Baclofen-Induced Changes In The Resting Brain Modulate Smoking Cue Reactivity: A Double-Blind Placebo-Controlled Functional Magnetic Resonance Imaging Study In Cigarette Smokers, Ariel Ketcherside, Kanchana Jagannathan, Sudipto Dolui, Nathan Hager, Nathaniel Spilka, Chaela Nutor, Hengyi Rao, Teresa Franklin, Reagan Wetherill

Psychology Faculty Publications

Objective: Smoking cue-(SC) elicited craving can lead to relapse in SC-vulnerable individuals. Thus, identifying treatments that target SC-elicited craving is a top research priority. Reduced drug cue neural activity is associated with recovery and is marked by a profile of greater tonic (resting) activation in executive control regions, and increased connectivity between executive and salience regions. Evidence suggests the GABA-B agonist baclofen can reduce drug cue-elicited neural activity, potentially through its actions on the resting brain. Based on the literature, we hypothesize that baclofen’s effects in the resting brain can predict its effects during SC exposure.

Methods: In this longitudinal, …

Preferences In Information Processing, Marginalized Identity, And Non-Monogamy: Understanding Factors In Suicide-Related Behavior Among Members Of The Alternative Sexuality Community, Robert J. Cramer, Jennifer Langhinrichsen-Rohling, Andrea R. Kaniuka, Corrine N. Wilsey, Annelise Mennicke, Susan Wright, Erika Montanaro, Jessamyn Bowling, Kristin E. Heron

Psychology Faculty Publications

Suicide-related behavior (SRB) is a mental health disparity experienced by the alternative sexuality community. We assessed mental health, relationship orientation, marginalized identities (i.e., sexual orientation minority, gender minority, racial minority, ethnic minority, and lower education), and preferences in information processing (PIP) as factors differentiating lifetime SRB groups. An online cross-sectional survey study was conducted in 2018. Members of the National Coalition for Sexual Freedom (NCSF; n = 334) took part. Bivariate analyses identified the following SRB risk factors: female and transgender/gender non-binary identity, sexual orientation minority identity, lower education, suicide attempt/death exposure, Need for Affect (NFA) Avoidance, depression, and anxiety. …

A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson

Psychology Faculty Publications

Since the publication of Unequal Treatment in 2003,¹ the number of studies investigating the implicit bias of health-care providers and its troubling consequences has increased exponentially. Bias can occur in all three psychological components: affects (ie, prejudice), cognition (ie, stereotypes), and behaviour (ie, discrimination). Implicit bias refers to prejudicial attitudes towards and stereotypical beliefs about a particular social group or members therein. These prejudicial attitudes and stereotypical beliefs are activated spontaneously and effortlessly, which often result in discriminatory behaviours.² This definition is consistent with how implicit bias is defined in psychology³ and in literature on health disparities. …

Dietary Fat And Sugar Differentially Affect Β-Adrenergic Stimulation Of Cardiac Erk And Akt Pathways In C57bl/6 Male Mice Subjected To High-Calorie Feeding, Sadia Ashraf, Gizem Yilmaz, Xu Chen, Romain Harmancey

Faculty, Staff and Student Publications

BACKGROUND: High dietary fat and sugar promote cardiac hypertrophy independently from an increase in blood pressure. The respective contribution that each macronutrient exerts on cardiac growth signaling pathways remains unclear.

OBJECTIVE: The goal of this study was to investigate the mechanisms by which high amounts of dietary fat and sugar affect cardiac growth regulatory pathways.

METHODS: Male C57BL/6 mice (9 wk old; n = 20/group) were fed a standard rodent diet (STD; kcal% protein-fat-carbohydrate, 29-17-54), a high-fat diet (HFD; 20-60-20), a high-fat and high-sugar Western diet (WD; 20-45-35), a high-sugar diet with mixed carbohydrates (HCD; 20-10-70), or a high-sucrose diet …

Efficacy Of Bariatric Surgery Compared To Non-Surgical Treatments For Morbid Obesity, Erica L. Donovan

Physician Assistant Scholarly Project Papers

The purpose of this research is to show the efficacy of Roux-en-Y gastric bypass and sleeve gastrectomy as compared to traditional diet and exercise models. Morbid obesity is related to increased blood pressure, incidence of diabetes, high cholesterol, and incidence of obstructive sleep apnea, all of which contribute to increased incidence of myocardial infarction, stroke, and vascular compromise. Finding ways to combat morbid obesity has resulted in invasive surgical techniques because traditional diets and exercise work infrequently and often fail. Systematic reviews, meta-analysis, randomized controlled trials, and retrospective studies were found using the database of CINAHL, SportsDiscus, PsycInfo, Embase, and …

The Safety And Efficacy Of Antidepressant Use In The Adolescent Population, Jason Marcello

Physician Assistant Scholarly Project Papers

This literature review was conducted to determine the safety and efficacy of antidepressants in the adolescent population based on the currently available research. Specifically, are antidepressants safe and efficacious in treating depression in adolescents and is their use associated with increased risk of suicide. Data was collected by searching medical databases including: Clinical Key, CINAHL Complete, PsycINFO, PubMed, DynaMed Plus, and Cochrane Review. The review of the literature included systematic reviews, meta-analysis, cross-sectional, longitudinal, randomized control trials, and survey methods. All literature works selected were published within the past 14 years. A focused search was performed to gather information on …

Comparison In The Effectiveness Of Mat In Patients With Oxycodone Vs Heroin Opioid Use Disorders, Casey Myklebust

Physician Assistant Scholarly Project Papers

The purpose of this research and systematic literature review is to determine if there is a measurable difference of effectiveness in medication assisted treatment (MAT) in patients with oxycodone and heroin use disorders, retention in treatment, and sustained sobriety. In this review, the databases searched included CINAHL, Clinical Key, and Embase. A variety of key terms and MeSH terms were used to define a set of literature discussing the topic. The works chosen for review were published between 2015 and 2019 were peer reviewed, and included randomized control trials, pilot studies, and systematic reviews. Sources that were excluded, included those …

Catheter Ablation Of The Accessory Pathway In The Asymptomatic Patient With Wolff-Parkinson-White, Erin Breann Mondry

Physician Assistant Scholarly Project Papers

Wolff-Parkinson-White (WPW) is a condition in which an accessory conduction pathway exists within the heart. This accessory pathway may or may not cause symptoms, in fact, the first manifestation of the condition may be sudden cardiac death. The management of this condition in asymptomatic individuals is controversial. The purpose of this research and literature review is to analyze the safety and efficacy associated with invasive catheter ablation of the accessory pathway, in comparison to risk of sudden cardiac death and malignant arrythmias in non-ablated, asymptomatic individuals with WPW. In this review, five databases were searched including CINAHL, Clinical Key, PubMed, …

An Analysis Of The Incidence And Severity Of Drug-Drug Interactions Between Prescribed Pharmaceuticals And Cannabinoids, Jennifer Lee Mcrae

Physician Assistant Scholarly Project Papers

The purpose of this research and systematic literature review is to identify the incidence and severity of drug-drug interactions between commonly prescribed medications and cannabinoids. In this review, four databases were searched including PubMed, CINAHL, and Embase from October 1 to January 5, 2019. A variety of key terms were used when searching. Works chosen for review were published after the year 2014, were peer reviewed, and included randomized control trials (RCTs), systematic literature reviews, and meta-analyses. For this review, 9 resources were selected. Much of the research presented shows evidence that medications that are substrates for CYP2C19, CYP2C9 and …

Analysis Of Tech-Based And Telemental Health Approaches Within The Adolescent And Young Adult Populations Of Rural America, Audrey Smeenk

Physician Assistant Scholarly Project Papers

Background: The incidences of depression and anxiety among adolescent and young adult populations are intensifying, and resources remain limited for the management of these diseases within rural America. Objective: The purpose of this literature review is to evaluate evidence-based practices regarding telemedicine and tech-based mental health interventions. Evaluation of different interventions will demonstrate the ability of access, efficacy, and patient adherence with the hope of decreasing the incidence of disease and increase the availability of resources to rural areas. Methods: A comprehensive literature review was completed by assessing journal articles and scientific databases from the last fifteen years using a …

Low-Dose Naltrexone For Treatment In Crohn’S Disease And Fibromyalgia, Hannah Rachel Tkach

Physician Assistant Scholarly Project Papers

The United States has experienced a dramatic increase in opioid abuse and overdoses, leading to a national epidemic. Contributing to this epidemic is the use of opioid therapy for complex chronic inflammatory and neuropathic conditions that remain difficult to treat. Many traditional treatments are ineffective or have intolerable side effects, forcing providers to utilize opioid therapy as a last resort. Recently, there is increased interest in the use of partial opioid antagonist naltrexone to treat Crohn’s disease and fibromyalgia. Previous research suggests the potential for naltrexone to provide analgesic effects when administered in low doses via its unique interaction with …

Holistic Lifestyle Counseling By Physical Therapists: Current Practice And Barriers To Improvement, Savannah Grogan

Honors College Theses

Context: Unhealthy lifestyle habits are a significant risk factor for chronic disease and death in the United States of America. The healthcare system is largely focused on symptom-management and disease treatment with seemingly little regard for prevention, but physical therapists are particularly well-placed to improve patients’ health through lifestyle counseling and modification. Objectives: To assess the current state of holistic health promotion among physical therapists and to identify barriers to improving these practices. Design: An electronic survey was completed by physical therapists in and around the state of Kentucky. Descriptive statistics were used to assess participant demographics and the state …

Do Recipients Of Cash Transfer Scheme Make The Right Decisions On Household Food Expenditure? A Study From A Rural District In Pakistan, Aminah Jahangir, Shehla Zaidi, Jai K. Das, Shifa Habib

Community Health Sciences

Objective: To assess spending by beneficiaries of Benazir Income Support Programme on monthly food commodities, and contribution of the cash grant programme on purchase of nutritious foods.
Methods: The descriptive cross-sectional survey of households enrolled in the Benazir Income Support Programme was conducted during July and August, 2013, in Matiari district of the Sindh province of Pakistan. Monthly household food expenditure on food commodities and use of the cash grant on type of food purchased was assessed through structured interviews of the beneficiaries. Results were computed in 2013 Pak rupees and converted to 2018 United States dollar. Women beneficiaries were …

Intimate Partner Violence Against Women In Pakistan: A Review Of Qualitative Research, Tazeen S. Ali, Rida Farhan, Michelle Ayub

Community Health Sciences

Objective: To consolidate research data and provide an insight into areas that need further research regarding intimate partner violence.
Methods: The review targeted qualitative research-based studies done in the English language and conducted in Pakistan from 2008 to 2018 regarding intimate partner violence against women. A thorough search of Google Scholar and PubMed databases was done. Data from each selected article was extracted using a data-extraction template.
Results: Of the 2,479 results, 21(0.8%) articles were selected along with 4(0.16%) texts from grey literature. An in-depth analysis led to six broad categories: experiences/perspectives of married women facing intimate partner violence; perspectives …

Transcriptomic Responses To Coaggregation Between Oral Bacteria, V R Mutha Naresh

Student Works (2020-2029)

Cell-cell interactions between genetically distinct oral bacteria form macroscopic clumps known as coaggregates. These interactions, termed coaggregation contribute to the formation of highly structured multispecies communities in oral cavity, known as oral biofilms. Individual species also compete and collaborate with other neighboring species through metabolic interactions allowing growth of other species by coaggregation. This study involves the mixing of selected pairs of oral bacteria to form coaggregates and quantifying differential gene expression levels in each pair in comparison with mono-species coaggregation. The dual RNA-Seq approach made it possible to see how bacteria respond to one another leading to different metabolic …

Relative Contribution Of Arms And Legs Through Repetitive Assisted Sit-To-Stand Motion In Individuals With Incomplete Spinal Cord Injury, Abd Aziz Musfirah

Student Works (2020-2029)

Sit-To-Stand (SitTS) exercise is one of important prerequisites to achieve some functional independence goals in everyday life especially for individuals undergoing rehabilitation In general, the execution of SitTS in spinal cord injury (SCI) patients involves motor function in both upper and lower extremities. The use of arm support in particular is a very significant element while executing SitTS movement for SCI population. In addition, application of functional electrical stimulation (FES) onto the quadriceps muscles is one of the prescribed management for incomplete SCI to improve muscle action for simple lower limb movements. However, the relative contribution of upper and lower …

The Relationahips Between Health Behaviors Of Women And Health Locus Of Control Among Black Caribbean Women And Black American Women With Hypertension, Camelle Charles

Theses & Dissertations

Background

Millions of Caribbean women have migrated to the United States, and a sizeable number of these women and Black American women suffer from hypertension and other cardiovascular health problems. This research showed the comparison of health behaviors of both groups of women and the difference in their health outcomes. Today, there are more migrants in the world than ever before; an estimated 272 million international migrants in 2019, which is an increase in 51 million since 2010 (United Nations, 2019) and Caribbean migrants are a substantial portion of this pool. Approximately 4.4 million Caribbean immigrants reside in the U.S. …

Gardner's "Friends Like Henry: Everything Your Family Needs To Know About Finding, Training And Learning From An Autism Companion Dog" (Book Review), Xin "Lucy" Bai

The Christian Librarian

No abstract provided.

Shanti's "The Recovery Mama Guide To Your Eating Disorder Recovery In Pregnancy And Postpartum" (Book Review), Elizabeth A. Nolan

The Christian Librarian

No abstract provided.

Behers' "Spiritual Care For People Living With Dementia Using Multisensory Interventions: A Practical Guide For Chaplains" (Book Review), Craighton Hippenhammer

The Christian Librarian

No abstract provided.

Macdonald's "Teen Substance Use, Mental Health And Body Image: Practical Strategies For Support" (Book Review), Jessica Shuck

The Christian Librarian

No abstract provided.

Peptoid And Antibody-Based Gfp Sensors, Solomon Isu

Graduate Theses and Dissertations

In this work, we have made and characterized a pair of immunobiosensors for detecting the green fluorescent protein (GFP) in an aqueous matrix. An anti-GFP antibody-based biosensor was assembled to detect GFP, while a novel peptoid (N-substituted oligomers of glycine designated as IOS-1) biosensor was also assembled for GFP detection. A quartz crystal microbalance (QCM) gold sensor was used as the supporting substrate for self-assembly of the immunobiosensors. Gravimetric measurements of the QCM gold sensor during immunobiosensor construction and operation were available in real-time using a QCM instrument. X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and Fluorescence microscopy were used …

Golf Director Competencies, Human Resource Management Practices And Customer Retention Within The Malaysian Golf Clubs, Partanian Samira

Student Works (2020-2029)

Golf is a popular sport worldwide. Many studies have described management competencies in several sport contexts and have revealed that human resource is the most common denominator for successful sports club practice. However, little work has been done to identify and explain contemporary Human Resource Management (HRM) practices of staff, including directors of golf clubs related to member retention. The purpose of this study was to examine the current level and the participants' quality perceptions in the relationship among competencies of directors, HRM practices of staff, and member retention within the Malaysian Golf Clubs to advance the causal relationships among …

Antioxidating Effect Of Ampelocissus Sp. (Isi Nyaru) On Streptozotocin-Induced Diabetic Rats, Zamri Elly Zulaikha

Student Works (2020-2029)

The Ampelocissus sp. locally known as Isi Nyaru has been traditionally used by native Malaysian for medical purpose. The tuber was extracted with hexane, petroleum-ether, chloroform, methanol and water solvents. The seperation and detection of bioactive compounds were done using Thin Layer Chromatography (TLC) and Gas Chromatography Mass Spectrometry (GCMS) methods. The TLC results showed the presence of phenolic acids, flavonoids and terpenoids. While in GCMS has revealed the presence of hydrocarbon groups such as alkene, ester and ether, amino acid groups, dicarboxylic acid and cyclic aromatic compound. The total phenol content and total flavonoid content were highest in methanolic …

How Nonprofit Healthcare Organizations Differ And Compare Based On Healthcare Professional Responses, Alexia Baugniet

Undergraduate Theses and Capstone Projects

As the demand for research increases over the years, healthcare will be in demand to improve. Currently, the effects of COVID-19 are bringing many questions to light in regards to the safety protocols in place in our various healthcare systems. In our world today, healthcare must be taken seriously, and programs should be put in place to help citizens better understand healthcare guidelines and safety protocols. In attempting to discover my passion and motivation, Suffolk University provided me the resources and tools to pursue my education in relation to Healthcare Management. For this senior capstone class, the overall goal was …

In Vitro Bioactivities Of Single Or Combined Extracts From Three Selected Asian Vegetables, Mahmud Norfaizah

Student Works (2020-2029)

Three underutilized folklore oriental-based vegetables Acalypha indica (AI), Centella asiatica (CA), and Sesbania grandiflora (SG) have been investigated for pharmacological activities relevant to wound healing process and synergistic actions. Single and combination of aqueous (A) and methanol (M) extracts of the three vegetables namely AI-A, CA-A, SG-A, AI-M, CA-M, SG-M, AI-A+CA-A, AI-A+SG-A, CA-A+SG-A, AI-M+CA-M, AI-M+SG-M, and CA-M+SG-M were assessed for stimulation of wound closure by normal human dermal fibroblast (NHDF) cells, antioxidant, protection against hydrogen peroxide (H2O2), stimulation of nitric oxide (NO) from RAW264.7 macrophages and antimicrobial activities. The combined vegetable extracts AI-A+CA-A (90.76%) showed the highest percentage of wound …

A Descriptive Study Of Racial Inequalities In Mortality From Hepatocellular Cancer Before And After Licensure Of Lifesaving Drugs For Hepatitis C Virus In The United States, Robert S Levine, Maria C Mejia, Jason L Salemi, Sandra J Gonzalez, Muktar H Aliyu, Baqar A Husaini, Roger J Zoorob, Charles H Hennekens

Faculty, Staff and Students Publications

BACKGROUND: Since 1979, mortality from hepatocellular cancer (HCC) has doubled in the United States (US). Lifesaving drugs, prohibitively expensive for some, were approved and marketed to treat hepatitis C virus (HCV), a major risk factor for HCC, beginning in 1997. After the prior introduction of other lifesaving innovations, including active retroviral drug therapy for human immunodeficiency virus and surfactant for respiratory distress syndrome of the newborn, racial inequalities in their mortalities increased in the US. In this descriptive study, we explored racial inequalities in mortality from HCC before and after licensure of HCV drugs in the US.

METHODS: The US …

Transition From Fixed-Dosing To Symptom-Triggered Management Of Alcohol Withdrawal Syndrome In The Intensive Care Unit Of A Community Hospital, Marianela Robainas, Heidi Clarke, Claudia Chang, Frances Ordieres Gonzalez, Lorenzo Porras Jr.

All Publications

Background/Purpose: In the United States, 2 to 7% of heavy alcohol users admitted to the hospital for general medical care will develop severe alcohol withdrawal (AW) requiring treatment. The most dangerous complications of AW are delirium tremens and seizures. Benzodiazepines (BZD) are considered first-line therapy, with varying modality options available to providers. Fixed-dosing has historically been used to manage AW. However, studies suggest that symptom-triggered therapy (STT) can decrease length of stay and BZD duration of therapy. The purpose of this study was to evaluate the current fixed-dose protocol and outline the transition to STT in the intensive care unit …

Perspectives Relating To Multicultural Training With Speech-Language Pathologists, Evy Jewell Hayes

Honors Theses

The goal of this project is to assess whether Speech-Language Pathologists (SLPs) feel adequately prepared and comfortable interacting with multicultural clients. To assess if an SLP feels prepared to interact with, to assess, to teach, or to treat a multicultural client, a 25-question survey was developed. The survey included questions pertaining to the SLPs’ experiences with other cultures, both professional and personal, if the SLP speaks more than one language, and if the SLP has received any formal training on how to interact with multicultural clients. The survey was sent out via email to 814 licensed SLPs practicing in pre-school, …

Prosthetic Valve Endocarditis From Trichosporon Asahii In An Immunocompetent Patient, Lizy Marial Paniagua, Deepthi Sudhakar, Lara Erika Perez, David Miranda, Pedro Urena, Igor Gregoric, Biswajit Kar, Hani Jneid, Jonalis Ramirez, David Paniagua

Faculty, Staff and Students Publications

Fungal endocarditis is a rare clinical entity. This report describes an unusual case of fungal endocarditis caused by infection with Trichosporon asahii in a 20-year-old immunocompetent man who received the diagnosis 1 year following biological aortic valve replacement. (Level of Difficulty: Beginner.)