Medicine and Health Sciences Commons^™

Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer is a complex, robust disease with multiple redundant disease pathways which lead to tumor development, growth, and eventually even death. Despite known redundancies, cancer therapeutics continue to be developed against a single protein target. Initial disease regression occurs followed by relapse in a drug resistant disease state. In response, combinational drug clinical trial targeting multiple pathways began, and have failed due to increased toxicity caused by adverse drug interactions. Development of a single drug that differentially targets multiple disease pathways will result in a more potent therapeutic while inducing minimal toxicity. This was done computationally through in-lab software packages, …

Relative Contribution Of Porcine Reproductive And Respiratory Syndrome Virus Open Reading Frames 2–4 To The Induction Of Protective Immunity, Katherine Kimpston-Burkgren, Ignacio Correas, Fernando A. Osorio, David Steffen, Asit K. Pattnaik, Ying Fang, Hiep L. X. Vu

Nebraska Center for Virology: Faculty Publications

The minor glycoproteins (GPs) of PRRSV, GP2, GP3, and GP4, form a heterotrimer that is required for viral infectivity, presumably due to its interaction with the key cellular receptor CD163. These 3 GPs are encoded by open reading frames (ORFs) 2a, 3, and 4 (herein referred to as ORFs 2–4), respectively. The goal of this study was to investigate the immunogenicity of the PRRSV-2 minor GPs. Through the use of reverse genetics, a chimeric virus (designated SDFL24) was constructed by replacing ORFs 2–4 of the PRRSV-1 strain SD01-08 with the corresponding genes of the PRRSV-2 strain FL12. While the parental …

Idarucizumab For Dabigatran Reversal - Full Cohort Analysis., Charles V. Pollack, Paul A. Reilly, Joanne Van Ryn, John W. Eikelboom, Stephan Glund, Richard A. Bernstein, Robert Dubiel, Menno V. Huisman, Elaine M. Hylek, Chak-Wah Kam, Pieter W. Kamphuisen, Jörg Kreuzer, Jerrold H. Levy, Gordon Royle, Frank W. Sellke, Joachim Stangier, Thorsten Steiner, Peter Verhamme, Bushi Wang, Laura Young, Jeffrey I. Weitz

Department of Emergency Medicine Faculty Papers

BACKGROUND: Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran.

METHODS: We performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time or ecarin clotting time. Secondary end points included the restoration …

Impact Of A Pre-Professional Clinical Education Experience With Adults With Autism Spectrum Disorder: Preparation Of Future Speech-Language Pathologists, Kaitlyn P. Wilson Ph.D., Ccc-Slp, Gregory S. Chasson Ph.D., Amanda C. Jozkowski Ph.D., Otr/L, Meghan V. Mulhern Ed.M.

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study was to (1) investigate the impact of a clinical experience with adults with autism spectrum disorder (ASD) on graduate speech-language pathology (SLP) students’ knowledge about ASD, and (2) explore the nature of the clinical experience and its impact on students’ preparation to work with adults with ASD. This study used a mixed-methods design. Quantitative methods were used to identify statistically significant changes in student knowledge about ASD following participation in a clinical experience with adults with ASD. Qualitative methods were used to explore student narratives to uncover details of the clinical experience and its impact. …

Interdisciplinary Ethics Learning In Higher Education: Students’ Perceptions, Carrie Knight, Robert Mayo, Michele Porter

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study is to evaluate speech-language pathology (SLP) students’ understandings of professional issues and ethics related to their own profession and to public health administration and to evaluate SLP students’ perceptions of interdisciplinary learning opportunities. Participants were second-year graduate students pursuing a Master of Arts degree in SLP (N = 24) enrolled in an interdisciplinary professional issues and ethics course. Students completed a pre- and post-test questionnaire regarding their perception of interdisciplinary learning opportunities, and their understanding of public health professions and codes of ethics, SLP code of ethics, and SLP professionals’ impact on other professionals …

Speech-Language Pathology Student Anxiety, Expectations, And Needs During Clinical Practicum, Laura W. Plexico, Allison M. Plumb, Daniel E. Phillips

Teaching and Learning in Communication Sciences & Disorders

The current study investigates clinical supervision with regard to millennial student clinician expectations, needs, and anxiety related to the supervisory process. Seven graduate students in speech-language pathology completed questionnaires at six points during their graduate education – The Student Clinician Anxiety Test (Sleight, 1985), as well as Larson’s Supervisory Expectations Rating Scale and Supervisory Needs Rating Scale (Larson, 1981). Results indicated that supervisory needs and expectations were significantly greater pre-practicum when compared to post-externship, with no significant changes in student clinician anxiety noted across six semesters of graduate training. Student clinicians demonstrated less anxiety than Sleight’s data, but had greater …

Bridging The Gap: An Integrated Approach To Facilitating Foundational Learning Of Neuroanatomy And Neurophysiology In Graduate-Level Speech-Language Pathology Coursework, Lisa A. Vinney, Jennine M.T. Harvey

Teaching and Learning in Communication Sciences & Disorders

The current study examined whether the integration of foundational neuroanatomy and neurophysiology content, across a pair of medically-based, disorder-specific courses (motor speech disorders and aphasia), promoted students’ abilities to describe common neurological constructs and apply them to clinical cases. Specifically, student responses to case questions were rubric-scored following their completion of five neuroanatomy and neurophysiology online modules independently and after in-class instructional augmentation of each module’s content. Students’ own perceptions of this integrated curriculum were also surveyed and coded into themes. Rubric scores, evaluating content knowledge of the brainstem, spinal cord, and the neuron, significantly improved from post-module to after …

Chronic Obstructive Pulmonary Disease (Copd), Jenna Trimmer

Nursing Student Class Projects (Formerly MSN)

COPD is said to be unappreciated with half of COPD patients going undiagnosed or under treated. The research of this assignment will help to increase the APNs knowledge of the disease, its pathophysiology, presentation of symptoms, and disease management for better patient outcomes.

Malignant Hyperthermia, Brandon Kinnamon

Nursing Student Class Projects (Formerly MSN)

Common anesthetic agents can trigger a pathological response in patients resulting in intracellular calcium release and hyper-metabolism. This condition is known as Malignant Hyperthermia (MH). It is vital for anesthesia professionals and critical care nurses to recognize MH and act quickly to limit rapid shifts of electrolytes which can ultimately lead to death. As soon as cardinal signs of malignant hyperthermia are identified, the medication dantrolene should be administered along with intensive nursing care. Significant signs and symptoms, the pathophysiology of MH, and implications for nursing care are all examined in greater detail.

Polycystic Ovarian Syndrome, Laura Quinter

Nursing Student Class Projects (Formerly MSN)

Polycystic ovary syndrome (PCOS) affects 8-10 percent of reproductive-aged females. “…PCOS happens when a woman's ovaries or adrenal glands produce more male hormones than normal. PCOS causes cysts (fluid-filled sacs) to grow on the ovaries” (Medline Plus, 2017). It is one of the most common diseases of endocrine dysfunction in women, but diagnosis is sometimes missed or delayed because patients with PCOS are often treated for the signs and symptoms of the condition without consideration for the underlying syndrome. Patients often present with complaints of acne, hair loss, hirsutism, irregular vaginal bleeding, and infertility. Many patients receive treatments for these …

Chiari Malformation, Karin Benner

Nursing Student Class Projects (Formerly MSN)

The well prepared advanced practice nurse will have a solid understanding of anatomy and physiology, as well as pathophysiological principles. The APN that practices in the emergency department or in the acute care setting should be familiar with a variety of common neurological disorders.

The National Institute of Neurological Disorders and Stroke (NIH) estimate that greater than 1 out of every 1000 persons will be identified with a Chiari malformation (CM) and the greater majority diagnosed will be female (National Institute of Neurological Disorders and Stroke [NIH], 2013, para. 6). Chiari malformations can be congenital or acquired and are staged …

Lyme Disease, Sondra Mcfadden

Nursing Student Class Projects (Formerly MSN)

Lyme disease is caused by the spirochete Borrelia burgdorferi and is a bacterial infectious disease that is spread by zoonotic transmission in which animals act as reservoir hosts and ticks are the primary vector or carrier and are considered arthropods. This poster presents Lyme disease, its pathophysiology, and nursing considerations for treating it.

Cooperation Not Competition: Bihemispheric Tdcs And Fmri Show Role For Ipsilateral Hemisphere In Motor Learning, Sheena Waters, Tobias Wiestler, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

What is the role of ipsilateral motor and premotor areas in motor learning? One view is that ipsilateral activity suppresses contralateral motor cortex and, accordingly, that inhibiting ipsilateral regions can improve motor learning. Alternatively, the ipsilateral motor cortex may play an active role in the control and/or learning of unilateral hand movements. We approached this question by applying double-blind bihemispheric transcranial direct current stimulation (tDCS) over both contralateral and ipsilateral motor cortex in a between-group design during 4 d of unimanual explicit sequence training in human participants. Independently of whether the anode was placed over contralateral or ipsilateral motor cortex, …

Shopping For Food In Nonmetropolitan Nebraska: 2017 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, L.J. Mcelravy, Timothy Meyer, Vanessa Wielenga

Rural Futures Institute: Publications

Conclusion

Rural Nebraskans purchase their food from a variety of stores. Almost four in ten buy most of their food from a supercenter (like Wal-Mart or Costco). Just over three in ten typically shop at a supermarket and just under three in ten buy most of their food at a small grocery store. Differences in the type of store most utilized occur by community size. Persons living in or near larger communities are more likely than persons living in or near smaller communities to purchase the majority of their food from either a supermarket or supercenter.

Persons living in or …

Quality Improvement And Patient Safety Posters In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

More than 30 new House Staff Quality Improvement and Patient Safety Posters have been loaded in the Jefferson Digital Commons. Below is a sample of the recent additions reflecting the wide range of topics covered:

Acute Bronchospasm Under General Anesthesia, Cody Rasmussen

Nursing Student Class Projects (Formerly MSN)

An acute bronchospasm during general anesthesia can become a life-threatening intraoperative condition for any patient. Bronchospasm occurs when the bronchial smooth muscle constricts which makes ventilating the patient difficult, and can ultimately lead to hypoventilation, hypoxemia, and metabolic acidosis. It’s imperative for any anesthesia provider to understand what a bronchospasm is, its pathophysiology, differential diagnosis, and algorithm of treatments. This poster presentation provides a summary based discussion of acute bronchospasm under general anesthesia.

Sepsis, Sarah Jones

Nursing Student Class Projects (Formerly MSN)

Sepsis is a dysregulation of the inflammatory response, termed systemic inflammatory response syndrome or SIRS, caused by stimulation of an infectious process. Sepsis often leads to organ dysfunction and increased morbidity, mortality and financial burdens. The goal of treatment is to initiate appropriate antimicrobial therapies, target the underlying infection, optimize intravascular volume, provide fluid resuscitation and maintain adequate perfusion and stroke volume (Taeb, Hooper & Marik, 2017).

Timing of treatment and early detection of sepsis is critical to patients with early warning signs. Sharing this information and potentially making a difference in the outcomes of patients presenting with early signs …

Role Of Metastasectomy And Chemotherapy In Carcinoma Of Uterine Cervix, Nasir Ali, Muhammad Atif Mansha, Ahmed Nadeem Abbasi, Bilal Mazhar Qureshi

Department of Radiation Oncology

Squamous cell carcinoma of uterine cervix is potentially a curable disease; however, many patients treated with definitive chemoradiotherapy develop distant metastases, with few of them having a single metastatic deposit. There are no guidelines for the treatment of patients with oligometastatic cervical cancer.We present a case of a patient with International Federation of Gynecology and Obstetrics (FIGO) Stage IIB squamous cell carcinoma of uterine cervix. She was successfully treated with concurrent chemoradiotherapy with definitive intent. One year later, she developed a solitary pulmonary nodule for which she underwent resection followed by chemotherapy. She is free of any local or distant …

Impact Of Cocaine Use On Acute Ischemic Stroke Patients: Insights From Nationwide Inpatient Sample In The United States, Rupak Desai, Upenkumar Patel, Chintan Rupareliya, Sandeep Singh, Manan Shah, Rikinkumar S. Patel, Smit Patel, Zabeen Mahuwala

Neurology Faculty Publications

Cocaine is the third most common substance of abuse after cannabis and alcohol. The use of cocaine as an illicit substance is implicated as a causative factor for multisystem derangements ranging from an acute crisis to chronic complications. Vasospasm is the proposed mechanism behind adverse events resulting from cocaine abuse, acute ischemic strokes (AIS) being one of the few. Our study looked into in-hospital outcomes owing to cocaine use in the large population based study of AIS patients. Using the national inpatient sample (NIS) database from 2014 of United States of America, we identified AIS patients with cocaine use using …

Rapid Automated Naming Performance Of Young Spanish-English Speaking Children, Carla L. Wood, Kristina N. Bustamante, Lisa Fitton, Dana M. Brown, Yaacov Petscher

Faculty Publications

The aim of this preliminary study was to examine the feasibility of a rapid automatic naming (RAN) task for young Spanish–English speaking dual language learners (DLLs) and to examine the relationship between children’s performance on RAN and other standardized language and literacy assessments. A total of 275 Spanish–English speaking children in kindergarten and first grade attempted a RAN task and completed assessments of language and early literacy. Correlational analyses and quantile regression was conducted to examine relationships. Overall the RAN task was feasible for 74% (n = 203) of the DLLs; however, 42% of participants in kindergarten were unable to …

Endothelial Function Is Associated With White Matter Microstructure And Executive Function In Older Adults, Nathan F. Johnson, Brian T. Gold, Christopher A. Brown, Emily F. Anggelis, Alison L. Bailey, Jody L. Clasey, David K. Powell

Physical Therapy Faculty Publications

Age-related declines in endothelial function can lead to cognitive decline. However, little is known about the relationships between endothelial function and specific neurocognitive functions. This study explored the relationship between measures of endothelial function (reactive hyperemia index; RHI), white matter (WM) health (fractional anisotropy, FA, and WM hyperintensity volume, WMH), and executive function (Trail Making Test (TMT); Trail B - Trail A). Participants were 36 older adults between the ages of 59 and 69 (mean age = 63.89 years, SD = 2.94). WMH volume showed no relationship with RHI or executive function. However, there was a positive relationship between RHI …

Future Orientation, Social Support, And Psychological Adjustment Among Left-Behind Children In Rural China: A Longitudinal Study, Shaobing Su, Xiaoming Li, Danhua Lin, Maoling Zhu

Faculty Publications

Existing research has found that parental migration may negatively impact the psychological adjustment of left-behind children. However, limited longitudinal research has examined if and how future orientation (individual protective factor) and social support (contextual protective factor) are associated with the indicators of psychological adjustment (i.e., life satisfaction, school satisfaction, happiness, and loneliness) of left-behind children. In the current longitudinal study, we examined the differences in psychological adjustment between left-behind children and non-left behind children (comparison children) in rural areas, and explored the protective roles of future orientation and social support on the immediate (cross-sectional effects) and subsequent (lagged effects) status …

The Relationship Between Sport Participation And Chronic Diseases Among Men In The Usa: An Examination Of The Behavioral Risk Factor Surveillance System, Jennifer Pharr, Nancy L. Lough

School of Public Health Faculty Research

Sport participation has been associated with lower rates of chronic diseases when compared to other forms of physical activity (PA) among women. However, we do not know if this relationship holds true for men. The purpose of this study was to examine the relationship between sport participation and men’s health and chronic diseases in the USA. This study was a secondary data analysis of the 2015 national Behavioral Risk Factor Surveillance System (BRFSS) survey. Participants were questioned extensively about their PA behaviors. Seventy-six different activities were identified and these activities were categorized as sport, conditioning exercise, recreation, or household tasks …

Department Of Surgery Update, August 2017, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, and more.

A Study To Assess The Practices Of Postoperative Surgical Site Dressing Among The Health Care Professionals In A Tertiary Hospital Of Udupi District, Sijimol S

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT (SIJIMOL S) A cross sectional study to assess the practices of postoperative surgical site dressing among the health care professionals in a tertiary hospital of Udupi district was conducted by Mrs Sijimol S in partial fulfilment of the requirements for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University. The objectives of the study were to assess the postoperative surgical site dressing practices and explore the perceived barriers to follow infection control measures in the dressing practices among the health care professionals. The conceptual framework of the study was based on Rosenstock, …

A Study To Assess The Knowledge And Practice On Methicillin Resistant Staphylococcus Aureus (Mrsa) Infection And The Carrier Status Among Healthcare Professionals Of A Tertiary Care Hospital, Udupi District., Diana Dmello

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT “A study to assess the knowledge and practice on Methicillin Resistant Staphylococcus aureus (MRSA) infection and the carrier status among healthcare professionals of a tertiary care hospital, Udupi District” was carried out at Manipal University, Manipal by Ms Diana D Mello for the award of M.Sc Nursing degree. The objectives of the study were to assess the infection control practices followed by healthcare professionals, their knowledge on MRSA infection and to assess the carrier status of MRSA infection among healthcare professionals of surgical units of Kasturba hospital, Manipal. The conceptual framework was based on Irwin Rosen Stocks Health Belief …

"A Study To Assess The Practice And Perceived Barriers Towards Infection Control Measures Among Health Care Workers (Hcws) In Dialysis Unit Of A Tertiary Hospital, Udupi District, Karnataka ", Jackline Prathibha

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A descriptive study to assess the practice and perceived barriers towards infection control measures among Health Care Workers (HCWs) in dialysis unit of a tertiary hospital, Udupi District, Karnataka was conducted by Jackline Prathibha in partial fulfilment of the requirements for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal University. The objectives of the study were to assess the knowledge of practice among healthcare workers regarding infection control measures, to assess the perceived barriers in following the infection control measures and to assess the practices among healthcare workers regarding infection control measures. …

Study To Evaluate The Infection Control Practices To Prevent Transmission Of Pulmonary Tuberculosis (Tb) Among Health Care Personnel Working In Selected Units Of A Tertiary Care Hospital At Udupi District Karnataka., Karishma Khaund

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled, “Study to evaluate the infection control practices to prevent transmission of Pulmonary Tuberculosis (TB) among health care personnel working in selected units of a tertiary care hospital at Udupi district, Karnataka” was carried out. Objectives of the study were to assess the knowledge and practices of infection control followed by health care personnel, assess the infection control resources and facilities available in Units which takes care of Patient with pulmonary tuberculosis and identify the factors which help in to improve the infection control practices to prevent transmission of pulmonary tuberculosis using focus group discussion. Conceptual …

Effectiveness Of Video Assisted Teaching Program On Knowledge And Preventive Practices Of Catheter Related Blood Stream Infections (Crbsis) Among Health Care Professionals In Selected Intensive Care Units (Icus) Of A Tertiary Care Hospital Udupi, Jeffin Thomas Jacob

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “Effectiveness of a video assisted teaching program on knowledge and preventive practices of Catheter Related Blood Stream Infections (CRBSIs) among health care professionals in selected Intensive Care Units (ICUs) of a tertiary care hospital, Udupi” was carried out at Manipal University, Manipal by Jeffin Thomas Jacob for the award of M.Sc. Nursing degree. The objectives of the study were to develop and validate a video on preventive practices of CRBSI, assess the CRBSI preventive practices and knowledge on prevention of CRBSI among health care professionals as measured by as observational checklists and structured knowledge questionnaire …

A Study To Assess The Knowledge On Practice Of Urinary Catheter Care And Compliance To Urinary Catheter Care Guidelines By The Staff Nurses Working In A Tertiary Care Hospital, Udupi District, Maryl Candida Cutinho

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “A study to assess the knowledge on practice of urinary catheter care and compliance to urinary catheter care guidelines by the staff nurses working in a tertiary care hospital, Udupi district” was carried out at Manipal University, Manipal by Ms Maryl Candida Cutinho. The objectives of the study were to assess the knowledge on practice of urinary catheter care and to assess the compliance to urinary catheter care guidelines by the staff nurses working in a tertiary care hospital, Udupi district. The conceptual framework used for the study was based on the “Radical Approach Model …