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2017

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Full-Text Articles in Medicine and Health Sciences

“A Comparative Study On Academic Performance, Anthropometric Measurements, Cognitive Development, Reaction Time And Self-Defence Mechanism Among Karate And Non-Karate Performers Of Selected Schools In Udupi District, Karnataka”., Jilu Saly Jose Aug 2017

“A Comparative Study On Academic Performance, Anthropometric Measurements, Cognitive Development, Reaction Time And Self-Defence Mechanism Among Karate And Non-Karate Performers Of Selected Schools In Udupi District, Karnataka”., Jilu Saly Jose

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A comparative study on academic performance, anthropometric measurements, cognitive development, reaction time and self-defence mechanism among karate and non-karate performers of selected schools in Udupi district, Karnataka.” was conducted by Ms Jilu Saly Jose in partial fulfilment of the requirement for the degree of Masters of Science in Nursing at Manipal College of Nursing Manipal, Manipal University, Karnataka.

The objectives of the study were to identify the academic performance of karate and non-karate performers, assess the anthropometric measurements of karate and non-karate performers and compare with the standard measurement, elicit the reaction time of karate …


“A Study To Assess The Effectiveness Of Puppet Show On Knowledge About Child Safety Based On Learning Styles Among 5th And 6th Standard Students Of Selected Kannada Medium Schools In The Rural Areas Of Udupi District”, Josvita Sandra Fernandes Aug 2017

“A Study To Assess The Effectiveness Of Puppet Show On Knowledge About Child Safety Based On Learning Styles Among 5th And 6th Standard Students Of Selected Kannada Medium Schools In The Rural Areas Of Udupi District”, Josvita Sandra Fernandes

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the effectiveness of puppet show on knowledge about child safety based on learning styles among 5th and 6th standard students of selected Kannada medium schools in the rural areas of Udupi district” was conducted by Ms Josvita Sandra Fernandes as a partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University.

The objectives of the study were to: identify the learning styles among 5th and 6th standard students of selected Kannada medium schools in the rural areas of Udupi …


“A Study To Assess The Sleep Quality And Academic Performance Among The Undergraduate Students Of Selected Nursing Colleges Of Udupi District, Karnataka”., Sally Jane J K Aug 2017

“A Study To Assess The Sleep Quality And Academic Performance Among The Undergraduate Students Of Selected Nursing Colleges Of Udupi District, Karnataka”., Sally Jane J K

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled, “A study to assess the sleep quality and academic performance among the undergraduate students of selected Nursing Colleges of Udupi District, Karnataka” was conducted by Ms. Sally Jane J.K in partial fulfillment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University, Karnataka.

The objectives of the study were to assess the sleep quality among the undergraduate students by using the Pittsburgh Sleep Quality Index Scale, assess the academic performance among the undergraduate students by using a structured questionnaire, explore the factors influencing the sleep …


“A Study To Assess The Knowledge, Stress And Coping Patterns Of Grandmothers Involved In Child-Rearing Practices Of Children Of Employed Mothers In Selected Areas Of Udupi District, Karnataka., Reena M Dsilva Aug 2017

“A Study To Assess The Knowledge, Stress And Coping Patterns Of Grandmothers Involved In Child-Rearing Practices Of Children Of Employed Mothers In Selected Areas Of Udupi District, Karnataka., Reena M Dsilva

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A study to assess the knowledge, stress and coping patterns of grandmothers involved in child-rearing practices of children of employed mothers in selected areas of Udupi district, Karnataka was carried out by Mrs Reena M D’Silva in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal University, Manipal, Karnataka.

The objectives of the study were to assess the knowledge of grandmothers involved in child-rearing practices, to assess the stress level of grandmothers involved in child-rearing practices, to assess the coping patterns of grandmothers involved in child-rearing practices and …


"A Study To Assess The Knowledge, Perception, Psycho Social Preparedness For Menarche And The Problems Experienced By The Adolescent Girls In Selected Schools Of Udupi District”., Charmaine Crystal Salins Aug 2017

"A Study To Assess The Knowledge, Perception, Psycho Social Preparedness For Menarche And The Problems Experienced By The Adolescent Girls In Selected Schools Of Udupi District”., Charmaine Crystal Salins

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT The study titled “A study to assess the knowledge, perception, psychosocial preparedness for menarche and the problems experienced by the adolescent girls in selected schools of Udupi district” was carried out by Mrs Charmaine Crystal Salins, in partial fulfilment of the award of Master’s degree in Nursing, at Manipal College of Nursing, Manipal.

Objectives of the study were to assess the knowledge of adolescent girls on menarche, assess the perception of adolescent girls towards menarche, determine the psycho social preparedness of adolescent girls for menarche, find the problems faced by the adolescent girls who had attained menarche, find the …


“A Study To Assess Students Adjustment To Their Professional Course And Academic Performance Among Undergraduate Nursing Students Studying In Selected Institutions Of Udupi District, Karnataka.”, Bijoylakshmi Sahoo Aug 2017

“A Study To Assess Students Adjustment To Their Professional Course And Academic Performance Among Undergraduate Nursing Students Studying In Selected Institutions Of Udupi District, Karnataka.”, Bijoylakshmi Sahoo

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess students adjustment to their professional course and academic performance among undergraduate nursing students studying in selected institutions of Udupi District, Karnataka” was conducted in partial fulfilment of the requirement of a degree of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University, Karnataka.

The present study is an attempt to determine the students adjustment to the professional course and their academic performance, which in turn will help the faculty to find out the students adjustmental problems in relation to professional course and thereby provide them with adequate …


A Study To Assess The Existing Practices Of Intravenous (Iv) Medication Management And Barriers For Safe Practices Among Healthcare Professionals In A Selected Hospital Of Udupi District, Karnataka., Madhurikranta Mukherjee Aug 2017

A Study To Assess The Existing Practices Of Intravenous (Iv) Medication Management And Barriers For Safe Practices Among Healthcare Professionals In A Selected Hospital Of Udupi District, Karnataka., Madhurikranta Mukherjee

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the existing practices of Intravenous

(IV) medication management and barriers for safe practices among healthcare professionals in a selected hospital of Udupi District, Karnataka” was conducted by Ms Madhurikranta Mukherjee in partial fulfilment of the requirement for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University, Karnataka.

The present study was an attempt to observe the existing practices and identify the barriers for safe IV medication management practices among healthcare professionals, thereby minimizing the medication error and infection rate.

The objectives of the study …


Added Sugar Consumption Among College Students, Maram Murad Aug 2017

Added Sugar Consumption Among College Students, Maram Murad

Theses & Dissertations

Added sugar consumption has been increasing in all age groups in the United States and worldwide, with the greatest increase in young adults. College-age years are a critical period in the young adult's life where many habits develop, including nutrition and food choices. An understanding of college-age students’ attitudes and behaviors toward added sugar consumption might help predict added sugar consumption within this population. This was a quantitative study of traditional-aged college students' added sugar consumption through a convenience sample at a private university in San Antonio, TX. A survey was administrated to undergraduate students at different classes. Subjects were …


Teaching And Learning Courageous Followership: An Action Research Study, Karen Walker Schwab Aug 2017

Teaching And Learning Courageous Followership: An Action Research Study, Karen Walker Schwab

Theses & Dissertations

Followership has been shown to be a developmental stage of leadership. Yet, there is a lack of followership theory in the health-care context. The purpose of this qualitative action research study was to explore how introducing Chaleff’s dimensions of courageous followership influences the undergraduate nursing students’ views of the follower role and informs their nursing practice. Secondary research questions asked how knowledge of these dimensions influences the nursing students’ views while advocating, collaborating, and addressing lateral violence. Using purposeful sampling, 12 participants were recruited for this study. After attending a followership seminar, they completed online reflections and participated in individual …


An Observational Study To Assess The Practice Of Infection Control Measures On Patients Undergoing Transvaginal Sonography And Pap Smear Procedure , Among Health Care Professionals In Obstetrical And Gynecological Outpatient Department Of A Tertiary Hospital In Udupi District, Karnataka, Priyanka Rekha Mondal Aug 2017

An Observational Study To Assess The Practice Of Infection Control Measures On Patients Undergoing Transvaginal Sonography And Pap Smear Procedure , Among Health Care Professionals In Obstetrical And Gynecological Outpatient Department Of A Tertiary Hospital In Udupi District, Karnataka, Priyanka Rekha Mondal

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “An observational study to assess the practice of infection control measures on patients undergoing Transvaginal sonography and Pap smear procedure , among health care professionals in Obstetrical and Gynecological outpatient department of a tertiary hospital in Udupi District, Karnataka” was conducted by Ms Priyanka Rekha Mondal in partial fulfillment of the requirements for the degree of Master of Nursing Science at Manipal College of Nursing Manipal, Manipal University, Manipal, Karnataka. The objectives of the study were to assess the practice of infection control measures during Transvaginal sonography procedure and Pap smear procedure among health care …


“A Study To Assess The Relationship Between Psychological Well-Being And Perceived Parenting Style Among Selected High School Students Of Udupi District”., Ansu Francis Aug 2017

“A Study To Assess The Relationship Between Psychological Well-Being And Perceived Parenting Style Among Selected High School Students Of Udupi District”., Ansu Francis

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT (150505004) A research study entitled “A study to assess the relationship between psychological well-being and perceived parenting style among high school students of Udupi district” was conducted by Ms Ansu Francis as a partial fulfillment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal University, Manipal, Karnataka.

The purpose of the study was to assess psychological well-being and perceived parenting style among high school students studying in 8th and 9th standard. The findings of the study may be used to plan for an awareness program for students to improve their …


A Study On Gender Stereotype, Self-Esteem And Their Determinants Among Adolescents Of Selected English Medium Secondary School Of Udupi District., Bhanu Chhetri Karki Aug 2017

A Study On Gender Stereotype, Self-Esteem And Their Determinants Among Adolescents Of Selected English Medium Secondary School Of Udupi District., Bhanu Chhetri Karki

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT The study titled, “A study on gender stereotype, self-esteem and their determinants among adolescents of selected English medium secondary schools of Udupi district.” was carried out by Ms Bhanu Chhetri Karki, in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal.

Objectives of the study were to assess the gender stereotype among the adolescents using the Children‟s Sex Role Inventory (CSRI), to measure the self- esteem of the adolescent using the Rosenberg Self-esteem scale and to find out the determinants of gender stereotype among the adolescents as measured …


A Correlational Study To Assess The Intergenerational Ambivalence And Psychological Wellbeing Among Mothers Of Young Adults Of Selected Areas Of Udupi District, Karnataka, Steffi Jenifer Quadras Aug 2017

A Correlational Study To Assess The Intergenerational Ambivalence And Psychological Wellbeing Among Mothers Of Young Adults Of Selected Areas Of Udupi District, Karnataka, Steffi Jenifer Quadras

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A correlational study to assess the intergenerational ambivalence and psychological wellbeing among mothers of young adults in selected areas of Udupi District, Karnataka” was carried out in Manipal University, Manipal by Miss Steffi Jenifer Quadras.

The objectives of the study were to assess the intergenerational ambivalence of the mothers, assess the psychological wellbeing of mothers, and determine the relationship between intergenerational ambivalence and psychological wellbeing of mothers of young adults of selected areas of Udupi District.

The conceptual framework used for the study was based on the “Dynamic process model of parent” (Resch, Benz, & Ellliot, 2012).

A descriptive …


A Study To Determine The Infection Control Practices By The Health Care Workers (Hcws) And Facilities In The Labor Theatre (Lt) Of A Selected Tertiary Referral Hospital Of Udupi District , Karnataka, Mitchelle S Lewis Aug 2017

A Study To Determine The Infection Control Practices By The Health Care Workers (Hcws) And Facilities In The Labor Theatre (Lt) Of A Selected Tertiary Referral Hospital Of Udupi District , Karnataka, Mitchelle S Lewis

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “Infection control practices by the Health Care Workers (HCWs) and facilities in the Labor Theatre (LT) of a selected tertiary referral hospital of Udupi District, Karnataka” was carried out at Manipal University, Manipal by Mitchelle S Lewis for the award of Master of Science in Nursing as a partial fulfilment of the course. The objectives of the study were to observe the infection control practices during procedures in the LT by each category of HCWs using observational checklists and observe the facilities available in the LT using Infection Control Assessment Tool (ICAT) observational checklists by …


A Retrospective Study To Assess The Incidence And Factors Predisposing To Surgical Site Infection (Ssi) In Patients Who Have Undergone Caesarean Section In Tertiary Care Hospital Of Udupi District, Karnataka., Debalina Ghosh Aug 2017

A Retrospective Study To Assess The Incidence And Factors Predisposing To Surgical Site Infection (Ssi) In Patients Who Have Undergone Caesarean Section In Tertiary Care Hospital Of Udupi District, Karnataka., Debalina Ghosh

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled, “A retrospective study to assess the incidence and factors predisposing to surgical site infection (SSI) in patients who have undergone caesarean section in tertiary care hospital of Udupi district, Karnataka” was conducted by Ms Debalina Ghosh in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal, Manipal University, Karnataka.

The objectives of the study were to determine the incidence of surgical site infection (SSI) in patients who have undergone caesarean section through record analysis and to identify the factors predisposing to surgical site infections …


Effectiveness Of Trainning Programme On Prevention Of Ventilator Associated Events (Vae) In Terms Of Knowledge And Practice Among Health Care Professionals Of Selected Intensive Care Units (Icu) Of A Tertiary Care Hospital Udupi, Arjun S Aug 2017

Effectiveness Of Trainning Programme On Prevention Of Ventilator Associated Events (Vae) In Terms Of Knowledge And Practice Among Health Care Professionals Of Selected Intensive Care Units (Icu) Of A Tertiary Care Hospital Udupi, Arjun S

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study “Effectiveness of training programme on prevention of Ventilator Associated Events (VAE) in terms of knowledge and practice among Health Care Professionals of selected Intensive Care Units (ICU) of a tertiary care hospital Udupi” was carried out at Manipal University, Manipal by Arjun S for the award of Master of Science in Nursing as a partial fulfilment of the course. The objectives of the study were to assess the knowledge regarding VAE prevention using a structured knowledge questionnaire, determine the VAE preventive practices among health care professionals of selected ICUs using observational checklist, determine the effectiveness of …


“A Descriptive Study To Assess The Immunization Compliance, Common Health Problems Of Immunized Under Five Children And Perceived Maternal Barriers For Immunization In Selected Rural Areas Of Udupi District”., Anusha C A Aug 2017

“A Descriptive Study To Assess The Immunization Compliance, Common Health Problems Of Immunized Under Five Children And Perceived Maternal Barriers For Immunization In Selected Rural Areas Of Udupi District”., Anusha C A

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A descriptive study to assess the immunization compliance, common health problems of immunized under five children and perceived maternal barriers for immunization in selected rural areas of Udupi district”, was conducted by Ms Anusha C.A in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal University, Manipal, Karnataka.

The objectives of the study were to: find out the immunization compliance of under five children in selected rural areas of Udupi district, identify the perceived maternal barriers for immunization among mothers of under five children, …


A Study To Assess The Knowledge And Practices Of Cleaning And Disinfection Among Health Care Workers (Hcws) In The Intensive Care Units (Icus) Of A Tertiary Care Hospital In Udupi District, Karnataka., Tincy Varghese Aug 2017

A Study To Assess The Knowledge And Practices Of Cleaning And Disinfection Among Health Care Workers (Hcws) In The Intensive Care Units (Icus) Of A Tertiary Care Hospital In Udupi District, Karnataka., Tincy Varghese

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A study to assess the knowledge and practices of cleaning and disinfection among Health Care Workers (HCWs) in the Intensive Care Units (ICUs) of a tertiary care Hospital in Udupi district, Karnataka was conducted by Ms. Tincy Varghese in partial fulfillment of the requirements for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University.

The objective of the study was to assess the knowledge and practice on cleaning and disinfection among the health care workers.

The conceptual framework was based on Radical approach model on educational process (1974).

The sample for observation …


A Study To Explore Bullying And Its Impact On The Psychosocial Wellbeing Among The Selected High School Students Of Udupi District, Karnataka., Reema Rai Aug 2017

A Study To Explore Bullying And Its Impact On The Psychosocial Wellbeing Among The Selected High School Students Of Udupi District, Karnataka., Reema Rai

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT The study titled “A study to explore bullying and its impact on the psychosocial wellbeing among the selected High School students of Udupi District, Karnataka” was carried out by Ms Reema Rai, for the partial fulfilment of requirement for the award of Degree of Master of Science in Nursing in Manipal College of Nursing Manipal, Manipal University, Karnataka. The objectives of the study were to explore bullying using Illinois Bullying Scale, to assess the psychosocial wellbeing of students using psychosocial wellbeing Scale, to determine the relationship between bullying and psychosocial wellbeing, to determine the association between bullying and selected …


A Study To Assess The Level Of Anger, Coping And Factors Influencing Anger Amongst Adolescents Of Selected Schools, Udupi District Karnataka., Pusahole Natso Aug 2017

A Study To Assess The Level Of Anger, Coping And Factors Influencing Anger Amongst Adolescents Of Selected Schools, Udupi District Karnataka., Pusahole Natso

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the level of anger, coping and factors influencing anger amongst adolescents of selected schools, Udupi District Karnataka” was conducted by Pusahole Natso , as a partial fulfillment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal.

The objectives of the study were to assess the level of anger, identify the factors influencing anger, assess coping among the adolescents and to determine the relationship between anger and coping among the adolescents.

The conceptual framework for the study was based on Roy’s Adaptation Model. …


Digital Breast Tomosynthesis: Outcomes And Tumor Characteristics In Women Recalled From Screening, Michelle Y. Giwerc Aug 2017

Digital Breast Tomosynthesis: Outcomes And Tumor Characteristics In Women Recalled From Screening, Michelle Y. Giwerc

Yale School of Medicine Physician Associate Program Theses

Breast cancer is the most frequently diagnosed and second leading cause of cancer deaths in women, accounting for 25% of cancer diagnoses and 15.4% of cancer deaths in developed countries. Thus, early detection of breast cancer through screening has become increasingly important in mortality reduction efforts. Yet, mammography has faced considerable controversy in balancing the benefits and harms associated with screening. Digital breast tomosynthesis has emerged as an important imaging technique which, compared to standard mammography alone, reduces recall rates and false positives, and improves cancer detection. Additional cancers detected with tomosynthesis have been poorly characterized in the literature to …


A Bittersweet Balance: Adjunct Therapy For Hyperglycemia In Critically Ill Patients, Caroline Argyros Aug 2017

A Bittersweet Balance: Adjunct Therapy For Hyperglycemia In Critically Ill Patients, Caroline Argyros

Yale School of Medicine Physician Associate Program Theses

Stress-induced hyperglycemia in critically ill patients negatively affects their recovery. Providers have struggled to balance the treatment of hyperglycemia with aggressive insulin therapy with the risk of hypoglycemia as an adverse effect. Both immobilization and continuous enteral nutrition are common in a critical care setting and have implications as contributors for further hyperglycemia due to decreased peripheral glucose uptake and worsening insulin resistance. We propose to determine if an aggressive early mobilization protocol and nutrition protocol in the form of bolus feeds will decrease the amount of insulin units needed to treat hyperglycemia in critically ill patients. To do so, …


Santa Clara Magazine, Volume 58 Number 3, August 2017, Santa Clara University Aug 2017

Santa Clara Magazine, Volume 58 Number 3, August 2017, Santa Clara University

Santa Clara Magazine

3 - PAINT BY NUMBERS By Harold Gutmann and Matt Morgan

4 - SUPERMAN By Sam Farmer

7 - A WILD GENEROSITY By Brian Doyle


2017-2018 Graduate Studies In Nursing Handbook, Otterbein Office Of Graduate Programs Aug 2017

2017-2018 Graduate Studies In Nursing Handbook, Otterbein Office Of Graduate Programs

Graduate School

A graduate handbook for the Graduate Studies in Nursing programs at Otterbein University.


Practical Pearl: Sleep Problems Associated With Adhd - August 2017, Stephen Boos Md Aug 2017

Practical Pearl: Sleep Problems Associated With Adhd - August 2017, Stephen Boos Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.


Increased Expression Of The Tight Junction Protein Tjp1/Zo-1 Is Associated With Upregulation Of Taz-Tead Activity And An Adult Tissue Stem Cell Signature In Carfilzomib-Resistant Multiple Myeloma Cells And High-Risk Multiple Myeloma Patients, Irene Riz, Robert G. Hawley Aug 2017

Increased Expression Of The Tight Junction Protein Tjp1/Zo-1 Is Associated With Upregulation Of Taz-Tead Activity And An Adult Tissue Stem Cell Signature In Carfilzomib-Resistant Multiple Myeloma Cells And High-Risk Multiple Myeloma Patients, Irene Riz, Robert G. Hawley

Anatomy and Regenerative Biology Faculty Publications

Tight junction protein 1 (TJP1) has recently been proposed as a biomarker to identify multiple myeloma (MM) patients most likely to respond to bortezomiband carfilzomib-based proteasome inhibitor regimens. Herein we report increased expression of TJP1 during the adaptive response mediating carfilzomib resistance in the LP-1/Cfz MM cell line. Moreover, increased TJP1 expression delineated a subset of relapsed/refractory MM patients on bortezomib-based therapy sharing an LP-1/Cfzlike phenotype characterized by activation of interacting transcriptional effectors of the Hippo signaling cascade (TAZ and TEAD1) and an adult tissue stem cell signature. siRNA-mediated knockdown of TJP1 or TAZ/TEAD1 partially sensitized LP-1/Cfz cells to carfilzomib. …


Why It’S Not Ok For Doctors To Participate In Executions, Robert F. Johnson Aug 2017

Why It’S Not Ok For Doctors To Participate In Executions, Robert F. Johnson

Peer Reviewed Articles

A plea for direct physician participation in executions was presented by Sandeep Jauhar in a New York Times Op-Ed (“Why It’s OK for Doctors to Participate in Executions”—April 21, 2017). Jauhar’s article is not a discussion of the ethics of capital punishment. He describes his own opposition “as a matter of principle, as a doctor.” However, since capital punishment is legal in 31 states, with required physician participation in several, he acquiesces to a utilitarian stance rather than the principled approach he acknowledges is expected of a physician in this circumstance.


A Novel Mechanism Of Non- Feminizing Estrogens In Neuroprotection, Elizabeth B. Engler-Chiurazzi, Douglas F. Covey, James W. Simpkins Aug 2017

A Novel Mechanism Of Non- Feminizing Estrogens In Neuroprotection, Elizabeth B. Engler-Chiurazzi, Douglas F. Covey, James W. Simpkins

Clinical and Translational Science Institute

Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of more than 70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor (ER) binding. We observed that neuroprotection could be enhanced by as much as 200-fold through modifications that positioned a large bulky group at the C2 or C4 position of the phenolic A ring of the estratriene. Further, substitutions on the B, C or D rings either reduced or did not markedly change neuroprotection. …


Anatomical And Technical Predictors Of Perioperative Clinical Outcomes After Carotid Artery Stenting, Ali F. Aburahma, Trevor Derderian, Nizar Hariri, Elliot Adams, Joseph Aburahma, L. Scott Dean, Aravinda Nanjundappa, Patrick A. Stone Aug 2017

Anatomical And Technical Predictors Of Perioperative Clinical Outcomes After Carotid Artery Stenting, Ali F. Aburahma, Trevor Derderian, Nizar Hariri, Elliot Adams, Joseph Aburahma, L. Scott Dean, Aravinda Nanjundappa, Patrick A. Stone

Clinical and Translational Science Institute

Background—A few other studies have reported the effects of anatomical and technical factors on clinical outcomes of carotid artery stenting (CAS). This study analyzed the effect of these factors on perioperative stroke/myocardial infarction/death after CAS. Methods—This was a retrospective analysis of prospectively collected data of 409 of 456 patients who underwent CAS during the study period. A logistic regression analysis was used to determine the effects of anatomical and technical factors on perioperative stroke, death, and myocardial infarction (major adverse events [MAEs]). Results—The MAE rate for the entire series was 4.7% (19 of 409), and the stroke rate was 2.2% …


Primary Endovascular Repair Of Ilio-Caval Injury Encountered During Anterior Exposure Spine Surgery: Evolution Of The Paradigm, Patrick C. Bonasso, Brandon P. Lucke-Wold, Alexandre D'Audiffret, Lakshmikumar Pillai Aug 2017

Primary Endovascular Repair Of Ilio-Caval Injury Encountered During Anterior Exposure Spine Surgery: Evolution Of The Paradigm, Patrick C. Bonasso, Brandon P. Lucke-Wold, Alexandre D'Audiffret, Lakshmikumar Pillai

Clinical and Translational Science Institute

Background—Rates of major venous injury are now being reported at between 1% and 15%. Risk factors for injury include the previous spine surgery, level of exposure, and number of retractors used. To review and describe the evolution of our use of stent grafts for repair of lifethreatening ilio-caval injuries encountered during anterior exposure lumbosacral (L-S) spine surgery from rescue utilization after failed direct repair to preferred modality using occlusion balloons and covered stents akin to the modern management of the ruptured abdominal aortic aneurysm (AAA) with endovascular aneurysm repair. Methods—Five-year retrospective review of all anterior and retroperitoneal spine procedures was …