Medicine and Health Sciences Commons^™

Prolonged Growth Hormone/Insulin/Insulin-Like Growth Factor Nutrient Response Signaling Pathway As A Silent Killer Of Stem Cells And A Culprit In Aging, Mariusz Ratajczak, Andrzej Bartke, Zbigniew Darzynkiewicz

NYMC Faculty Publications

The dream of slowing down the aging process has always inspired mankind. Since stem cells are responsible for tissue and organ rejuvenation, it is logical that we should search for encoded mechanisms affecting life span in these cells. However, in adult life the hierarchy within the stem cell compartment is still not very well defined, and evidence has accumulated that adult tissues contain rare stem cells that possess a broad trans-germ layer differentiation potential. These most-primitive stem cells-those endowed with pluripotent or multipotent differentiation ability and that give rise to other cells more restricted in differentiation, known as tissue-committed stem …

Ablation Of Long-Standing Persistent Atrial Fibrillation, B Mody, A Raza, Jason T. Jacobson, Sei Iwai, Daniel Frenkel, Rhadames Rojas, Wilbert Aronow

NYMC Faculty Publications

Atrial fibrillation (AF) is the most commonly encountered arrhythmia in the clinical setting affecting nearly 6 million people in United States and the numbers are only expected to rise as the population continues to age. Broadly it is classified into paroxysmal, persistent and longstanding persistent AF. Electrical, structural and autonomic remodeling are some of the diverse pathophysiological mechanisms that contribute to the persistence of AF. Our review article emphasizes particularly on long standing persistent atrial fibrillation (LSPAF) aspect of the disease which poses a great challenge for electrophysiologists. While pulmonary vein isolation (PVI) has been established as a successful ablation …

Towards A Personalized Cancer Gene Therapy: A Case Of Clear Cell Renal Cell Carcinoma, Dumitru Iacobas, Sanda Iacobas

NYMC Faculty Publications

No abstract provided.

Lifestyle Measures For Treating Hypertension, Wilbert S. Aronow

NYMC Faculty Publications

No abstract provided.

Splenic Trauma: Wses Classification And Guidelines For Adult And Pediatric Patients, F Coccolini, G Montori, F Catena, W Biffl, A Kirkpatrick, Rifat Latifi, L Ansaloni

NYMC Faculty Publications

Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions. Lastly, as the management of adults and children must be …

Defects In Skeletal Muscle Subsarcolmmal Mitochondria In A Non-Obese Model Of Type 2 Diabetes Mellitus, Nicola Lai, China Kummitha, Charles Hoppel

Electrical & Computer Engineering Faculty Publications

Skeletal muscle resistance to insulin is related to accumulation of lipid-derived products, but it is not clear whether this accumulation is caused by skeletal muscle mitochondrial dysfunction. Diabetes and obesity are reported to have a selective effect on the function of subsarcolemmal and interfibrillar mitochondria in insulin-resistant skeletal muscle. The current study investigated the role of the subpopulations of mitochondria in the pathogenesis of insulin resistance in the absence of obesity. A non-obese spontaneous rat model of type 2 diabetes mellitus, (Goto-Kakizaki), was used to evaluate function and biochemical properties in both populations of skeletal muscle mitochondria. In subsarcolemmal mitochondria, …

Blood Pressure And Visit-To-Visit Blood Pressure Variability Among Individuals With Primary Proteinuric Glomerulopathies., Christine B. Sethna, Kevin E C Meyers, Laura H. Mariani, Kevin J. Psoter, Crystal A. Gadegbeku, Keisha L. Gibson, Tarak Srivastava, Matthias Kretzler, Tammy M. Brady

Manuscripts, Articles, Book Chapters and Other Papers

Hypertension and blood pressure variability (BPV; SD and average real variability) in primary proteinuric glomerulopathies are not well described. Data were from 433 participants in the NEPTUNE (Nephrotic Syndrome Study Network). Hypertensive BP status was defined as previous history of hypertension or BP ≥140/90 mm Hg for adults/≥95th percentile for children at baseline. BPV was measured in participants with ≥3 visits in the first year. Two-hundred ninety-six adults (43 years [interquartile range, 32-57.8 years], 61.5% male) and 147 children (11 years [interquartile range, 5-14 years], 57.8% male) were evaluated. At baseline, 64.8% of adults and 46.9% of children were hypertensive. …

Driving Organizational Change From The Bedside: The Aacn Clinical Scene Investigator Academy., Susan R. Lacey, Caryl Goodyear-Bruch, Adrienne Olney, Dave Hanson, Marian S. Altman, Natasha S. Varn-Davis, Debbie Brinker, Ramón Lavandero, Karen S. Cox

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Staff nurses are pivotal in leading change related to quality improvement efforts, although many lack skills to steer change from the bedside. The American Association of Critical-Care Nurses (AACN) staff nurse leadership program, Clinical Scene Investigator (CSI) Academy, teaches and empowers staff nurses in leadership skills and change concepts to translate evidence into practice affecting patient outcomes.

OBJECTIVES: To describe the curriculum of the AACN CSI Academy that provides staff nurses with the leadership skills required to create unit-based change projects that positively impact patient/family outcomes.

METHODS: The curriculum of the Academy included leadership topics, communication, change concepts, quality …

The Transfer Of Problem-Based Learning Skills To Clinical Practice, Marie T. Stanton, Suzanne Guerin, Terry Barrett

Interdisciplinary Journal of Problem-Based Learning

The purpose of this article is to present and discuss the reported impact of a fully problem-based learning (PBL) master’s program on the way graduates worked with patients and colleagues in Ireland. These graduates had completed a sixteen-month fully PBL master’s in sonography while concurrently working in clinical practice. Semi-structured telephone interviews were used to collect qualitative data from graduates of the PBL program. PBL graduates reported four notable changes in their approach to clinical practice following the PBL MSc ultrasound program: (1) thinking more before, during, and after clinical practice; (2) more effective communication with patients; (3) improved communication …

Blogs As Channels For Disseminating Health Technology Innovations, Ashish Joshi, Rinzin Wangmo, Chioma Amadi

Publications and Research

Objectives: The objective of this study was to describe the features of health informatics blogs on the Internet.

Methods: A search was conducted in August, 2016 using the search engine, Google, and key words: ‘mobile health blog,’ ‘telehealth/telemedicine blog,’ ‘Electronic Health Record blog,’ ‘personalized health record blog,’ ‘population health decision support system blog,’ and ‘public/population health dashboard blog.’ The first 24 blogs resulting from each key word search were recorded, generating 144 blogs. A total of 109 unique blogs resulted after removing duplicates and non-functional sites.

Results: Blogs with ‘.com’ extensions were most prevalent (72%, n = 79). More than …

Implementing Clinical Practice Guideline Recommendations To Address Prenatal Smoking: A Practice Change In A Community Health Department, Rachel L. Danks

Doctoral Projects

According to the authors of current literature, pregnant women who smoke may be more resistant to change, and may not fully understand the harmful effects of smoking. Therefore, there is agreement among researchers that the use of psychosocial interventions for smoking cessation can be effective. At the time of this project many settings, including clinics, health departments, and providers, were implementing the 5As which guide healthcare and community workers to ask, advise, and assess the smoking status of pregnant women at every health visit, and then assist and arrange smoking cessation interventions if applicable. Despite these efforts, pregnant women are …

The Imperial County Community Air Monitoring Network: A Model For Community-Based Environmental Monitoring For Public Health Action., Paul B English, Luis Olmedo, Ester Bejarano, Humberto Lugo, Eduardo Murillo, Edmund Seto, Michelle Wong, Galatea King, Alexa Wilkie, Dan Meltzer, Graeme Carvlin, Michael Jerrett, Amanda Northcross

Environmental and Occupational Health Faculty Publications

The Imperial County Community Air Monitoring Network (the Network) is a collaborative group of community, academic, nongovernmental, and government partners designed to fill the need for more detailed data on particulate matter in an area that often exceeds air quality standards. The Network employs a community-based environmental monitoring process in which the community and researchers have specific, well-defined roles as part of an equitable partnership that also includes shared decision-making to determine study direction, plan research protocols, and conduct project activities. The Network is currently producing real-time particulate matter data from 40 low-cost sensors throughout Imperial County, one of the …

What's Happening: July 31, 2017, Maine Medical Center

What's Happening

No abstract provided.

Bayesian Model Averaging With Change Points To Assess The Impact Of Vaccination And Public Health Interventions., Esra Kürüm, Joshua L Warren, Cynthia Schuck-Paim, Roger Lustig, Joseph A Lewnard, Rodrigo Fuentes, Christian A W Bruhn, Robert J Taylor, Lone Simonsen, Daniel M Weinberger

Global Health Faculty Publications

Background: Pneumococcal conjugate vaccines (PCVs) prevent invasive pneumococcal disease and pneumonia. However, some low-and middle-income countries have yet to introduce PCV into their immunization programs due, in part, to lack of certainty about the potential impact. Assessing PCV benefits is challenging because specific data on pneumococcal disease are often lacking, and it can be difficult to separate the effects of factors other than the vaccine that could also affect pneumococcal disease rates.

Methods: We assess PCV impact by combining Bayesian model averaging with change-point models to estimate the timing and magnitude of vaccine-associated changes, while controlling for seasonality and other …

Using Mock Interviews To Evaluate An Interprofessional Education (Ipe) Curriculum, Ivy A. Click, Jodi Polaha, Leonard Brian Cross, Richard A. Hess, Adam C. Welch, Jessica Epley Burchette

ETSU Faculty Works

The aim of this study was to evaluate the influence of targeted team care training in our institution’s interprofessional practice and education (IPE) program on medical and pharmacy students' expression of knowledge and attitudes about team care as measured in a mock interview. Medical and Pharmacy students were recruited to participate in a 20-minute mock interview for an advanced placement position.

The Role Of Relationship Dynamics And Gender Inequalities As Barriers To Hiv-Serostatus Disclosure: Qualitative Study Among Women And Men Living With Hiv In Durban, South Africa, Divya S. Bhatia, Abigail D. Harrison, Muriel Kubeka, Cecilia Milford, Angela Kaida, Francis Bajunirwe, Ira B. Wilson, Christina Psaros, Steven A, Safren, David R. Bangsberg, Jennifer A. Smit, Lynn T. Matthews

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: This qualitative study investigated gender power inequalities as they contribute to relationship dynamics and HIV-serostatus disclosure among men and women living with HIV in Durban, South Africa. HIV serodiscordance among men and women within stable partnerships contributes to high HIV incidence in southern Africa, yet disclosure rates remain low. Given the emphasis on prevention for HIV-serodiscordant couples, this research supports the urgent need to explore how best to support couples to recognize that they are part of this priority population and to access appropriate prevention and treatment.

Methods: Thirty-five in-depth individual interviews were conducted with 15 HIV-positive men …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Third Annual Dietetic Internship Pinning Ceremony

Graduate Commencement, Philadelphia (2017), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus Graduate Program Commencement program, Class of 2017. Degrees include Doctor of Psychology in Clinical Psychology, Doctor of Psychology in School Psychology, Educational Specialist in School Psychology, Master of Science in School Psychology, Master of Science in Counseling and Clinical Health Psychology, Master of Science in Mental Health Counseling, Master of Science in Organizational Development and Leadership, Master of Science in Forensic Medicine, Master of Science in Biomedical Sciences, and Master of Science in Health Sciences – Physician Assistant Studies.

The Role Of Co-Opted Escrt Proteins And Lipid Factors In Protection Of Tombusviral Double-Stranded Rna Replication Intermediate Against Reconstituted Rnai In Yeast, Nikolay Kovalev, Jun-Ichi Inaba, Zhenghe Li, Peter D. Nagy

Plant Pathology Faculty Publications

Reconstituted antiviral defense pathway in surrogate host yeast is used as an intracellular probe to further our understanding of virus-host interactions and the role of co-opted host factors in formation of membrane-bound viral replicase complexes in protection of the viral RNA against ribonucleases. The inhibitory effect of the RNA interference (RNAi) machinery of S. castellii, which only consists of the two-component DCR1 and AGO1 genes, was measured against tomato bushy stunt virus (TBSV) in wild type and mutant yeasts. We show that deletion of the co-opted ESCRT-I (endosomal sorting complexes required for transport I) or ESCRT-III factors makes …

A Delphi Study: Guidelines For Researchers Working With Teenage Mothers, Alison M. Chamberlain

Nursing Theses and Dissertations

Problem: It is difficult to get teenage mothers to participate in studies, yet some researchers have been successful. Researchers who understand the barriers to conducting studies with a vulnerable population and are guided in ways to overcome these barriers, will experience greater success when doing studies with this group. Improved study methods can lead to larger numbers of teenage mothers who participate in studies. Researchers who follow developmentally appropriate guidelines are more likely to conduct and replicate studies with this population. Access is essential to advance the science related to care for teenage mothers who are at risk for many …

Application Of Support Vector Machine Modeling And Graph Theory Metrics For Disease Classification, Jessica M. Rudd

Published and Grey Literature from PhD Candidates

Disease classification is a crucial element of biomedical research. Recent studies have demonstrated that machine learning techniques, such as Support Vector Machine (SVM) modeling, produce similar or improved predictive capabilities in comparison to the traditional method of Logistic Regression. In addition, it has been found that social network metrics can provide useful predictive information for disease modeling. In this study, we combine simulated social network metrics with SVM to predict diabetes in a sample of data from the Behavioral Risk Factor Surveillance System. In this dataset, Logistic Regression outperformed SVM with ROC index of 81.8 and 81.7 for models with …

Medical School Watercooler Newsletter - July 30, 2017, Lindsey Lyle

Watercooler Newsletter

This is the July 30, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA’s Family Medicine Interest Group Recognized for Excellence

44th Research Day Features Keynote Speaker, Medical Student Presentations

USA Medicine Magazine Mailing Now

Dr. Michael Francis Awarded NIH Research Grant

August Med School Café - Chest Wall Deformities

Sibrava Studies, Teaches About Stress And Anxiety, Aldemaro Romero Jr.

Publications and Research

“There’s a cliché answer that you get from a lot of folks who say, ‘Well, I’ve always been interested in people,’ and that is true, but for me I always fan- tasized about being a lawyer when I grew up.” This is how Dr. Nicholas Sibrava explains his choice of career. In fact, he envisioned himself in a courtroom, just like in the movies.

It also explains why this native of Cleveland, Ohio obtained a bachelor’s degree in both criminology and psychology. The psychology part crept up on him while taking some psych courses. “Somewhere along the way I flip-flopped …

Collagen Complexity Spatially Defines Microregions Of Total Tissue Pressure In Pancreatic Cancer., Michael D. Nieskoski, Kayla Marra, Jason R. Gunn, P. Jack Hoopes, Marvin M. Doyley, Tayyaba Hasan, B. Stuart Trembly, Brian W. Pogue

Dartmouth Scholarship

The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions between hyaluronic acid (HA), collagen and the spatial origins of mechanical stresses that close off blood vessels was investigated here. Multiple localized pressure measurements were analyzed with spatially-matched histochemical images of HA, collagen and vessel perfusion. HA is known to swell, fitting a linear elastic model with total tissue pressure (TTP) increasing above interstitial fluid pressure (IFP) directly with collagen content. However, local …

Effectiveness Of Failure Modes Effect Analysis (Fmea) To Reduce Medical Error, Putri Ingen Setiasih, Purnawan Junadi

Journal of Indonesian Health Policy and Administration

One of the prevention efforts of medical errors that occur in health services is by identifying the potential failure of the service before the failure occurs. FMEA is one way to identify the risks of failure. Therefore, the authors wanted to find out whether FMEA was effective for reducing medical error based on previous studies. This article was a literature review using references in an online database such as EBSCOhost. The author found 280 articles while searching by using the keyword “FMEA”. After filtered by publication period from 2012 to 2017, full text and language, finally got 7 articles. Finally, …

Bilabial Substitution Patterns During Consonant Production In A Case Of Congenital Aglossia, Betty Mcmicken, Frederico Salles, Shelley Von Berg, Margaret Vento-Wilson, Kelly Rogers, Asterios Toutios, Shrikanth S. Narayanan

Communication Sciences and Disorders Faculty Articles and Research

Purpose: Congenital aglossia is a rare syndrome in which an individual is born without a tongue. The present paper examines articulatory details of the production of multiple consonants by an aglossic speaker.

Method: Real-time magnetic resonance imaging data of the upper airway were collected from the aglossic speaker. Air-tissue boundaries were determined from the video sequences using a segmentation algorithm, and dynamics of vocal-tract constrictions and cross-dimensions were calculated.

Results: The aglossic speaker produced the consonants /t, d, th, l ,r, f ,v, s, sh/ with a bilabial closure instead of a normal lingua-alveolar closure; however, in …

Hubungan Obesitas Dengan Kejadian Hipertensi Derajat 1 Di Pos Pembinaan Terpadu Penyakit Tidak Menular (Posbindu Ptm) Kantor Kesehatan Pelabuhan Bandung Tahun 2016, Teguh Dhika Rohkuswara, Syahrizal Syarif

Jurnal Epidemiologi Kesehatan Indonesia

Hipertensi sampai saat ini masih menjadi masalah kesehatan di dunia termasuk Indonesia. Prevalensi hipertensi di Indonesia, cukup tinggi yaitu sebesar 25,8% (Riskesdas, 2013). Sebagian besar penderita hipertensi termasuk dalam kelompok hipertensi derajat 1 dan separuhnya tidak menyadari sebagai penderita. Hipertensi bukan penyakit kausal tunggal, ada berbagai faktor yang berkontribusi terhadap munculnya hipertensi, salah satunya yang sering ditemukan adalah obesitas. Penelitian ini bertujuan untuk mengetahui besarnya hubungan antara obesitas dengan kejadian hipertensi derajat 1 di Posbindu PTM Kantor Kesehatan Pelabuhan Bandung. Desain penelitian adalah cross sectional, menggunakan data sekunder kegiatan Posbindu PTM KKP Bandung tahun 2016. Subjek penelitian adalah pegawai instansi …

Anesthesia Implications For Patients With Melas, Maxine Lemaster

Nursing Capstones

No abstract provided.

Determinant Of Timely First-Shot Hepatitis B Immunization In East Lombok, West Nusa Tenggara, Indonesia, Putri Bungsu Machmud, Dwi Gayatri, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Hepatitis B remains as one of health problems in the world. The results of several studies related to factors in predicting of the timely first-shot hepatitis B immunization were still inconsistent. Aim of this study is to identify determinant factors of the timely first-shot hepatitis B immunization in East Lombok, Indonesia. We used a cross sectional design study, and data derived from immunization coverage survey at six districts/ cities in 2013. A Total of 227 children aged 12 to 23 months who already got immunization of a first-shot hepatitis B vaccineand well documented were included as samples in this study. …

Pengaruh Konsumsi Fruktosa Pada Minuman Kemasan Terhadap Toleransi Glukosa Terganggu Pada Kelompok Usia Muda Di Perkotaan Di Indonesia, Nicolaski Lumbuun, Nasrin Kodim

Jurnal Epidemiologi Kesehatan Indonesia

Peningkatan konsumsi minuman kemasan (soft drinks/ bevereges) tampak nyata di dunia, termasuk Indonesia. Peningkatan ini terutama terjadi di kelompok usia muda. Konsumsi minuman tersebut berkaitan dengan gangguan metabolik, antara lain obesitas, toleransi glukosa terganggu (TGT) dan diabetes melitus. Hal ini disebabkan penggunaan pemanis tinggi fruktosa (high fructose corn syrup, HFCS). TGT terutama menjadi masalah kesehatan serius karena umumnya tidak menunjukkan gejala dan terlambat untuk dideteksi sehingga sering kali telah berprogresi menjadi diabetes mellitus. Penelitian ini bertujuan untuk melihat hubungan konsumsi tinggi fruktosa dengan kejadian TGT pada usia muda, serta prevalensi kekerapan mengkonsumsi minuman tinggi fruktosa, baik secara nasional maupun pada …