemic (as defined by the CDC, with the outbreak/pandemic required to be an important component of the story) were then selected. Cultural relevance …

Pathogen-Specific Neurocognitive Outcomes In Tropical Childhood Encephalitis, Christal Chow, Ashan Jayawickrama, Jithangi Wanigasinghe, Piyadasa Kodituwakku, Kurt Schwalm, Darrell Dinwiddie, John Phillips, Walter Dehority

2020 Pediatric Research Forum Session

Background:

Childhood encephalitis causes long-term neurocognitive disability, which may lead to secondary disabilities such as poor academic achievement and social isolation. This is particularly problematic in resource limited, tropical countries, where the burden of vector-borne viral encephalitis is substantial, yet the resources for identifying the myriad of pathogens involved and characterizing the resulting neurocognitive sequelae are limited. To our knowledge, comprehensive assessments of neurocognitive function following tropical childhood encephalitis have not been performed. We hypothesize that the risk of neurocognitive sequelae is pathogen-specific, and that the use of portable, on-site metagenomic Next Generation Sequencing of CSF in Sri Lankan children …

H. Advancing Your Education To The Doctoral Level: Dnp, Phd, Edd: Dr. Sheli Hicks Cain, Sheli Hicks Cain

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

F. Advancing Your Education To The Doctoral Level: Doctor Of Nursing Practice (Dnp), Marilyn Steinberg

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

J. Diet Advancement For Cesarean Section Patients In Postpartum Unit, Fereshteh Pirayesh, Joan Gahan, Ari Meyers

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

C. Blind Taste Testing: A Case Study Of An Emergency Room Rn With Covid-19 Anosmia & Hypogeusia (Loss Of Smell & Taste), Marietta Sperry, Kimberly Kohlieber

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

I. Interventions To Decrease Stroke Patient Falls On The Stroke Unit, Courtney Herron

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

A. Keynote: Broadcasting Stress In The Covid-19 Pandemic: Media, Collective Trauma, & Well-Being, E. Alison Holman (Invited Keynote Speaker)

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

K. Use Of A Standardized Procedure To Improve Care For Behavioral Health Patients, Elizabeth Winokur

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

B. The Effects Of The Safety Zone Process On Perception Of Safety, Workflow, Wellbeing And Teamwork When Caring For Covid-19 Patients, Claudia Skinner

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

A. Where Are We Now? Nursing Research In Southern California, Jan L. Keller-Unger

Year of the Nurse: Clinical Scholarship Presentations

No abstract provided.

2020-09-17_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.