Medicine and Health Sciences Commons^™

Prediktor Kejadian Tb Pada Odha Di Salah Satu Rs Pemerintah Bogor, Tahun 2014-2016, Ulya Qoulan Karima, Mondastri Korib Sudaryo, Nuning Maria Kiptiyah

Jurnal Epidemiologi Kesehatan Indonesia

TB merupakan tantangan bagi pengendalian Acquired Immunodeficiency Syndrome (AIDS) karena merupakan infeksi oportunistik terbanyak pada orang dengan HIV/AIDS (ODHA). TB dapat meningkatkan progresivitas HIV dan meningkatkan risiko kematian bagi penderita HIV. Tujuan penelitian ini adalah untuk mengetahui prediktor yang berhubungan dengan kejadian TB pada ODHA di salah satu RS tahun 2014-2016. Desain studi yang digunakan adalah cross sectional dengan menggunakan data register ART dan Rekam Medis. Sampel berjumlah 817 pasien HIV. Analisis data dilakukan dengan menggunakan multiple cox regression. Hasil analisis multivariat menunjukkan adanya peningkatan risiko TB pada kelompok dengan anemia (PR=1,54, 95% CI: 1,17-2,03) dibandingkan kelompok tanpa anemia, adanya …

Hubungan Pengetahuan Hiv/Aids Dengan Stigma Terhadap Orang Dengan Hiv/Aids Di Kalangan Remaja 15-19 Tahun Di Indonesia (Analisis Data Sdki Tahun 2012), Berliana Situmeang, Syahrizal Syarif, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Stigma terhadap ODHA menjadi salah satu hambatan paling besar dalam pencegahan, perawatan, pengobatan, dan dukungan HIV/AIDS. Pengetahuan tentang HIV/AIDS mempengaruhi terjadinya stigma terhadap ODHA. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan tentang HIV/AIDS dengan stigma terhadap ODHA di kalangan remaja usia 15-19 tahun di Indonesia. Penelitian ini menggunakan data Survei Demografi dan Kesehatan Indonesia (SDKI) Tahun 2012 dengan disain cross-sectional. Sampel penelitian sebanyak 8.316 orang. Hasil studi menunjukkan 71,63% remaja mempunyai stigma terhadap ODHA, 49,10% remaja mempunyai pengetahuan yang kurang tentang HIV. Pengetahuan yang kurang tentang HIV/AIDS berhubungan dengan stigma terhadap ODHA (PR= 1,210 95% CI: 1,149-1,273) setelah dikontrol oleh …

Pengaruh Jarak Kelahiran Terhadap Kematian Bayi Di Indonesia, Filipina, Dan Kamboja (Analisis Data Survei Demografi Kesehatan), Adelina Fitri, Asri Adisasmita, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Kematian bayi didefinisikan sebagai kematian yang terjadi pada tahun pertama kehidupan. Angka kematian bayi di Indonesia dan Kamboja sendiri masih berada diatas AKB Asia Tenggara, sedangkan Filipina sudah sama dengan AKB Asia Tenggara. Jarak kelahiran merupakan salah satu faktor yang memegang peran penting pada kematian bayi. Tujuan penelitian ini adalah untuk mengetahui pengaruh jarak kelahiran terhadap kematian bayi di Indonesia, Filipina dan Kamboja. Penelitian menggunakan data dari Demographic Health Survey (DHS). Desain penelitian adalah cross sectional dan sampel pada masing-masing negara berjumlah 10.162, 4.741 dan 4.330 bayi. Hasil penelitian memperlihatkan, jarak kelahiran < 18 bulan memiliki risiko paling besar terhadap kematian bayi di Indonesia (OR = 2,43: 95% CI 1,26 - 4,70), Kamboja (OR = 4,39: 95% CI 1,76 - 10,94) dibandingkan jarak kelahiran 18 - 23 bulan, 24 - 35 bulan dan > 36 bulan. Sedangkan di Filipina jarak kelahiran 18 …

Feeding Problems Sebagai Prediktor Kejadian Obestitas Pada Anak Autis, Qisty Afifah Noviyanti

Jurnal Epidemiologi Kesehatan Indonesia

Latar belakang: Obesitas merupakan masalah yang dapat terjadi pada anak autis. Hal ini disebabkan adanya perubahan perilaku dan pola makan akibat kondisi autisme. Akan tetapi, belum banyak studi yang menjelaskan hubungan perilaku makan bermasalah (feeding problems) dengan kejadian obesitas pada anak autis. Tujuan: Penelitian ini untuk melihat hubungan antara masalah perilaku makan (feeding problem) dengan kejadian obesitas anak autis. Metode: Peninjauan artikel dilakukan dengan kata kunci autism OR autism spectrum disorder AND feeding problem OR food selectivity dan autism AND childhood obesity. Dua studi ditemukan sesuai dengan kriteria inklusi yang dibuat Anak autis memiliki perilaku makan bermasalah yang lebih tinggi …

Analysis Of Policy Making Factors On The Prohibition Of Hormones And Antibiotics Use For Feed As A Public Health Protection, Zaima Amalia, Wiku Adisasmito

Journal of Indonesian Health Policy and Administration

Food safety is one of the current international emerging issues. The danger of using antibiotics in animal husbandry is one of the contributors to human resistance. In Indonesia, antibiotics are commonly used as growth promoters in animal husbandry. Prohibition on the use of hormones and antibiotics mixed into animal feed written in Law No. 18 of 2009 on Animal Husbandry and Health which is then clarified by the Minister of Agriculture Regulation No. 14/Permentan/PK.350/5/2017 on the Classification of Animal Drugs. The purpose of this study is to determine the factors which influence the formation of policy on the prohibition of …

Vorinostat Renders The Replication-Competent Latent Reservoir Of Human Immunodeficiency Virus (Hiv) Vulnerable To Clearance By Cd8 T Cells., Julia A Sung, Katherine Sholtis, Jennifer Kirchherr, Joann D Kuruc, Cynthia L Gay, Jeffrey L Nordstrom, Catherine M Bollard, Nancie M Archin, David M Margolis

Pediatrics Faculty Publications

Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the latent HIV reservoir, defined as the triggering of viral antigen production sufficient in quantity and duration to allow for recognition and clearance of persisting infection, we developed a latency clearance assay (LCA). The LCA is a quantitative viral outgrowth assay (QVOA) that includes the addition of immune effectors capable of clearing cells expressing viral antigen. Here we show a reduction in the recovery of replication-competent virus from …

Heat Exposure And Maternal Health In The Face Of Climate Change., Leeann Kuehn, Sabrina Mccormick

Environmental and Occupational Health Faculty Publications

Climate change will increasingly affect the health of vulnerable populations, including maternal and fetal health. This systematic review aims to identify recent literature that investigates increasing heat and extreme temperatures on pregnancy outcomes globally. We identify common research findings in order to create a comprehensive understanding of how immediate effects will be sustained in the next generation. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guide, we systematically reviewed articles from PubMed and Cochrane Reviews. We included articles that identify climate change-related exposures and adverse health effects for pregnant women. There is evidence that temperature extremes adversely …

Reducing Chemical Exposures At Home: Opportunities For Action., Ami R Zota, Veena Singla, Gary Adamkiewicz, Susanna D Mitro, Robin E Dodson

Environmental and Occupational Health Faculty Publications

Indoor environments can influence human environmental chemical exposures and, ultimately, public health. Furniture, electronics, personal care and cleaning products, floor coverings and other consumer products contain chemicals that can end up in the indoor air and settled dust. Consumer product chemicals such as phthalates, phenols, flame retardants and per- and polyfluorinated alkyl substances are widely detected in the US general population, including vulnerable populations, and are associated with adverse health effects such as reproductive and endocrine toxicity. We discuss the implications of our recent meta-analysis describing the patterns of chemical exposures and the ubiquity of multiple chemicals in indoor environments. …

Copd: Emphysema, Nicole Nuxol

Nursing Student Class Projects (Formerly MSN)

Chronic Obstructive Pulmonary Disease is the third leading cause of death in the United States and is affecting more than 32 million Americans (Mosenifar, 2017). The prevalence of the disease continues to rise and many people are unaware they even have the disease. Prevention is essential in decreasing the incidence of the disease and Advanced Practice Nurses (APN) play a vital role. Emphysema is abnormal permanent enlargement of air spaces distal to the terminal bronchioles, accompanied by the destruction of alveolar walls and without obvious fibrosis (Boka, 2016). Being able to understand the pathophysiology of emphysema will allow for providers …

Providers Perspectives On Self-Regulation Impact Their Use Of Responsive Feeding Practices In Child Care, Dipti A. Dev, Katherine E. Speirs, Natalie A. Williams, Samantha Ramsay, Brent A. Mcbride, Holly Hatton-Bowers

Department of Child, Youth, and Family Studies: Faculty Publications

Supporting children's self-regulation in eating through caregivers' practice of responsive feeding is paramount to obesity prevention, and while much attention has been given to supporting children's selfregulation in eating through parents' responsive feeding practices in the home setting, little attention has been given to this issue in childcare settings. This qualitative study examines childcare providers' perspectives on using responsive feeding practices with young children (2–5 years). Individual semistructured interviews were conducted with providers until saturation was reached. Data was analyzed using thematic analysis. The final sample included 18 providers who were employed full-time in Head Start or state-licensed center-based childcare …

Syk Inhibitors In Clinical Development For Hematological Malignancies, Delong Liu, Aleksandra Mamorska-Dyga

NYMC Faculty Publications

Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK) and is mainly expressed in hematopoietic cells. Syk was recognized as a critical element in the B-cell receptor signaling pathway. Syk is also a key component in signal transduction from other immune receptors like Fc receptors and adhesion receptors. Several oral Syk inhibitors including fostamatinib (R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659 are being assessed in clinical trials. The second generation compound, entospletinib, showed promising results in clinical trials against B-cell malignancies, mainly chronic lymphoid leukemia. Syk inhibitors are being evaluated in combination regimens in multiple malignancies.

Reversion Of Epithelial-Mesenchymal Transition By A Novel Agent Dz-50 Via Igf Binding Protein-3 In Prostate Cancer Cells, Zheng Cao, Shahriar Koochekpour, Stephen E. Strup, Natasha Kyprianou

Urology Faculty Publications

Dysregulation of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor (IGF) axis has been linked to reactive stroma dynamics in prostate cancer progression. IGF binding protein-3 (IGFBP3) induction is initiated by stroma remodeling and could represent a potential therapeutic target for prostate cancer. In previous studies a lead quinazoline-based Doxazosin® derivative, DZ-50, impaired prostate tumor growth by targeting proteins involved in focal adhesion, anoikis resistance and epithelial-mesenchymal-transition (EMT). This study demonstrates that DZ-50 increased expression of the epithelial marker E-cadherin, and decreased the mesenchymal marker N-cadherin in human prostate cancer cells. In DU-145 cells, the effect of DZ-50 on EMT …

Induction Of Mir-155 After Brain Injury Promotes Type 1 Interferon And Has A Neuroprotective Effect., Emily Harrison, Kathleen M. Emanuel, Benjamin G. Lamberty, Brenda M. Morsey, Min Li, Matthew L. Kelso, Sowmya V. Yelamanchili, Howard S. Fox

Journal Articles: Pharmacology & Experimental Neuroscience

Traumatic brain injury (TBI) produces profound and lasting neuroinflammation that has both beneficial and detrimental effects. Recent evidence has implicated microRNAs (miRNAs) in the regulation of inflammation both in the periphery and the CNS. We examined the expression of inflammation associated miRNAs in the context of TBI using a mouse controlled cortical impact (CCI) model and found increased levels of miR-21, miR-223 and miR-155 in the hippocampus after CCI. The expression of miR-155 was elevated 9-fold after CCI, an increase confirmed by in situ hybridization (ISH). Interestingly, expression of miR-155 was largely found in neuronal nuclei as evidenced by co-localization …

Neurometabolic And Electrophysiological Changes During Cortical Spreading Depolarization: Multimodal Approach Based On A Lactate-Glucose Dual Microbiosensor Arrays, Cátia F. Lourenço, Ana Ledo, Greg A. Gerhardt, João Laranjinha, Rui M. Barbosa

Center for Microelectrode Technology Faculty Publications

Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterations, which impacts on neuronal function. In this work we aimed to develop an innovative multimodal approach, encompassing metabolic, electric and hemodynamic measurements, tailored but not limited to study SD. This was based on a novel dual-biosensor based on microelectrode arrays designed to simultaneously monitor lactate and glucose fluctuations and ongoing neuronal activity with high spatial and temporal resolution. In vitroevaluation of dual lactate-glucose microbiosensor revealed an extended linear range, …

Myo-Inositol Reduces Β-Catenin Activation In Colitis, Emily M. Bradford, Corey A. Thompson, Tatiana Goretsky, Guang-Yu Yang, Luz M. Rodriguez, Linheng Li, Terrence A. Barrett

Internal Medicine Faculty Publications

AIM

To assess dietary myo-inositol in reducing stem cell activation in colitis, and validate pβ-catenin^S552 as a biomarker of recurrent dysplasia.

METHODS

We examined the effects of dietary myo-inositol treatment on inflammation, pβ-catenin^S552 and pAkt levels by histology and western blot in IL-10^-/- and dextran sodium sulfate-treated colitic mice. Additionally, we assessed nuclear pβ-catenin^S552 in patients treated with myo-inositol in a clinical trial, and in patients with and without a history of colitis-induced dysplasia.

RESULTS

In mice, pβ-catenin^S552 staining faithfully reported the effects of myo-inositol in reducing inflammation and intestinal stem cell activation. In a …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Faculty Named APHA Social Worker of the Year

Mismatch Repair Deficiency Predicts Response Of Solid Tumors To Pd-1 Blockade., Dung T Le, Jennifer N Durham, Kellie N Smith, Hao Wang, Bjarne R Bartlett, Laveet K Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon S Luber, Fay Wong, Nilofer S Azad, Agnieszka A Rucki, Dan Laheru, Ross Donehower, Atif Zaheer, George A Fisher, Todd S Crocenzi, James J Lee, Tim F Greten, Austin G Duffy, Kristen K Ciombor, Aleksandra D Eyring, Bao H Lam, Andrew Joe, S Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian Meyer, Shibin Zhou, Richard M Goldberg, Deborah K Armstrong, Katherine M Bever, Amanda N Fader, Janis Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M Pardoll, Nickolas Papadopoulos, Kenneth W Kinzler, James R Eshleman, Bert Vogelstein, Robert A Anders, Luis A Diaz

Articles, Abstracts, and Reports

The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death receptor-1 (PD-1). We have now expanded this study to evaluate the efficacy of PD-1 blockade in patients with advanced mismatch repair-deficient cancers across 12 different tumor types. Objective radiographic responses were observed in 53% of patients, and complete responses were achieved in 21% of patients. Responses were durable, with median progression-free survival and overall survival still not reached. Functional analysis …

Cahost: An Excel Workbook For Facilitating The Johnson-Neyman Technique For Two-Way Interactions In Multiple Regression, Stephen W. Carden, Nicholas S. Holtzman, Michael J. Strube

Psychology: Faculty Publications

When using multiple regression, researchers frequently wish to explore how the relationship between two variables is moderated by another variable; this is termed an interaction. Historically, two approaches have been used to probe interactions: the pick-a-point approach and the Johnson-Neyman (JN) technique. The pick-a-point approach has limitations that can be avoided using the JN technique. Currently, the software available for implementing the JN technique and creating corresponding figures lacks several desirable features–most notably, ease of use and figure quality. To fill this gap in the literature, we offer a free Microsoft Excel 2013 workbook, CAHOST (a concatenation of the first …

Enhancing The Well-Being Of Older Adults And Young Adults With Developmental Disabilities Through Participation In An Intergenerational Community Garden: Participatory Action Research, Diane L. Keen

Doctorate of Nursing Science Dissertations

The purpose of this Participatory Action Research (PAR) study was to discover ways to enhance well-being in young adults with DD and older adults in the Oak Grove community. This dissertation details how PAR was used in the Oak Grove community to identify ways to enhance purpose and meaningful activity for older adults while developing positive relationships with younger adults with DD through qualitative methods.

Ryff and Keyes (1995) discovered that although some elements of well-being remain stable as a person ages, purpose-in-life drops significantly in older adults. In addition, young adults with developmental disabilities (DD) lack meaningful relationships, which …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Faculty Named APHA Social Worker of the Year

Alarm Fatigue: Do You Hear What I Hear?., Lindsey R. Damiter Bsn, Rn, Eric M. Strauss Bsn, Rn, Bianca B. Garcia Bsn, Rn, Lindsay M. Hischak Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Sliding With Sally Tubes., Nicole Baro Bsn, Rn, Karen Holveck Bsn, Rn, Marina Zweifel Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Registered Nurse's Attitudes Of Caring For Patients With Alcohol And Drug Abuse Diagnoses., Chloe G. Bowman Bsn, Rn, Sarah Lichtenwalner Bsn, Rn, Natalie R. Medinas Bsn, Rn, Alexandra M. Neikam Bsn, Rn, Abbey L. Parrish Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Decreased Use Of Foley Catheters And Standarization Of Daily Weights To Improve Accurancy Of Fluid Status Monitoring., Sarah Wasley Bsn, Rn, Casey Stockman Bsn, Rn, Patricia L. Klein Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Ensuring Proper Administration Of Subcutaneous Heparin In Post-Operative Cardiothoracic Surgery Patients., Rachel Borger Bsn, Rn, Zachary Caldwell Bsn, Rn, Ashley Clemens Bsn, Rn, Christy Rouhana Bsn, Rn, Kaitlyn Zimmerman Nsn, Rn

Patient Care Services / Nursing

No abstract provided.

Verification Of Gastric Tube Placement: Identifying New Practice When The Evidence Is Inconclusive., Daniela Diehl Bsn, Rn, Andrew Hill Bsn, Rn, Alexandra A. Lazaridis Bsn, Rn, Megan J. Sevi Bsn, Rn, Christina M. Siracuse Bsn, Rn, William J. Watson Jr Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

In Adult Critical Care Patients Receiving Enteral Feedings, Would Volume Based Nutritional Intake Compared To Current Enteral Feeding Policy Help Patients Meet Their Nutirional Goals?., Mikayla K. Lentz Bsn, Rn, Caitlin N. Pasquale Bsn, Rn, Molly Moyer Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Comparing Education Methodology In The Emergency Department., Nicole J. Bensel Bsn, Rn, Karen N. Brunner Bsn, Rn, Michelle J. Henne Bsn, Ashley D. Roman Bsn, Rn, Amanda M. Tarantino Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

What You Know Makes A Difference: Physical Activity Maintenance And Adherence Of Collegiate Students, Vista Beasley, Brooke Thompson, Patrick R. Young, Itay Basevitch

Journal of Counseling and Psychology

For decades, exercise psychology researchers dismissed health/exercise knowledge as a determinant of physical activity (PA). We sought to overturn this misconception, showing that psychological theory may serve as a basis for informing physical education curriculum. Based on social cognitive and self-determined motivation theories, we examined health/exercise knowledge as a determinant of collegiate students’ PA maintenance (i.e., ≥ 6 months of regular PA involvement); adherence to United States Department of Health and Human Services (USDHHS) 2008 PA guidelines; and PA types (i.e., aerobic, weight training). Collegiate students (n = 231) provided data via online survey. ANOVA analyses revealed that knowledge …

Finding Common Ground: Learning From Leaders Who Have Utilized Conflict Transformation Behaviors In The Mental Health Field In The United States, Tamarah E. Tilos

Dissertations

Purpose: The purpose of this study was to discover and describe how exemplary leaders establish common ground and produce breakthrough results in the mental health field by utilizing the 6 domains of conflict transformation: collaboration, communication, problem solving, process, emotional intelligence, and ethics.

Methodology: This thematic, phenomenological study was accomplished through examination of the lived experiences of exemplary leaders with firsthand experience transforming conflict and finding common ground. The target population for this study included executive-level leaders of nonprofit organizations, governmental institutions, state and national associations, and private businesses serving adults and children with mental illness, developmental or behavioral disabilities, …