Medicine and Health Sciences Commons^™

Transcranial Direct Current Stimulation And Stroke Recovery: Opportunities And Challenges, Murtaza G, Hussain F, Iqbal M, Shahid Bashir

Pakistan Journal of Neurological Sciences (PJNS)

Transcranial direct current stimulation (tDCS) is one type of neuromodulation, which is an emerging technology that holds promise for the future studies on therapeutic and diagnosis applications in treatment of neurological and psychiatric diseases. However, there is a serious question among developing countries with limited financial and human resources, about the potential returns of an investment in this field and regarding the best time to transfer this technology from controlled experimental settings to health systems in the public and private sectors. This article reviews the tDCS as tools of neuromodulation for stroke and discusses the opportunities and challenges available for …

Spectrum Of Gullian Barre Syndrome In Children, Dr. Shaila Ali, Dr. M. Zia Ur Rehman, Dr. Tipu Sultan

Pakistan Journal of Neurological Sciences (PJNS)

GBS is a post-infectious poly-neuropathy involving mainly motor but sometimes also sensory and autonomic nerves. This is an epidemiological report on seasonal & monthly distribution of GBS & differences in GBS incidence between male & female in Punjab, Pakistan. Objective: To determine the seasonal variation, age and gender differentiation in children with GBS along with EMG/NCS findings. Study Design: Retrospective, observational,cross sectional study. Place and duration of study: Department of Neurology, Childrens Hospital & The Institute of Child Health, Lahore from January 2014 to December 2014. METHODS: We extracted data from multi centers retrospectively in a 1 year period (January …

A Giant Right Subclavian- Axillary Artery Aneurysm Presenting As Brachial Plexopathy, Mahnoor Hafeez,, Ateeque Ahmed Khan

Pakistan Journal of Neurological Sciences (PJNS)

We present a rare case of 60 years old lady with diabetes and uncontrolled systemic hypertension, who was referred to the Surgical Department of Civil Hospital Karachi in September 2016 with rapidly progressive mass at right shoulder region and acute onset of ipsilateral limb sensory and motor deficit for last 3 weeks. The nerve conduction studies (NCS) revealed right brachial plexopathy. Computed Tomography demonstrated an 8.2x8.7cm (width x length) fusiform giant aneurysm of right subclavian-axillary artery with reactive axillary lymphadenitis. Early Aneurysmectomy and arterial reconstruction with saphenous vein graft interposition was planned. Unfortunately, she succumbed to death due to spontaneous …

Intracranial Hypertension And Optic Nerve Sheath Fenestration, Irfan Jeeva

Pakistan Journal of Neurological Sciences (PJNS)

Intracranial Hypertension is a neurological condition secondary to raised intracranial pressure in the absence of identifiable intracranial pathology and with normal cerebrospinal fluid composition. It can be a challenging condition to manage. One of the treatment modalities, optic nerve sheath fenestration is an important, yet under utilized mode of treatment, particularly in patients with visual symptoms.

Central Nervous System Tuberculosis In Children, Tipu Sultan

Pakistan Journal of Neurological Sciences (PJNS)

Brain and spinal cord tuberculosis are one of the commonest neurological infection in developing countries. Its associated with high morbidity and mortality. Diagnosis is based on clinical features, cerebrospinal fluid and brain imaging. Combination of antituberculous drugs should be started as early as possible to prevent the complications. The patient's clinical stage at presentation is the most important prognostic factor. Surgical procedures are directed at management of the hydrocephalus. Focal lesions, intracranial tuberculomas, and tuberculous abscesses, are usually located in cerebral or cerebellar hemispheres, uncommonly in brainstem and very rarely in spinal cord. They do not usually require surgical intervention …

Mice With Infectious Colitis Exhibit Linear Growth Failure And Subsequent Catch-Up Growth Related To Systemic Inflammation And Igf-1, Mark D. Deboer, Vidhya Vijayakumar, Meiqing Gong, John L. Fowlkes, Rachel M. Smith, Fernando Ruiz-Perez, James P. Nataro

Barnstable Brown Diabetes Center Faculty Publications

In developing communities, intestinal infection is associated with poor weight gain and linear-growth failure. Prior translational animal models have focused on weight gain investigations into key contributors to linear growth failure have been lacking. We hypothesized that murine intestinal infection with Citrobacter-rodentium would induce linear-growth failure associated with systemic inflammation and suppressed serum levels of insulin-like growth factor-1 (IGF-1). We evaluated 4 groups of mice infected or sham-infected on day-of-life 28: uninfected-controls, wild-type C.-rodentium-infected, partially-attenuated C. rodentium-infected (with deletion of 3 serine protease genes involved in colonization), and pair-fed (given the amount of daily food consumed by the …

Patient-Rated Wrist/Hand Evaluation: A Cross-Cultural Adaptation And Evaluation In Thai Version, Hathaya Jongprasitkul, Titrison Sonthimaneerat, Sarawut Somana, Wasuwat Kitisomprayoonkul

Chulalongkorn Medical Journal

Background : The Patient Rated Wrist/Hand Evaluation (PRW/HE) is a specific questionnaire designed to measure wrist/hand pain and disabilities. The questionnaire was validated to provide various scales by asking questions regarding wrist-hand injury of a patient. It has also been translated into several languages. Therefore, we translated and adapted the questionnaire into Thai version for hand therapy clinic.Objectives : To translate and to cross-culturally adapt the PRW/HE into Thai (PRW/HEThai) and to evaluate it’s the reliability and validity.Methods : The original version PRW/HE was translated with cross cultural adaptation into Thai (PRW/HE-Thai). A total of 148 outpatients from Occupational therapy …

อาการปวดและความผิดปกติของข้อไหล่ที่พบบ่อยในเวชศาสตร์ฟื้นฟู, ณัฏฐิยา ตันติศิริวัฒน์

Chulalongkorn Medical Journal

อาการปวดและความผิดปกติของข้อไหล่เป็นปัญหาทางระบบกล้ามเนื้อและกระดูกที่พบในเวชปฏิบัติได้บ่อย และส่งผลกระทบอย่างมากต่อคุณภาพชีวิต เนื่องจากข้อไหล่เป็นข้อที่มีความจำเป็นต่อการประกอบกิจวัตรประจำวัน (activities of daily living) เช่น การอาบน้ำการใส่เสื้อผ้า การแต่งตัวและการใช้งานทั่ว ๆ ไปโดยเฉพาะอย่างยิ่งเป็นกิจกรรมประเภทที่ต้องยกมือขึ้นเหนือศีรษะ (overhead activities) ผู้ที่มีปัญหาปวดข้อไหล่ส่วนหนึ่งจะมีอาการปวดไหล่เรื้อรังปัญหาปวดไหล่ที่มีพยาธิสภาพเกิดจากข้อไหล่และเนื้อเยื่อรอบข้อไหล่ที่พบบ่อย ดังนี้ ภาวะไหล่ติดภาวะกระดูกทับเส้นเอ็น ภาวะการอักเสบและภาวะฉีกขาดของเอ็นกล้ามเนื้อกลุ่ม rotator cuffและภาวะการอักเสบของเอ็นกล้ามเนื้อ biceps เนื้อหามุ่งเน้นรายละเอียดการรักษาทางด้านเวชศาสตร์ฟื้นฟูอันประกอบด้วยการรักษาด้วยยาและหัตถการเพื่อลดอาการปวด การออกกำลังกายการรักษาทางด้านกายภาพบำบัดอื่น ๆ เช่น manual therapy และกายอุปกรณ์.

ความสัมพันธ์ระหว่างรูปแบบการสื่อสารภายในครอบครัวกับความฉลาดทางอารมณ์ของเด็กสมาธิสั้นในโรงพยาบาลจุฬาลงกรณ์, จิดาภา คงเจริญ, อลิสา วัชรสินธุ

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การศึกษาความสัมพันธ์ระหว่างรูปแบบการสื่อสารในครอบครัวกับความฉลาดทางอารมณ์ที่ผ่านมา ส่วนใหญ่ศึกษาในเด็กปกติ ซึ่งความฉลาดทางอารมณ์เป็นสิ่งสำคัญที่ทำให้เด็กมีความพึงพอใจในตนเอง สามารถควบคุมอารมณ์ได้และพร้อมที่จะพัฒนาตนเองวัตถุประสงค์ : เพื่อศึกษาความฉลาดทางอารมณ์ของเด็กสมาธิสั้น และรูปแบบการสื่อสารภายในครอบครัวของเด็กสมาธิสั้น รวมทั้งศึกษาความสัมพันธ์ระหว่างรูปแบบการสื่อสารภายในครอบครัวกับความฉลาดทางอารมณ์ของเด็กสมาธิสั้นตัวอย่างและวิธีการศึกษา : กลุ่มตัวอย่างผู้ปกครองของเด็กสมาธิสั้นที่อายุ 6 - 11 ปี ที่มารับการตรวจรักษาที่แผนกผู้ป่วยนอก หน่วยจิตเวชเด็กและวัยรุ่นโรงพยาบาลจุฬาลงกรณ์จำนวน 106 คน เก็บข้อมูลตั้งแต่ตั้งแต่เดือนพฤศจิกายน พ.ศ. 2558 ถึงเดือนมกราคม พ.ศ. 2559 โดยใช้แบบสอบถาม 3 ส่วน ประกอบด้วยแบบสอบถามข้อมูลทั่วไป รูปแบบการสื่อสารภายในครอบครัว ของปาริชาติ ธาราพัตราพร ตามแนวคิดของ Kanter and Lehr และแบบประเมินความฉลาดทางอารมณ์ของกรมสุขภาพจิต วิเคราะห์ข้อมูลโดยใช้สถิติเชิงพรรณนาการทดสอบค่าที การวิเคราะห์ความแปรปรวนแบบจำแนกทางเดียวสัมประสิทธิ์สหสัมพันธ์ของเพียร์สัน และสถิติถดถอยพหุคูณแบบขั้นตอนผลการศึกษา : เด็กสมาธิสั้นมีความฉลาดทางอารมณ์ด้านดีอยู่ในระดับปกติร้อยละ57.5 ด้านเก่งอยู่ในระดับปกติร้อยละ 66.0 ด้านสุขอยู่ในระดับปกติร้อยละ 49.1 และมีรูปแบบการสื่อสารในครอบครัวปิดในระดับสูงร้อยละ 70.8 ปัจจัยที่มีความสัมพันธ์กับความฉลาดทางอารมณ์อย่างมีนัยสำคัญทางสถิติ ได้แก่ อายุ อาชีพของผู้ปกครอง ผลการเรียนของเด็กสมาธิสั้น รูปแบบการสื่อสารในครอบครัวแบบเปิดมีความสัมพันธ์เชิงบวกกับคะแนนความฉลาดทางอารมณ์อย่างมีนัยสำคัญทางสถิติ (P <0.01) และปัจจัยที่สามารถทำนายความฉลาดทางอารมณ์ของเด็กสมาธิสั้นให้ดีขึ้นได้ คืออายุ อาชีพของผู้ปกครองผลการเรียนของเด็กสมาธิสั้น และรูปแบบการสื่อสารในครอบครัวแบบเปิดสรุป : เด็กสมาธิสั้นมีความฉลาดทางอารมณ์อยู่ในระดับปกติทั้ง 3 ด้านด้านดี ด้านเก่ง และด้านสุข ส่วนปัจจัยที่เกี่ยวข้องกับความฉลาดทางอารมณ์ของเด็กสมาธิสั้น คือ อายุ อาชีพของผู้ปกครองผลการเรียนของเด็กสมาธิสั้น และรูปแบบการสื่อสารในครอบครัวแบบเปิด.

Pre-Training Muscle Characteristics Of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness, Charles A. Stuart, Michelle L. Lee, Mark A. South, Mary E. A. Howell, Brian M. Cartwright, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

Pre-training muscle characteristics of subjects who are obese determine how well exercise training will improve their insulin responsiveness. J Strength Cond Res 31(3): 798–808, 2017—Only half of prediabetic subjects who are obese who underwent exercise training without weight loss increased their insulin responsiveness. We hypothesized that those who improved their insulin responsiveness might have pretraining characteristics favoring a positive response to exercise training. Thirty nondiabetic subjects who were obese volunteered for 8 weeks of either strength training or endurance training. During training, subjects increased their caloric intake to prevent weight loss. Insulin responsiveness by euglycemic clamps and muscle fiber composition, …

Reduced Skeletal Muscle Satellite Cell Number Alters Muscle Morphology After Chronic Stretch But Allows Limited Serial Sarcomere Addition, Matthew C. Kinney, Sudarshan Dayanidhi, Peter B. Dykstra, John J. Mccarthy, Charlotte A. Peterson, Richard L. Lieber

Physiology Faculty Publications

Introduction: Muscles add sarcomeres in response to stretch, presumably to maintain optimal sarcomere length. Clinical evidence from patients with cerebral palsy, who have both decreased serial sarcomere number and reduced satellite cells (SCs), suggests a hypothesis that SCs may be involved in sarcomere addition. Methods: A transgenic Pax7‐DTA mouse model underwent conditional SC depletion, and their soleii were then stretch‐immobilized to assess the capacity for sarcomere addition. Muscle architecture, morphology, and extracellular matrix (ECM) changes were also evaluated. Results: Mice in the SC‐reduced group achieved normal serial sarcomere addition in response to stretch. However, muscle fiber cross‐sectional …

Giant Ganglioneuroma In A 5-Year Child, Hamza Abdur Rahim Khan, Fazal Wahab Khan, Saulat H. Fatimi

Department of Surgery Docs

ABSTRACT We report a 5-year boy presenting with pain in the lower chest and upper abdomen. On evaluation with computed tomography scan of the chest, he was found to have a large 16 x 14 cm posterior mediastinal mass compressing the inferior vena cava and liver, and shifting the heart to the opposite side. Tumor was approached via right postero-lateral thoracotomy and dissected off from esophagus, heart, inferior vena cava and lungs. The entire tumor was resected without any complications. Postoperative course was unremarkable. Resection of the tumor was successful. The histopathology showed it to be giant ganglioneuroma with no …

Significance Of Animal Model Research In Homoeopathy, Raj Manchanda

Indian Journal of Research in Homoeopathy

No abstract provided.

Action Of Diosgenin And Homoeopathic Pathogenesis Of Dioscorea Villosa, Kisor Naskar, Ompriya Mishra

Indian Journal of Research in Homoeopathy

Background: Dioscorea villosa is a popular herbal remedy for pains. Early Americans used this to treat colic which is also established in homoeopathic proving and verified clinically along with other important phenomena. Diosgenin is its primary active ingredient. It has been investigated that all possible revealed actions of this plant are due to this ingredient. Objective: The aim of this study is to understand pathological background and prescribing areas of D. villosa by correlating and analyzing Homoeopathic pathogenesis with the knowledge of pathophysiological activities of Diosgenin. Study Method: Information was collected from various researches on animal and human models regarding …

Analysis Of Antioxidant Activity And Total Phenolic Content Of Some Homoeopathic Mother Tinctures, Saeed Ahmad, Tayyeba Rehman, Waheed Abbasi, Muhammad Zaman

Indian Journal of Research in Homoeopathy

Background: Antioxidant compounds are widely used in health protection. Homoeopathic mother tinctures are commonly prescribed for prevention and cure of many illnesses. Objective: The present study focused to determine the antioxidant potential of six commonly prescribed mother tinctures. i.e. Syzygium jambolanum, Damiana, Cinchona officinalis, Chelidonium majus, Convallaria majalis, Coca. Materials and Methods: Antioxidant activity was estimated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition assay. A volume of 0.1 mM solution of DPPH was used while mother tinctures (5, 2.5, and 1.25 μl volumes) were used for estimating antioxidant activity. Quercetin was taken as a standard control in antioxidant activity. Total phenolic content was …

Pharmacognostic And Physicochemical Evaluation Of Homoeopathic Drug: Erigeron Canadensis L., Padma Pogaku, Subramanian Palani, Sudhakar Penthala, P Narayana, Nagaraju Mukkamula

Indian Journal of Research in Homoeopathy

Background: Erigeron canadensis L. is an erect annual herb belonging to the family Asteraceae. Aerial parts are used in Homoeopathy for bruises, cough, dysuria, gonorrhea, haemorrhages, haemorrhoids, spermatorrhea, and wounds. Objective: The pharmacognostic and physicochemical studies have been carried out to facilitate the use of correct species and lay down standards of raw drug materials. Materials and Methods: Pharmacognostic studies of the leaf and stem of authentic samples of E. canadensis L. have been carried out. Physicochemical parameters of the raw drug include extractive values, ash value, and formulation; besides weight per mL, total solids, and alcohol content, high-performance thin …

Preclinical Evaluation Of Antiarthritic Activity Of Ultra-Diluted Preparations Of Capsaicin Alkaloids (Cp-10), Tumor Necrosis Factor-Alpha, And Magnesium Phosphoricum In Wistar Rats, Rajesh Shah, Sadhana Sathaye

Indian Journal of Research in Homoeopathy

Background: The use of animal models in the development of new medicine and research is common in the conventional medicine. Animal model for new drug discovery and efficacy testing for preclinical research is explored in Homoeopathy only by a few. This study explores the possibility to test in a controlled way the effects of homoeopathic remedies on experimental model of acute inflammation in rats. Methods: Wistar rats were divided into seven groups (seventy rats of 6–8 weeks' age); medicines were evaluated by oral administration in the Complete Freund's adjuvant (CFA)-induced arthritis. Two new homoeopathic preparations, a combination of Capsaicin and …

Characterization And Haemocompatibility Of Aurum Metallicum For Its Potential Therapeutic Application, Subrata Kar, Monalisa Chakraborty, Papiya Nandy, Ruma Basu, Sukhen Dasa, Durga Bhar, Raj Manchanda, Anil Khurana, Debadatta Nayak

Indian Journal of Research in Homoeopathy

Background: The objective of the study was to characterize homoeopathic nanomedicine Aurum metallicum and evaluate its biocompatibility, to explore its possible application as injectables. Metal-based homoeopathic medicine, Aurum metallicum, was chosen as a model drug and the haemocompatibility of the drug at three different potencies 6C, 30C, and 200C were studied to find the justification of the drug as an injectable candidate for clinical application. Methods: The model drug Aurum metallicum at the three potencies was characterized by dynamic light scattering (DLS), zeta potential, field emission scanning electron microscopy (FESEM), and energy dispersive X-ray analysis. Hemocompatibility of the homoeopathic medicine …

Safety Studies Of Homoeopathic Drugs In Acute, Sub-Acute And Chronic Toxicity In Rats, Surender Singh, Prerna Kalra, Ritu Karwasra, Anil Khurana, Raj Manchanda, Yogendra Gupta

Indian Journal of Research in Homoeopathy

Background: Homoeopathic drugs are frequently recommended in day to day life as therapeutic agents by homoeopathic practitioners. However, safety of homoeopathic drugs remains a challenge because of the high variability of chemical components involved. Aim: The objective of the present study was to investigate the acute, subacute, and chronic oral toxicity of different homoeopathic drugs (Ferrum phosphoricum 3X, Ferrum phosphoricum 6X, Calcarea phosphoricum 6X, and Magnesium phosphoricum 6X) in experimental models. Materials and Methods: In acute oral toxicity study, homoeopathic drugs were administered orally at 2000mg/kg body weight, and animals were observed for toxic symptoms till 10 days as per …

Homoeopathic Medicine Mercurius Solubilis Treatment Improves Cerebral Blood Flow And Memory In Experimentally Induced Dementia In Rats, Kashif Hanif, Manoj Kumar, Neetu Singh, Rakesh Shukla

Indian Journal of Research in Homoeopathy

Background: Mercurius solubilis (Merc. sol) is a known, accepted homoeopathic medicine for the treatment of various mouth, throat, eye, and ear infections. Previous studies suggested that Merc. sol has anti-inflammatory properties which could be beneficial in memory impairment. Objective: The present study was designed to investigate the effect of Merc. sol on learning and memory and cerebral blood flow (CBF) in the rat model of impaired learning and memory function induced by intracerebroventricularly (ICV) administered streptozotocin (STZ). Materials and Methods: The different potencies of Merc. sol (6, 30, 200, and 1M) were given for 17 days in memory-impaired rats, induced …

A Retrospective Study Of Homoeopathic Treatment In Patients With Heel Pain With Or Without Calcaneal Spur, Suraia Parveen

Indian Journal of Research in Homoeopathy

Background: Heel pain is a common clinical condition which significantly affects the quality of life. It is frequently associated with calcaneal spur (CS). Despite its high prevalence, the optimal treatment remains unclear. The aim and objective of this study is to evaluate the extent of CS in heel pain; correlation of CS with some sociodemographic and health-related factors; and outcome of homoeopathic treatment over a period of 6 months. Methodology: It was a retrospective study done at Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Kolkata. Samples were selected from the patients referred for ankle X-ray from August 2014 to …

Homoeopathic Treatment Of Ulcerative Colitis: A Case Report, Partha Pal, Madhu Ghosh, Abhijit Chakma

Indian Journal of Research in Homoeopathy

Ulcerative colitis (UC) is one of the most common inflammatory bowel diseases. As in most of the cases, the exact cause is unknown Homoeopathy, however, provides a better response in such conditions, one such case report is presented below. Patient attended out patient department (OPD) chiefly for complaints of frequent passage of bloody stool and abdominal pain. He was suffering from idiopathic UC for the past 10 years. After unsatisfactory outcome with modern medicine, patient turned to homoeopathic treatment. After detailed case-taking and repertorization, Hydrastis was given in low potency, and gradually, the potency was raised as per the response …

Learning From The Past: Review Of The Central Council For Research In Homoeopathy Quarterly Bulletin 2002 (Volume 24) And 2003 (Volume 25), Uttam Singh

Indian Journal of Research in Homoeopathy

No abstract provided.

Parvovirus B19 Ns1 Protein Induces Cell Cycle Arrest At G2-Phase By Activating The Atr-Cdc25c-Cdk1 Pathway., Peng Xu, Zhe Zhou, Min Xiong, Wei Zou, Xuefeng Deng, Safder S. Ganaie, Steve Kleiboeker, Jianxin Peng, Kaiyu Liu, Shengqi Wang, Shui Qing Ye, Jianming Qiu

Manuscripts, Articles, Book Chapters and Other Papers

Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest at G2-phase; however, a putative C-terminal transactivation domain (TAD2) within NS1 is responsible for G2-phase arrest. To fully understand the mechanism underlying B19V NS1-induced G2-phase arrest, we established two doxycycline-inducible B19V-permissive UT7/Epo-S1 cell lines that express NS1 or NS1mTAD2, and examined the function of the TAD2 domain during G2-phase arrest. The results confirm that the …

Impact Of Smartphone Digital Photography, Email, And Media Communication On Emergency Room Visits Post-Hypospadias Repair., Michael E. Chua, Megan A. Saunders, Paul R. Bowlin, Jessica M. Ming, Roberto Iglesias Lopes, Walid A. Farhat, Joana Dos Santos

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Advances in communication technology are shaping our medical practice. To date, there is no clear evidence that this mode of communication will have any effect on unnecessary postoperative emergency room (ER) visits. We aim to evaluate the effect of email and media communication with application of smartphone digital photography on post-hypospadias repair ER visit rates.

METHODS: This prospective cohort study included all patients who underwent hypospadias repair performed by a single surgeon from October 2014 to November 2015. Patients were categorized into two groups: Group A consented for smartphone photography and email communication and Group B declined. Reason for …

Clinical Impact Of An Antibiotic Stewardship Program At A Children's Hospital., Brian R. Lee, Jennifer Goldman, Diana Yu, Angela Myers, Leslie M. Stach, Erin Hedican, Mary Anne Jackson, Jason G. Newland

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Antibiotic stewardship programs (ASP) improve appropriate antibiotic use. Data are limited on the clinical benefit of ASPs in children's hospitals. This study's objective was to determine the impact of an ASP on length of stay (LOS) and readmission rate among patients admitted to children's hospitals.

METHODS: Data from a prospective-audit-with-feedback ASP were used to examine the ASP review characteristics, including antibiotic(s) prescribed, clinical indication, recommendations made by the ASP, and agreement with recommendations. Propensity score analysis was utilized to determine the impact of the ASP on LOS and 30-day readmission based on whether the patient received an ASP recommendation …

Is Apremilast (Otezla) Effective In Reducing Pruritus In Adults Over 18 Years Old With Plaque Psoriasis?, Stephanie N. Carnes

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not apremilast (Otezla) is effective in reducing pruritus in adults over 18 years old with plaque psoriasis

STUDY DESIGN: This review is based on three randomized controlled trials (RCTs) published in 2012, and 2015.

DATA SOURCES: Three randomized controlled trials comparing the effectiveness of apremilast to a placebo in reducing pruritus in adults over 18 years old with plaque psoriasis, found using PubMed.

OUTCOMES MEASURED: The outcome studied was improvement of the psoriatic plaques based on reduction in pruritus measured by the Pruritus …

Screening Of Nci-Dtp Library To Identify New Drug Candidates For Borrelia Burgdorferi, Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, R. Edward Watts, Kwang-Min Kim, Mansi B. Parekh, Abhijit Achyut Gurjarpadhye, David Solow-Cordero, Lobat Tayebi, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Lyme disease is the most rapidly growing tick borne zoonotic disease of the Northern Hemisphere and is among the 10 most commonly reported nationally notifiable diseases in the United States.¹ Clinical presentations include erythema migrans, fever, chills, muscle and joint pain.^{2, 3} Though these symptoms tend to fade away even without therapeutic intervention, a significant number of untreated patients develop arthritis and persistent myalgia following exposure to Borrelia burgdorferi.⁴ Furthermore, 10–20% of patients treated for Lyme disease develop symptoms considered typical, or even exaggerated, including muscle, joint pain and generalized fatigue^{5, 6}. This condition is …

Genetic Polymorphism Of Cytochrome P450-1a2 (Cyp1a2) And N-Acetyltransferase-2 (Nat2) Among Emiratis, Mohammed Majed Al-Ahmad

Theses

Brief introduction: There are limited studies on CYP1A2 and NAT2 polymorphisms among Emiratis. Aims: This study aims to determine CYP1A2 and NAT2 alleles and genotypes and correlate these genotypes with caffeine metabolism phenotypes among Emiratis. Methods: After obtaining informed consent, five hundred and eighty-one non-smoker subjects were given 300ml of caffeinated soft drink and were asked to provide a buccal swab and a urine sample two hours later. TaqMan Real Time PCR, PCR-RFLP, DNA sequencing were performed to determine CYP1A2 and NAT2 alleles and genotypes. Phenotyping was carried out by analysing the caffeine metabolites using HPLC analysis. Results: We found …

Reproductive Control In Elephant: A Tool For Population And Aggression Management, Chaleamchat Somgird, Janine L. Brown, Chatchote Thitaram

The Thai Journal of Veterinary Medicine

Although Asian elephant is listed among the endangered species, the number of populations is over the carrying capacity in some areas, resulting in human-elephant conflict, as well as African elephants. High aggression associated with musth and female reproductive pathology are observed in captive elephants. Thus, population and aggression management through reproductive control is an alternative method for mitigating these problems. This article reviews methods of reproductive control in both Asian and African elephants with an overview of male and female reproductive physiology. Hormonal control and immunocontraception, i.e. porcine zona pellucida and gonadotropin releasing hormone (GnRH), are described for the control …