Medicine and Health Sciences Commons^™

Addressing Antibiotic Resistance From Farm-Raised Fish Imported To The United States, Nicholas Ali

Bard Center for Environmental Policy

Misuse of medically important antibiotics in animal production threatens the effectiveness of drugs that are vital in combating disease and infections. Recently, the FDA implemented regulations to limit the use of and access to veterinary drugs. However, these regulations only affect domestic production operations. Because over 90% of seafood consumed in the U.S. is imported from countries with different regulatory standards and because the U.S. has an import inspection rate of less than 1%, antibiotic resistance stemming from imported aquaculture is still a risk that is not sufficiently accounted for. This research investigates how the U.S. has reacted to the …

Ivan Illich’S Medical Nemesis And The ‘Age Of The Show’: On The Expropriation Of Death, Babette Babich

Articles and Chapters in Academic Book Collections

What Ivan Illich regarded in his Medical Nemesis as the ‘expropriation of health’ is exacerbated by the screens all around us, including our phones but also the patient monitors and increasingly the iPads that intervene between nurse and patient. To explore what Illich called the ‘age of the show’, this essay uses film examples, like Creed and the controversial documentary Vaxxed, and the television series Nurse Jackie. Rocky’s cancer in his last film (and his option to submit to chemo to ‘fight’ cancer) highlights what Illich along with Petr Skrabanek called the ‘expropriation of death’. In contrast to what Illich …

Conventional Early Infant Diagnosis In Lesotho From Specimen Collection To Results Usage To Manage Patients: Where Are The Bottlenecks?, Appolinaire Tiam, Michelle M Gill, Heather J Hoffman, Anthony Isavwa, Mafusi Mokone, Matokelo Foso, Jeffrey T Safrit, Lynne M Mofenson, Thorkild Tylleskär, Laura Guay

Epidemiology Faculty Publications

Introduction

Early infant diagnosis is an important step in identifying children infected with HIV during the perinatal period or in utero. Multiple factors contribute to delayed antiretroviral treatment initiation for HIV-infected children, including delays in the early infant HIV diagnosis cascade.

Methods

We conducted a retrospective study to evaluate early infant diagnosis turnaround times in Lesotho. Trained staff reviewed records of HIV-exposed infants (aged-6-8 weeks) who received an HIV test during 2011. Study sites were drawn from Highlands, Foothills and Lowlands regions of Lesotho. Central laboratory database data were linked to facility and laboratory register information. Turnaround time geometric means …

Anesthetic Management Of Pheochromocytoma Resection In Adults With Single Ventricle Physiology, Giancarlo Suffredini, Natalia Diaz-Rodriguez, Krishnan Chakravarthy, Aarti Mathur, Heather K. Hayanga, Steve M. Frank, Riachard E. Ringel, Stephen Freiberg, Viachaslau M. Barodka, Jochen Steppan

Faculty & Staff Scholarship

Survival rates for patients with palliated congenital heart disease are increasing, and an increasing number of adults with cyanotic congenital heart disease (CCHD) might require surgical resection of pheochromocytoma-paraganglioma (PHEO-PGL). A recent study supports the idea that patients with a history of CCHD and current or historical cyanosis might be at increased risk for developing PHEO-PGL. We review the anesthetic management of two adults with single-ventricle physiology following Fontan palliation presenting for PHEO-PGL resection and review prior published case reports. We found the use of epidural analgesia to be safe and effective in the operative and postoperative management of our …

The Validity Of Height As A Determinant Of Takeoff Distance To Hurdle One In Ncaa Division Iii Hurdlers 2017, Phillip Wiltshire

Master's Theses

The purpose of this study was to determine if the relationships between the height of a hurdler and the takeoff distance to the first hurdle for men and women as reported by Frye (2008) were valid for NCAA Division III 100 m and 110 m hurdlers. With no specific research reported to validate Frye’s data, it is unclear how the suggested takeoff distances were developed. It is also unclear whether hurdler height or another factor is the main determinant of takeoff distance for the high hurdlers. Participants in this study were three female 100 m hurdlers and four male 110 …

Making Marble Powder Waste Profitable By Using Nano-Tio2 Surface Modification For Air Quality Improvement Applications, Yaxiong Ji, Xing Rong, Hong Zhong, Yuanhao Wang, Shifeng Wang, Lin Lu

Faculty of Science & Technology (THEi)

We report a brand new recycling route of waste marble powder, by means of surface modification with homemade nano-TiO2 particles to produce low cost coating materials for the application in air quality improvement. The as-prepared nano-TiO2 in anatase phase exhibits excellent photocatalytic characteristic, reflected by the high degradation rate of over 95% of methylene blue within 6 hours of UV irradiation. The prepared coating consisting of nano-TiO2 clad marble powder was tested by monitoring the decomposition rate of formaldehyde gas. A high degradation efficiency of about 95% within 9 hours of illumination is achieved, demonstrating a promising potential for removing …

Human Liver Sinusoid On A Chip For Hepatitis B Virus Replication Study, Young Bok (Abraham) Kang, Siddhartha Rawat, Nicholas Duchemin, Michael Bouchard, Moses Noh

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

We have developed a miniature human liver (liver-sinusoid-on-a-chip) model using a dual microchannel separated by a porous membrane. Primary human hepatocytes and immortalized bovine aortic endothelial cells were co-cultured on opposite sides of a microporous membrane in a dual microchannel with continuous perfusion. Primary human hepatocytes in this system retained their polygonal morphology for up to 26 days, while hepatocytes cultured in the absence of bovine aortic endothelial cells lost their morphology within a week. In order to demonstrate the utility of our human-liver-sinusoid-on-a-chip, human hepatocytes in this system were directly infected by Hepatitis B Virus (HBV). Expression of the …

High Prevalence Of Nontraumatic Shoulder Pain In A Regional Sample Of Female High School Volleyball Athletes, Kayt E. Frisch

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Background: Shoulder pain is becoming increasingly problematic in young players as volleyball gains popularity. Associations between repetitive motion and pain and overuse injury have been observed in other overhand sports (most notably baseball). Studies of adult athletes suggest that there is a shoulder pain and overuse problem present in volleyball players, but minimal research has been done to establish rates and causes in juvenile participants.

Purpose: To establish rates of shoulder pain, regardless of whether it resulted in a loss of playing time, in female high school volleyball players. A secondary goal was to determine whether high repetition volumes correlated …

Antimicrobial Resistance (Amr) And Multidrug Resistance (Mdr): Overview Of Current Approaches, Consortia And Intellectual Property Issues, Andrew Jenner, Niresh Bhagwandin, Stanley P. Kowalski

Law Faculty Scholarship

The supply of new diagnostics and treatments is insufficient to keep up with the increase in antimicrobial resistance (AMR) and multidrug resistance (MDR) as older medicines are used more widely and microbes develop resistance to them. At the same time, significant quantities of antibiotics are used on patients and animals that do not need them, while others who do need them lack access.

Effective responses to AMR/MDR require effort by both the public and private sectors to develop and disseminate new diagnostics, vaccines and treatments on a global scale, as well as to adapt them to local needs. This calls …

Cardiovascular Disease Risk Factors Related To Shift Work Among Korean Workers Aged From 30 To 49 Years, Su Jung Choi, Yeon Sook Kim, Eunok Park

Nursing Faculty Publications

This study was to compare health behaviors between day workers (DW ) and shift workers (SW), and to investigate the cardiovascular disease (CVD) risk factors among 30-49 years Korean workers. SW showed higher prevalence of smoking than DW. The proportion of adequate sleep was lower in SW than in DW. DW showed high.er prevalence of impaired fasting glucose, however, there were no significant differences in hypertension, obesity, hypercholesterolemia, and metabolic syndrome between DW and SW. Further research is recommended to include mediating factors such as organizational culture or working time, etc., for scrutinizing the association between work type and CVD …

Reference Values For Body Fat Percentage Obtained From Dual Energy X-Ray Absorptiometry In Adults, Mary T. Imboden, Whitney A. Welch, Ann M. Swartz, Alexander H.K. Montoye, Holmes W. Finch, Matthew P. Harber, Leonard A. Kaminsky

Faculty Publications - Department of Kinesiology

Background: Dual energy x-ray absorptiometry (DXA) is an established technique for the measurement of body composition. Reference values for these variables, particularly those related to fat mass, are necessary for interpretation and accurate classification of those at risk for obesity-related health complications and in need of lifestyle modifications (diet, physical activity, etc.). Currently, there are no reference values available for GE-Healthcare DXA systems and it is known that whole-body and regional fat mass measures differ by DXA manufacturer.

Objective: To develop reference values by age and sex for DXA-derived fat mass measurements with GE-Healthcare systems.

Methods: A de-identified sample of …

Stroke Survivor And Physical Therapist Perceptions Of Community-Based Exercise In Northwest Oregon: A Qualitative Pilot Study, Angela Grenier, Megan Hofstede, Matthew Hornback, Sara Mason, Breanne Myers, David Sjelin, Cindy Zablotny

Student-Faculty Research - College of Physical Therapy

Upon discharge from formal rehabilitation programs, individuals with chronic stroke are often constrained by physical limitations, leading to a diminished quality of life, participation restrictions, and an increased risk of further disability. (Rose et al, 2013) Community-based exercise (CBE) programs specific to individuals post-stroke may offer a mechanism to ameliorate these sequelae. (Pang et al, 2005) Current evidence supports the efficacy of CBEs in improving health-related outcomes, quality of life, and social participation post-stroke. (Lau et al, 2016)

The aim of this region-specific study is to explore current physical therapy practice in educating and preparing stroke survivors for CBE, from …

Pathophysiological Relevance Of Astroglial Angiotensin And The Endocannabinoid Signaling Systems In Shrs, Dhanush Haspula

Student Theses, Dissertations and Capstones

BACKGROUND: Spontaneously hypertensive rats (SHRs), an essential hypertension model, are characterized by pro-inflammatory states in brainstems. While Angiotensin (Ang) II, via activation of glial Ang Type 1 receptors (AT1Rs), has been shown to trigger a significant upsurge in pro-inflammatory cytokines, activation of astroglial Cannabinoid Type 1 Receptors (CB1Rs), elicits a potent anti-inflammatory response in the brain. Both brainstem AT1Rs and CB1Rs have also been reported to alter cardiovascular parameters in SHRs. Evidence of crosstalk between CB1Rs and AT1Rs has also emerged, further highlighting a need to understand their signaling interaction in cardiovascular diseases. APPROACH: The purpose of this study was …

Measuring Knowledge And Attitudes Regarding The Use Of Pharmacogenetic Testing Among Patients And Prescribers: Diffusion Of Innovation Theory, Suhaib Mohammad Muflih

Student Theses, Dissertations and Capstones

Background: Healthcare providers play a key role in patient care. Their knowledge and attitudes may play a critical role in the incorporation of pharmacogenetic (PGx) testing into routine practice. The knowledge and attitudes of patients are also equally important in determining the rate of diffusion and the adoption of PGx testing. This study aims to test Rogers’s diffusion of innovation theory to identify and evaluate the influence of knowledge, attitudes, and sociodemographic characteristics of patients and physicians on the adoption of PGx testing in current clinical settings. Method: A cross-sectional, descriptive survey design was implemented. The sample consisted of patients …

Using Rapid Reviews In Nursing And Midwifery Research: An Example From A Study Commissioned To Inform Policy-Making, Denise O'Leary, Mary Casey, Laserina O’Connor, Diarmuid Stokes, Gerard Fealy, Denise O’Brien, Rita Smith, Martin Mcnamara, Claire Egan

Articles

Aim: To illustrate the potential use of rapid review approaches in nursing and midwifery research by presenting a worked example from a study conducted to inform policy decision making.

Background: Rapid reviews, which can be defined as outputs of a knowledge synthesis approach that involves modifying or omitting elements of a systematic review process due to limited time or resources, are becoming increasingly popular in health research. This paper provides guidance on how a rapid review can be undertaken and discusses the strengths and challenges of the approach.

Data source and research design: Data from a rapid …

The Perceptions Of Key Stakeholders Of The Roles Of Specialist And Advanced Nursing And Midwifery Practitioners, Mary Casey, Laserina O'Connor, Emma Nicholson, Rita Smith, Denise O'Brien, Denise O'Leary, Gerard Fealy, Martin Mcnamara, Diarmuid Stokes, Claire Egan

Articles

Aim: To explore the perceptions of key stakeholders of the roles of specialist and advanced nursing and midwifery practitioners. Background: There is evidence that the contribution of these roles to patient care is poorly understood. Design: This research took place over 2 months in 2015 and is part of a larger study involving a rapid review to inform policy development on the specialist and advanced nursing and midwifery practice in Ireland. As an added value, a qualitative element involving thematic analysis was undertaken with key stakeholders. Methods: A phenomenological qualitative study was conducted incorporating semistructured interviews …

A Comparison Of Stimulus Presentation Methods In Temporal Discrimination Testing, Eavan M. Mcgovern, John Butler, Ines Beiser, Laura Williams, Brendan Quinlivan, Shruti Narasiham, Rebecca Beck, Sean O'Riordan, Richard B. Reilly, Michael Hutchinson

Articles

The temporal discrimination threshold (TDT) is the shortest time interval at which an individual detects two stimuli to be asynchronous (normal  =  30-50 ms). It has been shown to be abnormal in patients with disorders affecting the basal ganglia including adult onset idiopathic focal dystonia (AOIFD). Up to 97% of patients have an abnormal TDT with age- and sex-related penetrance in unaffected relatives, demonstrating an autosomal dominant inheritance pattern. These findings support the use of the TDT as a pre-clinical biomarker for AOIFD. The usual stimulus presentation method involves the presentation of progressively asynchronous stimuli; when three sequential stimuli are …

Cancer Care Annual Report 2016-2017, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center. This report has a focus on sarcomas.

Evolution Of Occupational Therapy Practice: Life History Of Nancy Rentfrow, Emma Lee, Maddi Buscho

Oral History Posters

This life history is one of 29 life history interviews which are part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of this project is to gather information about the history and evolution of occupational therapy (OT) practice in North Dakota and Wyoming through life histories of individuals who have been influential in developing OT in these two states. It is anticipated that the life history process will be a powerful way to gather this information. The study took place at the University of …

A Life History: Sarah Nielsen, Phd, Otr/L, Sarah Schwartz, Ashley Ystaas

Oral History Posters

This life history is one of 29 life history interviews which are a part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of the project is to gather information about the history and evolution of OT practice in North Dakota and Wyoming through life histories of individuals who have been influential in developing OT in these two states. It is anticipated that the life history process will be a powerful way to gather this information.

This study is intended to provide current and future …

Evolution Of Occupational Therapy Practice: Life History Of Lance Norman, Mot, Otr/L, Cht, Jade Clement, Miranda Hosking

Oral History Posters

Objective. The purpose of this life history study was to gather information regarding the history and evolution of occupational therapy (OT) practice in North Dakota and Wyoming. The life history of Lance Norman and his influence in developing OT in North Dakota was one of 29 stories explored.

Method. The qualitative study used a life history approach. A semi-structured interview was conducted with the participant that was assigned to the researchers via a purposive sampling method. The interview was recorded, transcribed, and an open coding process was used for data analysis. To guide the research process the Kawa model …

Lessons From The Field: Kinship As An Intervention (Library Resources), Holy Cross Libraries

Library Resources for Campus Events

A bibliography of resources available through the Holy Cross Libraries which provide additional information related to “Lessons from the Field: Kinship as an Intervention,” a lecture by Rev. Gregory Boyle, S.J., founder and executive director of Homeboy Industries, held at the College of the Holy Cross on February 6, 2017.

Homeboy Industries is the largest gang intervention, rehabilitation and re-entry program in the world

Surviving As A Cancer Survivor: A Case Report Of Radiation-Induced Autonomic Dysfunction, Daphne Sy, Mark Schauer

Research Day

While radiation and chemotherapy have achieved high rates of cure for Hodgkin lymphoma, the medical community is only now starting to characterize the long-term effects of treatment on these young cancer survivors, many decades later. Mantle radiation has been implicated in significantly increased cardiovascular risks, pulmonary fibrosis, other cancers, and thyroid disease over the patient’s lifetime. However, new syndromes are still being discovered within this population as they age. The purpose of this case study was to consider the unique health issues of cancer survivors, and how their treatment history should prompt us to broaden our differentials. Our patient presented …

The Therapeutic Relationship As A Context For Reformation, Kristine Lund

Luther Faculty Publications

Luther’s lifelong struggle with melancholy and anxiety is well documented in his own writings as well as by Luther scholars. Luther notes the importance of his relationship with Johannes Staupitz, his mentor and spiritual advisor in addressing the inner torment he experienced and the significant effect this had on his theology and quality of life. This paper explores Luther’s relationship with Staupitz as an important context for the transformation of Luther’s personal life and the concurrent reformation of Luther’s theology and understanding of grace. Their relationship serves as a framework for understanding the importance of the psychotherapeutic relationship as a …

Long-Term Outcome Of 487 Patients With Early-Stage Extra-Nodal Marginal Zone Lymphoma, S. Teckie, S. Qi, M. Chelius, S. Lovie, M. Hsu, A. Noy, C. Portlock, J. Yahalom

Journal Articles

No abstract provided.

Novel Wavelet-Based Segmentation Of Prostate Cbct Images With Implanted Calypso Transponders., Y. Liu, Z. Saleh, Y. Song, M. Chan, X. Li, C. Shi, X. Qian, X. Tang

Journal Articles

Segmentation of prostate Cone Beam CT (CBCT) images is an essential step towards real-time adaptive radiotherapy (ART). It is challenging for Calypso patients, as more artifacts generated by the beacon transponders are present on the images. We herein propose a novel wavelet-based segmentation algorithm for rectum, bladder, and prostate of CBCT images with implanted Calypso transponders. For a given CBCT, a Moving Window-Based Double Haar (MWDH) transformation is applied first to obtain the wavelet coefficients. Based on a user defined point in the object of interest, a cluster algorithm based adaptive thresholding is applied to the low frequency components of …

The More Igrt Systems, The Merrier?, B. Sun, J. Chang, Y. Rong

Journal Articles

No abstract provided.

Exploration Of Bioactive Compounds Of Ginger As A Folk Remedy For Migraines, Nathan Vorbes Aleger

Honors Undergraduate Theses

Ginger (Zingiber Officinale) has been used in Asia for centuries to treat various ailments. Ginger has been reported to alleviate migraine pain via four bioactive compounds that can reduce nitric oxide synthase (NOS) resulting in the inhibition of nitric oxide (NO). The inhibition of nitric oxide results in the vasoconstriction of the intracranial blood vessels alleviating migraine pain. It is hypothesized that ginger has structural similarities to vasoconstrictor drugs causing similar receptor interactions. A review of the bioactive compounds in ginger and popular vasoconstrictor drugs was done to determine structural similarities. The results of this study show that …

The Effect Of K562-Il21-2 Plasma Membrane Particles On The Proliferation Of Natural Killer Cells To Fight Cancer, Michelle Prophete

Honors Undergraduate Theses

Immunotherapy has emerged as a current and future paradigm of cancer treatment, which utilizes the body’s immune system to eradicate cancer. Natural Killer (NK) cells as part of the innate immune system have immense potential in their anti-tumor cytotoxic activities and host cell surveillance properties. NK cells comprise approximately five to fifteen percent of peripheral blood lymphocytes and can be proliferated in vitro using recently developed methods with co-cultures with feeder cells (derived from engineered tumor cells) or plasma membrane (PM) particles, produced from the fore mentioned feeder cells, in combination with soluble cytokines. For efficient growth and maintenance of …

It Takes An Instigator, Vision And Passion, Promoting Health In Haiti: Developing A Partnership Between An Impoverished Nation And An Ngo To Develop Advanced Practice Nursing Education, A Case Study, Carol Roye Edd, Rn, Andrea Sonenberg Phd, Whnp, Cnm-Bc

Wilson Center for Social Entrepreneurship

Four nurse educators went to Haiti after the 2012 earthquake to help rebuild the School of Nursing in Port-au-Prince. They were alarmed by the low level of health care in Haiti. Most people have no care, and those that do are treated by nurses who are not trained to do so. This article details the steps the nurses went through to start a family nurse practitioner program in Haiti to address the need for primary care and discusses how they created the partnerships necessary to start such an innovative program at the University of Haiti.