Medicine and Health Sciences Commons^™

Matlab Micro-Symposium, Mathworks

Science Seminar Series

Join us to learn how your colleagues and peers are crossing boundaries and using MATLAB in their work in areas such as chemistry, biology, pharmacy and bioengineering!

We will have four faculty speakers who will share their MATLAB uses in teaching, projects and research.

This will be followed by a coffee break that includes:

• Poster session with faculty and student projects using MATLAB
• The opportunity to talk to the MathWorks team about the tools they provide – learn about what’s new and ask your questions here!
• An opportunity to network with your fellow Pacific colleagues from other departments!

MATLAB is …

Direct Measurement Of Supra-Physiological Levels Of Ascorbate In Plasma Using A Nanophotometer, Bailey Wetherell, Jordan W. Witmer, Brett A. Wagner, Juan Dub, Joseph J. Cullen, Garry R. Buettner

Research in the Capitol

High dose intravenously administered vitamin C (ascorbate) is currently being tested in clinical trials as an adjuvant to current standard of care therapies in a variety of cancers. Intravenous infusion is used with a goal to achieve supraphysiological ascorbate concentrations in blood of at least 20 mM, 300 to 500 times normal healthy concentrations (0.04-0.08 mM). These trials need quick and easy access to information on the levels of ascorbate achieved in the blood to make clinical decisions. Previous methods that quantify ascorbate levels in blood require extensive preparation, time, and materials that may not always be present in clinical …

Disparities In Infant Mortality: Are Sociocultural Risk Factors Shaped By Institutionalized Racism? [Poster], Madison Grimm

Research in the Capitol

The United States has one of the highest infant mortality rates among countries with similar economies. In addition, significant disparities are present between races within this health indicator. According to the CDC, the infant mortality rate in 2013 among non-Hispanic whites was 5.06 infant deaths per 1,000 live births; the infant mortality rate for Black Americans was 11.11 - more than double. The purpose of this research is to explore a) sociocultural risk factors for disparities in infant mortality rates and b) whether institutionalized racism contributes to those risk factors. The social ecological model will be used as a theoretical …

Proteome Dynamics During Postnatal Mouse Corpus Callosum Development., Alexander I Son, Xiaoqin Fu, Fumikazu Suto, Judy S Liu, Kazue Hashimoto-Torii, Masaaki Torii

Pharmacology and Physiology Faculty Publications

Formation of cortical connections requires the precise coordination of numerous discrete phases. This is particularly significant with regard to the corpus callosum, whose development undergoes several dynamic stages including the crossing of axon projections, elimination of exuberant projections, and myelination of established tracts. To comprehensively characterize the molecular events in this dynamic process, we set to determine the distinct temporal expression of proteins regulating the formation of the corpus callosum and their respective developmental functions. Mass spectrometry-based proteomic profiling was performed on early postnatal mouse corpus callosi, for which limited evidence has been obtained previously, using stable isotope of labeled …

A Normative Spatiotemporal Mri Atlas Of The Fetal Brain For Automatic Segmentation And Analysis Of Early Brain Growth., Ali Gholipour, Caitlin K Rollins, Clemente Velasco-Annis, Abdelhakim Ouaalam, Alireza Akhondi-Asl, Onur Afacan, Cynthia M Ortinau, Sean Clancy, Catherine Limperopoulos, Edward Yang, Judy A Estroff, Simon K Warfield

Pediatrics Faculty Publications

Longitudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the rapid change in size, shape and volume of the developing brain, and the consequent lack of suitable algorithms for fetal brain image analysis. There is a need for an improved digital brain atlas of the spatiotemporal maturation of the fetal brain extending over the key developmental periods. We have developed an algorithm for construction of an unbiased four-dimensional atlas of the developing fetal brain by integrating symmetric diffeomorphic deformable registration in space with kernel regression in age. We applied this new …

Gene 33/Mig6 Regulates Apoptosis And The Dna Damage Response Through Independent Mechanisms, Cen Li, Soyoung Park, Leonard M. Eisenberg, Hong Zhao, Zbigniew Darzynkiewicz, Dazhong Xu

NYMC Faculty Posters

Gene 33 (Mig6, ERRFI1) is an inducible adaptor/scaffold protein whose expression can be induced by both stress and mitogenic signals. It contains multiple domains for protein-protein interaction and is involved in a broad spectrum of cellular functions. Gene 33 promotes apoptosis in a cell type-dependent manner. A recent study has linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium [Cr(VI)]. Here we show that Gene 33 induces apoptosis via both c-Abl/p73 and EGFR/AKT-dependent pathways in lung epithelial and lung carcinoma cells. Ectopic expression of Gene 33 also triggers DDR in an ATM-dependent fashion and through pathways …

Occurrence Of Potential Adverse Drug Events From Prescribing Errors In A Pediatric Intensive And High Dependency Unit In Hong Kong: An Observational Study, Chad A. Knoderer, Celeste L. Ewig, Hon Ming Cheung, Kwok Ho Kam, Hiu Lam Wong

Scholarship and Professional Work – COPHS

No abstract provided.

Evaluating Value-Based Frameworks Used For Relapsed Or Refractory Multiple Myeloma Regimens: Icer Report, Asco Value Framework, And Nccn Evidence Blocks, Laurence M. Djatche, Pharmd, Joseph Goble, Pharmd, Grace Chun, Pharmd, Stefan Varga, Pharmd

College of Population Health Posters

BACKGROUND: With the continuous rise in costs for oncology drugs, the Institute for Clinical and Economic Review (ICER), the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) have developed value-based frameworks (VBFs) to assist stakeholders in formulary and treatment decisionmaking. While emerging VBFs have the potential to significantly impact therapeutic options for patients, it is important to understand the differences associated with those VBFs within a therapeutic area. OBJECTIVE: To compare ICER, ASCO, and NCCN VBFs across three therapeutic options for relapsed or refractory multiple myeloma (RRMM).

METHODS: The values of carfilzomib (CFZ), elotuzumab (ELO), …

Maternal Characteristics And Obstetrical Complications Impact Neonatal Outcomes In Indonesia: A Prospective Study., Trisari Anggondowati, Ayman A E El-Mohandes, S Nurul Qomariyah, Michele Kiely, Judith J Ryon, Reginald F Gipson, Benjamin Zinner, Anhari Achadi, Linda L Wright

Medicine Faculty Publications

BACKGROUND: We investigated associations between maternal characteristics, access to care, and obstetrical complications including near miss status on admission or during hospitalization on perinatal outcomes among Indonesian singletons.

METHODS: We prospectively collected data on inborn singletons at two hospitals in East Java. Data included socio-demographics, reproductive, obstetric and neonatal variables. Reduced multivariable models were constructed. Outcomes of interest included low and very low birthweight (LBW/VLBW), asphyxia and death.

RESULTS: Referral from a care facility was associated with a reduced risk of LBW and VLBW [AOR = 0.28, 95% CI = 0.11-0.69, AOR = 0.18, 95% CI = 0.04-0.75, respectively], stillbirth …

Th1 Differentiation Drives The Accumulation Of Intravascular, Non-Protective Cd4 T Cells During Tuberculosis, Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber

United States Public Health Resources

Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL- 12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of …

First Year Physical Activity Findings From Turn Up The Heat (Healthy Eating And Activity Time) In Summer Day Camps, Robert Weaver, Keith Brazendale, Jessica L. Chandler, Gabrielle Turner-Mcgrievy, Justin B. Moore, Jennifer L. Huberty, Dianne S. Ward, Michael W. Beets

Faculty Publications

Background Summer day camps (SDCs) serve 14 million children yearly in the U.S. and aim to provide participating children with 60 minutes of moderate-to-vigorous physical activity (MVPA). This study evaluated an intervention designed to increase the percent of children meeting this MVPA guideline.

Design Two-group, pre-post quasi-experimental.

Setting/Participants Twenty SDCs serving 1,830 children aged 5–12 years were assigned to MVPA intervention (n = 10) or healthy eating attention control (n = 10).

Intervention

The STEPs (Strategies to Enhance Practice) intervention is a capacity-building approach grounded in the Theory of Expanded, Extended and Enhanced Opportunities. Camp leaders and staff receive training …

Mitogen-Activated Protein Kinase Phosphatase-3 (Mkp-3) In The Surgical Wound Is Necessary For The Resolution Of Postoperative Pain In Mice, Sladjana Skopelja-Gardner, Madhurima Saha, Perla Abigail Alvarado-Vazquez, Brenna S. Liponis, Elena Martinez, E Alfonso Romero-Sandoval

Dartmouth Scholarship

Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) and its substrates (extracellular signal-regulated kinase [ERK] and p38) play an important role in pathophysiological mechanisms of acute postoperative and chronic neuropathic pain in the spinal cord. This study aimed to understand the role of MKP-3 and its target MAPKs at the site of surgical incision in nociceptive behavior. Wild-type (WT) and MKP-3 knockout (KO) mice underwent unilateral plantar hind paw incision. Mechanical allodynia was assessed by using von Frey filaments. Peripheral ERK-1/2 and p38 phosphorylation were measured by Western blot. Cell infiltration was determined using hematoxylin and eosin histological staining. Peripheral phosphorylated ERK-1/2 …

Model Pembelajaran Berbasis Penstimulasian Multiple Intelligences Siswa, Edy Legowo

Jurnal Kajian Bimbingan dan Konseling

This article discusses the application of multiple intelligences theory in learning at school. The discussion begins by outlining the development of the concept of intelligence and multiple intelligences. Followed by explaining the impact of multiple intelligences theory in the field of education and learning in schools. The next section describes the implementation of multiple intelligences theory in classroom learning practices, namely how providing student learning experiences facilitated by teachers can stimulate students' multiple intelligences. Evaluation of student learning outcomes from the perspective of the application of multiple intelligences theory should be carried out using authentic assessments and portfolios which better …

Clostridium Septicum Aortitis With Synchronous Ascending Colon And Rectal Adenocarcinoma., Deepanshu Jain, Andrew C. Kistler, Patricia L. Kozuch

Division of Gastroenterology and Hepatology Faculty Papers

Clostridium septicum (C. septicum) aortitis is a rare condition frequently associated with colon adenocarcinoma and carries a poor prognosis. We report the case of a 66-year-old man who presented with abdominal pain, blood in the stool, fever and chills. Laboratory tests were significant for leukocytosis and microcytic anemia. Abdominal imaging revealed a right colon mass and aortitis. Colonoscopy confirmed the right colon mass and also discovered a rectal mass, both adenocarcinomas. Treatment consisted of antibiotics, aortic repair, right hemi-colectomy and later trans-anal excision of the rectal mass. Blood cultures and the aortic specimen grew C. septicum. The patient improved and …

Tingkat Prokrastinasi Akademik Siswa Sekolah Menengah Pertama Muhammadiyah 9 Yogyakarta, Martika Laely Munawaroh, Said Alhadi, Wahyu Nanda Eka Saputra

Jurnal Kajian Bimbingan dan Konseling

Academic procrastination is one of problems that may occur among junior high school students. This study aims to describe the level of academic procrastination of junior high school students in Sekolah Menengah Pertama Muhammadiyah 9 Yogyakarta. This research uses descriptive quantitative research. The results of this study showed that 17,2% of subjects have high academic procrastination, 77,1% of them have the moderate one, and 5,7% of them have the low one. Based on those results, it is recommended for the next researcher to use Solution-Focused Brief Counseling in reducing academic procrastination in SMP Muhammadiyah 9 Yogyakarta.

Pengembangan Paket Bimbingan Perencanaan Studi Lanjut Dengan Model Creative Problem Solving Bagi Siswa Sekolah Menengah Atas, Agrery Ayu Nadiarenita, Muslihati Muslihati, Yuliati Hotifah

Jurnal Kajian Bimbingan dan Konseling

This study aims to produce a package of guidance planning further studies with a model of creative problem solving for high school students who meet the acceptability aspects are aspects accuracy, usability, convenience and attractiveness. The guidance package consists of counselors guide book that contains the steps to the stage of providing guidance in career planning and student guide book that contains the materials and evaluation. The research method was adapted from models of Research and Development (R & D) procedural Borg & Gall (1983). Experts and field trials is limited (potential users) are analyzed using inter-rater agreement models (Gregory, …

Tracer Study Alumni: Upaya Pengembangan Prodi Bimbingan Konseling Universitas Negeri Makassar, Muhammad Ilham Bakhtiar, Suciani Latif

Jurnal Kajian Bimbingan dan Konseling

The aim of research to determine: (1) the profile of alumni student guidance and counseling; (2) a waiting period of alumni guidance and counseling; (3) the relevance of courses to the needs of the labor market; (4) the alumni users. This study is a qualitative research using descriptive survey method. The analysis conducted by the percentage and using three stages of data reduction, data presentation and conclusions. The results of this study through the instrument tracer study provides an overview achievement graduate GPA average of 78% or between 2.75 to 3.50 and there are 22% or 3.50 to 4.00 cum …

Whose Expertise Is It? Evidence For Autistic Adults As Critical Autism Experts, Kristen Gillespie-Lynch, Steven K. Kapp, Patricia J. Brooks, Jonathan Pickens, Ben Schwartzman

Publications and Research

Autistic and non-autistic adults’ agreement with scientific knowledge about autism, how they define autism, and their endorsement of stigmatizing conceptions of autism has not previously been examined. Using an online survey, we assessed autism knowledge and stigma among 636 adults with varied relationships to autism, including autistic people and nuclear family members. Autistic participants exhibited more scientifically based knowledge than others. They were more likely to describe autism experientially or as a neutral difference, and more often opposed the medical model. Autistic participants and family members reported lower stigma. Greater endorsement of the importance of normalizing autistic people was associated …

Police Say Leadership Is Ignoring Ptsd., Tiffany Thomas

Capstones

Nearly one in every five officer has symptoms of PTSD according to the National Alliance on Mental Illness. Depression, PTSD, anxiety and suicidal thoughts are all results of unmanaged stressors. These issues can have a huge impact on an officer’s physical and mental well-being, and can accumulate over the course of his or her career. As police are under fire for a series of killings of innocent black people, they believe their PTSD issues are being overlooked.

Police officers are on the front line of violence and high risk situations but the toll on their mental health is often overlooked. …

Bimbingan Kelompok Dengan Pengajaran Formula Abcde Pendekatan Rasional Emotif Behavior Untuk Meningkatkan Self Efficacy Mahasiswa Calon Guru, Ismarini Bekti Setiani, Agus Taufiq, Suherman Suherman

Jurnal Kajian Bimbingan dan Konseling

The aim of this research is to formulate and develop a group guidance intervention design by teaching the ABCDE formula with a rational emotive behavior approach and testing the effectiveness of the intervention design in increasing the self-efficacy of prospective teachers in the Department of Agro-Industrial Technology Education, Indonesian Education University (UPI). The research uses mixed methods with a concurrent embedded strategy (quantitative as the primary method and qualitative as the secondary method). Data analysis techniques use quantitative (primary) and qualitative (secondary) data analysis. The results of the research show that quantitatively, group guidance using the ABCDE formula teaching with …

Effect Of A Poloxamer 407-Based Thermosensitive Gel On Minimization Of Thermal Injury To Diaphragm During Microwave Ablation Of The Liver., Li-Li Zhang, Gui-Min Xia, Yu-Jiang Liu, Rui Dou, John R. Eisenbrey, Ji-Bin Liu, Xiao-Wei Wang, Lin-Xue Qian

Department of Radiology Faculty Papers

AIM: To assess the insulating effect of a poloxamer 407 (P407)-based gel during microwave ablation of liver adjacent to the diaphragm.

METHODS: We prepared serial dilutions of P407, and 22.5% (w/w) concentration was identified as suitable for ablation procedures. Subsequently, microwave ablations were performed on the livers of 24 rabbits (gel, saline, control groups, n = 8 in each). The P407 solution and 0.9% normal saline were injected into the potential space between the diaphragm and liver in experimental groups. No barriers were applied to the controls. After microwave ablations, the frequency, size and degree of thermal injury were compared …

How Could Repealing Key Provisions Of The Affordable Care Act Affect Community Health Centers And Their Patients?, Sara J. Rosenbaum, Jessica Sharac, Thao-Chi Tran, Anne Rossier Markus, David Reynolds, Peter Shin

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

Analyses of repeal of the Affordable Care Act (ACA) have tended to focus on coverage. This study, which gauges the potential effects of repealing certain ACA provisions, looks at the question of primary health care access itself, with a focus on medically underserved communities. A survey developed and fielded in early 2017 asked community health centers to estimate the impact of ending the Health Centers Fund established under the ACA as well as ending expanded Medicaid coverage and subsidies designed to make private insurance affordable for lower income patients. Forty-one percent of health centers responded; 69 percent were located in …

Broadly Neutralizing Antibodies As Treatment: Effects On Virus And Immune System., Jinal N Bhiman, Rebecca M Lynch

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Purpose of Review

The purpose of this study is to summarize recent advances in the use of broadly neutralizing antibodies (bNAbs) as therapeutics in human clinical trials and in non-human primate (NHP) models. We seek to highlight lessons from these studies with an emphasis on consequences to the virus and immune system.

Recent Findings

In the past 10 years, advances in HIV-1 trimer structure and B cell isolation methods have precipitated the identification of “new-generation” anti-HIV antibodies with broad and potent neutralization. In the past 2 years, the concept of using these bNAbs as therapeutic tools has moved from NHP …

What's Happening: March 27, 2017, Maine Medical Center

What's Happening

No abstract provided.

Modeling Timelines For Translational Science In Cancer; The Impact Of Technological Maturation, Laura M. Mcnamee, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

This work examines translational science in cancer based on theories of innovation that posit a relationship between the maturation of technologies and their capacity to generate successful products. We examined the growth of technologies associated with 138 anticancer drugs using an analytical model that identifies the point of initiation of exponential growth and the point at which growth slows as the technology becomes established. Approval of targeted and biological products corresponded with technological maturation, with first approval averaging 14 years after the established point and 44 years after initiation of associated technologies. The lag in cancer drug approvals after the …

Bisphosphonate Related Osteonecrosis Of The Jaw: Osce Case Study, Shannoah May

Nursing Capstones

No abstract provided.

Shingles Case Report, Rocklynne Rakowitz

Nursing Capstones

No abstract provided.

March 2017, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Neutralizing Anti-Interleukin-1Β Antibodies Reduce Ischemia-Related Interleukin-1Β Transport Across The Blood-Brain Barrier In Fetal Sheep, Aparna Patra, Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Yow-Pin Lim, James F. Padbury, William A. Banks, Barbara S. Stonestreet

Pediatrics Faculty Publications

Hypoxic ischemic insults predispose to perinatal brain injury. Pro-inflammatory cytokines are important in the evolution of this injury. Interleukin-1β (IL-1β) is a key mediator of inflammatory responses and elevated IL-1β levels in brain correlate with adverse neurodevelopmental outcomes after brain injury. Impaired blood-brain barrier (BBB) function represents an important component of hypoxic-ischemic brain injury in the fetus. In addition, ischemia-reperfusion increases cytokine transport across the BBB of the ovine fetus. Reducing pro-inflammatory cytokine entry into brain could represent a novel approach to attenuate ischemia-related brain injury. We hypothesized that infusions of neutralizing IL-1β monoclonal antibody (mAb) reduce IL-1β transport across …

Trends In Management Of Radial Head And Olecranon Fractures., Matthew Motisi, Jennifer Kurowicki, Derek D Berglund, Jacob J Triplet, Shanell Disla, Timothy Niedzielak, Jonathan C Levy

Surgery Articles

BACKGROUND: Advancement in surgical techniques and implants has improved the ability to manage radial head and olecranon fractures. However, trends in management of these fractures are largely unstudied.

OBJECTIVE: This purpose of this study is to evaluate management trends for these common fractures.

METHODS: A retrospective review of a comprehensive Humana database was performed using Pearl Diver supercomputer (Warsaw, IN, USA) for radial head and neck (RHNF) and olecranon fractures (OF) between 2007 and 2014. Treatment methods including open reduction internal fixation (ORIF), radial head arthroplasty (RHA), and non-operative treatment were reviewed. Total reported incidence of office visits and utilization …