Medicine and Health Sciences Commons^™

The Methods Used For Eradication Of Polio Versus The Defense Efforts That Are Being Conducted For Global Defense Against Ebola, Kalyn Johnson

Undergraduate Research Conference

Poliovirus eradication has been a long-lasting and difficult process that has become a global issue. The World Health Organization and the European Union have been trying to end the terrible reign of this abhorrent disease since the 1980s and are continually fighting the virus today. Poliomyelitis is an Old World disease, much like smallpox. It has been easily, through a twenty year process, eradicable through mass vaccination and circle vaccination.

However, as poliovirus is coming to the end of its reign, a more recent danger lurks nearby. Ebola virus is considered a non-traditional disease in that it requires more developed …

Food Traditions Of The Three Abrahamic Religions, Sarah A. Ross, Justin D. Pelham

Undergraduate Research Conference

No abstract provided.

2017 April 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Unification Of De Novo And Acquired Ibrutinib Resistance In Mantle Cell Lymphoma., Xiaohong Zhao, Tint Lwin, Ariosto Silva, Bijal Shah, Jiangchuan Tao, Bin Fang, Eduardo Sotomayor, +Several Additional Authors

Medicine Faculty Publications

The novel Bruton’s tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acquired ibrutinib resistance. We demonstrate that MCL cells develop ibrutinib resistance through evolutionary processes driven by dynamic feedback between MCL cells and TME, leading to kinome adaptive reprogramming, bypassing the effect of ibrutinib and reciprocal activation of PI3K-AKT-mTOR and integrin-β1 signalling. Combinatorial disruption of B-cell receptor signalling and …

The Value Of Cancer Immunotherapy Summit At The 2016 Society For Immunotherapy Of Cancer 31st Anniversary Annual Meeting, Howard L. Kaufman, Michael B. Atkins, Adam Dicker Md, Phd, Heather S. Jim, Louis P. Garrison, Roy S. Herbst, William T. Mcgivney, Steven Silverstein, Jon M. Wigginton, Peter P. Yu

Department of Medicine Faculty Papers

As healthcare costs continue to rise, there has been great interest in understanding and defining the value of current therapeutic strategies for the treatment of cancer. Cancer immunotherapy has emerged as a clinically beneficial alternative to conventional therapies for a variety of malignancies. Characterized by broad clinical activity, durable response rates, distinct side effects, and unique response kinetics, immune-based agents are vastly different compared with traditional cytotoxic or targeted therapies. To date, however, value assessments in oncology have not focused on the unique aspects of cancer immunotherapy, which has resulted in a lack of understanding of the true value of …

Posterior Interosseous Nerve Localization Within The Proximal Forearm - A Patient Normalized Parameter, Srinath Kamineni, Crystal R. Norgren, Evan M. Davidson, Ellora P. Kamineni, Andrew S. Deane

Orthopaedic Surgery and Sports Medicine Faculty Publications

AIM

To provide a "patient-normalized" parameter in the proximal forearm.

METHODS

Sixty-three cadaveric upper extremities from thirty-five cadavers were studied. A muscle splitting approach was utilized to locate the posterior interosseous nerve (PIN) at the point where it emerges from beneath the supinator. The supinator was carefully incised to expose the midpoint length of the nerve as it passes into the forearm while preserving the associated fascial connections, thereby preserving the relationship of the nerve with the muscle. We measured the transepicondylar distance (TED), PIN distance in the forearm's neutral rotation position, pronation position, supination position, and the nerve width. …

Cultural Competence Of Pre-Licensure Nursing Faculty, Colleen Marzilli, Beth Mastel-Smith

Nursing Faculty Publications and Presentations

The purpose of this study was to determine the level of cultural competence (CC) in Texas pre-licensure nursing faculty and examine the relationships between demographics and CC scores. The researchers conducted a study to determine if demographics predicted the level of CC and explored the perceptions of CC. A convergent parallel mixed-methods design used data from a 2014 online survey with a qualitative interview component. Demographics were evaluated with descriptive statistics and CC was measured with The Nurses’ Cultural Competence Scale (NCCS). Qualitative data were analyzed using a constant comparative method. The level of CC was low to moderate. Three …

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling And Is A Therapeutic Target In Pulmonary Arterial Hypertension., Jiwang Chen, Justin R Sysol, Sunit Singla, Shuangping Zhao, Aya Yamamura, Daniela Valdez-Jasso, Taimur Abbasi, Krystyna M. Shioura, Sakshi Sahni, Vamsi Reddy, Arvind Sridhar, Hui Gao, Jaime Torres, Sara M. Camp, Haiyang Tang, Shui Q. Ye, Suzy Comhair, Raed Dweik, Paul Hassoun, Jason X-J Yuan, Joe G N Garcia, Roberto F. Machado

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide adenine dinucleotide levels and cellular redox state, regulates histone deacetylases, promotes cell proliferation, and inhibits apoptosis. We hypothesized that NAMPT promotes pulmonary vascular remodeling and that inhibition of NAMPT could attenuate pulmonary hypertension.

METHODS: Plasma, mRNA, and protein levels of NAMPT were measured in the lungs and isolated pulmonary artery endothelial cells from patients with pulmonary arterial hypertension and in the lungs of rodent models of pulmonary hypertension.Nampt+/- mice were …

A Unique Cause Of Anion Gap Metabolic Acidosis: Euglycemia Dka., Ross Cohen Do, Pgy-4, Kevin Weaver D.O.,Facoep

Department of Emergency Medicine

No abstract provided.

Bilingual Language Assessment, Carmen Wittkopp

Honors Theses

Purpose: To describe language assessments that benefit bilingual students in the correct diagnosis of a language disorder.

Method: A systematic review of the literature was completed to examine the assessment tools used for bilingual children. The most common peer-reviewed journals in the field of speech-language pathology were examined to find articles that researched and discussed bilingual assessment practices. The information collected in the articles focused on the procedures needed for the correct assessment of a bilingual speaker.

Results: The literature mainly focused on assessment techniques of Conceptual Scoring, Dynamic Assessment, Nonword Repetition Task, and the Bilingual English Spanish Oral Screener. …

Perceived Sources Of Academic Stress In The Nursing Program, Iana Fontanilla

Honors Theses

University students in health disciplines face many different sources of stress and challenges during their experience in their individual programs. However, a study shows that baccalaureate nursing students experience higher levels of stress as well as higher levels of physiological and psychological symptoms than students in other health-related disciplines (Beck et al., 1997). In order to create interventions to improve student performance and self-efficacy in the nursing program, both the professors and students in the program must understand the most significant stressors that can negatively impact the overall performance of the nursing students.

A survey was conducted to identify the …

Association Of Magnet Status With Hospitalization Outcomes For Ischemic Stroke Patients., Kimon Bekelis, Symeon Missios, Todd A. Mackenzie

Department of Neurosurgery Faculty Papers

BACKGROUND: It is not clear whether Magnet recognition by the American Nurses Credentialing Center (nursing excellence program) is associated with improved patient outcomes. We investigated whether hospitalization in a Magnet hospital is associated with improved outcomes for patients with ischemic stroke.

METHODS AND RESULTS: We performed a cohort study of patients with ischemic stroke from 2009 to 2013, who were registered in the New York Statewide Planning and Research Cooperative System database. Propensity-score-adjusted multivariable regression models were used to adjust for known confounders, with mixed effects methods to control for clustering at the facility level. An instrumental variable analysis was …

Implementing Shared Decision Making In The Nhs: Lessons From The Magic Programme, Natalie Joseph-Williams, Amy Lloyd, Adrian Edwards, Lynne Stobbart, David Tomson, Sheila Macphail, Carole Dodd, Glyn Elwyn, Richard Thomson

Dartmouth Scholarship

No abstract provided.

Low Acuity Pediatric Patients Presenting Uncomplicated Colds And Nonspecific Upper Respiratory Symptoms In U.S. Emergency Departments, Margaret Berry

Honors Theses

Emergency departments serve as the nation’s hub for patients faced with life-threatening injuries and illnesses. Although the role of emergency departments (EDs) may seem clear by its title, U.S EDs are overcrowded with patients presenting nonurgent symptoms. A significant population of nonurgent ED users are pediatric patients presenting nonspecific upper respiratory symptoms and uncomplicated colds. Findings have uncovered that although pediatric upper respiratory infections (URIs) are one of the most uncommon reasons for hospital admittance from an ED, it is one of the most common reasons pediatric patients are brought into emergency departments. It appears that inappropriate facility usage is …

Effects Of Yoga On Perceived Stress Level And Cognitive Ability In College-Aged Females, Faith Flanders, Rachel V. Taylor, Lauren Willams, Delaney Lister, Allison Esposito

Georgia College Student Research Events

Purpose: The purpose of this study was to determine if perceived stress levels and response inhibition scores (measure of cognitive function) differ in female college students who regularly participate in yoga compared to female college students who do not. Methods: College-aged females ranging from 19-24 years of age were recruited to participate in this study. Subjects filled out a personal information sheet followed by a perceived stress level questionnaire to measure the amount of yoga each participant performed and assess their perceived stress level, respectively. Response inhibition and accuracy (cognitive function) were measured via a computerized Stroop Effect test consisting …

Implementing A Home-Based Blood Pressure Monitoring Program To Improve Hypertension Management, Nicole S. Bello

Georgia College Student Research Events

Hypertension is a major problem in the United States. It is critical to identify effective strategies to treat and manage hypertension. An experimental design was utilized to determine the effectiveness of home-based blood pressure monitoring (HBPM) in the management of prehypertension, newly diagnosed, or uncontrolled hypertension. A randomized convenience sample of 20 adults was recruited into a control (n=9) and experimental (n=11) group. The translational care project was conducted over 60 days where participants measured their blood pressures as instructed for the intervention and control groups. An independent t-test was conducted to analyze the effectiveness of HBPM on the participants’ …

Benefits Of Having A Pet At College: Perception Of Today’S College Students, Morgan Jenkins

Georgia College Student Research Events

The present literature review examined data from 10 studies that examined the benefits of pet therapy and well-being. Florence Nightingale, a pioneer of nursing, recognized these benefits in the early 1800s when she used animals to provide support to mentally ill patients. Since then, pets, but mainly dogs, have been used across various populations and in numerous settings such as with geriatrics in nursing homes, in disaster relief, with war veterans suffering from PTSD, with inmates in correctional facilities, with terminal patients in hospice care, and with pediatric patients in the hospital setting. In all of these scenarios, findings suggest …

Comparison Of Low And High Glycemic Index Effects On Athletic Performance, Dillon B. Tanner, Lucas Johnson

Georgia College Student Research Events

I submitted my abstract via additional files.

Effects Of Interval Training On Memory Function, In College Students, Matthew Young, Jennifer Spencer, Lisa Schick

Georgia College Student Research Events

The purpose of this study was to further investigate if exercise in the form of moderate intensity interval training influences memory function. While past studies have shown cognitive function improvements prior to both acute continuous moderate intensity exercise and high intensity interval training, no studies have been conducted to explore the effects of high intensity interval training on cognitive function. These previous studies also used a different method of measurement, a Stroop test, to measure cognitive function. This method is significantly different than the word recall test used in this study, which was designed to specifically assess cognitive function in …

Injury History In The Collegiate Equestrian Athlete: Part Ii: Head, Upper And Lower Extremities, Michael L. Pilato, Timothy Henry, Drussila Malavase

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

ABSTRACT

Purpose: Equestrian sports are known to have a high risk and rate of injury. While there is injury data available on acute injuries in the equestrian population, it is of a general nature. Within that data appears to be a lack of information on the collegiate equestrian athlete. Thus, the purpose of the current study and this analysis is to describe the incidence of upper and lower extremity injuries and head injuries, sans concussion, in intercollegiate equestrian athlete. Method: A survey was developed with input from each author and implemented in Mach forms. It was sent to 43 equestrian …

Injury History In The Collegiate Equestrian Athlete: Part I: Mechanism Of Injury, Demographic Data And Spinal Injury, Michael L. Pilato, Timothy Henry, Drussila Malavase

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

ABSTRACT

Purpose: Equestrian sports are known to have a high risk and rate of injury. While there is injury data available on acute injuries in the equestrian population, it is of a general nature. Within that data appears to be a lack of information on the collegiate equestrian athlete. Thus, the purpose of the current study and this analysis is to describe the demographics and incidence of spinal injuries found in intercollegiate equestrian athlete. Method: A survey was developed with input from each author and implemented in Mach forms. It was sent to 43 equestrian coaches in the Eastern United …

Examining The Experiences Of Athletic Trainers As They Transition Into Their First Full-Time Position, Stephanie M. Mazerolle, Mclain Whitney, Christy Eason

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Transition to clinical practice is an important topic in athletic training, as it can be a period of time that presents challenges for the athletic trainer. Most of the research pertaining to transition to practice focuses on the skills and knowledge necessary for clinical practice, yet we know that stress can manifest from not only being an independent practitioner but also from learning how to balance one’s roles. We wanted to understand the perspective of today’s novice athletic trainers and how they feel in their first full-time position, specifically relating to their professional development and establishment or maintenance of work-life …

Investigation Of The Concussion Goggle™ Education Program With Secondary School Athletic Teams: A Pilot Study, Ellen K. Payne, William S. Gear, Maureen Burke

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Background: Researchers have investigated different types of concussion education programs within various populations with mixed results. To date, no research has been published using the Concussion Goggles™ educational program Objective: To compare secondary school student-athletes’ knowledge about concussions before and after attending a concussion education program using the Concussion Goggles™. Design: Pre- posttest. Setting: Public secondary school. Patients or Other Participants: 41 secondary school students (14 girls soccer players, 14 boys basketball players, and 13 girls basketball players) with a mean age of 15.37 ± 1.22 years. Intervention(s): Participants completed the Concussion Goggles™ concussion …

Oriented Clonal Cell Dynamics Enables Accurate Growth And Shaping Of Vertebrate Cartilage., Marketa Kaucka, Tomas Zikmund, Marketa Tesarova, Daniel Gyllborg, Andreas Hellander, Josef Jaros, Jozef Kaiser, Julian Petersen, Bara Szarowska, Phillip T. Newton, Vyacheslav Dyachuk, Lei Li, Hong Qian, Anne-Sofie Johansson, Yuji Mishina, Joshua D. Currie, Elly M. Tanaka, Alek Erickson, A T. Dudley, Hjalmar Brismar, Paul Southam, Enrico Coen, Min Chen, Lee S. Weinstein, Ales Hampl, Ernest Arenas, Andrei S. Chagin, Kaj Fried, Igor Adameyko

Journal Articles: Genetics, Cell Biology & Anatomy

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by …

Ada News - 04/17/2017, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Post-Intensive Care Syndrome: Comparison Of Educational Interventions To Educate Parents Of Children Hospitalized In The Pediatric Intensive Care Unit At St. Louis Children’S Hospital, Stephanie A. Esses

Dissertations

Background: Family members of children hospitalized in the pediatric intensive care unit (PICU) can develop cognitive, psychological, and physical manifestations of post-intensive care syndrome (PICS). Targeted education to help parents/caregivers recognize the signs and symptoms of PICS may result in better awareness of the syndrome and greater willingness to seek and receive support during their child’s PICU admission.

Objective: to evaluate three targeted PICS educational interventions to increase PICS awareness among parents/caregivers in the St. Louis Children’s Hospital (SLCH) PICU.

Results: A total of 62 parents/caregivers received one of three educational interventions: informational brochures (n=22), scripted informational conversation (n=20), or …

Improving New Graduate Critical Care Nurse Practitioner Knowledge And Retention Using A Dedicated Orientation And Mentoring Program, Katherine Huffer

Dissertations

Abstract

Background: There has been a significant amount of research into the many challenges that nurse practitioners (NPs) face as they transition from school to practice, however, there is limited research on how to improve this transition. Regardless of the setting in which the NPs are working, novices NPs alike report feelings of being unprepared and experiencing high levels of stress, anxiety, fear, and frustration. New research suggests that a comprehensive NP orientation and residency programs may provide a way to integrate the new NPs into their practice environment successfully.

Method: Kern’s Six Step Approach to Curriculum Development for Medical …

The Acute Care Pediatric Nurse Practitioner In Missouri: An Analysis Of Needs Assessment, Jessica L. Mann

Dissertations

Introduction: Due to an increasing number of acutely ill pediatric patients and changing healthcare demands, there is an even greater need for nurse practitioners (NPs) to work in the area of pediatric acute care (AC). There is a lack of alignment of education and certification with the scope of practice of the AC Pediatric Nurse Practitioner (PNP). The development and implementation of a graduate level AC PNP program in Missouri will support the alignment of education, clinical training, and certification with the scope of practice of the AC PNP and improve access to a quality program for nurses that currently …

Implementation Of A Daily Checklist To Improve Patient Safety And Quality Of Care In A Pediatric Intensive Care Unit, Catherine Reese

Dissertations

Background

Multiple industries have demonstrated checklists to be of great value in reducing errors of omission and improving communication. In healthcare, checklists have been shown to ensure patients receive evidence-based, safe care. In a fast paced environment of a critical care unit, adverse events are common and can have significant consequences on patient outcome. Safety guardrails are necessary to minimize naturally occurring human error. Safety checklists help support best practices to standardize care and support processes to improve outcome.

Objectives

To develop and implement a daily safety checklist in a pediatric intensive care unit (PICU) to enhance clinical care and …

2nd Place Contest Entry: Patient Activation Among Diverse Populations: A Systematic Review, Megan Kenney

Kevin and Tam Ross Undergraduate Research Prize

This is Megan Kenney's submission for the 2017 Kevin and Tam Ross Undergraduate Research Prize, which won second place. She wrote about the patient activation (a measure of an individual’s knowledge, skill, and confidence in managing his or her own health and health care) among diverse populations. You can read the final essay that came out of her research here.

Megan is a senior at Chapman University, majoring in Kinesiology. Her faculty mentor is Dr. Elizabeth DeBaets.