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2020-09-17_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-09-17_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Renal Proximal Tubular Nemo Plays A Critical Role In Ischemic Acute Kidney Injury, Sang Jun Han, Ryan M. Williams, Mihwa Kim, Daniel A. Heller, Vivette D'Agati, Marc Schmidt-Supprian, H. Thomas Lee

Publications and Research

We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle–encapsulated NEMO binding peptide (NBP MNP). We subjected renal PT NEMO–deficient mice, WT mice, and C57BL/6 mice to sham surgery or 30 minutes of renal ischemia and reperfusion (IR). C57BL/6 mice received NBP MNP or empty MNP before renal IR injury. Mice treated with NBP MNP and mice deficient in renal PT NEMO were protected against ischemic AKI, having decreased renal tubular …

Defining Pain And Interference Recovery Trajectories After Acute Non-Catastrophic Musculoskeletal Trauma Through Growth Mixture Modeling, Joshua Y. Lee, David M. Walton, Paul Tremblay, Curtis May, Wanda Millard, James M. Elliott, Joy C. Macdermid

Bone and Joint Institute

© 2020 The Author(s). Background: Recovery trajectories support early identification of delayed recovery and can inform personalized management or phenotyping of risk profiles in patients. The objective of this study was to investigate the trajectories in pain severity and functional interference following non-catastrophic musculoskeletal (MSK) trauma in an international, mixed injury sample. Methods: A prospective longitudinal cohort (n = 241) was formed from patients identified within four weeks of trauma, from attendance at emergency or urgent care centres located in London, ON, Canada, or Chicago, IL, USA. Pain interference was measured via the Brief Pain Inventory (London cohort) or the …

A Century Later: Rural Public Health's Enduring Challenges And Opportunities., Erika C. Ziller Phd, Carly Milkowski Mph

Population Health

The US public health community has demonstrated increasing awareness of rural health disparities in the past several years. Although current interest is high, the topic is not new, and some of the earliest public health literature includes reports on infectious disease and sanitation in rural places. Continuing through the first third of the 20th century, dozens of articles documented rural disparities in infant and maternal mortality, sanitation and water safety, health care access, and among Black, Indigenous, and People of Color communities. Current rural research reveals similar challenges, and strategies suggested for addressing rural-urban health disparities 100 years ago resonate …

Ambivalence In How To Address Adolescent Marijuana Use Among School-Based Health Center Providers, Rachel A. Sebastian, Lara M. Gunderson, Cathleen E. Willging, Mary M. Ramos

2020 Pediatric Research Forum Session

Objective:

As part of a larger study to evaluate the implementation of Screening, Brief Intervention, and Referral to Treatment (SBIRT) at school-based health centers (SBHCs), we interviewed SBHC providers regarding their perceptions of substance use among adolescents seen at their SBHCs, experiences providing care for students with substance use and other mental health issues, and their concerns around marijuana specifically.

Methods:

We interviewed 12 primary and behavioral health providers who worked at five SBHCs in New Mexico. The interviews lasted approximately 1 hour and were digitally recorded and professionally transcribed. Two research team members independently analyzed the transcripts. We undertook …

An Institutional Experience With Emicizumab In Pediatric Patients With Heophilia A, Shirley Abraham, Lisa Jung, Janet Ratte, Valerie Lowe

2020 Pediatric Research Forum Session

Background: Emicizumab is a recombinant, humanized, bispecific monoclonal antibody that substitutes for the function of FVIII by binding to activated factor IX and X. It is currently indicated for routine prophylaxis in adults and children of all ages with hemophilia A, with or without inhibitors. Despite basic guidelines provided by MASAC and the drug package insert, there is significant inter-institutional variability regarding monitoring and follow up in patients on emicizumab.

Objective: To outline our institutional experience in pediatric patients on emicizumab.

Method: Retrospective and prospective chart review of our patients on emicizumab. Information collected included age of patient, hemophilia severity, …

Increased Incidence Of Asthma In Children With Prenatal Opioid Exposure, Isabella Cervantes, Shikhar Shrestha, Sharon Ruyak, Jessie R. Maxwell

2020 Pediatric Research Forum Session

Prenatal opioid exposure (POE) has increased dramatically in the last 10 years, with nearly 100 babies born daily in the United States with Neonatal Opioid Withdrawal Syndrome (NOWS). The impact on long-term outcomes continues to be investigated. Given the proinflammatory state that results from POE, we hypothesized that infants with POE or NOWS diagnoses during the newborn hospitalization would have an altered immune reactivity that persisted into childhood, defined by asthma diagnosis within the first 8 years.

A retrospective cohort design utilizing a comprehensive CERNER HealthFacts U.S. national database was completed, which accesses clinical data from 800 hospitals across the …

A Technical Assistance Model To Facilitate Use Of The School Health Index To Assess Chronic Health Condition Management In Schools, Grace L. Mccauley, Sarah Sanders, Anne Marlow-Geter, Elizabeth Yakes Jimenez

2020 Pediatric Research Forum Session

Introduction:

Chronic health conditions, such as asthma and food allergies, affect a substantial proportion of school-aged children in New Mexico (NM). School health services, policies, programs, and practices can affect daily management of chronic pediatric health conditions. The Center for Disease Control and Prevention’s School Health Index (SHI) is a self-assessment and planning guide that evaluates school services, policies, and programs for promoting health and safety. Our aim was to determine if a technical assistance (TA) model could effectively support school districts in using the SHI to complete a chronic disease needs assessment (CDNA).

Methods:

Seven public and one charter …

Comparison Of Virulence Gene Carriage In Staphylococcus Aureus Isolates Colonizing Human Skin And Those Associated With Soft Tissue Osteoarticular Infections, Kylie Disch, Jon Femling, Parisa Mortaji, Kurt Schwalm, Aimee Yousey, Rebekkah Varjabedian, Darrell Dinwiddie, Walter Dehority

2020 Pediatric Research Forum Session

Background:

Osteoarticular infections (OAI), most commonly caused by S. aureus, cause extreme morbidity in children and may result in permanent sequelae (e.g. limb-length discrepancies). However, S. aureus is also a common colonizing bacteria of skin and a cause of soft tissue abscesses. Virulence determinants for S. aureus are likely complex, and may include the genetic composition of the isolate, the host immune response and the transcriptomic profile of the organism. A necessary first-step in characterizing these virulence factors includes assessing virulence gene carriage between S. aureus isolates from children with OAIs and from less virulent isolates.

Methods:

S. aureus …

Baseline Results From The Strategic Implementation Of Screening, Brief Intervention And Referral To Treatment (Sbirt) In School‐Based Health Centers Initiative, Grace Mccauley, Timothy Ozechowski, Julia Martinez, Elizabeth Yakes Jimenez, Mary M. Ramos

2020 Pediatric Research Forum Session

Introduction:

The rates of substance use among teens in NM are among the highest in the US. Regular use of illicit drugs during adolescence can compromise mental and physical health and contribute to poorer longer-term outcomes. The Strategic Implementation of Screening, Brief Intervention and Referral to Treatment (SBIRT) in School‐Based Health Centers (SBHCs) [SISS] initiative implements and evaluates the SBIRT model, with a goal of identifying, reducing, and preventing substance use in New Mexico (NM) adolescents. For this analysis, we describe baseline data on the provision of SBIRT to adolescents at‐risk for substance abuse.

Methods:

From October to December 2019, …

The Window Ductus, A Rare Finding, And The Importance Of Perinatal Echocardiography, Storm Dorrough, Gavin Mccullough, Michelle Grenier

2020 Pediatric Research Forum Session

Category: Case Report

We present a case of an unusual form of the ductus arteriosus termed “window ductus,” and highlight the importance of early recognition echocardiogram. The patient presented as a 22 week fetus due to advanced maternal age, maternal cardiomyopathy, and an abnormal 4-chamber view on the fetal anatomy ultrasound. Fetal images were consistent with polyvalvular disease with redundancy of the mitral, tricuspid and aortic valves. There was an extremely abnormal pulmonic valve that was thickened, stenotic, and regurgitant due to relative immobility of the cusps, creating a narrow, tunnel-like orifice and post-stenotic dilated main pulmonary artery. The right …

Microglial-Associated Responses To Comorbid Amyloid Pathology And Hyperhomocysteinemia In An Aged Knock-In Mouse Model Of Alzheimer's Disease, David J. Braun, Edgardo R. Dimayuga, Josh M. Morganti, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer's disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any benefit to cognition. In the context of amyloid pathology, dietary-induced HHcy is known to enhance amyloid deposition and certain inflammatory responses. Little is known, however, about whether there is a more specific effect on microglia resulting from combined amyloid and HHcy pathologies.

METHODS: The present study used a knock-in mouse model of amyloidosis, aged to 12 months, given 8 weeks of …

2020-09-17_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …

Prenatal Alcohol Exposure And Placental Insufficiency Results In Reduced Neuronal Complexity In The Rat Prefrontal Cortex, Nathaniel Pavlik, Jessie Newville, Clement P. Jose, Suzy Davies, Jennifer Wagner, Jonathan Brigman, Daniel Savage, Jessie R. Maxwell

2020 Pediatric Research Forum Session

Prenatal Alcohol Exposure (PAE) can produce long-term neurodevelopmental deficits and impaired executive function. Alcohol exposure during gestation is associated with impaired fetal development caused by placental insufficiency. The impact following PAE and placental insufficiency (PI) remains unknown. Utilizing a three-dimensional (3D) Sholl analysis, we hypothesized that PAE+PI will result in decreased neuronal complexity within the frontal cortex, a region critical to executive functioning.

Pregnant Long-Evans rats voluntarily drank 5% ethanol or saccharin water until embryonic day 18 (E18) to mimic moderate PAE. On E19, a laparotomy was performed to occlude the uterine artery for 60 minutes to induce PI. The …

Emergency Department "Bounce-Back" Rates As A Function Of Emergency Medicine Training Year., Janine Curcio, Andrew Little, Chelsea Bolyard, Anand Gupta, Michelle Secic, Meenal Sharkey

OhioHealth Research Institute Articles

INTRODUCTION: Since the 1990s, the emergency department (ED) unscheduled return visit (URV), or "bounce-back," has been used as a quality of care measurement. During that time, resident training was also scrutinized and uncovered a need for closer resident supervision, especially of second-year residents. Over the years, bounce-backs have continued to be analyzed with vigor, but research on residency training and supervision has lagged with few studies concurrently investigating residency supervision and bounce-backs. Other literature on resident supervision suggests that with adequate attending supervision, resident performance is equivalent to attending performance. With that in mind, it was hypothesized that resident bounce-back …

Ocho Pasos: A Quality Improvement Pilot To Improve Outpatient Clinic Breastfeeding Support, Julia M. Martinez, Timothy J. Ozechowski, Rachel A. Sebastian, Emilie A. Sebesta, Mary M. Ramos

2020 Pediatric Research Forum Session

Purpose of Study:

Only a third of US mothers achieve three months of exclusive breastfeeding (BF) despite the American Academy of Pediatrics (AAP) recommendation to exclusively BF for six months. National experts have recently published evidence-based guidelines for outpatient clinics to support longer durations of BF. Our pilot study sought to evaluate the feasibility of an intervention to improve support for BF in outpatient primary care clinics.

Methods Used:

We compared evidence-based BF-friendly guidelines from the AAP, Academy of Breastfeeding Medicine, California’s 9 Steps, and Washington’s 10 Steps to create Ocho Pasos (Eight Steps),guidelines tailored to the New Mexico population. …

Improving Support Of Breastfeeding At A Baby-Friendly™ Designated Hospital In Albuquerque, New Mexico, Troy Hatfield, Connie Peceny, Julia M. Martinez, Priscilla Mendoza, Timothy J. Ozechowski, Rachel A. Sebastian, Emilie A. Sebesta, Mary M. Ramos

2020 Pediatric Research Forum Session

Purpose:

Breastfeeding has conclusively proven to be the healthiest feeding option for infants. Baby-Friendly™designated hospitals and birthing centers follow the Ten Steps to Successful Breastfeeding, which are considered to be the gold standard for supporting mothers who wish to breastfeed. However, even a Baby-Friendly™designated hospital may have room for improvement. The University of New Mexico Hospital (UNMH) is an urban hospital serving a predominantly Hispanic and Native American population, and the majority of pediatric patients are covered by Medicaid. Despite its Baby-Friendly™ designation, UNMH had low rates of physician documentation of discussing the health impacts of breastfeeding in the postpartum …

Erlotinib Therapy For Recurrent Respiratory Paillomatosis And Extralaryngeal Spread In Pediatrics, Shirley Abraham, John Kuttesch, Erica Bennett

2020 Pediatric Research Forum Session

Background:

Recurrent respiratory papillomatosis (RRP) can be a potentially life-threatening condition and a treatment challenge. Local therapies are associated with significant scarring and detrimental effects on voice and respiratory status. EGFR inhibitors have been reported to be an effective adjunctive therapy in patients with RRP.

Objective:

To report our institutional experience with Erlotinib in two pediatric patients with severe RRP.

Method:

Retrospective chart review of 2 pediatric patients with severe RRP.

Results:

Patient 1 is a 19y/o female who was referred to us at the age of 11. Patient was diagnosed with respiratory papillomatosis at birth. Since age 1.5yrs, she …

Food And Housing Insecurity Screening Practices Among Unmh Pediatric Providers, Crystal Avila-Schroeder, Kyle Randolph, Lorena Galvan, Ana Duran, Maria Velazquez-Campbell

2020 Pediatric Research Forum Session

Introduction:

The American Academy of Pediatrics recommends food insecurity (FI) screening at all pediatric visits. Despite an existing EMR screening tool, how our pediatric providers screen FI and housing insecurity (HI) is unknown. Our objective was to collect formative data on FI and HI screening practices of UNMH pediatric providers to allow for the design of a quality improvement (QI) project.

Methods:

We performed a baseline cross-sectional survey with UNMH pediatric residents and attendings in May 2020.

Results:

Fifty-two individuals completed the survey (40.4% attendings, 59.6% residents). In inpatient settings, 67.8% of residents and 33.3% of attendings screen FI occasionally …

Operability, Usefulness, And Task-Technology Fit Of An Mhealth App For Delivering Primary Health Care Services By Community Health Workers In Underserved Areas Of Pakistan And Afghanistan: Qualitative Study, Shehla Zaidi, Abdul Momin Kazi, Atif Riaz, Ammarah Ali, Rabia Najmi Taha, Rawshan Jabeen, Umerdad Khudadad, Saleem Sayani

Community Health Sciences

Background: The recent proliferation of digital health technology in low- and middle-income countries has made it possible for community health workers (CHWs) to use mobile health (mHealth) to perform tasks such as data collection and training. Although most studies focus on the prospect of digital apps to motivate and connect CHW, only a few have captured end-user experiences with mobile-based apps. We examined the experience of frontline health workers with a move towards digitalized real-time data to record maternal and childcare services in remote areas of Afghanistan and Pakistan.
Objective: Our study aimed to explore CHW perceptions on the operability …

Localized Intravascular Coagulopathy Of Venous Malformation Involving The Labia As A Mimic Of Child Sexual Abuse: A Case Report, Leslie Strickler, Lan Anh Van-Dinh, Christopher Torrez, Jessica Williams

2020 Pediatric Research Forum Session

Given location and relative rarity, ano-genital injuries in children often prompt concern for maltreatment. We present a case of localized intravascular coagulopathy as a complication of venous malformation, which mimicked abusive trauma leading to an evaluation for maltreatment. Comprehensive assessment identified the underlying medical cause. This case represents an example of the importance of objective assessment in unusual case presentations to ensure diagnostic accuracy, and appropriate direction of medical and child protection resources.

Lamotrigine Overdose Presenting As Shock And Pulmonary Edema, Savannah P. Ellenwood, John A. Mason, Nathaniel E. Link, Robert C. Hellinga, Natasha C. James, Anjali V. Subbaswamy

2020 Pediatric Research Forum Session

Abstract:

Lamotrigine is a broad-spectrum anti-epileptic drug with a good safety profile used to treat general and focal epilepsy. Toxicity is uncommon and usually mild, and symptoms usually include rash, headache, nausea, abdominal pain, somnolence, dizziness, and aggravated seizure activity. More severe adverse reactions are rare, but have been reported and include encephalopathy, hypotension, wide complex tachycardia, cardiac arrest, and death. Lamotrigine drug levels do not consistently correlate with either therapeutic effect or toxicity, though higher levels are thought to have a higher risk of toxicity. Also, the level is typically a send out test with a 1 to 3 …

Screening For And Diagnosing Malnutrition In Hospitalized Pediatric Patients, Samuel Thompson, Erin Lamers-Johnson, Kathryn Kelley, Lindsay Woodcock, Julie Long, Courtney Bliss, Jenica K. Abram, Alison Steiber, Elizabeth Yakes Jimenez

2020 Pediatric Research Forum Session

Background:

Malnutrition is often underdiagnosed, and consequently undertreated, in hospitalized patients. A nationwide study is being conducted to validate indicators (the Malnutrition Clinical Characteristics [MCC]) to diagnose malnutrition in hospitalized patients.

Methods:

For the full study, sixty pediatric hospitals will collect patient medical history, patient STRONGKids malnutrition screening score, and nutrition intervention data. Six hundred pediatric patients will be randomly selected from the cohort to be assessed for the MCC and the Nutrition Focused Physical Exam (NFPE). Medical outcomes will be collected for all patients for a three-month period thereafter. Baseline data from a subset of sites that have started …

What Procedural Skills Are Practiced By Pediatricians In New Mexico?, Christal P. Chow, Anne Greene, Grace Mccauley

2020 Pediatric Research Forum Session

Background:

By the end of residency, pediatric residents are expected to be competent in 13 clinical procedures (bag mask ventilation, neonatal endotracheal intubation, umbilical catheter placement, lumbar puncture, simple laceration repair, incision and drainage of abscess, reduction of simple dislocation, temporary splinting of fractures, giving immunizations, bladder catheterization, peripheral intravenous catheter placement, removal of foreign body, and venipuncture). These procedural skills were initially identified as essential for practice in the general pediatric setting. However, procedures performed vary based on location, patient population, practice type, tertiary care support, etc. There are few studies available that evaluate the procedural skills used in …

Healers Of Tomorrow Zia Youth Project, Eliana Garcia, Emelia Pino, Anthony Fleg, Daisy Belmares-Ortega, Kevin Dileanis, Talyia Torres

2020 Pediatric Research Forum Session

This youth advocacy effort follows the story of high school student Emelia Pino and Healers of Tomorrow leaders as they work to address health inequities in her home of Zia Pueblo, one of the communities hit hardest in New Mexico by the pandemic.

While taking part in The Healers of Tomorrow Program, a mentorship program for underrepresented high school students, Emelia conveyed the hardships her people were experiencing to program leaders. This kickstarted allied relief efforts in response to rising COVID-19 cases. Emilia and her mentors worked alongside several organizations, including NHI and Protect New Mexico, to gather PPE and …

Semmes Weinstein Sensory Testing At The Fingertip: Should 2.83 Be The Norm?, Emily Moore, Ogochukwu Nwagbologu, Samantha Specht, Rebecca A. Dutton, Patricia Siegel

2020 Pediatric Research Forum Session

Category: In-Progress Research

The Semmes-Weinstein monofilament test (SWM) is an objective test of sensation that is commonly used to identify sensory impairments in the hand.

Objective:

To determine if male and female subjects aged 25 and older with no history of sensory symptoms or known neurologic conditions would feel the 2.83 (normal) Semmes Weinstein monofilament, and if a relationship between the detected monofilament and grip strength exists.

Outcome Measures:

Ability to detect the 2.83 (normal) monofilament at the fingertip. Participants were dichotomized into two groups: the 2.83 “normal” (ability to detect the 2.83 monofilament in three or …

A Sonographer’S Step-By-Step Approach For Preventing Transmission Of Covid-19, Corinne Wessner, Joann Nelson, Sarah Mott, Maria Francesco, Laurence Needleman

Department of Radiology Faculty Papers

The 2019 novel coronavirus, known as COVID-19, has greatly affected the way sonographers care for their patients. Sonography can be a useful imaging tool for surveillance and diagnosis of various conditions associated with COVID-19 patients or patients under investigation (PUIs). Currently, there are limited resources and protocols for preventing the transmission of COVID-19 from ultrasound equipment. Our institution has created a detailed protocol for scanning COVID-19 patients or PUIs to address this important issue.

Supporting Coordination Of Children With Asd Using Neurological Music Therapy: A Pilot Randomized Control Trial Comparing An Elastic Touch-Display With Tambourines, Franceli L. Cibrian, Melisa Madrigal, Marina Avelais, Monica Tentori

Engineering Faculty Articles and Research

Aim

To evaluate the efficacy of Neurologic Music Therapy (NMT) using a traditional and a technological intervention (elastic touch-display) in improving the coordination of children with Autism Spectrum Disorder (ASD), as a primary outcome, and the timing and strength control of their movements as secondary outcomes.

Methods

Twenty-two children with ASD completed 8 NMT sessions, as a part of a 2-month intervention. Participants were randomly assigned to either use an elastic touch-display (experimental group) or tambourines (control group). We conducted pre- and post- assessment evaluations, including the Developmental Coordination Disorder Questionnaire (DCDQ) and motor assessments related to the control of …

Etv6 Germline Mutations Cause Hdac3/Ncor2 Mislocalization And Upregulation Of Interferon Response Genes., Marlie H. Fisher, Gregory D. Kirkpatrick, Brett Stevens, Courtney Jones, Michael Callaghan, Madhvi Rajpurkar, Joy M. Fulbright, Megan A. Cooper, Jesse Rowley, Christopher C. Porter, Arthur Gutierrez-Hartmann, Kenneth Jones, Craig Jordan, Eric M. Pietras, Jorge Di Paola

Manuscripts, Articles, Book Chapters and Other Papers

ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to malignancy; however, molecular mechanisms defining the role of ETV6 in megakaryocyte development have not been well established. Using a combination of molecular, biochemical, and sequencing approaches in patient-derived PBMCs, we demonstrate abnormal cytoplasmic localization of ETV6 and the HDAC3/NCOR2 repressor complex that led to overexpression of HDAC3-regulated interferon response genes. This transcriptional dysregulation was also reflected in patient-derived platelet transcripts and drove aberrant proplatelet formation …