Medicine and Health Sciences Commons^™

Toward A Rapid Production Of Multivirus-Specific T Cells Targeting Bkv, Adenovirus, Cmv, And Ebv From Umbilical Cord Blood, Hema Dave, Min Luo, J.W. Blaney, Shabnum Patel, Cecilia Barese, Conrad Russell Cruz, Elizabeth J. Shpall, Catherine M. Bollard, Patrick J. Hanley

Pediatrics Faculty Publications

Umbilical cord blood (CB) has emerged as an effective alternative donor source for hematopoietic stem cell transplantation. Despite this success, the prolonged duration of immune suppression following CB transplantation and the naiveté of CB T cells leave patients susceptible to viral infections. Adoptive transfer of ex vivo-expanded virus-specific T cells from CB is both feasible and safe. However, the manufacturing process of these cells is complicated, lengthy, and labor-intensive. We have now developed a simplified method to manufacture a single culture of polyclonal multivirus-specific cytotoxic T cells in less than 30 days. It eliminates the need for a live virus …

Malignant Peripheral Nerve Sheath Tumors State Of The Science: Leveraging Clinical And Biological Insights Into Effective Therapies., Aerang Kim, Douglas R Stewart, Karlyne M Reilly, David Viskochil, Markku M Miettinen, Brigitte C Widemann

Pediatrics Faculty Publications

Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in patients with neurofibromatosis type 1. In 2002, an MPNST consensus statement reviewed the current knowledge and provided guidance for the diagnosis and management of MPNST. Although the improvement in clinical outcome has not changed, substantial progress has been made in understanding the natural history and biology of MPNST through imaging and genomic advances since 2002. Genetically engineered mouse models that develop MPNST spontaneously have greatly facilitated preclinical evaluation of novel drugs for translation into clinical trials led by consortia efforts. Continued work in identifying alterations that contribute …

Engagement And Outcomes In A Digital Diabetes Prevention Program: 3-Year Update., S Cameron Sepah, Luohua Jiang, Robert J. Ellis, Kelly Mcdermott, Anne L. Peters

Global Public Health | Faculty Scholarship

OBJECTIVE: Translations of the Diabetes Prevention Program (DPP) have proliferated in recent years, with increasing expansion to digital formats. Although these DPP translations have consistently shown favorable clinical outcomes, long-term data for digital formats are limited. This study's objective was to examine clinical outcomes up to 3 years post-baseline and the relationship between program engagement and clinical outcomes in a digital DPP.

RESEARCH DESIGN AND METHODS: In a single-arm, non-randomized trial, 220 patients previously diagnosed with prediabetes were enrolled in the Omada Health Program, a commercially available, 16-week DPP-based weight loss intervention followed by an ongoing weight maintenance intervention. Changes …

The Effects Of Rape Myth Acceptance, Benevolent Sexism, Characterological Self-Blame, And Behavioral Self-Blame On Posttraumatic Stress Disorder Symptom Severity, Jacob Whitaker Camp

Theses, Dissertations and Capstones

Roughly 35 to 50 percent of victims of sexual assault begin to suffer from posttraumatic stress disorder (PTSD) relatively early after the assault (Elklit, Due, & Christiansen, 2009). Many victims of sexual assault who are diagnosed with PTSD continue to experience symptoms long after the incident occurred (Peter-Hagene & Ullman, 2015). Rape has serious effects on the psychological health of the victims. Although no study had been done directly examining the relationship between rape myth acceptance and PTSD symptom severity, studies have shown that benevolent sexism affects rape myth acceptance and that rape myth acceptance affects how individuals attribute blame …

Employing The Enzyme Cofactor Function Of Ascorbic Acid To Affect Oncogenic Pathways In Human Melanoma: Modulating Hypoxia Inducible Factor-1Α And Dna Demethylation To Reduce Malignant Potential, Adam Patrick Fischer

Theses, Dissertations and Capstones

Dioxygenase enzymes such as the HIF hydroxylases (PHD1-3, FIH) and the Ten-eleven translocation (TET1-3) enzymes regulate the activity of the hypoxia inducible factor-1_a (HIF1_a) transcription factor and the DNA methylation status of cells, respectively. Aberrant accumulation and activation of HIF-1_a can allow malignant cells to acquire attributes that promote progression, chemotherapy resistance, and survival, while aberrant hypermethylation of gene promoters can silence the expression of tumor suppressor genes essential to preventing tumorigenesis. Inadequate levels of intracellular ascorbic acid (AA), a necessary cofactor for optimal dioxygenase enzyme function, could potentiate these tumorigenic conditions. In fact, plasma levels …

Assessing For Post Operative Urinary Retention (Pour) In Ambulatory Adult Spinal Surgery Patients, Paula Essig, Coco Mcgraw-Smith, Lori Penney

All Nursing Boot Camp Posters

No abstract provided.

Com Outlook Winter 2017, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

A Conversation Analysis Of Therapist-Client Interactional Patterns In Single Session Therapy: A Researcher's Interpretation, Nozomu Ozaki

Department of Family Therapy Dissertations and Applied Clinical Projects

In response to the growing awareness of the issue of accessibility to mental health services (World Health Organization, 2013), single session therapy (SST) has been implemented in various settings throughout the world. (Hoyt &Talmon, 2014b; Miller, 2008; Miller & Slive, 2004; Talmon, 2014). Although there has been much advancement in the knowledge and application of SST, an understanding of therapist-client interactional patterns that enfold in SST is extremely scarce. In this study, I investigated how therapists collaboratively improved the talk in SST turn by turn in such a way that promoted therapeutic improvement. I utilized conversation analysis (Sacks et al., …

The Roles Of Perceived Stress, Coping Styles, And Perceived Social Support On The Alcohol Consumption Among American College Students, Jesse Wynn

Electronic Theses and Dissertations

The intention of this study was to better understand how certain aspects in a college student's life (i.e., perceived stress, styles of coping, and social support) or how combinations of these variables may contribute to higher levels of alcohol consumption. The present study examined the relationship between perceived stress, functional coping strategies, dysfunctional coping strategies, and perceived social support using Lazarus and Folkman's model of stress, appraisal, and coping. A sample of (N = 201) University of Denver undergraduate students between the ages of 18-25 complete measures of perceived stress, coping strategies, perceived social support, and alcohol use. Results …

Evaluating Adn Faculty Job Satisfaction, Karen M. Thies

Doctor of Nursing Practice Projects

Background

The U.S. is facing a critical shortage of nurses as the aging baby boomer generation is requiring more nursing care. Contributing to the nursing shortage is the inability to educate larger numbers of nurses, attributable to a lack of nursing faculty. Insufficient numbers of nursing faculty results in qualified applicants being turned away from nursing programs.

Project Design

This project evaluated faculty job satisfaction in 703 accredited Associate Degree Nursing (ADN) programs in the U.S. The Index of Work Satisfaction (IWS) (Stamps, 1997), was designed to measure specific factors of nurses' job satisfaction and was emailed to all full …

Ua61/1 Msn Student Handbook, Wku School Of Nursing

WKU Administration Documents

Handbook for students in the MSN program of the WKU School of Nursing.

Ua12/4 Stall Street Journal, Vol. 9, Wku Health Services

WKU Administration Documents

Broadsides developed by WKU Health Services to convey public health information in students in bathroom stalls. Incomplete run.

Virginia Dental Journal (Vol. 94, No. 4, 2017)

Virginia Dental Journal

No abstract provided.

Stakeholder Considerations For Prep Introduction To Adolescent Girls And Young Women: Laying The Groundwork For Research Utilization In Tanzania, Population Council

HIV and AIDS

In collaboration with the Tanzania National AIDS Control Programme and CSK Research Solutions Ltd., the Population Council is conducting an implementation science research study in that country to build needed evidence to inform decisionmaking around oral pre-exposure prophylaxis (PrEP) introduction to adolescent girls and young women (AGYW) aged 15–24. The study uses quantitative and qualitative methods to gather data from AGYW, policymakers and other stakeholders, health providers, and AGYW’s parents and male partners to: assess their knowledge and attitudes toward oral PrEP; determine opportunities and approaches for providing PrEP; and identify potential facilitators and barriers to PrEP introduction and use. …

Systematic Review Of Scientific Evidence Supporting Yoga As An Alternative Treatment For Generalized Anxiety Disorder, Alexandria Keller

Master of Public Health Program Student Publications

Background: This study was a systematic review of scientific evidence investigating yoga as a treatment for GAD. Assessing the scientific validity of alternative health practices is necessary for proposals of inclusion in public health practices.

Methods: A comprehensive search for peer-reviewed biomedical research was conducted for literature describing interventions for GAD using yoga and its practices (e.g. physical postures, meditation, breathing exercises). Systematic research was conducted on academic literature databases available through Wright State University (Web of Science, PubMed, Cochrane Library) using search terms selected based on key words for Diagnostic and Statistical Manual, 5th Edition and the Sanskrit variation …

Engineering For Humans: A New Extension To Systems Theoretic Process Analysis, Megan France, John Thomas

International Symposium on Aviation Psychology - 2017

Systems Theoretic Process Analysis (STPA) is a new hazard analysis method developed at MIT to address a broad range of accident causal factors including dysfunctional interactions among components, design flaws, and requirements problems. This paper presentsa new extension for analyzing human interactions with automation and understanding why unsafe behaviors may appear appropriate in the operational context. The extension is demonstrated by applying it to pilot control of aircraft pitch control during stall recoveryusing scenarios from theAir France 447 accident

An Interdisciplinary Approach To Evaluating U.S. Army Aviation Training, Martin S. Goodwin, Lauren Reinerman-Jones, Brian F. Goldiez, Robert A. Crapanzano

International Symposium on Aviation Psychology - 2017

The U.S. Army is seeking to update and expand its use of simulation-based aviation trainingto address operational and fiscal concerns that are driving the need for more efficient training solutions.This has created a needto evaluate whether lower-cost, game-based simulations may potentially augment higher-cost, traditional simulation-based trainingfor specific aviation training tasks.However, current approaches to Training Effectiveness Evaluation (TEE) do not address the complete range of factors to adequately evaluate today’s increasingly sophisticated simulation training environments. Leveraging recent research and drawing from the tools and techniques of human performance assessment, instructional science, and phenomenology, an interdisciplinary approach to performing TEEs is introduced …

Increasing Acceptance Of Haptic Feedback In Uav Teleoperations By Visualizing Force Fields, Victor Ho, Clark Borst, Rene Van Paassen, Max Mulder

International Symposium on Aviation Psychology - 2017

In tele-operating an UAV, human operators fully rely on cameras to control thevehicle from a distance. To increase operator situation awareness and reduce workload, haptic feedback on the control stick has been developed which acts as an automatic collision avoidance system. A virtual force field surrounding the moving vehicle interacts with obstacles surrounding it,yielding repulsive forces on the stick that leadthe vehicle away from them. Albeit successful in significantly reducing the number of collisions,thehaptic interfacereceivedlow user acceptance ratings.Operators do not always fully understand the collision avoidance automation intentions, and they experience the haptic forces as intrusive. This paper discusses thedevelopment …

Human Decision Making And Threat-Awareness Response During Emergency Aircraft Evacuations, Sarah Hubbard, Tim Ropp

International Symposium on Aviation Psychology - 2017

Aircraft emergencies requiring evacuation present unique safety challenges to both crew and passengers due to theconfined space and the speed at which fire, extreme heatand smoke propagate. In thisscenario, where a one or two second delay can literally determine survivability, rapid evacuation is paramount. Although evacuation capability is demonstrated through requiredand controlleddrillsfor aircraft certification, during a real emergencyhuman factorsaffect passenger decision making, in some cases resulting in the decisionto retrieve personal items during actual emergency evacuations. This may pose a significant threat to post-accident survivability. This research evaluates evacuation decision making and the associated impact on passenger exit flow, during …

Work Dynamics Of Task Work And Teamwork In Function Allocation For Manned Spaceflight Operations, Martijn Ijtsma, Lanassie M. Ma, Amy R. Pritchett, Karen M. Feigh

International Symposium on Aviation Psychology - 2017

This paper proposes a methodology for human-robot function allocation for future manned space exploration missions that uses fast-time computational simulation. Dynamics of taskwork and teamwork often result in emergent work patterns that are difficult to predict from static analysis of function allocations. Wemodel thedynamics of taskwork and teamwork and demonstrate our approach through a case study that explores the function allocation design space for an on-orbit maintenancemissioninvolving humans and various robots. The case study highlightsthe method’s ability to predict possible concerns associated with limited availability of physical resources, action interdependencies, and communication requirements with possible time delays, and shows the …

Empirically Evaluating Representational Aids For Target Tracking And Sensor Management, Taleri Hammack, Jared Neely, Terry Stanard, Jason Roll, John Flach

International Symposium on Aviation Psychology - 2017

Today, security officers at military and civilian installations are often required to track people and vehicles (targets) movingin a remote space using a distributed array of stationary security cameras. A pervasive tracking challenge is maintaining view of the target as it moves through the restricted fields of view of different cameras. The current research explores how different displaydesigns indicating camera fields of viewimpact the operator’s situation awareness of the next best camera to continue viewing a moving target. Three different interface displays(Full North-Up Map, Peripheral Display, and Track-Up Mini-Map) wereevaluated over four experimental conditions.While having all display types available was …

Human Performance Assessment: Evaluation And Experimental Use Of Wearable Sensors For Brain Activity Measures, Kurtulus Izzetoglu, Dale Richards, Lei Ding, Chen Ling, Ben Willems

International Symposium on Aviation Psychology - 2017

The emerging wearable human performance monitoring technologies can help evaluate the cognitive status and capacities of the crew in the cockpit as well as those operating ground control stations. Traditionally the use of behavioral measures and subjective metrics has been used to address cognitive factors associated with pilots or operators of safety critical systems. However, the advance in wearable physiologytechnologies could provide additional performance metrics directly driven from brain based measures, potentially validating subjective assessments and ultimately bringing us closer towardsmaintaining safe and effective performance. Furthermore, these techniques may also aidthe design and evaluation of new technologies that are being …

Student Perceptions On The Usefulness Of Simulation-Based Training, Andrea M. Georgiou, Megan E. Wertheimer, Megan E. Snodgrass

International Symposium on Aviation Psychology - 2017

The NASA Flight Operations Center Unified Simulation (FOCUS) lab is a high-fidelity simulation of an airline operations center. Its purpose is to train senior aerospace students to collaborate and communicate effectively with team members in a highly interdependent environment that mirrors the airline industry. Data wascollected from the participants on their perceptions and the lessons learned from running the lab. These results were analyzed across elevensemestersover the last five years. Specifically,the quantitative data captured student perceptions about whether the lab was helpful in preparing them for their future job demands. The qualitative questions assessed their most important lessons learned, the …

Toward Identifying Risk In Operational Performance Of Atc Procedures, Paul Krois, Julia Pounds

International Symposium on Aviation Psychology - 2017

Managing operationalperformance to reduce risk in the execution of air traffic control (ATC) procedures depends on understanding human performance in relation to patterns established in procedures. Procedures specify performance requirements meant to minimize unintended variation that is outside expected performance criteria and tolerances.We define human performance risk as unintended variation outside theenvelope of applicable procedures.

The Effect Of Surprise On Upset Recovery Performance, Annemarie Landman, Eric L. Groen, M.M. (René) Van Paassen, Adelbert W. Bronkhorst, Max Mulder

International Symposium on Aviation Psychology - 2017

Introducing the element of surprise is one of the main challenges in simulator training of in-flight emergencies. In this simulator study, we investigated the differences in performance betweenpredictable and surprising circumstances, in order to obtaininsight into the transferof training between predictable training settings and surprising circumstances in operational practice. This was done bytestingtwenty airline pilots who recovered froman aerodynamic stall in two conditions: one anticipationcondition and one surprise condition. All pilots practiced beforehand using predictable, or non-surprising scenarios. The results show that pilots had significantly more difficulties in adhering to components of the FAA-commissioned recovery template in the surprise condition …

A Study Of Accidents And Incidents Of Landing On Wrong Runways And Wrong Airports, Linfeng Jin, Edmund Lo

International Symposium on Aviation Psychology - 2017

This paper addresses the landings on wrong runways/ at wrong airports happened between 03/26/1992 and 05/08/2012. The visibility, intended landing runway heading, accident landing runway heading, pilots’ flight hours, and the ages of those pilots are studied to test whether they have correlationswith the number of personnel injury, the number of personneldeath, and the degrees of aircraft damage. Some significantfindings are: the most likely angular difference between the supposed landing runwayheadings and wrong runway headings among wrong runway/airport landingsis 180 degrees,and there is a weaknegative correlation between aircraft damage and pilot flight hours. All the data used in the paper …

Is Rho The Key To Hazardous Weather Avoidance?, William R. Knecht

International Symposium on Aviation Psychology - 2017

Current in-cockpit looping Next-Generation Radar (NEXRAD) is inadequate to maintain safe (20 nm) aircraft separation from heavy weather (> 40 dBZ reflectivity). This assertion issupported by mathematical information analysis and an empirical study (Knecht, 2016), as well as numerous previous empirical studies. The current work revisitsthe ecological analysis by examining the putative affordance (rho) specifying when weather-avoidance maneuver should begin, as suggested by General Tau Theory (Lee, 2009).With“gapdefined as the distance between the on-screen aircraft icon and the weather hazard, is specified by the ratio ((dg/dt)/g)(t), the instantaneous gap contraction rate divided by the instantaneous gap size. In current …

A Case Study Using The Human Factors Analysis And Classification System Framework, Flavio A.C. Mendonca Ph.D., Chenyu Huang Ph.D., Julius Keller Ph.D.

International Symposium on Aviation Psychology - 2017

Aircraft accidents are generally the end result of a number of latent conditions arising in the organizational and managerial sectors. These conditions frequently permit or even motivatethe unsafe acts by the flight crew. The Human Factors Analysis and ClassificationSystem (HFACS) is a system safety tool for the investigation and analysis of underlying human causal factors in aircraft accidents. Using the HFACS framework, four researchers classified the human factors identified by the Brazilian Aeronautical AccidentsInvestigation and Prevention Center (CENIPA) during the investigation of a mishap(PR-AFA) that happened in Brazil in 2014. CENIPA argued that errors and violations by both pilots contributed …

Usaf Spatial Disorientation Prevention: A Meta-Analytical Human Systems Integration Perspective, Patrick O'Neil, Booz Allen Hamilton, Michael Miller

International Symposium on Aviation Psychology - 2017

Human Systems Integration involvesthe systematic consideration of tradeoffs in system structure or behavior, which affect sevenhuman-centered domains to optimize total system performance and life cycle cost.All too often, HSI is overlooked or poorly practiced, despite the specific directive within DoDI 5000.02 for program managers to plan for and conduct HSI. In the worst of cases, poor consideration of human capabilitiesandlimitations leads to errors, mishaps, and death or serious injury. One such human limitation in aviation is the inability of the pilot to maintain proper spatial orientationduring flight,asmismatches between the stimuli present during flight create an erroneous perception of aircraft attitude …

Understanding Pilots’ Explanations Of Automation Surprises, Robert Mauro, Loukia Loukopoulou, Julia Trippe

International Symposium on Aviation Psychology - 2017

Automation surprise may result from inadequate or mistaken “mental models” of the automation (Sarter and Woods, 1995). To study pilots’ mental models of their automation, 202 airline pilots were asked to explain five different events involving unexpected behaviors of aircraft automation. Pilots’ abilities to correctly explain the behavior of the automation differed systematically across the scenarios. The number of complete and correct responses varied from 19% to 86%, depending on the scenario. As the complexity of the automation increased, understanding decreased. Performance on the scenarios was not related to flight experience, automation experience, or source of automation training. But pilots’ …