Incidence Of Seizure Exacerbation And Seizures Reported As Adverse Events During Adjunctive Treatment With Eslicarbazepine Acetate: A Pooled Analysis Of Three Phase Iii Controlled Trials, Mar Carreño, Selim Benbadis, Francisco Rocha, David Blum, Hailong Cheng

Neurology Faculty Publications

No abstract provided.

Necrotizing Fasciitis Secondary To Aeromonas Infection Presenting With Septic Shock, Nikhil Bhatia, Manuel Castro-Borobio, John N. Greene, Sowmya Nanjappa

Pediatrics Faculty Publications

This report describes a case of necrotizing fasciitis presenting with septic shock due to an Aeromonas infection. The patient cut his foot while mowing the lawn and then spent time in a pool with black mold. He began feeling ill and developed swelling and a quarter-sized black area on his right lower extremity. Despite being hemodynamically unstable with systolic blood pressure in the low 70s, the patient was transferred to our facility from outside hospital 100 miles away. Upon arriving to facility, the patient appeared to be septic and the infected area of skin had grown. Irrigation and debridement were …

Assessment Of An Intervention To Improve Clinical Inertia In Patients With Uncontrolled Hypertension In A Primary Care Setting, Alyssa M. Sutton

DNP Projects

Purpose: A quality improvement project was undertaken in an internal medicine clinic to evaluate provider adherence with the Eighth Joint National Committee (JNC 8) hypertension (HTN) medication management guidelines for adult patients diagnosed with HTN, evaluate characteristics associated with clinical inertia (CI) in patients with uncontrolled HTN, and evaluate the utility of a brief educational intervention to decrease CI.

Methods: The project used the plan-do-study-act method to assess JNC 8 prescribing guideline adherence by consenting providers. Medical records were randomly selected from patients with HTN seen at provider visits 10 days before (January 31-February 13, 2017) and 10 days after …

Parent Perception Of Child’S Developmental And Coordination Skills Related To Participation In The Gymnastics Through Early Movement Program, Allison M. Theobald

DNP Projects

This study aims to evaluate the effectiveness of the Gymnastics through Early Movement program in increasing motor ability in children with motor developmental delay or coordination deficits through the perception of the parent. The Gymnastics through Early Movement program is a therapeutic gymnastics program developed by a pediatric nurse and professional member of United States of America Gymnastics. The program was designed specifically for pre-school aged children who experience motor challenges. Over the course of six weeks, each 45-minute lesson included activities and obstacles focusing on fundamental preschool gymnastics skills to develop strength, coordination, and flexibility. The American Academy of …

Oncoplastic Surgery: Keeping It Simple With 5 Essential Volume Displacement Techniques For Breast Conservation In A Patient With Moderate- To Large-Sized Breasts, Abhishek Chatterjee, Deniz Dayicioglu, Nazanin Khakpour, Brian J. Czerniecki

Surgery Faculty Publications

Oncoplastic surgery is an evolving field in breast surgery combining the strengths of breast surgical oncology with plastic surgery. It provides the surgeon the ability to excise large areas of the breast in the oncologic resection without compromising, and possibly improving, its aesthetic appearance. The purpose of this review is to provide a guide that could help a breast surgeon excise breast cancer in most areas of the breast using 5 oncoplastic techniques. These techniques would be used depending primarily on the location of the cancer in the breast and also on the size of the tumor.

Acculturation And Filial Piety As Mediators Of The Relationship Between Caregiver Burden And Gender-Role Expectations In Hispanic-American Rehabilitation Services Students, Roy K. Chen, Bryan S. Austin, Chien-Chun Lin

Internet Journal of Allied Health Sciences and Practice

Purpose: Hispanic-Americans are the largest ethnic minority group in the United States. The need to care for older Hispanics has become an important issue as they now enjoy longer life expectancies due to better access to healthcare and less labor participation in hazardous occupations. The present study examined whether the association between caregiver burden and gender-role expectations is mediated by acculturation and filial piety. Method: The sample consisted of 93 Mexican-American rehabilitation services students enrolled at a large public university in Texas. The four instruments used in the study were the Zarit Burden Interview, the Bem Sex-Role Inventory, the Acculturation …

A Pilot Study To Measure Dynamic Elasticity Of The Bladder During Urodynamics, Andrew F. Colhoun, Adam P. Klausner, Anna S. Nagle, Ashley W. Carroll, Robert W. Barbee, Paul H. Ratz, John E. Speich

Surgery Publications

AIMS: Previous studies using isolated strips of human detrusor muscle identified adjustable preload tension, a novel mechanism that acutely regulates detrusor wall tension. The purpose of this investigation was to develop a method to identify a correlate measure of adjustable preload tension during urodynamics.

METHODS: Patients reporting urgency most or all of the time based on ICIq-OAB survey scores were prospectively enrolled in an extended repeat fill-and-empty urodynamics study designed to identify a correlate of adjustable preload tension which we now call dynamic elasticity. Cystometric capacity was determined during initial fill. Repeat fills to defined percentages of capacity with passive …

Characterization Of Lower Urinary Tract Symptoms In Patients With Idiopathic Normal Pressure Hydrocephalus, Sarah C. Krzastek, William M. Bruch, Samuel P. Robinson, Harold F. Young, Adam P. Klausner

Surgery Publications

AIMS: The purpose of this study was to evaluate lower urinary tract symptoms (LUTS) in idiopathic normal pressure hydrocephalus (iNPH).

METHODS: Patients with new-onset iNPH were prospectively evaluated for LUTS via detailed history and physical, and administration of questionnaires from the International Consultation on Incontinence to assess incontinence (ICIq-UI), overactive bladder (ICIq-OAB), and quality of life (ICIq-LUTqol), as well as the American Urological Association Symptom Score bother scale. All patients with moderate-to-severe LUTS were offered urodynamic testing. Sub-analysis was performed based on gender, medical comorbidities, and age.

RESULTS: Fifty-five consecutive patients with iNPH completed the initial evaluation and surveys. Total …

Preferential Lineage-Specific Differentiation Of Osteoblast-Derived Induced Pluripotent Stem Cells Into Osteoprogenitors, Casey L. Roberts, Silvia S. Chen, Angela C. Murchison, Rebecca A. Ogle, Michael P. Francis, Roy C. Ogle, Patrick C. Sachs

School of Medical Diagnostics & Translational Sciences Publications

While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for generating cells vastly different from the reprogrammed cells' origins, it could be advantageous for the reliable generation of germ-layer specific cell types for future therapeutic use. Here we use human osteoblast-derived iPSCs (hOB-iPSCs) to generate induced osteoprogenitors (iOPs). Osteoblasts were successfully reprogrammed and demonstrated by endogenous upregulation of Oct4, Sox2, Nanog, TRA-1-81, TRA-16-1, SSEA3, and confirmatory hPSC Scorecard Algorithmic Assessment. The hOB-iPSCs formed embryoid bodies …

A Neighborhood-Wide Association Study (Nwas): Example Of Prostate Cancer Aggressiveness, Shannon M. Lynch, Nandita Mitra, Michelle Ross, Craig Newcomb, Karl Dailey, Tara Jackson, Charnita M. Zeigler-Johnson, Harold Riethman

School of Medical Diagnostics & Translational Sciences Publications

Purpose

Cancer results from complex interactions of multiple variables at the biologic, individual, and social levels. Compared to other levels, social effects that occur geospatially in neighborhoods are not as well-studied, and empiric methods to assess these effects are limited. We propose a novel Neighborhood-Wide Association Study(NWAS), analogous to genome-wide association studies(GWAS), that utilizes high-dimensional computing approaches from biology to comprehensively and empirically identify neighborhood factors associated with disease.

Methods

Pennsylvania Cancer Registry data were linked to U.S. Census data. In a successively more stringent multiphase approach, we evaluated the association between neighborhood (n = 14,663 census variables) and prostate …

Effect Of Exercise Position On Percent Changes In Serratus Anterior Muscle Thickness, Joseph M. Day

Physical Therapy Faculty Publications

Objective: A reliable method for measuring SA thickness with ultrasound imaging has been reported, yet the ability to detect differences in levels of contractility has yet to be established. The purpose of this study was to determine if there are differences in the percent change in thickness of the SA during four different exercise positions performed by healthy individuals.

Design: Observational study

Setting: Laboratory

Participants: Twenty-eight healthy participants, mean age 26 (SD 4, 57% female, 100% right handed)

Methods: Volunteers were positioned in a standardized sitting posture and anatomical landmarks were marked for ultrasound probe positioning. Two resting and two …

Neonatal Hypoglycemia In Diabetic Mothers: A Systematic Review, Brook T. Alemu, Olaniyi Olayinka, Hind A. Baydoun, Matthew Hoch, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

Hypoglycemia occurs in approximately 8-30% of neonates born to mothers with diabetes. The full extent of the individual and contextual risk factors of hypoglycemia remains unclear and no systematic review of the available studies exists to date. We identified published studies using PubMed and EBSCO host search engines. A modified STROBE statement was used to assess studies' strengths, weaknesses, and generalizability. A total of 16 articles were eligible for full text review. The clinical risk factors in these studies were broadly classified into two: infant-related and mother-related risk factors. The identified infant-related risk factors were SGA, macrosomia, prematurity, lower cord …

Workplace Violence And Hospital Security Programs: Regulatory Compliance, Program Benchmarks, Innovative Strategies, James D. Blando, Maryalice Nocera, Marilyn L. Ridenour, Daniel Hartley

Community & Environmental Health Faculty Publications

The authors describe the issue of workplace violence in hospitals, a New Jersey state law and regulations regarding workplace violence in healthcare, and some innovative strategies that are being utilized to help reduce the occurrence and risk of violence. The authors also discuss compliance with the New Jersey regulations.

Tuberous Sclerosis Complex In The Western Cape, South Africa: The Clinical Presentation Features, E. Kija, B. Schlegel, Pauline Samia, M. Wessels, J. M. Wilmshurst

Paediatrics and Child Health, East Africa

Tuberous sclerosis complex (TSC) is a genetic neurocutaneous condition, which affects multiple organ systems. This study aimed to determine the presenting features of children with TSC in Cape Town, South Africa. A cross-sectional study was conducted at a TSC clinic, and clinical features at presentation were prospectively collected. Thirty-nine children (23 boys; median age 10 (range 1 - 26) years; median diagnosis age 16 (0 - 153) months) were recruited. Twenty-one (54%) children presented with focal seizures. Seven (18%) children had epileptic spasms. Skin manifestations led to a diagnosis in 13 (33%) and neuroimaging in 22 (56%) children. Antenatal screening …

The 17th International Congress On Infectious Diseases Workshop On Developing Infection Prevention And Control Resources For Low- And Middle-Income Countries, Sangeeta Sastry, Nadia Masroor, Gonzalo Bearman, Rana Hajjeh, Alison Holmes, Ziad Memish, Britta Lassmann, Didier Pittet, Fiona Macnab, Rachel Kamau, Evelyn Wesangula, Paras Pokharel, Paul Brown, Frances Daily, Fatma Amer, Jaime Torres, Miguel O’Ryan, Gunturu Revathi, Andre Bulabula, Shaheen Mehtar

Pathology, East Africa

Hospital-acquired infections (HAIs) are a major concern to healthcare systems around the world. They are associated with significant morbidity and mortality, in addition to increased hospitalization costs. Recent outbreaks, including those caused by the Middle East respiratory syndrome coronavirus and Ebola virus, have highlighted the importance of infection control. Moreover, HAIs, especially those caused by multidrug-resistant Gram-negative rods, have become a top global priority. Although adequate approaches and guidelines have been in existence for many years and have often proven effective in some countries, the implementation of such approaches in low- and middle-income countries (LMICs) is often restricted due to …

Living With Multiple Myeloma: A Focus Group Study Of Unmet Needs And Preferences For Survivorship Care, L Monterosso, K Taylor, V Platt, Elizabeth A. Lobb, T Musiello, C Bulsara, K Stratton, M Krishnasamy

Nursing Papers and Journal Articles

Purpose: To describe the unmet informational, psychological, emotional, social, practical, and physical needs and preferences for posttreatment survivorship care of individuals living with multiple myeloma to inform the development of relevant, personcentered, survivorship services.

Methods: An exploratory, descriptive study using 2 focus groups with 14 participants, 6 to 49 months postdiagnosis. Results: Thematic analysis revealed 7 key themes: information needs, experience with health-care professionals, coping with side effects, communicating with family and friends, dealing with emotions, support needs, and living with the chronicity of myeloma. Participants described key characteristics of survivorship care relevant to their needs and indicated they would …

Backward Masking With Simultaneous Early, Middle And Late Evoked Potentials, Silas Smith

Graduate Student Theses, Dissertations, & Professional Papers

Auditory processing disorders (APDs) affect a diverse range of people. These types of disorders impair auditory function, despite the outer, middle and inner ear maintaining proper function and health. APD is not necessarily related to auditory thresholds. When people with APD have difficulty discriminating sounds in connected speech, it may be due in part to an effect called Backward Masking (BM). Masking occurs when one stimulus inhibits another, which can lead to a variety of impairments. The neural locus of APDs is for the most part unknown, including the specific conditions which cause BM. A better understanding of these processes …

Sex Education In Montana Schools: An Assessment Of The Needs Of Sexual And Gender Minority Youth, Elizabeth A. Redinger, Annie Sondag

Graduate Student Theses, Dissertations, & Professional Papers

Youth are particularly vulnerable to infection from HIV and STIs. According to the Centers for Disease Control and Prevention, youth between the ages of 13 and 24 accounted for about 26% of all new HIV transmission cases in the United States in 2010, In young MSM specifically, there was a 22% increase in new infections from 2008 to 2010 (CDC, 2015). Education is one of the factors that plays a role in sexual health practices starting in high schools, yet in Montana there is no clear set of guidelines as to what is covered during sex education classes in the …

Restoration Of Attentional Deficits After Concussion, Katharine B. Earle

Cal Poly Humboldt theses and projects

Difficulties with concentration and attention are among the most prevalent symptoms experienced after concussion. Rest has been the most common form of recovery from concussion; however, new research is suggesting mild mental exertion to be an effective aid in recovery. Drawing from Attention Restoration Theory, this study evaluated the idea that cognitive engagement with natural environments can mitigate post-concussion directed-attention deficits. A between subjects repeated measures design was used to test directed-attention after video exposure to restorative/nature and nonrestorative/city environments. Measures of mood, connectedness to environment, and symptomology scores were also collected. No meaningful difference between exposure type was found …

Effects Of Active Versus Passive Recovery On Blood Lactate And Performance In Repeated Wingate Tests, Madison Kirkpatrick

Cal Poly Humboldt theses and projects

The purpose of this study is to determine if an active recovery of a long duration at a moderate intensity or a passive recovery is more beneficial for subsequent anaerobic performance by tracking blood lactate and comparing anaerobic performance variables across Wingate tests. Currently, there is a lack of research on the effect of a longer duration active recovery protocol on blood lactate levels and power output in repeated Wingate tests as compared to passive recovery. A significant interaction was found between recovery and time for blood lactate (F = 6.935; p = 0.000). Blood Lactate levels were significantly …

Electrosensitization Increases Antitumor Effectiveness Of Nanosecond Pulsed Electric Fields In Vivo, Claudia Muratori, Andrei G. Pakhomov, Loree Heller, Maura Casciola, Elena Gianulis, Sergey Grigoryev, Shu Xiao, Olga N. Pakhomova

Bioelectrics Publications

Nanosecond pulsed electric fields are emerging as a new modality for tissue and tumor ablation. We previously reported that cells exposed to pulsed electric fields develop hypersensitivity to subsequent pulsed electric field applications. This phenomenon, named electrosensitization, is evoked by splitting the pulsed electric field treatment in fractions (split-dose treatments) and causes in vitro a 2- to 3-fold increase in cytotoxicity. The aim of this study was to show the benefit of split-dose treatments for in vivo tumor ablation by nanosecond pulsed electric field. KLN 205 squamous carcinoma cells were embedded in an agarose gel or grown subcutaneously as tumors …

The Evolution Of Parental Self-Efficacy In Knowledge And Skill In The Home Care Of Preterm Infants, A Ribeiro, Jordan Kase

NYMC Faculty Publications

No abstract provided.

Nutritional Needs In Collegiate Female Soccer Athletes, Alysa M. Brown

Graduate Student Theses, Dissertations, & Professional Papers

Brown, Alysa, ATC, Spring 2017 Athletic Training

Nutritional Needs in Collegiate Female Soccer Athletes

Chairperson: Dr. Valerie Moody

Many times, athletes do not have enough time to meet their nutritional needs. They are busy going to school, attending meetings, lifting weights, receiving treatments and attending practices and may forget to eat or simply do not have enough time. Several studies suggest nutritional knowledge and habits directly impact how well an athlete will perform. Due to the rigorous training regimen of a collegiate athlete, they should be fueling their bodies throughout the day to maximize their performance. The Women’s soccer team …

Lgbtq-Inclusive Sexuality Education In Montana Public High Schools: An Assessment Of The Needs Of Health Enhancement Teachers, Andrew G. Johnson

Graduate Student Theses, Dissertations, & Professional Papers

BACKGROUND

LGBTQ youth face many unique health challenges. Rates of depression and suicide are exponentially higher for LGBTQ youth than for their heterosexual, cisgender peers. Rates of HIV and STI infection are rising among this demographic. Comprehensive sexuality education has demonstrated the potential to address some of these health challenges. Specifically, it has been shown to delay the onset of sexual intercourse, and to reduce pregnancy and transmission rates of HIV and STIs among youth. Several studies have looked at LGBTQ-inclusive sexuality education from the perspective of LGBTQ students, but few have looked at this issue from the perspective of …

Self Reported Knowledge Of Concussion Symptoms And Management By Middle And High School Club Lacrosse Coaches, Logan Ellis

Graduate Student Theses, Dissertations, & Professional Papers

TITLE: Self-reported knowledge of concussion symptoms and management by middle and high school club lacrosse coaches

AUTHORS: Logan Ellis

BACKGROUND: With an increase in sport participation across all levels, concussion prevalence has increased as well as reliance on coaches to recognize a concussed player. Little research has been done investigating how effective our current educational materials are with Lacrosse coaches of grades 6-12.

STUDY DESIGN: Cross- Sectional

LEVEL of EVIDENCE: Level 4

METHODS: Self-administered, online survey that included closed ended questions regarding recognition of signs and symptoms, consequences of inappropriate care, perception of own knowledge, …

Sms Parent Action Intervention (Span): A Pilot Study To Assess The Feasibility Of Using Text Messaging To Promote Child Health On An American Indian Reservation, Julia M. Malich

Graduate Student Theses, Dissertations, & Professional Papers

Abstract

Purpose: Childhood obesity and its associated health risks are widely recognized as a major public health crisis in the United States (Johnson & Johnson, 2014; Proctor, 2008; Rogers et al, 2013; Vinci et al, 2016) and worldwide (Elías-Boneta, Toro, Garcia, Torres, & Palacios, 2015). Among children in low-income families, American Indian/Alaska Native (AIAN) children have the highest prevalence of obesity (21.1%) compared to other racial/ethnic groups (14.74% overall) (Pan et al, 2015). Parents play an important role in introducing healthy foods and encouraging physical activity in young children (Birch & Ventura, 2009; Lindsay et al., 2006; Natale et al., …

Conversion Of An Instantaneous Activating K+ Channel Into A Slow Activating Inward Rectifier, Dirk Baumeister, Brigitte Hertel, Indra Schroeder, Sabrina Gazzarrini, Stefan M. Kast, James L. Van Etten, Anna Moroni, Gerhard Thiel

James Van Etten Publications

The miniature channel, Kcv, is a structural equivalent of the pore of all K⁺ channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.

Structure Of The N-Glycans From The Chlorovirus Ne-Jv-1, Immacolata Speciale, Irina Agarkova, Garry Duncan, James L. Van Etten, Cristina De Castro

James Van Etten Publications

Results from recent studies are breaking the paradigm that all viruses depend on their host machinery to glycosylate their proteins. Chloroviruses encode several genes involved in glycan biosynthesis and some of their capsid proteins are decorated with N-linked oligosaccharides with unique features. Here we describe the elucidation of the N-glycan structure of an unusual chlorovirus, NE-JV-1, that belongs to the Pbi group. The host for NE-JV-1 is the zoochlorella Micractinium conductrix. Spectroscopic analyses established that this N-glycan consists of a core region that is conserved in all of the chloroviruses. The one difference is that the residue 3OMe-l-rhamnose is …

Emergency Medical Services (Ems) Training In Kenya: Findings And Recommendations From An Educational Assessment, Benjamin Nicholson, Chelsea Mccollough, Benjamin Wachira, Nee-Kofi Mould-Millman

Emergency Medicine, East Africa

Background: Over the past twenty years, Kenya has been developing many important components of a prehospital emergency medical services (EMS) system. This is due to the ever-increasing demand for emergency medical care across the country. To better inform the next phase of this development, we undertook an assessment of the current state of EMS training in Kenya.

Methods: A group of international and Kenyan experts with relevant EMS and educational expertise conducted an observational qualitative assessment of Kenyan EMS training institutions in 2016. Three assessment techniques were utilised: semi-structured interviews, document review, and structured observations. Recommendations were reached through a …

Impact Of Diabetes In The Friedreich Ataxia Clinical Outcome Measures Study, Ashley Mccormick, Jennifer Farmer, Susan Perlman, Martin Delatycki, George Wilmot, Katherine Matthews, Grace Yoon, Chad Hoyle, Sub H. Subramony, Theresa Zesiewicz, David R. Lynch, Shana E. Mccormack

Neurology Faculty Publications

Objective Friedreich ataxia (FA) is a progressive neuromuscular disorder caused by GAA triplet repeat expansions or point mutations in the FXN gene. FA is associated with increased risk of diabetes mellitus (DM). This study assessed the age-specific prevalence of FA-associated DM and its impact on neurologic outcomes.

Research Design and Methods Participants were 811 individuals with FA from 12 international sites in a prospective natural history study (FA Clinical Outcome Measures Study, FACOMS). Physical function was assessed, using validated instruments. Multivariable regression analyses examined the independent association of DM with outcomes.

Results Mean age of participants was 30.1 years (SD …