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2020

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Articles 20341 - 20370 of 20660

Full-Text Articles in Medicine and Health Sciences

Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong Jan 2020

Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Seasonal influenza viruses commonly cause respiratory disease and have a considerable impact on public health threats which annually estimates 3 to 5 million cases of severe illness worldwide. The triggering of the seasonal influenza epidemic results from a complex interplay between viral, host and external factors such as climate. Although vaccination is an effective tool for influenza prevention and its complications, the composition of vaccine strain has been changed every year due to influenza constantly evolving. Here, we aim to examine the association between influenza activity and local climate factors, host immunity, genetic and antigenic variation and evolution pattern among …

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Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek Jan 2020

Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek

Chulalongkorn University Theses and Dissertations (Chula ETD)

Liver cancer is one of the most cancer-related mortality with high incidence worldwide. Hepatocellular carcinoma (HCC) is the most common liver cancer type. Currently, Liquid biopsy is known as a non-invasive biomarker tool that specifically represents tumor appearance, leading to improved patient outcomes. Therefore, the novel biomarkers of liquid biopsy in Thai HCC patients are still unexplored and needed for precision medicine. The main aims of this study were First, to explore genetic profiles from liquid biopsies of circulating cell-free DNA (cfDNA) and peripheral blood mononuclear cells (PBMCs) using next-generation sequencing (NGS) and identify novel biomarkers for HCC from these …

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A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat Jan 2020

A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To compare the efficacy and safety of topical bevacizumab eye drop versus intra-meibomian gland injection of bevacizumab when used with the standard lid hygiene in meibomian gland dysfunction (MGD) patients. Methods: 60 eyes of 30 MGD patients with lid margin telangiectasia were randomized to receive 0.05% bevacizumab eye drop or single 2.5% intra-meibomian gland bevacizumab injection plus standard lid hygiene. The primary outcomes were telangiectasia grading and the computerized lid margin neovascularized area (LMNA). The secondary outcomes were the ocular surface disease index (OSDI) score, corneal staining, meibomian gland quality, meiboscore, conjunctival redness, fluorescein break up time (FBUT), noninvasive …

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Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo Jan 2020

Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: In recent years, microablative fractional carbon dioxide (CO2) laser becomes popular in treatment of vaginal symptoms including vaginal atrophy. This study aimed to evaluate efficacy of vaginal CO2 laser in treatment of vaginal atrophy, compared to the sham procedure. Methods: Between June 2016 and May 2017, postmenopausal women with moderate to severe intensity of any symptoms of vaginal atrophy were invited to the study. A total of 88 women were randomized for treatment with vaginal CO2 laser or sham procedure every 4 weeks for 3 sessions. The participants were blinded to the intervention they received. The operator was also …

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Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam Jan 2020

Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam

Chulalongkorn University Theses and Dissertations (Chula ETD)

This descriptive study aimed to examine the relationship between age, self-efficacy, functional status, pain, dyspnea, social support, and health-related quality of life in patients with acute coronary syndrome in west java, Indonesia. The participants were 186 patients who has acute coronary syndrome or history of acute coronary syndrome visited cardiovascular outpatient clinic in the main national public hospital type A in west java province, Indonesia. The instruments used for data collection were Demographic Questionnaire, General Self-efficacy Scale, Seattle Angina Questionnaire, Rose Questionnaire for Angina, Rose Dyspnea Questionnaire, ENRICH Social Support, and MacNew Health Related Quality of life. These instruments were …

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A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet Jan 2020

A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet

Chulalongkorn University Theses and Dissertations (Chula ETD)

This cross-sectional correlation study aimed to develop and test a causal relationship among alcohol consumption, illness perception, social support, fatigue, and functional status among persons with liver cirrhosis. The hypothesized model was constructed based on the theory of unpleasant symptoms and the review of the literature. A stratified three-stage random sampling approach was utilized to recruit 400 persons with liver cirrhosis aged 40 years old and older who visited four hospitals from three regions of Thailand. Research instruments consisted of the demographic data form, Alcohol Use Disorders Identification Test Consumption, Brief Illness Perception Questionnaire, Multidimensional Scale of Perceived Social Support, …

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Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet Jan 2020

Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: (1) To compare means of nutritional scores and means of depression scores from 2016 and 2020 (2) To investigate relationship between nutritional scores and depression scores (3) To establish nutritional score prediction model. Methodology: A longitudinal retrospective survey study was performed. Population were human immunodeficiency virus (HIV)-infected Thai elderly patients aged 50 years and above who were receiving HIV care and had previously participated in the aging cohort study conducted from March 2016 to April 2017 at the HIV-NAT Center, Bangkok, Thailand. Sample size for multiple regression analysis is calculated as 15 cases per 1 independent variable. This study …

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Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul Jan 2020

Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The dynamic processes of brain development during perinatal period are vulnerable to neurotoxic insults leading to changes in brain structure and functions. Hippocampus plays an important role in learning and memory. Hippocampal formation can be influenced by substance used during brain developmental processes including neuron differentiation and synaptogenesis. Brain-derived neurotrophic factor (BDNF) regulates neuron development and neuroplasticity via its receptor TrkB. Methamphetamine (MA) abused and the risk of MA exposed during pregnancy have increased recently. The present study aimed to elucidate the effects of prenatal MA exposure on learning and memory. Prenatal effects of MA on neuronal morphology and synaptogenesis, …

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Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus Jan 2020

Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2016, Phramongkutklao hospital has implemented Extended Dispensing Policy (EDP), which increasing prescription length from 30-day to 90-day, with the purpose to increase adherence of patient to their medication prescribed. The objectives of this study were to determine the effects of the increasing in maximum prescription refill length from 30-day to 90-day on medication adherence, clinical outcomes such as HbA1c level and cholesterol level, economic outcomes including total healthcare costs, hospitalization costs, and total medication costs among diabetes and dyslipidemia patients in the Phramongkutklao hospital. This study is a quasi-experiment, pre-post, using a retrospective database from a hospital between …

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Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee Jan 2020

Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew Jan 2020

Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacteria, exposed to stress from the environment or competition, release toxins called bacteriocins. Bacteriocins are classified by their mode of cytotoxicity such as pore former, endonuclease, etc. Colicins are the member of bacteriocins produced by Escherichia coli (E.coli). Among several types of colicins cytotoxicity, Pore-forming colicins has been reported in both bacteria and various type of cancer cells. Colicin N is also a pore-forming colicin and the anticancer activity of colicin N has not been extensively reported. Here we examined the cytotoxic effects of colicin N and its domain on cancer cells. The expression and purification of recombinant full-length and …

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Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari Jan 2020

Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari

Chulalongkorn University Theses and Dissertations (Chula ETD)

To investigate the phytochemicals of the entire plants of Dendrobium braianense brought about in the isolation of three bibenzyls, which included chrysotoxin, moscatilin and gigantol. From the whole plant of D. kentrophyllum three flavonoids, namely, quercetin, kaempferol and rutin were isolated, the structures of which were decided by means of analysis of spectroscopic data to compare the values already reported. They were assessed for their alpha-glucosidase inhibitory activity. Gigantol, quercetin and kaempferolwere found to exhibit strong alpha-glucosidase inhibitory activity when compared with the positive control acarbose, while chrysotoxin, moscatilin and rutin were devoid of activity.

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Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin Jan 2020

Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Inventory management (IM) analysis in a state-level hospital pharmacy of Myanmar was done by using qualitative and quantitative analysis to classify the drug categories that require different levels of management control. Workflow analysis was qualitatively conducted using in-depth interviews of pharmacists. The annual expenditure consumed on each drug of pharmacy for the years 2016 and 2017 was analyzed and application of ABC, VEN, ABC-VEN matrix analysis was performed. The study showed a lack of classification for drug procurement, monitoring, and reporting. There was a lack of appropriate communication between hospital and central procurement, shortage of pharmacists, lack of training about …

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Development Of Hyaluronic Acid-Based Nanogel Platform For Improved Stability And Polyvalent Ligand Display Of Poly(I:C) As An Effective Immunostimulatory Adjuvant In Cancer Immunotherapy, Nararat Kotcharat Jan 2020

Development Of Hyaluronic Acid-Based Nanogel Platform For Improved Stability And Polyvalent Ligand Display Of Poly(I:C) As An Effective Immunostimulatory Adjuvant In Cancer Immunotherapy, Nararat Kotcharat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this research was to develop a nanogel formulation-based on modified natural polymer, hyaluronic acid (HA), as a biodegradable material for adjuvant delivery. Polyinosinic:polycytidylic acid (poly(I:C)) have been approved by FDA as a promising adjuvant candidate for the TLR3 (Toll-Like Receptor 3) activation. However, it suffers from being poor stability and is subjected to rapid enzymatic hydrolysis in serum, so that it requires high administered dose leading to adverse effects. To augment the adjuvant stability and protection from the degradation, the nano-particulate carriers were herein designed with self-assembly of HA scaffold grafted with poly (N-isopropylacrylamide), or pNIPAM. The …

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Comparison Of Area Under The Curves For Vancomycin From One- And Two-Compartment Models Using Sparse Data, Nyein Hsu Maung Jan 2020

Comparison Of Area Under The Curves For Vancomycin From One- And Two-Compartment Models Using Sparse Data, Nyein Hsu Maung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vancomycin pharmacokinetics has been described by 1- and 2-compartment models. One-compartment models built from routine monitoring data, which were mainly trough samples, are commonly used to predict area under the curves (AUC), the useful indicator for vancomycin efficacy. The question stands whether AUCs from 1-compartment models with sparse data can sufficiently represent the true AUC. This study aimed to compare AUCs from 1- and 2-compartment models using sparse data. A previously published model was used to simulate full individual profiles for 100 patients. From these data, the reference AUC (AUCref) was calculated and two depleted datasets (trough-only and peak-trough) were …

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Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan Jan 2020

Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human epidermal growth factor (hEGF) is a short polypeptide that has gained clinical importance in the recent decade for wound healing. Currently, plant-based expression system is considered as an alternative viable platform for low-cost recombinant protein production. Hence, this study aims to produce hEGF in Nicotiana benthamiana plants via., transient expression using a geminiviral vector. The hEGF gene constructs were designed into six different constructs. The optimal expression was observed from the construct targeting the endoplasmic reticulum with C-terminal histidine tag at the yield level up to 15.695 µg/g LFW or 0.499% TSP. The plant-produced hEGF was purified by using …

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Effect Of Dietary Advice On The Components Of Metabolic Syndrome In Hiv/Aids Patients With Metabolic Syndrome, Patcharee Ketchaleaw Jan 2020

Effect Of Dietary Advice On The Components Of Metabolic Syndrome In Hiv/Aids Patients With Metabolic Syndrome, Patcharee Ketchaleaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metabolic syndrome is a complication found in HIV/AIDs patients. The patients with metabolic syndrome had increased risk of cardiovascular disease. An appropriate dietary advice may help ameliorate this problem. This study aimed to investigate the effect of dietary advice on components of metabolic syndrome including anthropometric parameters, lipid profiles, fasting blood sugar, and blood pressure in the HIV/AIDs with metabolic syndrome who were on highly active antiretroviral therapy. This study was a randomized controlled trial. Sixty participants were randomly assigned into an intervention group (n = 30) and a control group (n = 30). All patients received the advice with …

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Pharmacokinetic And Metabolomic Studies Of Standardized Extract Of Centella Asiatica (Eca 233) Capsule In Thai Healthy Volunteers, Phanit Songvut Jan 2020

Pharmacokinetic And Metabolomic Studies Of Standardized Extract Of Centella Asiatica (Eca 233) Capsule In Thai Healthy Volunteers, Phanit Songvut

Chulalongkorn University Theses and Dissertations (Chula ETD)

A well-characterized standardized extract of Centella asiatica (ECa 233) being developed as a phytopharmaceutical product for human use was explored in this clinical study. The first objective of this research was to understand changes in disposition kinetics after oral administration of both the original-formula capsule and a newly-modified enhanced-dissolution capsule of ECa 233. Secondly, this study aimed to investigate alteration of human metabolomes following administration of the modified capsule of ECa 233, using an NMR-based metabolomics approach. For pharmacokinetics, the study involved a phase I clinical trial in twelve healthy Thai volunteers, who each received 250 and 500 mg of …

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Development Of Nanoparticle-In-Microsphere(Nimos) System For Oral Delivery Of Vaccine And Antibody Against Ped Virus For Swine, Rachatapan Junchay Jan 2020

Development Of Nanoparticle-In-Microsphere(Nimos) System For Oral Delivery Of Vaccine And Antibody Against Ped Virus For Swine, Rachatapan Junchay

Chulalongkorn University Theses and Dissertations (Chula ETD)

PED virus is a major barrier to the animal farming industry, and it is the main cause of the mortality of suckling piglets up to 95% by enteric infection. The 2C10 monoclonal antibody (mAb) obtained from Nicotiana benthamiana produced by transient expression was indicated as one of the potential candidates is an antibody against PEDV by oral delivery. The biologics are a new wave of pharmaceuticals and have been continuously developing, which has various benefits of low toxicity and high specificity. However, it unsuitable for use with oral drug delivery owing to limitations of the strong acidity and protease of …

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Factors Contributing To Pharmacists' Turnover Intention: A Systematic Review, Su Myat Thin Jan 2020

Factors Contributing To Pharmacists' Turnover Intention: A Systematic Review, Su Myat Thin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pharmacist turnover could negatively impact not only work efficiency, organizational performance, work productivity, and customer satisfaction but also the quality of pharmaceutical services and patient safety. The turnover intention was a core antecedent of turnover, therefore, this study aimed to systematically review the extent of pharmacists' actual turnover and their intention to leave their jobs or the pharmacy profession, and to elaborate on the factors affecting the pharmacists' turnover intention and their associations. Studies related to any factors affecting pharmacists' turnover intention in all pharmacy settings were included. The QualSyst assessment tool was used for assessing the quality of the …

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Protective Effects Of Lusianthridin On Hemin-Induced Low Density Lipoprotein Oxidation And Foam Cell Formation Of Raw 264.7 Macrophage Cells, Su Wutyi Thant Jan 2020

Protective Effects Of Lusianthridin On Hemin-Induced Low Density Lipoprotein Oxidation And Foam Cell Formation Of Raw 264.7 Macrophage Cells, Su Wutyi Thant

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oxidation of low-density lipoprotein (LDL) take parts in a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin and cause oxidative stress-promoting vascular complications in thalassemia patients. Hemin was used as an oxidizing agent for LDL oxidation. Lusianthridin (LST) from Dendrobium venustum is a plant phenolic compound and possess antioxidant activity. The aim of this study is to evaluate the protective effect of lusianthridin on hemin-induced LDL oxidation (he-oxLDL) and foam cell formation in RAW 264.7 macrophage cell loaded with he-oxLDL treated with LST. Various concentrations of LST (0.25, 0.5, 1 and …

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Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin Jan 2020

Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Anti-RANKL monoclonal antibody is a fully human monoclonal antibody (mAb) available for treatment of osteoporosis. In this study, anti-RANKL mAb was transiently expressed using the Geminiviral expression system in Nicotiana benthamiana. Moreover, the structure of plant-produced mAb was characterized and functional activity was also determined. The result indicated that anti-RANKL mAb was produced with the maximum expression level on 8 days post infiltration and estimated to be 0.5 mg/g leaf fresh weight. The recombinant mAb from crude extracts was purified by using protein A affinity column chromatography. The plant-produced mAb provided in vitro affinity binding with human RANKL, determined by …

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Anti-Migratory And Anti-Invasive Activities Of 22-O-(N-Boc-L-Glycine) Ester Of Renieramycin M Against Human Lung Cancer H460 Cells, Yamin Oo Jan 2020

Anti-Migratory And Anti-Invasive Activities Of 22-O-(N-Boc-L-Glycine) Ester Of Renieramycin M Against Human Lung Cancer H460 Cells, Yamin Oo

Chulalongkorn University Theses and Dissertations (Chula ETD)

The incidence of metastasis stage crucially contributes to high recurrence and mortality rate in lung cancer patients. Unfortunately, no available treatment inhibits migration, a key metastasis process in lung cancer. In this study, the effect of 22-O-(N-Boc-L-glycine) ester of renieramycin M (22-Boc-Gly-RM), a semi-synthetic amino ester derivative of bistetrahydroisoquinolinequinone alkaloid isolated from Xestospongia sp., on migratory behavior of human lung cancer cells was investigated. Following 24 h of treatment, 22-Boc-Gly-RM at non-toxic concentrations (0.5-1 µM) effectively restrained motility of human lung cancer H460 cells assessed through wound healing, transwell migration and multicellular spheroid models. The capability to invade through matrix …

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Efficacy And Safety Of Mulberry Leaves On Glycemic Control In Patients With Obesity And Patients With Type 2 Diabetes, Thanchanit Thaipitakwong Jan 2020

Efficacy And Safety Of Mulberry Leaves On Glycemic Control In Patients With Obesity And Patients With Type 2 Diabetes, Thanchanit Thaipitakwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work was divided into three study phases: the two-phase randomized controlled clinical trials and proteomics study. First, the phase I clinical trial aimed to determine efficacy and safety of mulberry leaves on postprandial glucose following the 50-g sucrose ingestion in healthy nondiabetic adults and to explore the optimal administered dose of 1-deoxynojirimycin (DNJ), the major antihyperglycemic compound of mulberry leaves. The results showed the alleviation of postprandial hyperglycemia by mulberry leaves in a dose-dependent fashion. Adverse effects of mulberry leaves included bloating and flatulence, loose stool, and nausea. In addition, 12 mg of DNJ was considered the optimal dose …

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การศึกษาหาปัจจัยที่ใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ, ปิโยรส เลิศสงวนสินชัย Jan 2020

การศึกษาหาปัจจัยที่ใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ, ปิโยรส เลิศสงวนสินชัย

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มาและความสำคัญ: ผู้ป่วยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติในประเทศไทย และในประเทศต่างๆของทวีปเอเชียซึ่งมีปัญหาในแง่เศรษฐานะ โดยส่วนใหญ่จะได้รับการรักษาด้วยยาวาร์ฟาริน เพื่อป้องกันการเกิดหลอดเลือดสมองอุดตัน และภาวะลิ่มเลือดหลุดลอยไปอุดตันหลอดเลือดแดงต่างๆ โดยพบว่าประสิทธิภาพของยาวาร์ฟารินขึ้นกับค่าของ Time in therapeutic range (TTR) และพบว่าค่า TTR ที่น้อยกว่าร้อยละ 65 จะทำให้ประสิทธิภาพของยาวาร์ฟารินลดลงอย่างมาก ในปัจจุบันมีการใช้คะแนน SAMe-TT2R2 ในการพยากรณ์ค่า TTR แต่การศึกษาส่วนใหญ่เป็นการศึกษาในประชากรผิวขาว และพบว่าคะแนนSAMe-TT2R2 ให้คะแนนคนเอเชียเริ่มที่ 2 คะแนนตั้งแต่ต้น ดังนั้นจากปัจจัยด้านเชื้อชาติ อาจส่งผลทำให้การประเมินผู้ป่วยที่จะไม่ได้ประสิทธิภาพจากยาวาร์ฟารินมากเกินความเป็นจริง วัตถุประสงค์: เพื่อศึกษาหาปัจจัยที่มีผลต่อการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (โดยมีค่า TTR ที่น้อยกว่าร้อยละ 65)ในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ และหา New scoring system ขึ้นมาใหม่ เพื่อใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (โดยมีค่า TTR ที่น้อยกว่าร้อยละ 65) และเปรียบเทียบ New scoring system กับคะแนนSAMe-TT2R2 ในการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ ในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ ระเบียบวิธีวิจัย: ทำการศึกษาแบบทบทวนย้อนหลังจากเวชระเบียนผู้ป่วยนอกและในโรงพยาบาลจุฬาลงกรณ์ โดยรวบรวมผู้ป่วยภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติที่ได้รับการรักษาด้วยยาวาร์ฟารินทุกราย ตั้งแต่วันที่ 1 มกราคม พ.ศ.2557 ถึงวันที่ 31 ธันวาคม พ.ศ.2561 ในงานวิจัยนี้จะคำนวณค่า TTR ด้วย Rosendaal's Method และ ใช้ค่า TTR ที่น้อยกว่าร้อยละ 65 เพื่อบ่งบอกถึงการใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ ผลการศึกษา: ผู้ป่วยภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติที่ได้รับการรักษาด้วยยาวาร์ฟารินที่เข้ามาในงานวิจัยมีทั้งหมด 864 คน มีค่าเฉลี่ยอายุ 73.6 ± 11.58 ปี มีค่าเฉลี่ยค่า TTR คิดเป็นร้อยละ 48.1 ± 25.2 และพบว่าผู้ป่วย 637 คน คิดเป็นร้อยละ 73.7 ที่มีค่า TTR น้อยกว่าร้อยละ 65 จากการวิเคราะห์หาปัจจัยที่สัมพันธ์กับการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (TTRน้อยกว่าร้อยละ 65) …

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Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak Jan 2020

Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Health care personnel are one of most affected by COVID-19 situation. The aim of this study was to identify the prevalence of stress, depression and suicidal risk and associated factors among health care personnel during COVID-19 second outbreak in Thailand. This study was cross-sectional study, which used secondary data collected during December 17, 2020 to February 23, 2021. Total of 4,970 health care personnel participated in this research. The instruments of this research were ST-5, 9Q and 8Q. Multivariable logistic regression analysis was performed to identify factors associated with stress, depression and suicidal risk outcomes. The prevalence of stress, depression …

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Prevalence And Factors Associated With Maternal Near-Miss In Magway Regional Hospital, Magway, Myanmar, Aye Myo Thet Jan 2020

Prevalence And Factors Associated With Maternal Near-Miss In Magway Regional Hospital, Magway, Myanmar, Aye Myo Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Maternal mortality is an important public health concern. Women die every day from pregnancy complications, delivery-related issues, and childbirth. Pregnancy related morbidity and mortality in Myanmar were dramatically increased from 17.6% in 2012 to 20.2% in 2018. In Myanmar, there are limited studies on maternal near miss. Therefore, this study aimed to estimate the prevalence and determine the factors associated with maternal near miss in Magway Regional Hospital, Myanmar. Method: This cross-sectional study employed a health facility-based secondary data analysis to estimate the prevalence of maternal near miss cases, and examine factors associated with maternal near miss in Magway …

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Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman Jan 2020

Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Diagnosis of Pulmonary Rifampicin Resistant Tuberculosis (RR-TB) with the Drug-Susceptibility Test (DST) is costly and time-consuming, and the GeneXpert for rapid diagnosis is not widely available in Indonesia. This study aims to develop an Artificial Neural Network model and evaluate the deployed model performance for RR-TB screening. Methods: A cross-sectional study involved suspected RR-TB patients with complete sputum Lowenstein Jensen DST (reference) and 19 clinical, laboratory, and radiology parameter results, retrieved from medical records in hospitals under the Faculty of Medicine, Hasanuddin University Indonesia, from January 2015-December 2019. The Artificial Neural Network (ANN) models were built along with other …

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Phytochemical Screening, In Vitro Antimalarial Activity And Genetic Diversity Of Selected Asteraceae Medicinal Plants Indigenous To Thailand, Desy Liana Jan 2020

Phytochemical Screening, In Vitro Antimalarial Activity And Genetic Diversity Of Selected Asteraceae Medicinal Plants Indigenous To Thailand, Desy Liana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The emergence of artemisinin resistance leaded the effort to find the new antimalarial drug or artemisinin activity booster. Due to the chance that secondary metabolites can be evolutionary conserved, combining phylogeny with ethnobotanical data for screening antimalarial activity may be helpful to predict bioactivity and minimize the expenditure and time for laboratory research. The aimed of this study is screening the antimalarial activity, phytochemicals and genetic diversity of selected Asteraceae medicinal plants generated by combinatorial phylogeny and ethnobotanical data. 733 medicinal plants were obtained from literature search however only 340 taxa were met the inclusion and exclusion criteria hence these …

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Effects Of Mcs Program On Brain-Derived Neurotrophic Factor, Interleukin-6, 25-Hydroxy Vitamin D And Depression Among Office Workers With Mild Depression, Chirra Taworntawat Jan 2020

Effects Of Mcs Program On Brain-Derived Neurotrophic Factor, Interleukin-6, 25-Hydroxy Vitamin D And Depression Among Office Workers With Mild Depression, Chirra Taworntawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Globally, major depressive is the primary cause of disability. A large part of cases is reported among the working-class. Literature reviews suggest that the disorder is tied in with immune dysregulation and inflammatory response. This study aimed to assessed MCS (mindfulness meditation + curcumin supplementation + sunlight exposure) program by comparing with a control group among mildly depressed office workers. Methods: A quasi experiment was conducted with a total of 68 male and female office workers, n=34 being treatment group (TG) and n=34 being control group (CG). The groups were compared in terms of (a) serum brain-derived neurotrophic factor …

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