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2017

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Full-Text Articles in Medicine and Health Sciences

Healthcare Management Primer, Students Of Health Management 721.01 (2017), University Of New Hampshire, Mark Bonica Oct 2017

Healthcare Management Primer, Students Of Health Management 721.01 (2017), University Of New Hampshire, Mark Bonica

Open Educational Resources

This primer was written by students enrolled in HMP 721.01, Management of Health Care Organizations, in the Health Management & Policy Program, College of Health and Human Services, University of New Hampshire. This course was taught by Professor Mark Bonica in Fall 2017.


Predicting Unplanned Transfers To The Intensive Care Unit: A Machine Learning Approach Leveraging Diverse Clinical Elements, Ben Wellner, Joan Grand, Elizabeth Canzone, Matt Coarr, Patrick Brady, Nathan Dean, +Additional Authors Oct 2017

Predicting Unplanned Transfers To The Intensive Care Unit: A Machine Learning Approach Leveraging Diverse Clinical Elements, Ben Wellner, Joan Grand, Elizabeth Canzone, Matt Coarr, Patrick Brady, Nathan Dean, +Additional Authors

Pediatrics Faculty Publications

Background: Early warning scores aid in the detection of pediatric clinical deteriorations but include limited data inputs, rarely include data trends over time, and have limited validation.

Objective: Machine learning methods that make use of large numbers of predictor variables are now commonplace. This work examines how different types of predictor variables derived from the electronic health record affect the performance of predicting unplanned transfers to the intensive care unit (ICU) at three large children’s hospitals.

Methods: We trained separate models with data from three different institutions from 2011 through 2013 and evaluated models with 2014 data. Cases consisted of …


Ua42 Regional Review: Reaching New Heights In The Region Fall 2017 (Vol.4, No.1), Heather Garcia , Editor Oct 2017

Ua42 Regional Review: Reaching New Heights In The Region Fall 2017 (Vol.4, No.1), Heather Garcia , Editor

Regional Campuses Publications

Sections include:

Save the date Chat with the Chancellor, Campus News, and Awesome Achievements for each of the three regional campuses.


Ua61/3 Research Focus (Fall 2017), Jean Neils-Strunjas, Susan Megahee, Editor, Creative, Hannah Guy, Student Editor, Wku Communication Sciences & Disorders Oct 2017

Ua61/3 Research Focus (Fall 2017), Jean Neils-Strunjas, Susan Megahee, Editor, Creative, Hannah Guy, Student Editor, Wku Communication Sciences & Disorders

Communication Sciences & Disorders Publications

Contents:

Graduate Student Spotlight.

Awards & Recognition

News

Alumni

ASHA Publications


Community Perception Of The Hiv Vaccine In Western Kenya: Acceptability, Potential Behavior Changes, And Views On Compulsory Vaccination, Deborah Keen Oct 2017

Community Perception Of The Hiv Vaccine In Western Kenya: Acceptability, Potential Behavior Changes, And Views On Compulsory Vaccination, Deborah Keen

Independent Study Project (ISP) Collection

Human Immunodeficiency Virus (HIV) suppresses the immune system by attacking T cells, leading to the development of acquired immunodeficiency syndrome (AIDS). HIV affects over 30 million people around the world and 1.6 million people in Kenya. On August 18, 1987, the FDA sanctioned the first human testing of a candidate vaccine for HIV. Currently, multiple HIV vaccines—projected to be on the market in five to ten years—are being tested for efficacy and safety. The goal of this study was to explore opinions related to the HIV vaccine so that there is a guide for future policy development in Western Kenya. …


Sex Work And Compromised Health: Health Conditions And The Barriers To Accessing Treatment Services In Pelourinho, Salvador, Amelia Fox Oct 2017

Sex Work And Compromised Health: Health Conditions And The Barriers To Accessing Treatment Services In Pelourinho, Salvador, Amelia Fox

Independent Study Project (ISP) Collection

Sex workers remain one of the most marginalized populations in Brazilian society, both coming from and living within realities defined by poverty and poor health. Through partnership with Força Feminina – an organization located in Salvador, dedicated to aiding local sex workers– I explored the day-to-day health complications sex workers encounter and the impact these problems have on quality of life. I then questioned how discrimination and stigma impact a woman’s willingness to prioritize her health and seek out healthcare services. To pursue these questions, I utilized participant observation, interviews with 4 staff members – a pastoral educator, financial coordinator, …


Let's Talk Speech! Volume 10 Issue 1, Barbara T. Schmidt Ph.D. Oct 2017

Let's Talk Speech! Volume 10 Issue 1, Barbara T. Schmidt Ph.D.

Communication Sciences and Disorders Newsletter

As many of you know, this is the last Newsle􀆩er that I will be working on for the Communication Sciences and Disorders Department (CSD). My new role as Assistant Vice President for Academic Affairs at Molloy College will not allow me the opportunity to continue in a full time faculty position in CSD. While I am excited about the challenges I face in my new position, I am very sad to leave my daily interactions with friends, colleagues, and students in CSD. It has been a long, fruitful, and enjoyable career in this program. I have had the pleasure of …


How I Learned To Communicate My Inner Life With Asperger’S: Ted Talk Annotated Resource List, Meghan Rice Oct 2017

How I Learned To Communicate My Inner Life With Asperger’S: Ted Talk Annotated Resource List, Meghan Rice

Undergraduate Research Award

No abstract provided.


Ua10/1 Cec Newsletter, Mary Lloyd Moore, Wku Suzanne Vitale Clinical Education Complex Oct 2017

Ua10/1 Cec Newsletter, Mary Lloyd Moore, Wku Suzanne Vitale Clinical Education Complex

CEC Publications

Topics include:

-Summer CDC Interships

-Special Needs Expo

-Special Needs Summit

-Autism Family Fun Day


Ua12/2/2 2017 Talisman: Power, Wku Student Affairs Oct 2017

Ua12/2/2 2017 Talisman: Power, Wku Student Affairs

WKU Administration Documents

2017 Talisman yearbook.

  • Gibson, Helen. Letter from the Editor
  • Edwards, Aly. What's Your Superpower?
  • Mattison, Reed. Dangerous Heights - George Clark, Mountaineering
  • Voorhees, Jessica. Innovative Energy - Wei-Ping Pan
  • Voorhees, Jessica. Counterpunch - Rock Steady Boxing
  • Barritt, Brooklyn. B.G. Bosses - Small Business
  • Frint, Hunter. Cason's Cove: The Power of Family
  • Mitchell, McKenna. Picking Up the Mic - Reuben Bynes, Waco Bell
  • Mohr, Olivia. Hidden in Plain Sight - Human Trafficking
  • Mattingly, Evan. Voice Off - Noah Hancock, Deaf Persons
  • Robb, Hayley. Game, Set, Unmatched - Phillip Cole, Tennis
  • Good, Hannah. Damage Control - Post Traumatic Stress Disorder
  • Gordon, Zora. …


Santa Clara Magazine, Volume 58 Number 4, Fall 2017, Santa Clara University Oct 2017

Santa Clara Magazine, Volume 58 Number 4, Fall 2017, Santa Clara University

Santa Clara Magazine

18 - TIME FOR A BIG SHIFT We work and save for decades. And then what? A behavioral finance expert writes about the tough transition many face. By Meir Statman. Illustrations by Hanna Barczyk.

22 - WHAT WE OWE At the very least: stories that capture the contour of a life. A Pulitzer Prize– winning reporter on tales of human strife and resilience. By Tatiana Sanchez ’10.

28 - THE MOST IMPORTANT Lawsuit on the Planet It was first filed against the Obama administration and draws on decades of government records. It seeks no monetary damages. But advocates and critics …


Hst 2700 – Marketing Concepts For Health Promotion Professionals/3 Semester Hours Fall 2017/Section 001, Lauri J. Deruiter-Willems Oct 2017

Hst 2700 – Marketing Concepts For Health Promotion Professionals/3 Semester Hours Fall 2017/Section 001, Lauri J. Deruiter-Willems

Faculty Research and Creative Activity

No abstract provided.


Hcm 4910: Applied Health Communication /3 Semester Hours Fall 2017/Section 600: Online, Lauri J. Deruiter-Willems Oct 2017

Hcm 4910: Applied Health Communication /3 Semester Hours Fall 2017/Section 600: Online, Lauri J. Deruiter-Willems

Faculty Research and Creative Activity

Course Description: An examination of applied health communication in the interpersonal, organizational, and mediated contexts. Emphasis is on higher order application of skills from different occupational perspectives.


The Path Report Special Edition, Pathology Department, New York Medical College Oct 2017

The Path Report Special Edition, Pathology Department, New York Medical College

The Path Report

No abstract provided.


Wound Healing In Rabbit Corneas After Flapless Refractive Lenticule Extraction With A 345 Nm Ultraviolet Femtosecond Laser, Christian M. Hammer, Corinna Petsch, Jörg Klenke, Katrin Skerl, Christian Wüllner, Christof Donitzky, Friedrich Paulsen, Michael Scholz, Theo Seiler, Friedrich E. Kruse, Johannes Menzel-Severing Oct 2017

Wound Healing In Rabbit Corneas After Flapless Refractive Lenticule Extraction With A 345 Nm Ultraviolet Femtosecond Laser, Christian M. Hammer, Corinna Petsch, Jörg Klenke, Katrin Skerl, Christian Wüllner, Christof Donitzky, Friedrich Paulsen, Michael Scholz, Theo Seiler, Friedrich E. Kruse, Johannes Menzel-Severing

Biomedicine and Animal Models in Research Collection

Purpose

To characterize corneal wound healing in a rabbit model after flapless refractive lenticule extraction with a 345 nm ultraviolet femtosecond laser.

Setting

Departments of Ophthalmology and Anatomy II, University of Erlangen-Nürnberg and Wavelight GmbH, Erlangen, Germany.

Design

Methods

Flapless refractive lenticule extraction was performed in 1 eye each of 20 New Zealand white rabbits (−5.0 diopters). Groups of 4 animals were euthanized after 48 hours, 1 week, 2 weeks, 4 weeks, and 3 months, respectively. Corneal samples were prepared for histology and fluorescence microscopy. To assess corneal cell death, proliferation, and myofibroblastic transdifferentiation, terminal uridine deoxynucleotidyl nick end-labeling (TUNEL) …


Restoration Of Completely Transected Common Bile Duct Continuity Using Single Operator Cholangioscopy, Saad Emhmed Ali, Houssam Mardini, Mohsin Salih, Steven J. Krohmer, Wesam M. Frandah Oct 2017

Restoration Of Completely Transected Common Bile Duct Continuity Using Single Operator Cholangioscopy, Saad Emhmed Ali, Houssam Mardini, Mohsin Salih, Steven J. Krohmer, Wesam M. Frandah

Internal Medicine

Common bile duct (CBD) injury, ranging from a partial tear to a complete transection, is a major surgical complication of cholecystectomy with significant morbidity and mortality. Proper management of these complex injuries depends on the type and extent of injury and time of recognition. Identifying and repairing injuries during cholecystectomy can prevent development of complications, but this only occurs in about one-third of cases. We report a novel technique to reconnect a transected CBD with assistance of single-operator cholangioscopy.


College Of Nursing, South Dakota State University Oct 2017

College Of Nursing, South Dakota State University

College of Nursing Magazine

Impacting policies
[Page] 2 South Dakota State alumni contributed to “The House of Nursing” as it supported the passing of SB61.
[Page] 4 Graduates lead the South Dakota Board of Nursing.
[Page] 5 Damgaard and Young create virtual nursing-care model. 6 Soholt’s drive helped pass SB61.
[Page] 7 Berkland’s career now has her in executive role for Sanford Health.
[Page] 8 Students attend national summit in D.C.
[Page] 10 Researchers review tobacco-free policies for state’s health-care facilities.
[Page] 12 Social media campaign helps living kidney donations among Native Americans.

College news
[Page] 14 Three students present at NANAINA.
[Page] 16 …


Ransomware In Healthcare Facilities: The Future Is Now, Nikki Spence, David P. Paul Iii, Alberto Coustasse Oct 2017

Ransomware In Healthcare Facilities: The Future Is Now, Nikki Spence, David P. Paul Iii, Alberto Coustasse

Management Faculty Research

Cybercriminals have begun to target the healthcare industry with a type of malware called ransomware, malware that encrypts an infected device and any attached devices or network drives. After encryption, cybercriminals demand a sum of money, also known as a “ransom,” to release the devices from encryption. Without adequate disaster recovery and backup plans, many businesses are forced to pay the ransom. The purpose of this study was to determine the extent of recent ransomware infections in healthcare settings, the risk liabilities and cost associated with such infections, and to determine possible risk mitigation tactics. Financial costs associated with business …


Will Vestibulo-Ocular Reflex And Balance Rehabilitation Reduce Visual Deficits & Improve Stability Of A Patient With Multiple Sclerosis?, Natalie Hunt, Jennifer Kiggins Oct 2017

Will Vestibulo-Ocular Reflex And Balance Rehabilitation Reduce Visual Deficits & Improve Stability Of A Patient With Multiple Sclerosis?, Natalie Hunt, Jennifer Kiggins

Sacred Heart University Scholar

Context: Identification of rehabilitation exercises to decrease symptomology in a patient with Multiple Sclerosis (MS) is necessary for enhancing quality of life. Various vestibulo-ocular reflex (VOR) rehabilitation exercises can help patients adapt to balance problems. Currently, no researcher has utilized the VSR™ Sport and inVision™ systems by NeuroCom® for rehabilitation among patients with MS.

Objective: The purpose of the study was to create a rehabilitation protocol incorporating VOR and balance exercises to decrease visual deficits and improve stability in a patient with MS. This study will examine the effects of rehabilitation and determine if scores improve from baseline testing.

Design: …


Tibetan Women’S Experiences With Childbirth: A Comparative Study Of Present-Day Shangri-La And Previous Studies In Tibetan Communities, Billie Dunn-Mcmartin Oct 2017

Tibetan Women’S Experiences With Childbirth: A Comparative Study Of Present-Day Shangri-La And Previous Studies In Tibetan Communities, Billie Dunn-Mcmartin

Independent Study Project (ISP) Collection

What are the experiences of Tibetan women living in and around Shangri-La with pregnancy, childbirth, and motherhood? In order to explore this topic, one must first understand the context in which this topic exists: Tibetan Buddhism and culture. This paper gives a short background on women and the female body in Tibetan Buddhism, the Tibetan Medical system, and the current accessibility and regulation of hospitals, before entering into the topic of Tibetan women’s experiences with childbirth. The experiences and traditional practices of childbirth are important, as birth is universally significant as well as particularly religiously significant in Tibetan Buddhism, and …


The Shifting Roles Of Dai Maas: An Intersection Of Healthcare And Female Empowerment In Rural Udaipur, Julie Morel Oct 2017

The Shifting Roles Of Dai Maas: An Intersection Of Healthcare And Female Empowerment In Rural Udaipur, Julie Morel

Independent Study Project (ISP) Collection

Traditional Birth Attendants (TBAs), known as dais in an Indian context, have historically served as women’s primary caregivers throughout their pregnancies and during childbirth in rural regions where access to formal healthcare institutions is nearly impossible. With a heavy reliance on traditional knowledge passed down through generations, dais have aided with home deliveries for millennia. Approximately 15 years ago, however, groups such as WHO, UNICEF, World Bank, and the UN began addressing India’s high maternal mortality rate (MMR), thereby instigating the discouragement of home deliveries in favor of the encouragement of institutional deliveries. Infrastructural changes were established to improve accessibility …


Increasing Empathy And Conflict Resolution Skills Through Nonviolent Communication (Nvc) Training In Latino Adults And Youth, Marcianna Nosek, Maite Durán Oct 2017

Increasing Empathy And Conflict Resolution Skills Through Nonviolent Communication (Nvc) Training In Latino Adults And Youth, Marcianna Nosek, Maite Durán

Nursing and Health Professions Faculty Research and Publications

Background: Children of Latino immigrants often are torn between their native homes and new communities. Having supportive interpersonal relationships increases resilience to delinquent and violent behaviors stemming from immigration challenges. Communication fostering empathy may improve conflict resolution and supportive relationships.

Objectives: Community-based participatory research (CBPR) was conducted to evaluate the impact of nonviolent communication (NVC) trainings in Latino adults and youth.

Methods: Four sessions in NVC were provided by bilingual Latino trainers for Latino adults and youth. Pre- and post-training focus groups evaluated effectiveness of training.

Results: Three themes emerged from adult post training focus groups—enter the others’ shoes, making …


New Dentist News (October 2017), Ada Committee On The New Dentist Oct 2017

New Dentist News (October 2017), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.


Examining The Relationship Between Home Literacy Environment And Neural Correlates Of Phonological Processing In Beginning Readers With And Without A Familial Risk For Dyslexia: An Fmri Study, Sara J. Powers, Yingying Wang, Sara D. Beach, Georgios D. Sideridis, Nadine Gaab Oct 2017

Examining The Relationship Between Home Literacy Environment And Neural Correlates Of Phonological Processing In Beginning Readers With And Without A Familial Risk For Dyslexia: An Fmri Study, Sara J. Powers, Yingying Wang, Sara D. Beach, Georgios D. Sideridis, Nadine Gaab

Center for Brain, Biology, and Behavior: Faculty Publications

Developmental dyslexia is a language-based learning disability characterized by persistent difficulty in learning to read. While an understanding of genetic contributions is emerging, the ways the environment affects brain functioning in children with developmental dyslexia are poorly understood. A relationship between the home literacy environment (HLE) and neural correlates of reading has been identified in typically developing children, yet it remains unclear whether similar effects are observable in children with a genetic predisposition for dyslexia. Understanding environmental contributions is important given that we do not understand why some genetically at-risk children do not develop dyslexia. Here we investigate for the …


Nursing [Career Paper], Tradesha Chatman Oct 2017

Nursing [Career Paper], Tradesha Chatman

Undergraduate Research Award

No abstract provided.


Robust Head Ct Image Registration Pipeline For Craniosynostosis Skull Correction Surgery, Shusil Dangi, Hina Shah, Antonio Porras, Beatriz Paniagua, Cristian Linte, Marius George Linguraru, Andinent Enquobahrie Oct 2017

Robust Head Ct Image Registration Pipeline For Craniosynostosis Skull Correction Surgery, Shusil Dangi, Hina Shah, Antonio Porras, Beatriz Paniagua, Cristian Linte, Marius George Linguraru, Andinent Enquobahrie

Radiology Faculty Publications

Craniosynostosis is a congenital malformation of the infant skull typically treated via corrective surgery. To accurately quantify the extent of deformation and identify the optimal correction strategy, the patient-specific skull model extracted from a pre-surgical computed tomography (CT) image needs to be registered to an atlas of head CT images representative of normal subjects. Here, the authors present a robust multi-stage, multi-resolution registration pipeline to map a patient-specific CT image to the atlas space of normal CT images. The proposed registration pipeline first performs an initial optimisation at very low resolution to yield a good initial alignment that is subsequently …


Graduate Studies Newsletter, Graduate Studies Office Oct 2017

Graduate Studies Newsletter, Graduate Studies Office

Newsletters

Pg. 2 & 3 - Faculty Spotlight: Dr. Marisol Cortes Rincon

Pg. 5 - Important Dates and Deadlines

Pg. 6 - Graduate Student Orientation Recap

Pg. 7 - Thesis & Project Submission Process Guide

Pg. 8 - Graduate Student & Alumni Profiles


Mutations In Keops-Complex Genes Cause Nephrotic Syndrome With Primary Microcephaly, Daniela A Braun, Jia Rao, Geraldine Mollet, David Schapiro, Marie-Claire Daugeron, Weizhen Tan, Olivier Gribouval, Olivia Boyer, Patrick Revy, Tilman Jobst-Schwan, Johanna Magdalena Schmidt, Jennifer A Lawson, Denny Schanze, Shazia Ashraf, Jeremy F P Ullmann, Charlotte A Hoogstraten, Nathalie Boddaert, Bruno Collinet, Gaëlle Martin, Dominique Liger, Svjetlana Lovric, Monica Furlano, I Chiara Guerrera, Oraly Sanchez-Ferras, Jennifer F Hu, Anne-Claire Boschat, Sylvia Sanquer, Björn Menten, Sarah Vergult, Nina De Rocker, Merlin Airik, Tobias Hermle, Shirlee Shril, Eugen Widmeier, Heon Yung Gee, Won-Il Choi, Carolin E Sadowski, Werner L Pabst, Jillian K Warejko, Ankana Daga, Tamara Basta, Verena Matejas, Karin Scharmann, Sandra D Kienast, Babak Behnam, Brendan Beeson, Amber Begtrup, Malcolm Bruce, Gaik-Siew Ch'ng, Shuan-Pei Lin, Jui-Hsing Chang, Chao-Huei Chen, Megan T Cho, Patrick M Gaffney, Patrick E Gipson, Chyong-Hsin Hsu, Jameela A Kari, Yu-Yuan Ke, Cathy Kiraly-Borri, Wai-Ming Lai, Emmanuelle Lemyre, Rebecca Okashah Littlejohn, Amira Masri, Mastaneh Moghtaderi, Kazuyuki Nakamura, Fatih Ozaltin, Marleen Praet, Chitra Prasad, Agnieszka Prytula, Elizabeth R Roeder, Patrick Rump, Rhonda E Schnur, Takashi Shiihara, Manish D Sinha, Neveen A Soliman, Kenza Soulami, David A Sweetser, Wen-Hui Tsai, Jeng-Daw Tsai, Rezan Topaloglu, Udo Vester, David H Viskochil, Nithiwat Vatanavicharn, Jessica L Waxler, Klaas J Wierenga, Matthias T F Wolf, Sik-Nin Wong, Sebastian A Leidel, Gessica Truglio, Peter C Dedon, Annapurna Poduri, Shrikant Mane, Richard P Lifton, Maxime Bouchard, Peter Kannu, David Chitayat, Daniella Magen, Bert Callewaert, Herman Van Tilbeurgh, Martin Zenker, Corinne Antignac, Friedhelm Hildebrandt Oct 2017

Mutations In Keops-Complex Genes Cause Nephrotic Syndrome With Primary Microcephaly, Daniela A Braun, Jia Rao, Geraldine Mollet, David Schapiro, Marie-Claire Daugeron, Weizhen Tan, Olivier Gribouval, Olivia Boyer, Patrick Revy, Tilman Jobst-Schwan, Johanna Magdalena Schmidt, Jennifer A Lawson, Denny Schanze, Shazia Ashraf, Jeremy F P Ullmann, Charlotte A Hoogstraten, Nathalie Boddaert, Bruno Collinet, Gaëlle Martin, Dominique Liger, Svjetlana Lovric, Monica Furlano, I Chiara Guerrera, Oraly Sanchez-Ferras, Jennifer F Hu, Anne-Claire Boschat, Sylvia Sanquer, Björn Menten, Sarah Vergult, Nina De Rocker, Merlin Airik, Tobias Hermle, Shirlee Shril, Eugen Widmeier, Heon Yung Gee, Won-Il Choi, Carolin E Sadowski, Werner L Pabst, Jillian K Warejko, Ankana Daga, Tamara Basta, Verena Matejas, Karin Scharmann, Sandra D Kienast, Babak Behnam, Brendan Beeson, Amber Begtrup, Malcolm Bruce, Gaik-Siew Ch'ng, Shuan-Pei Lin, Jui-Hsing Chang, Chao-Huei Chen, Megan T Cho, Patrick M Gaffney, Patrick E Gipson, Chyong-Hsin Hsu, Jameela A Kari, Yu-Yuan Ke, Cathy Kiraly-Borri, Wai-Ming Lai, Emmanuelle Lemyre, Rebecca Okashah Littlejohn, Amira Masri, Mastaneh Moghtaderi, Kazuyuki Nakamura, Fatih Ozaltin, Marleen Praet, Chitra Prasad, Agnieszka Prytula, Elizabeth R Roeder, Patrick Rump, Rhonda E Schnur, Takashi Shiihara, Manish D Sinha, Neveen A Soliman, Kenza Soulami, David A Sweetser, Wen-Hui Tsai, Jeng-Daw Tsai, Rezan Topaloglu, Udo Vester, David H Viskochil, Nithiwat Vatanavicharn, Jessica L Waxler, Klaas J Wierenga, Matthias T F Wolf, Sik-Nin Wong, Sebastian A Leidel, Gessica Truglio, Peter C Dedon, Annapurna Poduri, Shrikant Mane, Richard P Lifton, Maxime Bouchard, Peter Kannu, David Chitayat, Daniella Magen, Bert Callewaert, Herman Van Tilbeurgh, Martin Zenker, Corinne Antignac, Friedhelm Hildebrandt

Paediatrics Publications

Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced …


Appraisal Of: Role Of Physical Therapists In The Management Of Individuals At Risk For Or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline, Saravanan Esakki, Joy C. Macdermid Oct 2017

Appraisal Of: Role Of Physical Therapists In The Management Of Individuals At Risk For Or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline, Saravanan Esakki, Joy C. Macdermid

Bone and Joint Institute

No abstract provided.


Titanium Addition Influences Antibacterial Activity Of Bioactive Glass Coatings On Metallic Implants, Omar Rodriguez, Wendy Stone, Emil H. Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R. Towler Oct 2017

Titanium Addition Influences Antibacterial Activity Of Bioactive Glass Coatings On Metallic Implants, Omar Rodriguez, Wendy Stone, Emil H. Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R. Towler

Bone and Joint Institute

© 2017 The Authors In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these …