Medicine and Health Sciences Commons^™

Lack Of Effect Of Vitamin D3 Supplementation In Autism: A 20-Week, Placebo-Controlled Rct, Conor Kerley, Clare Power, Louise Gallagher, David Coghlan

Articles

No abstract provided.

From Food To Food Justice: Pathways And Narratives Of Young Food Activists In New York City, Amy Kwan

Dissertations and Theses

With a rise in obesity and other non-communicable, diet-related health problems and the persistence of food insecurity among many vulnerable populations, the involvement of young people in the current, burgeoning food-justice movement has the potential to bring forth transformative changes to our food system and thus improve population health. While much is known about the outcomes of providing opportunities for young people to be actively and civically engaged in their communities, there is a lack of research on the pathways, narratives, and experiences that bring young people into food justice activism.

Through semi-structured, in-depth interviews with 25 young food activists …

Discriminative And Reinforcing Effects Of Cocaine-Levamisole Combinations, Zachary J. Zimmermann

Dissertations

The behavioral and neurochemical effects of cocaine are well established, and it is one of the most widely abused illicit drugs. Illicit cocaine is often adulterated with levamisole, which is an anthelmintic that was withdrawn from the U. S. market in 2000. It has been hypothesized that levamisole, unlike other common adulterants which are added as simple bulking agents, has effects of its own which may be responsible for its use as an adulterant. Although these effects are speculative, the addition of levamisole to cocaine has become an increasing public health concern, as serious adverse effects (e.g., vasculitis, neutropenia) of …

Mechanistic Mathematical Models: An Underused Platform For Hpv Research, Marc Ryser, Patti Gravitt, Evan R. Myers

Global Health Faculty Publications

Health economic modeling has become an invaluable methodology for the design and evaluation of clinical and public health interventions against the human papillomavirus (HPV) and associated diseases. At the same time, relatively little attention has been paid to a different yet complementary class of models, namely that of mechanistic mathematical models. The primary focus of mechanistic mathematical models is to better understand the intricate biologic mechanisms and dynamics of disease. Inspired by a long and successful history of mechanistic modeling in other biomedical fields, we highlight several areas of HPV research where mechanistic models have the potential to advance the …

Igfbp2 Produces Rapid-Acting And Long-Lasting Effects In Rat Models Of Posttraumatic Stress Disorder Via A Novel Mechanism Associated With Structural Plasticity, Jeffrey Burgdorf, Elizabeth Colechio, N Ghoreishi-Haack, A Gross, C Rex, Xiao Lei Zhang, Patric Stanton, R Kroes, J Moskal

NYMC Faculty Publications

Background: Posttraumatic stress disorder is an anxiety disorder characterized by deficits in the extinction of aversive memories. Insulin-like growth factor 1 (IGF1) is the only growth factor that has shown anxiolytic and antidepressant properties in human clinical trials. In animal studies, insulin-like growth factor binding protein 2 (IGFBP2) shows both IGF1-dependent and IGF1-independent pharmacological effects, and IGFBP2 expression is upregulated by rough-and-tumble play that induces resilience to stress. Methods: IGFBP2 was evaluated in Porsolt, contextual fear conditioning, and chronic unpredictable stress models of posttraumatic stress disorder. The dependence of IGFBP2 effects on IGF1- and AMPA-receptor activation was tested using selective …

Lisinopril Or Coreg Cr In Reducing Cardiotoxicity In Women With Breast Cancer Receiving Trastuzumab: A Rationale And Design Of A Randomized Clinical Trial, Maya Guglin, Pamela Munster, Angelina Fink, Jeffrey Krischer

Internal Medicine Faculty Publications

Background—Trastuzumab (TZB) is an established therapy for HER2 positive breast cancer. The use of TZB is commonly associated with cardiotoxicity manifesting as asymptomatic decrease in left ventricular ejection fraction (LVEF) or overt heart failure. Several studies demonstrated favorable effects of angiotensin converting enzyme (ACE) inhibitors and beta blockers (BB) in the prevention of chemotherapy-induced cardiotoxicity. We hypothesize that patients, randomized to receive an ACE inhibitor or a beta-blocker during trastuzumab therapy for breast cancer, will maintain a higher LVEF than patients randomized to placebo.

Methods and Results—We designed a prospective, multicenter, randomized, phase II placebo-controlled clinical trial to …

Effects Of Kdt501 On Metabolic Parameters In Insulin-Resistant Prediabetic Humans, Philip A. Kern, Brian S. Finlin, Dorothy Ross, Tania Boyechko, Beibei Zhu, Neile Grayson, Robert Sims, Jeffrey S. Bland

Internal Medicine Faculty Publications

Context: KDT501 is an isohumulone drug that has demonstrated beneficial effects on metabolic parameters in mice.

Objective: This study was intended to examine potential improvements in metabolism in humans.

Design and Setting: Changes in carbohydrate and lipid metabolism, along with inflammatory markers, were evaluated in prediabetic humans in a clinical research center.

Participants: Nine obese patients participated. All had prediabetes or normal glucose tolerance plus three features of metabolic syndrome.

Intervention: All participants were treated with escalating doses of KDT501 to a maximum dose of 1000 mg every 12 hours for a total of 28 days.

Outcome Measures: Changes in …

Development Of Mentorship Module And Its Feasibility For Community Midwives In Sindh, Pakistan: A Pilot Study, Amber Hussain Sayani, Rafat Jan, Susan Lennox, Yasmeen Jan Mohammad

Journal of Asian Midwives (JAM)

Numerous articles describe the concept of mentorship for providing professional support in midwifery settings in different countries; however, in Pakistan the concept is under developed. Before implementing the concept in the Pakistani context, it was important to first develop a mentorship module and pilot test the idea. Therefore, the aim of the present study was to develop and test a mentorship module to determine its feasibility for educating community midwives about providing mentoring, so that a formal mentorship program could be established in the future. The training aimed to provide skill focused mentorship training to experienced midwives, so that they …

Are We On The Cross Roads Of The Medical Profession?, Ajoy Kumar Singh

Manipal Journal of Medical Sciences

No abstract provided.

India And Its Health Care System, B M Hegde

Manipal Journal of Medical Sciences

No abstract provided.

Mentoring In Medical Education: A Neglected Essentiality, Shally Awasthi

Manipal Journal of Medical Sciences

No abstract provided.

Evaluation Of Anti-Inflammatory Activity Of Hyoscine In Albinowistar Rats, Suresha R N, Nagma Firdose

Manipal Journal of Medical Sciences

Objective: 1) To evaluate the anti-inflammatory (AI) potential of hyoscine 2) To compare it with indomethacin in acute/sub-acute animal model Method/Methodology: Fully grown albinowistar rats which weighed 150-200 grams were divided into three groups of six animals each. The control, standard, and test constituted different groups and had received normal saline 5ml/kg of body weight, indomethacin 10 mg/kg of body weight and hyoscine 9 mg/kg of body weight, respectively. Acute/sub-acute AI activity was assessed through Carrageenan Induced Paw Oedema (CIRPEM), and Cotton Pellet Induced Granuloma Model (CPIGM), respectively. Results: In CIRPEM, the percentage of inhibition of the paw oedema, which …

Estimated Probability Of Becoming A Case Of Drug Dependence In Relation To Duration Of Drug-Taking Experience: A Functional Analysis Approach, Olga A. Vsevolozhskaya, James C. Anthony

Biostatistics Faculty Publications

Measured as elapsed time from first use to dependence syndrome onset, the estimated "induction interval" for cocaine is thought to be short relative to the cannabis interval, but little is known about risk of becoming dependent during first months after onset of use. Virtually all published estimates for this facet of drug dependence epidemiology are from life histories elicited years after first use. To improve estimation, we turn to new month-wise data from nationally representative samples of newly incident drug users identified via probability sampling and confidential computer-assisted self-interviews for the United States National Surveys on Drug Use and Health, …

Incentives And Ethics In The Economics Of Body Parts, Nicola Lacetera

Osgoode Hall Law Journal

Research shows that properly devised economic incentives increase the supply of blood without hampering its safety; similar effects may be expected also for other body parts such as bone marrow and organs. These positive effects alone, however, do not necessarily justify the introduction of payments for supplying body parts, because these activities concern contested commodities or repugnant transactions. Societies may want to prevent these transactions even if they increase supply, because of ethical concerns. When transactions involve contested commodities, therefore, there often is tension between the efficiency-enhancing effects of trades mediated by a monetary price and the moral opposition to …

Development Of A Dna-Liposome Complex For Gene Delivery Applications, Morteza Rasoulianboroujeni, G. Kupgan, F. Moghadam, A. Boughdachi, Payam Khoshkenar, J. J. Ambrose, N. Kiaie, Daryoosh Vashaee, J. D. Ramsey, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The association structures formed by cationic liposomes and DNA(Deoxyribonucleic acid)-liposome have been effectively utilized as gene carriers in transfection assays. In this research study, cationic liposomes were prepared using a modified lipid film hydration method consisting of a lyophilization step for gene delivery applications. The obtained results demonstrated that the mean particle size had no significant change while the polydispersity (PDI) increased after lyophilization. The mean particle size slightly reduced after lyophilization (520 ± 12 nm to 464 ± 25 nm) while the PDI increased after lyophilization (0.094 ± 0.017 to 0.220 ± 0.004). In addition. The mean particle size …

Central Xanthoma Of The Jaw Bones: A Benign Tumor, Yeshwant B. Rawal, Srinivasa R. Chandra, James M. Hall

School of Dentistry Faculty Research and Publications

Extragnathic xanthomas are seen in the bones or as soft tissue masses. They are often associated with hyperlipidemia and are considered as reactive or metabolic lesions. Only 19 cases of xanthomas of the jaws have been reported so far in the English literature. A total of ten cases of central xanthoma of the jaw bones were identified from the Oral and Maxillofacial Pathology biopsy services of the University of Washington and the Tufts University School of Dental Medicine, between the years 2000–2016. The demographic and clinical information on these cases was tabulated logically on the basis of age, gender, location …

Oral Health And Dental Anxiety In A German Practice-Based Sample, Arndt Guentsch, Christiane Stier, Gregor F. Raschke, Andre Peisker, Mina D. Fahmy, Harald Kuepper, Ina Schueler

School of Dentistry Faculty Research and Publications

Objective

Does dental anxiety have an effect on dental and periodontal health?

Methods

Survey data was collected from n = 200 adults (53 % females, average age 49 years) in a cross-sectional study. Dental anxiety was measured with the modified dental anxiety scale (MDAS, score 1–5, the greater the score, the greater the anxiety). Clinical parameters including probing depth (PD), clinical attachment level (CAL), plaque index (SLI), and bleeding on probing (BoP) as well as the DMFT index were recorded and statistically analyzed.

Results

Rating of dental anxiety was higher in women than in men (65 vs 35 %). Subjects …

A Method Of Facilitating The Fabrication Of Access Openings For Implant-Supported Complete Fixed Dental Prostheses, Seok-Hwan Cho, Geoffrey A. Thompson

School of Dentistry Faculty Research and Publications

This report describes a method for fabricating access openings for implant-supported complete fixed dental prostheses (ICFP) by using a dental milling machine and silicone putty matrix. The method can help clinicians achieve the accurate and precise fabrication of access openings for ICFPs without excessive grinding.

Evaluation Of Glycated Albumin (Ga) And Ga/Hba1c Ratio For Diagnosis Of Diabetes And Glycemic Control: A Comprehensive Review, Sara Yazdanpanah, Mohammad Rabiee, Mohammadreza Tahriri, Mojgan Abdolrahim, Asodollah Rajab, Hossein E. Jazayeri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and non-ketotic hyperosmolar coma. In addition, possible long-term complications include impotence, nerve damage, stroke, chronic kidney failure, cardiovascular disease, foot ulcers, and retinopathy. Historically, universal methods to measure glycemic control for the diagnosis of diabetes included fasting plasma glucose level (FPG), 2-h plasma glucose (2HP), and random plasma glucose. However, these measurements did not provide information about glycemic control over a long period of time. To …

Positive Thinking Training Intervention For Caregivers Of Persons With Autism: Establishing Fidelity, Abir K. Bekhet

College of Nursing Faculty Research and Publications

More than 3.5 million in the US are diagnosed with autism spectrum disorder (ASD) and caregivers experience stress that adversely affects their well-being. Positive thinking training (PTT) intervention can minimize that stress. However, before testing the effectiveness of PTT, its fidelity must be established. This pilot intervention trial examined fidelity of an online PTT intervention for ASD caregivers with a random assignment of 73 caregivers to either the online PTT intervention or to the control group. Quantitative data [Positive Thinking Skills Scale (PTSS)] and qualitative data (online weekly homework) were collected. The mean scores for the PTSS improved for the …

An Essential Role Of Pi3k In The Control Of West Nile Virus Infection, L Wang, Long Yang, E Fikrig, Penghua Wang

NYMC Faculty Publications

The phosphatidyl-inositol-3 kinases (PI3K) pathway regulates a variety of cellular processes, including cell proliferation, RNA processing, protein translation, autophagy, apoptosis and antiviral immunity. Many viruses depend on PI3K signaling for replication. However, its role in flaviviral infection has not been clearly defined. Here we report that PI3K signaling is critical for the control of West Nile virus (WNV) infection by regulating type I IFN (IFN-I) response. Inhibition of PI3K activity by 3-methyl adenine (3-MA), Wortmannin (WM) and LY294002 (LY) increased viral titers by 3-16 folds in primary mouse macrophages, embryonic fibroblasts and human cell lines. Both 3-MA and LY repressed …

Differential Growth Of Francisella Tularensis, Which Alters Expression Of Virulence Factors, Dominant Antigens, And Surface-Carbohydrate Synthases, Governs The Apparent Virulence Of Ft Schus4 To Immunized Animals, K Holland, S Rosa, K Kristjansdottir, D Wolfgeher, B Franz, Chandra Bakshi, K Hazlett, K Hazlett

NYMC Faculty Publications

The gram-negative bacterium Francisella tularensis (Ft) is both a potential biological weapon and a naturally occurring microbe that survives in arthropods, fresh water amoeba, and mammals with distinct phenotypes in various environments. Previously, we used a number of measurements to characterize Ft grown in Brain-Heart Infusion (BHI) broth as (1) more similar to infection-derived bacteria, and (2) slightly more virulent in naive animals, compared to Ft grown in Mueller Hinton Broth (MHB). In these studies we observed that the free amino acids in MHB repress expression of select Ft virulence factors by an unknown mechanism. Here, we tested the hypotheses …

Cardiovascular Disease Risk Profile Of Ncaa Division Iii Intercollegiate Football Athletes: A Pilot Study, Cynthia J. Wright, Elizabeth Abbey, Barbara A. Brandon, Edward J. Reisman, Christina M. Kirkpatrick

Health Sciences Faculty Scholarship

Concerns about the long-term cardiovascular health implications of American football participation have been investigated at the professional and Division I levels, but limited research is available at the less resourced Division III level. Therefore, the objective of this pilot study was to assess the cardiovascular disease risk profile of NCAA Division III intercollegiate football athletes.

A Study Protocol For A Randomised Controlled Trial Of An Interactive Web-Based Intervention: Cancercope, Suzanne K. Chambers, Lee Ritterband, Frances Thorndike, Lisa Nielsen, Joanne Aitken, Samantha Clutton, Paul Scuffham, Philippa Youl, Bronwyn Morris, Peter Baade, Jeffrey Dunn

Research outputs 2014 to 2021

Introduction:

Approximately 35% of patients with cancer experience clinically significant distress, and unmet psychological supportive care needs are prevalent. This study describes the protocol for a randomised controlled trial (RCT) to assess the efficacy and cost-effectiveness of an internet-based psychological intervention for distressed patients with cancer.

Methods and analysis:

In phase I, the intervention was developed on an interactive web platform and pilot tested for acceptability using a qualitative methodology with 21 patients with cancer. Phase II is an RCT underway with patients with or at risk of elevated psychological distress comparing: (1) static patient education website with (2) …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis And Management In Young People: A Primer, P Rowe, R Underhill, K Friedman, A Gurwitt, Marvin Medow, M Schwartz, N Speight, Julian Stewart, R Vallings, K Rowe

NYMC Faculty Publications

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that affects children and adolescents as well as adults. The etiology has not been established. While many pediatricians and other health-care providers are aware of ME/CFS, they often lack essential knowledge that is necessary for diagnosis and treatment. Many young patients experience symptoms for years before receiving a diagnosis. This primer, written by the International Writing Group for Pediatric ME/CFS, provides information necessary to understand, diagnose, and manage the symptoms of ME/CFS in children and adolescents. ME/CFS is characterized by overwhelming fatigue with a substantial loss of physical and mental stamina. …

Bioactivity Of Oral Linaclotide In Human Colorectum For Cancer Chemoprevention., David S. Weinberg, Jieru E. Lin, Nathan R. Foster, Gary Della'zanna, Asad Umar, Drew Seisler, Walter K. Kraft, David M. Kastenberg, Leo C. Katz, Paul J. Limburg, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA-approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined. Here, we demonstrate that administration of 0.87 mg of oral linaclotide daily for 7 days to healthy …

Nutrinews Volume 29, June, 2017, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Fruit Consumption & Diabetes, Let's go for a walk!, and Do Multi-Vitamins help the heart?

Nutrinews, Volume 30, July 2017, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Diabetes on the Rise, Effect of Avocado, and Consumers and "Clean Food"

Online Nutrition And T2dm Continuing Medical Education Course Launched On State-Level Medical Association, Kristen Hicks, P. Murano

Nutrition and Dietetics Faculty Research and Scholarship

Objective: The purpose of this research study was to determine whether a 1-hour online continuing medical education (CME) course focused on nutrition for type 2 diabetes would result in a gain in nutrition knowledge by practicing physicians. Methods: A practicing physician and dietitian collaborated to develop an online CME course (both webinar and self-study versions) on type 2 diabetes. This 1-hour accredited course was launched through the state-level medical association’s education library, available to all physicians. Results: Physicians (n=43) registered for the course, and of those, 31 completed the course in its entirety. A gain in knowledge …

A Retrospective Lateral Cephalometric Growth Study Of Sagittal Airway Changes, Grace H. Woo

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This study retrospectively examined the average sagittal dimensions in the pharyngeal airway from skeletal and dental Class I males and females from 7 to 16 years of age utilizing longitudinal data from the American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection. The study evaluated whether average sagittal airway dimensions differed between males and females at each age, and whether the sagittal airway dimension changed with increasing age. Materials and Methods: Sagittal airway dimension based on identifiable anatomical landmarks were digitally traced and measured from the longitudinal lateral cephalograms of 30 females and 32 males from the AAOF Growth …