Medicine and Health Sciences Commons^™

Week Of March 27, 2017, New York Medical College

InTouch

• Robert M. Califf, M.D., Will Deliver 158th Commencement Address
• Graduate Student Research Forum Showcases Impressive Scientific Work
• NYMC Hosts Women's Heart Health Discussion with Expert Panel
• Nicholas S. Janiga, J.D., Is Named Chief Counsel
• HSL Hosts Exhibit and Special Presentation on Violence Against Women
• Research Day Highlights Scientific Works of Residents

Inflammatory Potential Of Diet, Weight Gain, And Incidence Of Overweight/Obesity: The Sun Cohort, Alyson Haslam, Sara Wagner Robb, James R. Hébert, Hanwen Huang, Michael David Wirth, Nitin Shivappa, Mark H. Ebell

Faculty Publications

Objective

The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person’s diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition.

Design

Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models.

Setting

Ten cancer screening centres across the USA.

Subjects

Participants were those included in the screening arm …

Mass-Spectrometry Based Proteomics Of Age-Related Changes In Murine Microglia, Antwoine Flowers

USF Tampa Graduate Theses and Dissertations

The last century has seen a steady increase in the extension of the average lifespan. This has concomitantly produced higher incidences of age-related chronic degenerative diseases like Alzheimer’s and Parkinson’s diseases. Age is the single greatest risk factor for the development of not just these degenerative conditions but cancer as well. The aged niche undergoes a number of maladaptive changes that allow underlying conditions to present and progress. Exactly which changes, contribute to the progression of which disease is currently an area of intense study. However, these answers often present therapeutic targets for disease prevention. Age is characterized by a …

Mothers Voices: The Lived Experience Of The Human Milk Banking Association Of North America Milk Donor, Laura Marie Dambra-Candelaria

Theses & Dissertations

Objectives: The purpose of this study was to examine the lived experience of the milk donor who donated milk to a hospital-based bank regulated under the policies and procedures set forth by the Human Milk Banking Association of North America (HMBANA). The literature has examined and established the life-saving benefits of donor milk for the vulnerable infant. Currently, there is a shortage of donor milk available for vulnerable and premature infants. Learning more about the experience of donation from the perspective of the donating mother can aid in the future education, recruitment, and retention of donors. Method: This study utilized …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Distinguished Lecture Series April 6

Genetic Pleiotropy Between Age-Related Macular Degeneration And 16 Complex Diseases And Traits, Felix Grassmann, Christina Kiel, Martina E. Zimmermann, Mathias Gorski, Veronika Grassmann, Klaus Stark, Iris M. Heid, Bernhard H.F. Weber, Lars G. Fritsche, John Blangero

School of Medicine Publications

Background: Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. Methods: For each of 60 complex diseases/traits with publicly available genome-wide significant association data, the lead genetic variant per independent locus was extracted and a genetic score was calculated for each disease/trait as the weighted sum of risk alleles. The association with AMD was estimated based on 16,144 AMD cases …

Medical School Watercooler Newsletter - March 26, 2017, Lindsey Lyle

Watercooler Newsletter

This is the March 26, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

‘Kindness is a Universal Language’

USA PsychSIGN Hosting Drive for Homeless Community

'What You Can Learn about a Heart Attack from a Microbiologist'

A Prototypical First-Generation Electronic Cigarette Does Not Reduce Reports Of Tobacco Urges Or Withdrawal Symptoms Among Cigarette Smokers, Arit M. Harvanko, Catherine A. Martin, Richard J. Kryscio, William W. Stoops, Joshua A. Lile, Thomas H. Kelly

Psychology Faculty Publications

It is unknown whether first-generation electronic cigarettes reduce smoking urges and withdrawal symptoms following a 24 h deprivation period. This study tested whether a first-generation electronic cigarette reduces smoking urges and withdrawal symptoms in cigarette smokers. Following 24 h of tobacco deprivation, using a within-subjects design, eight nontreatment seeking tobacco cigarette smokers (3 females) administered 10 puffs from a conventional cigarette or a first-generation electronic cigarette containing liquid with 0, 8 or 16 mg/ml nicotine. Conventional cigarettes ameliorated smoking urges and electronic cigarettes did not, regardless of nicotine concentration. First-generation electronic cigarettes may not effectively substitute for conventional cigarettes in …

Driving Simulators – More Than A Video Game!, William D. Mcquilken B.A., Judith M. Schultz B.A.

Department of Surgery

Background: This study aimed to investigate teenager, young adult, and adult knowledge levels on distracted and impaired driving through the use of educational driving simulators. The distracted and impaired driving simulators were customized to instruct participants on the dangers of driving distracted or impaired utilizing consequence videos. The simulators were taken to high schools, colleges/universities, and businesses over a four year period where we hypothesized that they would play a significant role in raising knowledge about the dangers and penalties of these risky driving behaviors and would also help to increase seat belt usage.

Setting: High schools, colleges / universities, …

47th Annual Wku Student Research Conference, Student Research Council,

Student Research Conference Select Presentations

See document below for project abstracts

The Use Of Sglt2 Inhibitor, Empagliflozin, To Reduce Cardiovascular Risk In Type 2 Diabetes Mellitus Patients, Cassandra M. Hunt

Nursing Capstones

No abstract provided.

Neurofeedback Or Neuroplacebo?, Robert T. Thibault, Michael Lifshitz, Amir Raz

Psychology Faculty Articles and Research

This scientific commentary refers to ‘Better than sham? A double-blind placebo-controlled neurofeedback study in primary insomnia’, by Schabus et al.. (doi:10.1093/brain/awx011).

Emerging Technologies And The Measurement Of Consciousness, Kristin Corona

Community of Scholars Day—Posters

With significant advancements in science and technology, along with increased focus on neuroplasticity, new ways to measure consciousness and changes in consciousness are emerging. Advanced neuroimaging technologies are being succeeded by more holistic methods of gathering data with the use of electroencephalogram (EEG) monitoring. The implications are better tools for the scientific community to assess medical conditions and cognitive states as well as higher awareness and integration of consciousness into our everyday lives.

William J. Richardson, S.J.: Reflections In Memoriam, Babette Babich

Articles and Chapters in Academic Book Collections

Fr. William J. Richardson, S.J., was born in Brooklyn, New York on the 2nd of November, 1920. He died at the Jesuit Campion Health Center, in Weston, Massachusetts, on the 10th of December, 2016.

Leo O’Donovan, S.J., Richard Kearney, and Jeffrey Bloechl, each in different ways gathered the diffusions of mourning friends, students, colleagues, patients, and admirers of the late William J. Richardson, via email over the days leading up to and after his funeral.

As Bill was one of the founding members of the Heidegger Circle (Penn State, 1967) and was present at the first conference on Heidegger’s thought …

Cigarette Smoke Impairs A2a Adenosine Receptor Mediated Wound Repair Through Up-Regulation Of Duox-1 Expression., Zhi Tian, Hui Zhang, Jendayi Dixon, Nicole Traphagen, Todd A. Wyatt, Kusum K. Kharbanda, Samantha Simet, Narasaiah Kolliputi, Diane S Allen-Gipson

Journal Articles: Pulmonary & Critical Care Med

Cigarette smoke (CS) exposure and intrinsic factors such as the NADPH oxidases produce high levels of reactive oxygen species (ROS), ensuing inflammatory tissue injury. We previously demonstrated that CS-generated ROS, particularly hydrogen peroxide (H2O2), impaired adenosine stimulated wound repair. We hypothesized that CS exposure modulates expression of Dual oxidase 1 (Duox-1), a NADPH oxidases known to generate H2O2. To test this hypothesis, we used human bronchial epithelial cell line Nuli-1 and C57BL/6 mice. Cells were treated with 5% CS extract (CSE) for various periods of time, and mice were exposed to whole body CS for six weeks. Both CSE and …

Effect Of Low-Level Co2 On Innate Inflammatory Protein Response To Organic Dust From Swine Confinement Barns., David Schneberger, Jane M. Devasure, Kristina L. Bailey, Debra J. Romberger, Todd A. Wyatt

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Organic hog barn dust (HDE) exposure induces lung inflammation and long-term decreases in lung function in agricultural workers. While concentrations of common gasses in confined animal facilities are well characterized, few studies have been done addressing if exposure to elevated barn gasses impacts the lung immune response to organic dusts. Given the well documented effects of hypercapnia at much higher levels we hypothesized that CO2 at 8 h exposure limit levels (5000 ppm) could alter innate immune responses to HDE.

METHODS: Using a mouse model, C57BL/6 mice were nasally instilled with defined barn dust extracts and then housed in …

Effect Of Low-Level Co2 On Innate Inflammatory Protein Response To Organic Dust From Swine Confinement Barns., David Schneberger, Jane M. Devasure, Kristina L. Bailey, Debra J. Romberger, Todd A. Wyatt

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Organic hog barn dust (HDE) exposure induces lung inflammation and long-term decreases in lung function in agricultural workers. While concentrations of common gasses in confined animal facilities are well characterized, few studies have been done addressing if exposure to elevated barn gasses impacts the lung immune response to organic dusts. Given the well documented effects of hypercapnia at much higher levels we hypothesized that CO2 at 8 h exposure limit levels (5000 ppm) could alter innate immune responses to HDE.

METHODS: Using a mouse model, C57BL/6 mice were nasally instilled with defined barn dust extracts and then housed in …

Probiotics And Cardiovascular Disease, Jennifer Burman

Nursing Capstones

No abstract provided.

Targeted Aav5-Smad7 Gene Therapy Inhibits Corneal Scarring In Vivo, Suneel Gupta, Jason T. Rodier, Ajay Sharma, Elizabeth A. Giuliano, Prashant R. Sinha, Nathan P. Hesemann, Arkasubhra Ghosh, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

Corneal scarring is due to aberrant activity of the transforming growth factor β (TGFβ) signaling pathway following traumatic, mechanical, infectious, or surgical injury. Altered TGFβ signaling cascade leads to downstream Smad (Suppressor of mothers against decapentaplegic) protein-mediated signaling events that regulate expression of extracellular matrix and myogenic proteins. These events lead to transdifferentiation of keratocytes into myofibroblasts through fibroblasts and often results in permanent corneal scarring. Hence, therapeutic targets that reduce transdifferentiation of fibroblasts into myofibroblasts may provide a clinically relevant approach to treat corneal fibrosis and improve long-term visual outcomes. Smad7 protein regulates the functional effects of TGFβ signaling …

Best Practices To Increase Breastfeeding Self-Efficacy In Breastfeeding Mothers, Sarah Van Wyk

Nursing Capstones

No abstract provided.

Identification Of Kansarl As The First Cancer Predisposition Fusion Gene Specific To The Population Of European Ancestry Origin, Jeff Xiwu Zhou, Xiaoyan Yang, Shunbin Ning, Ling Wang, Kesheng Wang, Yanbin Zhang, Fenghua Yuan, Fengli Li, David D. Zhuo, Liren Tang, Degen Zhuo

ETSU Faculty Works

Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six KANSARL (KANSL1-ARL17A) transcripts that resulted from the fusion between the KANSL1 and ARL17A genes using a RNA splicingcode model. Five of these six KANSARL fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that KANSARL fusion transcripts were rarely detected in …

The Role Of Neurotrophic Factors In Dental Pulp Stem Cell, Nan (Tori) Xiao, Kamille Mercado

All Dugoni School of Dentistry Faculty Presentations

Objectives: The objective of the study is to investigate the role of neurotrophic factors in the DPSCs mediated tissue regeneration.

Methods: Human DPSCs cells were gift from Dr. Songtao Shi, Chair and Professor Department of Anatomy & Cell Biology, University of Pennsylvania School of Dental Medicine DPSCs mRNA was extracted from samples of five different patients, and reverse transcripted into cDNA. Primer sequences were designed with Primer3web online software. Quantitative PCR was performed on the cDNA samples using a 7900HT detection system (Applied Biosystems). All PCR reactions were carried out in triplicate. Quantification of the samples was calculated with the …

The Role Of Neurotrophic Factors In Dental Pulp Stem Cell, Nan (Tori) Xiao, Kamille Mercado

All Dugoni School of Dentistry Faculty Presentations

Objectives: The objective of the study is to investigate the role of neurotrophic factors in the DPSCs mediated tissue regeneration.

Methods: Human DPSCs cells were gift from Dr. Songtao Shi, Chair and Professor Department of Anatomy & Cell Biology, University of Pennsylvania School of Dental Medicine DPSCs mRNA was extracted from samples of five different patients, and reverse transcripted into cDNA. Primer sequences were designed with Primer3web online software. Quantitative PCR was performed on the cDNA samples using a 7900HT detection system (Applied Biosystems). All PCR reactions were carried out in triplicate. Quantification of the samples was calculated with the …

Back Muscle Endurance As Measure By Ito Test Duration, Ronald Figueredo

USF Tampa Graduate Theses and Dissertations

Lower back pain remains one of the most common problems in public health throughout the industrialized world (Strine and Hootman) (Shiri, Solovieva and K.). The prevalence is about 39-54% annually and 60-65% in a lifetime (Hillman, Wright and Rajaranam) (Leboeuf-Yde, N. and Lauritzen). In the United States, lower back pain is the second most common cause of disability, and is the highest cause of disability among men (Center for Disease Control, 2009). An individual quantitative physical examination to detect muscle deficiencies would be very useful for proper placement of workers in demanding physical jobs where back injuries are common. Trunk …

The Role Of Asb3 Gene Single Nucleotide Polymorphism In The Progression To Bronchopulmonary Dysplasia In Extremely Low Birth Weight Infants, Anna Zylak, Leewen Hsu, Asma Amin, Shaili Amatya, Sharina Rajbhandari, Alexander Feldman, Umesh Paudel, Lance A. Parton

NYMC Faculty Posters

No abstract provided.

Rock2 Gene Single Nucleotide Polymorphisms And Association With Bronchopulmonary Dysplasia In Extremely Low Birth Weight Infants, Sharina Rajbhandari, Asma Amin, Shaili Amatya, Leewen Hsu, Anna Zylak, Umesh Paudel, Lance A. Parton

NYMC Faculty Posters

No abstract provided.

Ang1 Treatment Reduces Muscle Pathology And Prevents A Decline In Perfusion In Dmd Mice, Kelly M. Gutpell, Nikola Tasevski, Boaz Wong, William Thomas Hrinivich, Feng Su, Lise Desjardins, Ting-Yim Lee, Lisa Marie Hoffman

Anatomy and Cell Biology Publications

Vascular endothelial growth factor (VEGF) and other pro-angiogenic growth factors have been investigated to enhance muscle tissue perfusion and repair in Duchenne muscular dystrophy (DMD). Current understanding is limited by a lack of functional data following in vivo delivery of these growth factors. We previously used dynamic contrast-enhanced computed tomography to monitor disease progression in murine models of DMD, but no study to date has utilized this imaging technique to assess vascular therapy in a preclinical model of DMD. In the current study, we locally delivered VEGF and ANG1 alone or in combination to dystrophic hind limb skeletal muscle. Using …

Notice Of 04-11-2017 Hsc Committee Meeting, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Tiered Vs. Traditional Daily Undulating Periodization For Improving Powerlifting Performance In Trained Males, Andres Vargas

USF Tampa Graduate Theses and Dissertations

Daily undulating periodization represents an increasingly popular trend in exercise science with which a traditional model has been established. Tiered daily undulating periodization pairs the DUP approach with a tiered training system which allows volume and intensity to be more evenly distributed throughout a given graining cycle. The concept of tiered daily undulating periodization is a novel form of periodization and has not been investigated. As such, a comparison of traditional and tiered daily undulating periodization has yet to be examined. Therefore, the purpose of this study was to compare the effects of traditional and tiered daily undulating periodization models …

Virus-Mediated Suppression Of Host Non-Self Recognition Facilitates Horizontal Transmission Of Heterologous Viruses, Songsong Wu, Jiasen Cheng, Yanping Fu, Tao Chen, Daohong Jiang, Said A. Ghabrial, Jiatao Xie

Plant Pathology Faculty Publications

Non-self recognition is a common phenomenon among organisms; it often leads to innate immunity to prevent the invasion of parasites and maintain the genetic polymorphism of organisms. Fungal vegetative incompatibility is a type of non-self recognition which often induces programmed cell death (PCD) and restricts the spread of molecular parasites. It is not clearly known whether virus infection could attenuate non-self recognition among host individuals to facilitate its spread. Here, we report that a hypovirulence-associated mycoreovirus, named Sclerotinia sclerotiorum mycoreovirus 4 (SsMYRV4), could suppress host non-self recognition and facilitate horizontal transmission of heterologous viruses. We found that cell death in …