Medicine and Health Sciences Commons^™

Comparison Of The Effects Of A Pharmaceutical Industry Decision Guide And Decision Aids On Patient Choice To Intensify Therapy In Rheumatoid Arthritis, Richard W, Martin, Ryan D. Enck, Donald J. Tellinghuisen, Aaron T. Eggebeen

University Faculty Publications and Creative Works

To compare the effects a pharmaceutical industry decision guide and International Patient Decision Aids Standard (IPDAS) compliant patient decision aids (PtDA) on patient medication beliefs and choice to intensify therapy. Methods. Rheumatoid arthritis (RA) patients, who had never taken etanercept (Enbrel), took part in a mail survey. They were presented with a hypothetical decision scenario where they were asked to consider adding etanercept to their current regimen. Each patient was randomized to review 1 of 3 forms of an etanercept-specific decision support: a long PtDA (LONG DA), a short PtDA (SHORT DA), or the manufacturer's Enbrel decision guide (Pharm Booklet). …

หลวงเฉลิมคัมภีร์เวชช์ (ศ.นพ.เฉลิม พรมมาส): 70 ปี คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, สิทธิศักดิ์ หรรษาเวก

Chulalongkorn Medical Journal

ณ โอกาสนี้ คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ขอต้อนรับนิสิตแพทย์ใหม่ทุกคนด้วยความยินดียิ่ง ในฐานะที่เข้ามาเป็นสมาชิกใหม่ในสถาบันแห่งนี้ และเป็นรุ่นที่เข้ามาพร้อมกับครบรอบ 70 ปี แห่งการก่อตั้ง คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย จึงควรรู้รากฐานในอดีต โดยขอยกคำกล่าวต้อนรับบางส่วนของศาสตราจารย์นายแพทย์เฉลิม พรมมาส หรือ หลวงเฉลิม คัมภีร์เวชช์ ซึ่งเป็นผู้ค้นพบและรายงานวงจรชีวิตของพยาธิตัวจี๊ดเป็นครั้งแรกของโลก และเคยดำรงตำแหน่งเป็นอดีตคณบดีคณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยซึ่งเคยกล่าวกับบรรดาอาจารย์และนิสิตแพทย์ ในวันที่ 11 มิถุนยายน พ.ศ. 2490 ย้อนกลับไปเมื่อ 70 ปีก่อน ซึ่งเป็นวันแรกแห่งการเปิดเรียนของคณะแพทยศาสตร์โรงพยาบาลจุฬาลงกรณ์

Continuous Glucose Dynamics Monitoring In Diabetic Patients With Peritoneal Dialysis, Somporn Wongraoprasert, Talerngsak Karnjanabuch, Napat Leeaphorn, Kuakoon Piyachomkwan, Sompongse Suwanwalaikorn, Somchai Eiam-Ong, Krit Pongpirul

Chulalongkorn Medical Journal

Background : Glucose dynamics in patients on peritoneal dialysis (PD) is influencedby many factors.Objectives We evaluated the dynamics of interstitial fluid (ISF) glucose in diabeticpatients undergoing PD, controlled for caloric food intake, daily activities,and hypoglycemic agents.Methods : We studied all type-2 diabetic patients at the PD clinic of KingChulalongkorn Memorial Hospital between 2007 and 2008. They received1.5% or 4.25% glucose during continuous ambulatory peritoneal dialysis(CAPD 1.5% or 4.25%), or 1.5% glucose continuous cycling peritonealdialysis (CCPD 1.5%). Continuous glucose monitoring system andfinger-stick were used to assess ISF and blood glucose levels for72 hours, respectively. Sixteen patients (9 CAPD and 7 CCPD) …

Addison’S Disease Due To Disseminated Histoplasmosis: A Case Report, Krittaya Rattanakorn, Ratchathorn Panchaprateep

Chulalongkorn Medical Journal

Addison’s disease, also known as primary adrenal insufficiency, can manifest asgeneralized mucocutaneous hyperpigmentation. The common causes of Addison’s disease indeveloping countries are mycobacterium and fungal infections. Histoplasma capsulatum is adimorphic fungi, which may disseminate to the adrenal glands and skin, causing Addison’sdisease and skin lesions such as macules, acneiform pustular eruptions, erythematous papules,nodules, keratotic plaques with or without crust and mucosal ulceration.We present a case of a 45-year-old male with Addisonian pigmentation for one yeartogether with multiple skin-colored flat top papules on both inguinal areas 3 months earlier.Cutaneous lesions were carefully physical examined might easily lead to the cause of …

Adobe Medicus 2017 4 July-August, Health Sciences Library And Informatics Center

adobe medicus

The bimonthly newsletter published by UNM's Health Sciences Library and Informatics Center, adobe medicus announces new programs, services and activities at the library and at the UNM Health Sciences Center. It also reports on recent activities, events and awards associated with the library and includes articles about services that patrons may not be aware of.

Mk2 Promotes Colorectal Cancer Development, Invasion, And Growth Through Mk2-Induced Cytokines, Anita Lynne Ray

Biomedical Sciences ETDs

Colorectal cancer (CRC) is the third most common malignancy in the United States for men and women. A major risk factor for CRC development and progression is inflammation, in particular the inflammatory cytokines IL-1, IL-6, and TNF-α. These proteins promote critical cancer functions, such as proliferation, invasion, survival, and migration. Control of inflammation is one potential area of therapeutic intervention for some cancers. Because signaling of these cytokines overlaps in many of the same pathways, targets upstream of protein production could prove an effective strategy to reduce inflammation. MAPK-activated protein kinase 2 (MK2) pathway controls production of these cytokines within …

Low Serum Sodium Levels At Hospital Admission: Outcomes Among 2.3 Million Hospitalized Patients, Saleem M. Al Mawed

Biomedical Sciences ETDs

Background: Hyponatremia is the most common electrolyte disorder among hospitalized patients. Controversies still exist over the relationship between hyponatremia and outcomes of hospitalized patients. Methods: To analyze the association of low serum sodium levels at hospital admission with in-hospital mortality and patient disposition and to compare the distribution of the risk of death associated with hyponatremia across the lifespan of hospitalized patients, we conducted an observational study of 2.3 million patients using data extracted from the Cerner Health Facts database between 2000 and 2014. Logistic regression models were used in the analyses. Results: 14.4% of hospitalized patients had serum sodium …

New Approaches To Melanoma Prevention, June K. Robinson, Katie Baker, Joel J. Hillhouse

ETSU Faculty Works

Skin cancer is a major public health concern, and tanning remains a modifiable risk factor. Multidimensional influences, including psychosocial, individual, environmental, and policy-related factors, create the milieu for individuals to engage in tanning. Parents and physicians can modify the behavior of teens and young adults using strategies based on harm reduction. Environmental and policy-related factors similar to those used to limit smoking by restricting access of minors to cigarettes in the United States in the 20th century need to be created. Federal regulations can restrict direct advertising and the excise tax can be increased to a prohibitive amount. Social networking …

Caries Classification, Diana V. Macri, Annie Chitlall

Publications and Research

It has been 10 years since Featherstone and colleagues presented their evidence-based model of caries management: caries management by risk assessment (CAMBRA). This approach relies on a careful analysis of a patients’ risk factors and protective factors. International and national organizations have long recognized the need for a new caries classification system that incorporates evidence-based approaches to halt progression of caries lesions and minimize the need for surgical intervention. Thus, the International Caries Detection and Assessment System (ICDAS) and the American Dental Association Caries Classification System (ADA CCS) were created. The purpose of this article is to briefly review the …

Knowledge Of Health Insurance Concepts And The Affordable Care Act Among Rural Residents, Erika C. Ziller Phd

Health System Reform

Health insurance literacy is central to identifying eligibility for coverage and subsidies, choosing a plan, and using optimal healthcare services under the Affordable Care Act (ACA) or other insurance reform initiatives. To fully benefit from policy efforts to improve health insurance access, rural residents must have the ability to select the plan that best meets their healthcare needs. However, a higher proportion of rural residents possess characteristics that may put them at risk of lower health insurance literacy, including lower incomes and educational attainment, less experience with private insurance, and historically higher uninsured rates. Using Health Reform Monitoring Survey data …

Effects Of Palatal Expansion On Speech Production, Jason Milton Meinhardt

Master's Theses (2009 -)

Introduction: Rapid palatal expanders (RPEs) are a commonly used orthodontic adjunct for the treatment of posterior crossbites. RPEs are cemented to bilateral posterior teeth across the palate and thus may interfere with proper tongue movement and linguopalatal contact. The purpose of this study was to identify what specific role RPEs have on speech sound production for the child and early adolescent orthodontic patient. Materials and Methods: RPEs were treatment planned for patients seeking orthodontics at Marquette University. Speech recordings were made using a phonetically balanced reading passage (“The Caterpillar”) at 3 time points: 1) before RPE placement; 2) immediately after …

The Effect Of Heat Treatment On The Bending Properties Of A Cobalt-Chromium Orthodontic Wire, Alex Schwab

Master's Theses (2009 -)

Introduction: Elgiloy, a brand name of the original cobalt-chromium orthodontic wire, has been around for more than 50 years; yet despite this, little literature is available. Most of the literature on Elgiloy wires tends to evaluate the wires in tension. For these reasons, this study aimed to determine the bending properties of the four available tempers of Elgiloy wires and how heat treatment affects the wires’ bending properties. Materials and Methods: All four tempers of Elgiloy (red, yellow, green, and blue) were ordered in straight lengths containing 20 wires per pack that are each 0.018 inches in diameter and 14 …

Reliability Of Digital Dental Cast Measures As Compared To Cone-Beam Computed Tomography For Analyzing The Transverse Dimension, Brian Michel

Master's Theses (2009 -)

The purpose of this study was to assess the consistency in diagnosing the transverse dimension on cone-beam computed tomography (CBCT) images as compared to digital dental models. The study consisted of 11 patients with posterior crossbite at the level of the first molar and 17 patients with no crossbite at the level of the first molar. 13 patients were male and 15 patients were female with an overall mean age of 13.6 years. Eight linear measurements and two angular measurements were made on CBCT images of the patients and six linear measurements were made on the corresponding digital dental casts. …

Thermal Properties Of Commonly Used Clear Aligner Systems As-Received And After Clinical Use, Louis Wenger

Master's Theses (2009 -)

Background/Objectives: The purpose of this study was to investigate the thermal properties, particularly glass transition temperature, of the polymers that are used to fabricate three different types of modern orthodontic aligners. Invisalign, (Align Technology, Inc, Santa Clara, CA, USA), Simpli5 (Allesee Orthodontic Appliances, Sturtevant, WI, USA), and ClearCorrect (ClearCorrect, Round Rock, TX, USA) were examined both as-received and after clinical use to determine if any differences were present both between and within aligners. Materials/Methods: Orthodontic aligners were collected from three different patients using the systems under investigation after two weeks of intraoral use. Duplicate, un-used samples were obtained from the …

Direct Visual Approximation Of Arch Length Discrepancy And Cephalometric Measurements, Bradley J. Wurm

Master's Theses (2009 -)

Introduction: Arch length discrepancy and cephalometric analysis are critical components of orthodontic treatment planning. Both have direct effects on the decision to extract teeth or not and treatment mechanics as well. Visual approximation is the most common method used to analyze arch length discrepancy among practitioners. Current trends show a decrease in the amount of orthodontists completing a cephalometric analysis. Previous studies have shown a tendency for orthodontists to overestimate the degree of crowding when visually approximating on dental casts. No previous study has assessed the ability to visually approximate cephalometric angle measurements. The purpose of this survey was to …

Evaluating Wall Shear Stress Indices To Uncover Stimuli For Restenosis And Malapposition In Stented Coronary Arteries, Ali A. Aleiou

Master's Theses (2009 -)

The cause of coronary artery neointimal thickening leading to restenosis in ~10% of drug-eluting stents is unknown. Although research suggests adverse values of traditional wall shear stress (WSS) indices may contribute, studies to date have not accounted for stent geometry, which dictates local WSS patterns influencing drug concentration. Recently proposed WSS indices such as WSS variability and WSS exposure time (WSSET) may shed further light on restenosis or, the opposite effect, resorption. The objective of this investigation was to locally evaluate traditional and recently proposed post-stenting metrics and their respective impact on restenosis or resorption. This study used de-identified data …

Development Of Kinematic Templates For Automatic Pronunciation Assessment Using Acoustic-To-Articulatory Inversion, Deriq K. Jones

Master's Theses (2009 -)

Computer-aided pronunciation training (CAPT) is a subcategory of computer-aided language learning (CALL) that deals with the correction of mispronunciation during language learning. For a CAPT system to be effective, it must provide useful and informative feedback that is comprehensive, qualitative, quantitative, and corrective. While the majority of modern systems address the first 3 aspects of feedback, most of these systems do not provide corrective feedback. As part of the National Science Foundation (NSF) funded study “RI: Small: Speaker Independent Acoustic-Articulator Inversion for Pronunciation Assessment”, the Marquette Speech and Swallowing Lab and Marquette Speech and Signal Processing Lab are conducting a …

Do Adults Diagnosed With Autism Spectrum Disorders Have An Advantage In Real-World Visual Search Tasks?, Nicholas Charles Russell

Theses and Dissertations

Individuals with Autistic Spectrum Disorders (ASD) often perform better than typically developing (TD) individuals in simple, albeit difficult, visual search tasks. This ability is often attributed to a lack of drive for coherence or superior local processing. We compare thirty adults with ASD with forty-nine TD individuals and twenty-seven adults with anxiety (ANX) across two real-world visual search tasks. Individuals had to find either a number superimposed over a real-world scene ("œno context" condition) or an object located in a contextually relevant location ("œcontext" condition). Each participant completed forty-one trials in each condition, each with a unique scene. Eye movements …

The Efficacy Of A Literature-Based Social Communication Intervention On Teacher Report Of Withdrawal For Children With Language Impairment, Cammy G. Peterson

Theses and Dissertations

Research shows that children with language impairment (LI) often have deficits in social communication. The purpose of this study was to examine the effectiveness of a social communication intervention targeting emotion understanding on teacher perceptions of withdrawal in six elementary-aged boys with LI. The intervention incorporated four elements into treatment sessions: a) Story sharing of children's literature that was rich in emotional content and prosocial behaviors; b) Story enactment of the same children's literature; c) identification and discussion of pictures of facial expressions; and d) journaling to help internalize and reflect on emotions and social behaviors targeted. Two withdrawal subscales …

Investigating Motivations For Using Dating Websites And Geosocial Apps, Sean Calvin Aaron

Theses and Dissertations

Using the internet to meet dating partners is increasingly popular and may have ramifications that are not yet fully realized. Although many dating sites have been operating for years, new online dating platforms continue to draw millions of new users. By using a large sample of people who use online dating platforms (n=1,286) we identified similarities and differences in what motivates people to use geosocial apps and dating sites. Motivations previously considered in the literature were supported and brought together in a single theory driven confirmatory factor analysis for each type of dating platform. A motivation to seek amusement was …

A Pilot Study Examining The Role Of Treatment Type And Gender In Cortisol Functioning, Stephanie Young Davis

Theses and Dissertations

This pilot study examined the effectiveness of Emotionally Focused Couples Therapy (EFT) compared to Treatment As Usual (TAU) in improving cortisol functioning among distressed couples. It also investigated the role of gender in cortisol functioning. Measures for cortisol were collected at five time points, both at pre- and posttreatment. Data were collected from a total of 60 couples, 20 of which received EFT and 40 of which received TAU. Overall, results from a two-way analysis of variance suggest that there are no significant differences between men or women, nor among couples in EFT and TAU, in posttreatment cortisol functioning. Directions …

Ixazomib Enhances Parathyroid Hormone-Induced Β-Catenin/T-Cell Factor Signaling By Dissociating Β-Catenin From The Parathyroid Hormone Receptor., Yanmei Yang, Hong Lei, Ya-Wei Qiang, Bin Wang

Center for Translational Medicine Faculty Papers

The anabolic action of PTH in bone is mostly mediated by cAMP/PKA and Wnt-independent activation of β-catenin/T-cell factor (TCF) signaling. β-Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR. Ixazomib (Izb) was recently approved as the first orally administered proteasome inhibitor for the treatment of multiple myeloma; it acts in part by inhibition of pathological bone destruction. Proteasome inhibitors were reported to stabilize β-catenin by the ubiquitin-proteasome pathway. However, how Izb affects PTHR activation to regulate β-catenin/TCF signaling is poorly understood. In the present study, using CRISPR/Cas9 genome-editing technology, we show that …

Clinical Pharmacogenetics Implementation Consortium Guideline (Cpic) For Cyp2d6 And Cyp2c19 Genotypes And Dosing Of Tricyclic Antidepressants: 2016 Update., J K. Hicks, K Sangkuhl, J J. Swen, V L. Ellingrod, D J. Müller, K Shimoda, J R. Bishop, E D. Kharasch, T C. Skaar, Andrea Gaedigk, H M. Dunnenberger, T E. Klein, K E. Caudle, J C. Stingl

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Revealing The Cytotoxic Potential Of Medicinal Folklore: Bombax Ceiba L., Hafiz Tahsin Ullah Jan, Syeda Masooma Ali, Amna Shabbir, Bakht Nasir, Syeda Saniya Zahra

Journal of Bioresource Management

Current study was intended to investigate the cytotoxic potential of Bombax ceiba L.by executing a wide range of in vitro assays. Brine shrimp lethality assay showed that stem wood’s chloroform (CH) extract was highly toxic (LC₅₀ 42.41 ± 3.40 µg/ml) followed by acetone : ethyl acetate (AC:EA) extract with LC₅₀ value of 72.92 ± 4.41 µg/ml. n-Hexane (NH) extract of root wood part caused 70.95 ± 1.77% inhibition of THP-1 cell line at 20 μg/ml concentration (IC₅₀ 15 ± 0.56 µg/ml). NH and CH extracts of stem wood part showed promising results in protein kinase inhibitory assay …

Measuring Outcomes In Competence And Confidence In Clinical Skills Through The Use Of Standardized Patients, Jennifer W. Cuchna

Health Services Research Dissertations

Limited literature is available concerning the use of standardized patients (SPs) in physical therapy education related to outcomes which are assessed. The purpose of our study was to investigate the effects SP implementation had on first year, doctor of physical therapy (DPT) student’s communication and patient interviewing skills and their confidence in those skills.

Our study utilized a comparison group, repeated measures design with the collection of four survey instruments at pre-test and two posttest time points. The instruments for our study measured general self-efficacy (GSE), task-specific self-efficacy (Self-Perceived Communication Competence (SPCC) and Froehlich Communication Competence (FroCom) and confidence (Standardized …

Unmet Needs And Service Utilization By Informal Caregivers, Ryan Marie Diduk-Smith

Health Services Research Dissertations

The number of Americans expected to live into their 80’s and 90’s is growing at an increased rate in the United States, and the numbers of those aging adults with multiple chronic conditions also continues to grow. It is estimated that by 2050, there will be 89 million adults over the age of 65 years living in the United States. For a variety of reasons, including policy, personal, and financial reasons, many aging adults are choosing to “age in place” or to remain in the community. With the increase in the numbers of aging adults in the community, the ability …

Expression Of Placental Regulatory Genes Is Associated With Fetal Growth, Maya A. Deyssenroth, Qian Li, Marina Lacasaña, Yoko Nomura, Carmen Marsit, Jia Chen

Publications and Research

The placenta is the principal organ regulating respiratory, nutritional, endocrine and metabolic functions on behalf of the developing fetus. Changes in gene expression patterns of placenta-specific genes may influence fetal growth. We profiled the expression of 17 genes related to placenta functioning in term placentas (n=677) to identify genes differentially expressed across birth weight categories [small (SGA), appropriate (AGA) and large (LGA) for gestational age]. ABCG2, CEBPB, CRH, GCM1, GPC3, INSL4, PGF and PLAC1 were inversely associated with LGA status, with odds ratios (ORs) and 95% confidence intervals (CI) ranging from GCM1 (OR=0.44, 95% CI: 0.29, 0.70) to CRH (OR=0.73, …

Characterization Of Transmembrane Protein 35 Expression: Considerations Of Sex And Ovarian Hormones, Amanda M. Vanderplow

All NMU Master's Theses

The recently discovered novel neuropeptide transmembrane protein 35 (TMEM35), is believed to modulate chemical signaling within the nervous system. Notably, the TMEM35 protein is detectable in humans, non-human primates and rodents, suggesting a conserved and critical function. Despite this, the functions of TMEM35 are ill-defined in the nervous system and insufficiently studied (currently only three publications). Previous work has identified high expression of TMEM35 in both the ventromedial hypothalamus (VMH) and the limbic circuit of the mouse brain. Due to the known functions of these two regions, this pattern of expression indicates possible roles of this neuropeptide in social behavior …

Vitamin C To Decrease The Effects Of Smoking In Pregnancy On Infant Lung Function (Vcsip): Rationale, Design, And Methods Of A Randomized, Controlled Trial Of Vitamin C Supplementation In Pregnancy For The Primary Prevention Of Effects Of In Utero Tobacco Smoke Exposure On Infant Lung Function And Respiratory Health, Cindy T. Mcevoy, Kristin F. Milner, Ashley J. Scherman, Diane G. Schilling, Christina J. Tiller, Brittany Vuylsteke, Lyndsey E. Shorey-Kendrick, Eliot R. Spindel, Robert Schuff, Julie Mitchell, Dawn Peters, Jill Metz, David Haas, Keith Jackson, Robert S. Tepper, Cynthia D. Morris

OHSU-PSU School of Public Health Faculty Publications and Presentations

Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in > 450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial. Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) is a randomized, double-blind, placebo-controlled trial to evaluate pulmonary function at 3 months of age …

The Scoop, Vol. 4 Issue 3-4, Summer 2017, Health Sciences Library

Volume 4

Latest news and events from the Health Sciences Library in our monthly newsletter for Summer 2017.