Medicine and Health Sciences Commons^™

Sharing Extended Summary Data From Contemporary Genetics Studies Is Unlikely To Threaten Subject Privacy, Silviu-Alin Bacanu

Psychiatry Publications

Background

Starting from a forensic problem, Homer et al. showed that it was possible to detect if an individual contributes only 0.5% of the DNA in a pool. The finding was extended to prove the possibility of detecting whether a subject participated in a small homogeneous GWAS. We denote this as the detection of a subject belonging to a certain cohort (SBCC). Subsequently, Visscher and Hill showed that the power to detect SBCC signal for an ethnically homogeneous cohort depends roughly on the ratio of the number of independent markers and total sample size. However, it …

A Preliminary Longitudinal Study Of White Matter Alteration In Cocaine Use Disorder Subjects, Liangsuo Ma, Joel L. Steinberg, Qin Wang, Joy M. Schmitz, Edward L. Boone, Ponnada A. Narayana, F. Gerard Moeller

Radiology Publications

Background

Previous diffusion tensor imaging (DTI) studies have consistently shown that subjects with cocaine use disorder (CocUD) had altered white matter microstructure in the corpus callosum. It is believed that these alterations are due to preexisting factors, chronic cocaine use, or both. However, there is no published longitudinal DTI study on human cocaine users yet which could shed light on the relationship between cocaine use and DTI findings.

Methods

This study used a longitudinal design and DTI to test if the white matter microstructure shows quicker alteration in CocUD subjects than controls. DTI data were acquired from eleven CocUD subjects …

A Randomized Prospective Long-Term (> 1 Year) Clinical Trial Comparing The Efficacy And Safety Of Radiofrequency Ablation To 980nm Laser Ablation Of The Great Saphenous Vein, Malcolm Sydnor, John Mavropoulos, Natalia Slobodnik, Luke Wolfe, Brian Strife, Daniel Komorowski

Radiology Publications

Purpose

To compare the short- and long-term (>1 year) efficacy and safety of radiofrequency ablation (ClosureFAST™) versus endovenous laser ablation (980 nm diode laser) for the treatment of superficial venous insufficiency of the great saphenous vein.

Materials and methods

Two hundred patients with superficial venous insufficiency of the great saphenous vein were randomized to receive either radiofrequency ablation or endovenous laser ablation (and simultaneous adjunctive therapies for surface varicosities when appropriate). Post-treatment sonographic and clinical assessment was conducted at one week, six weeks, and six months for closure, complications, and patient satisfaction. Clinical assessment of each patient was conducted …

Medical Literary Messenger (Vol. 5, No. 1, Fall/Winter 2017)

Medical Literary Messenger

Home Visit / Melissa Fournier -- Stiffness / Hannah Shea -- Exile / Lane Falcon -- Good Intentions / Laura Foley -- Resurrection / Les Cohen -- Visits / Craig W. Steele -- That Last Night / Laura Foley -- Taste / Dan Campion -- Bumblebees Don’t Always Sting / Diane M. Parker -- Mental Status Exam / Melissa Fournier -- Dystrophia I / Ashley Purdy -- Muck Out / Mitchell Krockmalnik Grabois -- Endoscope / Lane Falcon -- Leftovers / Erynn Porter -- Another Autumn / Deborah Fleming -- Autism / Laura Foley -- Nearly Sunset / Craig W. …

The Role Of Kinase Fusion Dnajb1-Prkaca In Fibrolamellar Hepatocellular Carcinoma, Yi Guo

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Regulation Of Biliary Progenitor Cell Proliferation By Hedgehog Signaling In In Vivo And Ex Vivo Organoid Models, Nataliya Razumilava M.D., Junya Shiota M.D., Ramon Ocadiz-Ruiz Ph.D., Nureen Hanisah Mohamad Zaki, Kais Zakharia M.D., Michael Mathew Hayes, Juanita Lynn Merchant M.D., Ph.D.

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Glypican-3 And Cd81 Promote Development Of Hepatocellular Carcinoma And Hepatoblastoma Through Negative Selection., Yuhua Xue, Wendy Mars, William Bowen, Aatur D. Singhi, Sarangarajan Ranganathan, George K. Michalopoulos

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

The Molecular Mechanism Of Β-Catenin Mutations And Akt Synergize Induced Lipogenic Hcc In Mice, Junyan Tao 8598903, Sucha Singh, Emily Xu, Na Zhan, Xin Chen, Satdarshan P. S. Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Innate Lymphoid Cells In Mouse Models Of Hcc And Nash, Bernd Heinrich, Tim F. Greten

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Hepatic Stellate Cell-Derived Cancer Associated Fibroblasts Sustain Tumor Growth In Intrahepatic Cholangiocarcinoma, Silvia Affo, Le-Xing Yu, Xin Chen, Robert F. Schwabe

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Locomotor Adaptability In Persons With Unilateral Transtibial Amputation, Benjamin J. Darter, Amy J. Bastian, Erik J. Wolf, Elizabeth M. Husson, Bethany A. Labrecque, Brad D. Hendershot

Physical Medicine and Rehabilitation Publications

Background

Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood.

Objective

Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA).

Methods

The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds. In the split condition, participants walked for 15 minutes with the respective belts …

Genomic Analysis Of Chimeric Human Cytomegalovirus Vaccine Candidates Derived From Strains Towne And Toledo, Nicolás M. Suárez, Betty Lau, George M. Kemble, Ronzo Lee, Edward S. Mocarski, Gavin W. G. Wilkinson, Stuart P. Adler, Michael A. Mcvoy, Andrew J. Davison

Pediatrics Publications

Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised patients and a major cause of congenital birth defects when acquired in utero. In the 1990s, four chimeric viruses were constructed by replacing genome segments of the high passage Towne strain with segments of the low passage Toledo strain, with the goal of obtaining live attenuated vaccine candidates that remained safe but were more immunogenic than the overly attenuated Towne vaccine. The chimeras were found to be safe when administered to HCMV-seronegative human volunteers, but to differ significantly in their ability to induce seroconversion. This suggests that chimera-specific genetic differences …

Chronic Health Conditions As A Risk Factor For Falls Among The Community-Dwelling Us Older Adults: A Zero-Inflated Regression Modeling Approach, Yoshita Paliwal, Patricia W. Slattum, Scott M. Ratliff

Pharmacotherapy and Outcomes Science Publications

Falls are an important health concern among older adults due to age-related changes in the body. Having a medical history of chronic health condition may pose even higher risk of falling. Only few studies have assessed a number of chronic health conditions as risk factor for falls over a large nationally representative sample of US older adults. In this study, Behavioral Risk Factor Surveillance System (BRFSS) 2014 participants aged 65 years and older (n = 159,336) were evaluated. It was found that 29.7% (n = 44,550) of the sample experienced at least one fall and 16.3% (n = 20,444) …

Baystate Medical Practices Annual Report - 2017, Andrew Artenstein Md

Baystate Medical Practices Annual Report

No abstract provided.

Contextualizing The Relevance Of Basic Sciences: Small-Group Simulation With Debrief For First- And Second-Year Medical Students In An Integrated Curriculum., S. B. Ginzburg, J. Brenner, M. Cassara, T. Kwiatkowski, J. M. Willey

Journal Articles

There has been a call for increased integration of basic and clinical sciences during preclinical years of undergraduate medical education. Despite the recognition that clinical simulation is an effective pedagogical tool, little has been reported on its use to demonstrate the relevance of basic science principles to the practice of clinical medicine. We hypothesized that simulation with an integrated science and clinical debrief used with early learners would illustrate the importance of basic science principles in clinical diagnosis and management of patients.Small groups of first- and second-year medical students were engaged in a high-fidelity simulation followed by a comprehensive debrief …

Nfatc3 And Vip In Idiopathic Pulmonary Fibrosis And Chronic Obstructive Pulmonary Disease, A. M. Szema, E. Forsyth, B. Ying, S. A. Hamidi, J. J. Chen, S. Hwang, J. C. Li, D. S. Dwyer, J. M. Ramiro-Diaz, L. V. Gonzalez Bosc, +1 Additional Author

Journal Articles

No abstract provided.

Neurosurgery Concepts: Key Perspectives On Imaging Characteristics Of Spinal Metastases, Surgery For Low Back Pain, Anesthesia For Disc Surgery, And Laminectomy Versus Laminectomy And Fusion For Lumbar Spondylolisthesis., Carlito Lagman, Lawrance K Chung, Luke Macyszyn, Winward Choy, Zachary A Smith, Nader S Dahdaleh, Angela M Bohnen, Jin M Cho, Chaim B Colen, Edward Duckworth, Anand V Germanwala, Peter Kan, Alexander A Khalessi, Chae-Yong Kim, Sandi Lam, Gordon Li, Michael Lim, Jonathan H Sherman, Vincent Y Wang, Gabriel Zada, Isaac Yang

Neurological Surgery Faculty Publications

No abstract provided.

Silencing Science.Pptx, Kai Hung

Faculty Research & Creative Activity

This is a non-peer reviewed teaching resource.

National Children’S Dental Health Month - Program Planning Guide (2017), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

Libro De Actividades Por El Mes Nacional De La Salud Dental Infantil [Spanish Language Version: National Children's Dental Health Month Activity Book] (2017), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

College Of Health Care Sciences Doctor Of Philosophy Ph.D. In Health Sciences Online Program Entering Class 2017, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Evaluating Prescribing Patterns Of Long-Acting Injectable Antipsychotics At A Community Health System, Chelsea L Ferguson Pharmd, Jamie Gaul Pharmd, Bcps, Jared Netley Pharmd

Parkview Pharmacy Department

2017 ASHP Midyear Clinical Meeting / Orlando, Florida / Poster 10-084

Poster Presentation

Objective: Describe prescribing patterns for long-acting injectable antipsychotics and identify knowledge gaps in prescribing within our health system.

Burnout-Depression Overlap: A Study Of New Zealand Schoolteachers, Renzo Bianchi, Irvin Sam Schonfeld, Eric Mayor, Eric Laurent

Publications and Research

We examined the overlap of burnout with depression in a sample of 184 New Zealand schoolteachers. Burnout and depressive symptoms were strongly correlated with each other (r = .73; disattenuated correlation: .82) and moderately correlated with dysfunctional attitudes, ruminative responses, and pessimistic attributions. All the participants with high frequencies of burnout symptoms were identified as clinically depressed. Suicidal ideation was reported by 36% of those participants. Three groups of teachers emerged from a two-step cluster analysis: “low burnout-depression,” “medium burnout-depression,” and “high burnout-depression.” The correlation between the affective-cognitive and somatic symptoms of depression was similar in strength to the burnout-depression …

Combat Vascular Trauma_ From Characterization To Innovation.Pdf, Shane Smith

Data and Test Instruments

The way that soldiers are injured in modern conflicts has changed. Bullet and ballistic weapons are causing fewer casualties, and more commonly Improvised Explosive Devices (IED) are injuring them. The purpose of this thesis is to characterize the injury pattern of the antipersonnel IED (AP-IED) in victims from the Afghanistan conflict, to retrospectively examine the incidence and type of vascular trauma in a Canadian level 1 trauma center and to develop and novel device for control of junctional vascular injuries.The injury pattern of 100 consecutive AP-IED victims was recorded. Multiple amputations occurred in 70% of IED victims: 5 quadruple amputations, …

Short-Term Compliance With Stabilization Splints In A Group Of Thai Patients With Temporomandibular Disorders, Siriya Pakanimit, Atinuch Malakul, Suknipa Vongthongsri

Chulalongkorn University Dental Journal

Objectives To investigate short-term compliance rate in the usage of stabilization splint in temporomandibular disorders (TMD) patients and to analyze the difference in compliance rate classified by the treatment outcome of occlusal splint therapy. Materials and methods A prospective observational study was conducted. The sample group consisted of 90 TMD patients receiving stabilization splint treatment in the Department of Occlusion, Faculty of Dentistry, Chulalongkorn University during January to June 2016. Patients were asked to complete a questionnaire during a period of 14 days after splint insertion in order to determine the compliance to occlusal splint therapy, experience of adverse effects …

Curcumin Promotes Bone Marrow Stromal Cell Viability And Attenuates Tnf- -Induced Prostaglandin E2 Synthesis Via Cyclooxygenase-2 Suppression, Varittha Thongtan, Supaporn Suttamanatwong

Chulalongkorn University Dental Journal

Background Prostaglandin E2 (PGE2) is the main mediator for receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone resorption in periodontitis. Bone marrow stromal cells (BMSCs) secrete PGE2 in response to pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). Curcumin, a polyphenolic compound from the turmeric plant, possesses an anti-inflammatory effect by downregulating key mediators of inflammation. Objectives This study examined the effect of curcumin on the process of PGE2 biosynthesis in TNF-α-stimulated BMSCs. Materials and methods To investigate curcumin cytotoxicity, mouse ST2 BMSCs were treated with 1-50 μM curcumin and cell viability was determined by the MTT assay. …

Evaluation Of Technical Image Quality And Radiation Dose Of A Thai Cone-Beam Ct Scanner, Ruben Pauwels, Saowapak Thongvigitmanee, Sorapong Aootaphao, Chalinee Thanasupsombat, Walita Narkbuakaew, Reinhilde Jacobs, Hilde Bosmans, Soontra Panmekiate, Pairash Thajchayapong

Chulalongkorn University Dental Journal

Objectives The aim of this study is to evaluate the technical image quality and radiation dose of the DentiiScan 2.0 cone-beam computed tomography (CBCT) scanner before widespread clinical use. Materials and methods Image quality was measured for 4 scanning protocols of the DentiiScan 2.0, using 2 dedicated test objects: the SEDENTEXCT IQ phantom and the QRM-ConeBeam phantom. The following image quality parameters were evaluated: contrast-detail, contrast-to-noise ratio (CNR), spatial resolution, grey value uniformity, metal artefacts, and geometric accuracy. Radiation dose was measured using a calibrated ionization chamber placed at the isocenter of rotation, allowing for the calculation of the dose-area …

Childhood Obesity: Physiological And Psychological Implications And Ethical Responsibilities, Connie S. Lewis

Journal of Health Ethics

Childhood obesity continues to be a health concern in the United States with physiological and psychological consequences. Research conducted in schools may address the physiological effects and exacerbate negative psychological effects, including weight bias and stigmatization. In the home, children are dependent on parents/caregivers to provide a healthy diet and exhibit a healthy lifestyle.The ethical theory, ethics of care, emphasizes dependence and interdependence on others, and ethical and moral responsibilities in the parent/child relationship. The assurance of ethical considerations involving children in research and parental provision for healthy dietary provision is of utmost importance. Any action or inaction that results …

Legalization Of Euthanasia And Physician-Assisted Dying: Condemnation Of Physician Participation, Samira Mazloom, Alireza Hamidian Jahromi, Bahar Bastani

Journal of Health Ethics

The topic of physician-assisted dying has always been a controversial topic raising a strong ethical dilemma. Currently six states in USA (Oregon, Vermont, Washington, Montana, California, Colorado) have developed regulations legalizing physician-assisted dying (medical euthanasia). We propose that physicians, because of their Hippocratic oath, should be exempted of participating in it. We suggest experts in professional assisted dying (“Euthanasia Specialists”) be ethically and to some degree medically trained to perform such a task when deemed appropriate.

Prophylactic Use Of Metformin To Decrease The Incidence Of Breast Cancer In High Risk, Predisposed Women, Aly Dahl

Physician Assistant Scholarly Project Posters

• Breast cancer is one of the most common types of cancer in American women and is the second leading cause of mortality.

• In 2015, 234,190 new diagnoses were made and 40,730 deaths from breast cancer.

• Along with a thorough history from the patient, there are also several risk assessment models that should be utilized, such as the common Gail-2 model.

• Any women with a significant family history should also be educated on genetic counseling and/or testing to detect a BRCA1 or 2 mutation.

• Numerous individuals who are positive for this gene elect to undergo prophylactic …