Medicine and Health Sciences Commons^™

In Vitro Three-Dimensional Skin Tissue Constructs, Tinashe Dereck Gombedza

Theses

Human skin provides fortification against peripheral threats which may compromise the integrity and health of the human body. Its presence as the largest human organ forms a protective barrier making it an effective first line of defence against pathogenic, chemical and physical damage. Tissue engineering technology has enabled the development of in vitro three-dimensional (3D) organotypic skin cultures in order to understand the skin's physiology and architecture. This advancement has enabled the use of 3D skin model platforms to study skin diseases and conditions as well as facilitate drug discovery, clinical research and cosmetic product development.

In this study, an …

Intelligent Profiling Of Blood Donors In Ireland, Joanna Kossakowska

Theses

The demand for blood products in Ireland is constantly rising due to population growth and population ageing. It is believed that within the next decade these two factors will present challenges to blood donor recruitment and the availability of blood supplies. Improving the retention of blood donors will have a positive impact on the availability of blood products. Identification of suitable donors with the potential for long-term donating can potentially enhance the predictability of blood supply levels.

This research proposes that the patterns of blood donation behaviours of donors can be isolated from blood donor databases held by blood collecting …

Exploring The Impact Of A Training Programme On Acute Healthcare Professionals' Attitudes And Understanding Of Dementia, Orla Quirke

Theses

Acute healthcare professionals lack education and training in dementia care. This results in people with dementia having poorer outcomes when admitted to the acute healthcare setting. An overarching aim of The National Dementia Strategy (2014) is the provision of optimal care for people with dementia in all healthcare and community settings. In response to this, Dementia Elevator a national inter-professional suite of educational programmes were developed by Dublin City University and the Health Service Executive to help individuals, communities and health systems engage positively with people with dementia. This study aimed to evaluate the impact of a four-hour dementia training …

Integrating A Code Of Professional Conduct And Ethics: An Action Research Approach, Ciara Kissane

Theses

A new version of the Code of Professional Conduct and Ethics for Registered Nurses and Registered Midwives (NMBI, 2014a) was published in 2014. A nurse’s fitness to practice, and the associated patient experience, is determined by the extent to which the nurse accords with the duties outlined in the Code. Professional misconduct among members of the nursing profession has been highlighted within recent reports and enquiries. The failure to act on unethical care is also a feature. The literature suggests that Codes are poorly understood and can be problematic to integrate in practice. This study sought to; explore the impact …

Caregiver Training Program On Emergent Literacy Development Of Augmentative And Alternative Communication Users, Meghan Bowers

Murray State Theses and Dissertations

Teaching early literacy to typically developing individuals is widely practiced and has a vast amount of research backing its success (Strum et. al., 2006). Current research has shown that both children and adult augmentative and alternative (AAC) users are underachieving in the development of reading and spelling skills, but the underachievement in these areas is not correlated to a lack of cognitive and linguistic abilities (Sandberg, Smith, Larsson, 2010). Like their typically developing peers, AAC users must have the same repeated opportunities to participate in a wide range of literacy tasks to attain literacy skills (Strum et. al., 2006).

Children …

The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff

Murray State Theses and Dissertations

Contrary to popular belief, pet overpopulation is caused more by owners failing to keep their dog than with accidental or intentional breeding (Moulton et al., 1991). Factors related to relinquishment have been researched, and concluded that behavioral problems are the most reoccurring reasons observed (Bailey, 1992; Miller at al., 1996; Patronek et al., 1996; Serpell, 1966; Salman et al., 1998, 2000; Scarlett et al, 1999; New et al., 2000; Shore et al., 2003, 2005; Mondelli 2004, Blackwell et al., 2008). When animals are relinquished to the shelter, the likelihood of the animal being euthanized increases. The purpose of this research …

The Effect Of Sport Participation On Bone, Maggie M. Minett

Electronic Theses and Dissertations

Mechanical loading – or physical activity – is essential in the bone remodeling process as well as optimizing the densitometric and geometric properties of bone throughout the lifespan. Participation in sports is a common mode of physical activity that can enhance bone mass accrual at younger ages and facilitate bone mass maintenance at older ages. Research suggests that sport participation continued from adolescence into high school and college provides added benefits on aBMD and cortical bone measures and these benefits remain 10-15 years after retirement from sport. However, in most studies, the higher rates of bone loss after sport cessation …

Enhanced Breast Cancer Classification With Automatic Thresholding Using Support Vector Machine And Harris Corner Detection, Mohammad Taheri

Electronic Theses and Dissertations

Image classification and extracting the characteristics of a tumor are the powerful tools in medical science. In case of breast cancer medical treatment, the breast cancer classification methods can be used to classify input images as benign and malignant classes for better diagnoses and earlier detection with breast tumors. However, classification process can be challenging because of the existence of noise in the images, and complicated structures of the image. Manual classification of the images is timeconsuming, and need to be done only by medical experts. Hence using an automated medical image classification tool is useful and necessary. In addition, …

Health-Promoting Behaviors, Hope, And Health-Related Quality Of Life In Persons Impacted By Parkinson’S Disease, Amy K. Forbes

Electronic Theses and Dissertations

Objective: The purpose of the study was to determine the relationship between hope, health-promoting behaviors, and health-related quality of life (HRQOL) in persons with Parkinson’s disease.
Background: The incidence of Parkinson’s disease is high in Midwest and Northeast regions of the United States. Parkinson’s disease affects motor and non-motor symptoms and has a variety of complications. Parkinson’s disease is related to genetic and environmental factors. HRQOL decreases in Parkinson’s disease; thus, the effect of hope and health-promoting behaviors on health is crucial as the disease advances.
Methods: A descriptive correlational design was used to guide the study. A convenience sample …

Relationship Of Stress, Sleep, Physical Activity, And Food Insecurity On Eating Behaviors And Obesity, Amy Lee Richards

Electronic Theses and Dissertations

There is an urgent need to find effective interventions to prevent and reduce obesity as it is associated with chronic disease and decreased quality of life. Gaining a better understanding of how modifiable variables such as stress, sleep, physical activity, and food insecurity are related to eating behaviors associated with obesity is essential to guide the direction of future interventions and research. Interventions that hold promise need to be tested to determine if they have merit or not. This dissertation presents three papers. Two papers are cross-sectional studies evaluating associations between eating behaviors, obesity, and modifiable variables (stress, sleep, physical …

Cardiovascular Risk, Remote Ischemic Postconditioning, And Endothelial Ischemia-Reperfusion Injury, Brian A. Hemenway

Electronic Theses and Dissertations

Remote ischemic postconditioning (rIpost) is a potent vasculoprotective stimulus that is thought to reduce reperfusion injury associated with heart disease. However, certain animal models of cardiometabolic risk factors such as dyslipidemia, diabetes, and hypertension suggest the beneficial effects of rIpost to lessen reperfusion injury may be diminished. These findings have not been studied in clinically relevant humans. The aim of this study was to determine whether the protective effects of rIpost are reduced in the context of raised cardiometabolic risk in humans. Seven participants with raised cardiometabolic risk burden (age:57±7 years; BMI: 31±4kgm²participated in this 2X2 randomized cross-over …

Gopher Fitstep Pro Accuracy When Measuring Steps And Moderate-To-Vigorous Physical Activity, Ali Brian, Justin A. Haegele

Human Movement Studies & Special Education Faculty Publications

Background: The Gopher FITStep Pro (GFSP) is a commercially available objective physical activity monitor that records steps taken and moderate-to-vigorous physical activity (MVPA).

Objective: The purpose of this study was to evaluate the accuracy of the GFSP for measuring steps taken in a guided walking condition and MVPA during planned fitness activities.

Method: University-aged participants (N = 35, M_age = 20) wore two GFSP (right and left side) pedometers and one ActiGraph GT3X+ accelerometer during both conditions.

Results: Paired samples t-tests determined that self-step counts in the guided walking condition were not significantly different …

Physical Activity And Sedentary Behaviors In Urban Chinese Children: Grade Level Prevalence And Academic Burden Associations, Xihe Zhu, Justin A. Haegele, Yan Tang, Xueping Wu

Human Movement Studies & Special Education Faculty Publications

The objectives of this study were (a) to report grade level prevalence in physical activity and sedentary behaviors and (b) to examine academic burden associations with these behaviors. School-aged children (n = 48,118) reported their physical activity, perception of physical activity sufficiency, factors for activity insufficiency, homework hours, and screen time in a typical week. Data were analyzed using general linear models and logistic regression models of Complex Samples. Prevalence results showed that children had lower physical activity and lower screen viewing time, but higher homework time during transition grades (6th, 9th, and 12th) and high school years. Academic burden …

The Impact Of Rivalry Antecedents On Mediated Demand For An Individual Sport, Lamar Reams, Terry Eddy

Human Movement Studies & Special Education Faculty Publications

In contrast to research examining the social-psychological aspects of how sport fans perceive rivalry games in team sports, far less is known regarding the impact rivalries have on mediated consumer demand, a marketing outcome of interest to sport researchers and practitioners. Guided by economic demand theory, the current study developed a model to empirically examine the impact of Tyler and Cobbs' (2015) rivalry antecedents (conflict, peer, bias) on fan interest for an individual sport. The three-dimensional framework provided the foundation for the selection of thirteen rivalry-related variables, in addition to control determinants established from prior literature. Results from the estimation …

Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson

Electronic Theses and Dissertations

To determine the effects of a diet that provides 30% energy from protein with ½ as lean, red meat on risk factors of metabolic syndrome in humans. This pilot study was a 3- month, randomized, control, intervention trial with 33 participants (Beef-Intervention n=18; DASH-Control n=15) who displayed markers of metabolic syndrome. Registered Dietitians Nutritionists recruited and educated participants on Beef-Intervention Lean Beef Pattern, (30% of energy from protein with ½ as lean red meat, 40% carbohydrate, 30% fat) or DASH-Control dietary pattern, (15% of energy from protein, 55% carbohydrate and 30 % fat). Of the 33 participants who completed the …

The Indirect Effect Of Bvdv On Immune Suppression: The Role Of Infected Macrophages In Lymphocyte Apoptosis, Karim Abdelsalam

Electronic Theses and Dissertations

BVDV is an important pathogen of cattle that affects both the dairy and beef industry causing severe economic losses. The main problem of BVDV is the immune suppression that is associated with lymphoid depletion shortly post infection. The mechanism of this immune suppression is not well understood. In this in vitro study, we sought to determine the indirect effect of BVDV infection in macrophages as a key player in the pathogenesis of BVD especially, the apoptotic effect induced on lymphocytes. We infected bovine monocyte-derived macrophages (MDM) with either high or low virulent strains of cytopathogenic or non-cytopathogenic strains of BVDV …

Comprehensive Structural, Thermal And Toxicological Characterization Of 1-Ethyl-3-Methylimidazolium Alkylbenzenesulfonate Ionic Liquids, Hiranmayee Kandala

Electronic Theses and Dissertations

Synthesis and characterization of 1-ethyl-3- methylimidazolium alkylbenzenesulfonate ionic liquids for extraction of lignin from prairie cord grass have been studied. The ionic liquids (ILs) 1-ethyl-3- methylimidazolium benzenesulfonate (EBS), 1-ethyl-3- methylimidazolium toluenesulfonate (ETS) and 1-ethyl-3- methylimidazolium xylenesulfonate (EXS) have been synthesized in this research. An extensive structural, physical, thermal and toxicological characterization has been performed to understand the behavior of these ionic liquids. The reaction yield for the synthesis of EBS, ETS, and EXS ionic liquids was determined to be 91.2 ± 1.5 %, 96.1 ± 0.7 %, 99.0 ± 0.5 % respectively. Spectral analysis using NMR and FTIR confirms the …

Intranasal Immunization Of Pigs With Porcine Reproductive And Respiratory Syndrome Virus Like Particles Plus 2’, 3’ –Cgamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge, Alexandria Marie Van Noort

Electronic Theses and Dissertations

Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically devastating virus that causes a persistent infection and spreads quickly. The virus causes abortions in sows and respiratory diseases in young piglets. Current PRRSV vaccines appear to provide limited cross-protection. A virus-like particles (VLPs) vaccine is made up of key PRRSV structural proteins, which could be cross protective among the different strains. We tested PRRSV VLPs as a vaccine candidate with a 2’, 3’-cGAMP VacciGradeTM adjuvant against pigs infected with PRRSV after intranasal immunization to evaluate the immune response and protective efficacy by the VLPs and adjuvant. The VLPs contain …

The Relationship Between Relative Strength Levels To Sprinting Performance In Collegiate 100-400m Sprinters, Philip Reuer

Electronic Theses and Dissertations

The purpose of this study was to determine the relationship between relative maximal (1RM) strength (i.e. back squat and power clean) to sprinting performance in 60-400m collegiate sprinters. A secondary purpose was to determine the distribution of athletes within the theoretical relationship between relative squat strength and performance capabilities. Fifty-six (n = 56) male and sixty-four (n = 64) female collegiate track and field sprinters were observed from DI (n = 88) and DII schools (n = 32) that participated in a year round strength and conditioning program. Maximal strength was divided by body weight to calculate relative strength and …

Effectiveness Of A Shoulder Strengthening Intervention On The Incidence Rate Of Glenohumeral Joint Instability Injuries, Michael Aderman

Electronic Theses and Dissertations

Context: Shoulder injuries are frequently sustained in American football due to the contact and collision aspect of the sport. Injuries to the shoulder account for about 10% to 20% of all musculoskeletal injuries that occur in football and the shoulder is the fourth most commonly injured joint behind the hand, knee and ankle. The effectiveness of the dynamic stabilizers of the glenohumeral joint is a factor that could affect the rate of injuries that occur at the joint. The CKCUEST has been shown to be an effective test for assessing the dynamic stability of the glenohumeral joint.
Objective: The purpose …

Surveillance Of Emerging Livestock Viruses, Faten A. Okda

Electronic Theses and Dissertations

Accurate and rapid diagnostic tests are essential for the management and control of emerging infectious diseases. Therefore, the overall goals of studies presented in this dissertation were to provide improved diagnostic and surveillance capabilities for several emerging viral diseases impacting the livestock industry and to provide insight into appropriate control strategies. Recent, severe outbreaks of porcine epidemic diarrhea virus (PEDV) in Asia and North America highlighted the need for well-validated diagnostic tests for identification of PEDV infected animals and evaluation of their immune status. PEDV was first detected in the U.S. in May 2013 and another swine coronavirus, porcine deltacoronavirus …

Community-Based Advance Care Planning Seminars: Increasing Knowledge In Decisional Adults, Molly Kuehl

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Healthcare workers care for patients with many comorbidities- many of whom enter the system without a clear understanding of their values and preferences. Private discussions about advance directives (ADs) are effective, but cost-prohibitive. Community-wide education campaigns may result in improved quality of life (QOL) (Blackford & Street, 2012a; Bomba & Orem, 2015; Pecanac, Repenshek, Tennenbaum, & Hammes, 2014; Wilson, Kottke, & Schettle, 2014). The purpose of this project was to determine whether community-based seminars about advance care planning (ACP) increase knowledge in decisional adults 18 and older. This project combined discussion format with an ACP presentation. The presentation was delivered …

Short Message Service (Sms) Appointment Reminder Project, Kathryn Wermers

Doctor of Nursing Practice (DNP) Practice Innovation Projects

The purpose of this quality improvement project was to decrease the appointment no-show rate at a mid-western primary care clinic by implementing short message service (SMS) appointment reminders. The project director analyzed the cost of the SMS appointment reminders and patient satisfaction with the intervention via telephone participant opinion surveys. The guiding theoretical framework was Nola Pender’s Health Promotion model (HPM). The subjects involved were the primary care patients who had access to cellular phones with SMS capability. The project assistant received verbal consent to send the SMS appointment reminder for a participant. Then the participant’s cellular phone number was …

Blending Qualitative, Quantitative, And Rhetorical Methods To Engage Citizens In Public Deliberation To Improve Workplace Breastfeeding Support, Jenn Anderson, Rebecca A. Kuehl, Sara A. Mehltretter Drury

Communication Studies Publications

To improve breastfeeding support in local businesses in Brookings, SD, researchers from South Dakota State University partnered with Brookings Health System, the Brookings Area Chamber of Commerce, local breastfeeding advocates, and an expert public deliberation moderator to conduct community-based participatory research leading to a public deliberation event. The collaborative team took a mixed-methods approach, using qualitative, quantitative, and rhetorical methods to collect and analyze data across two phases of the project: formative research (Phase I) and implementation (Phase II). During Phase I, the team conducted focus groups and marketed the project. Results from Phase I shaped the conversations at the …

Speed Of Processing Training Results In Lower Risk Of Dementia, Jerri D. Edwards, Huiping Xu, Daniel O. Clark, Lin T. Guey, Lesley A. Ross, Frederick W. Unverzagt

Psychiatry & Behavioral Neurosciences Faculty Publications

Introduction: Cognitive training improves cognitive performance and delays functional impairment, but its effects on dementia are not known. We examined whether three different types of cognitive training lowered the risk of dementia across 10 years of follow-up relative to control and if greater number of training sessions attended was associated with lower dementia risk.

Methods: The Advanced Cognitive Training in Vital Elderly (NCT00298558) study was a randomized controlled trial (N = 2802) among initially healthy older adults, which examined the efficacy of three cognitive training programs (memory, reasoning, or speed of processing) relative to a no-contact control condition. …

Fdg Avid Breast Cancer Bone Metastases Silent On Ct And Scintigraphy: A Case Report With Radiologic-Pathologic Correlation, Daniel Jeong, Marilyn Bui, Daniel Peterson, Jaime Montilla-Soler, Kenneth L. Gage

Pathology and Cell Biology Faculty Publications

Bone is the one of the most common distant metastatic sites in breast cancer. Routine initial breast cancer staging evaluation typically includes computed tomography (CT) and skeletal scintigraphy while 18F fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is reserved for clinically high-risk cases. Since FDG PET-CT is not routinely performed during staging or surveillance evaluations, it is important for radiologists and clinicians to appreciate the limitations of bone metastasis detection on CT and scintigraphy. We present a case of bony metastases of invasive ductal carcinoma of the breast which were not detected on diagnostic CT or skeletal scintigraphy but were …

Carotid Endarterectomy In A Patient With Severe Internal Carotid Artery Stenosis With Persistent Trigeminal Artery And Ischemia Of The Anterior And Posterior Circulation, Melanie R. F. Greenway, Hussam A. Yacoub, Shweta Varade, Yevgeniy Isayev

Neurology Faculty Publications

Occurrence of cerebral ischemia in the posterior circulation as a result of severe internal carotid artery disease and persistent trigeminal artery is rare. An 81-year-old man with medical history of hypertension and ischemic stroke presented with dizziness, nausea, and mild dysarthria. Magnetic resonance imaging of the brain revealed acute infarcts in the left internal carotid artery territory. CT angiogram revealed a persistent trigeminal artery (PTA) and severe atherosclerosis. The patient developed new neurological symptoms and repeat imaging revealed new acute infarcts in the PTA distribution. After undergoing a left carotid endarterectomy with no complications, the patient was discharged to a …

Hippocampal Cholinergic Neurostimulating Peptide As A Possible Modulating Factor Against Glutamatergic Neuronal Disability By Amyloid Oligomers, Toyohiro Sato, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Hiroshi Takase, Tetsuko Kanamori, Cesar V. Borlongan, Akira Haji, Noriyuki Matsukawa

Neurosurgery and Brain Repair Faculty Publications

Despite having pathological changes in the brain associated with Alzheimer's disease (AD), some patients have preserved cognitive function. A recent epidemiological study has shown that diet, exercise, cognitive training, and vascular risk monitoring interventions may reduce cognitive decline in at-risk elderly people in the general population. However, the details of molecular mechanisms underlying this cognitive function preservation are still unknown. Previous reports have demonstrated that enriched environments prevent the impairment of hippocampal long-term potentiation (LTP) through β2-adrenergic signals, when LTP is incompletely suppressed by synthetic amyloid-β (Aβ) oligomers. The cholinergic network from the medial septal nucleus (MSN) is also a …

Genetic And Histological Alterations Reveal Key Role Of Prostaglandin Synthase And Cyclooxygenase 1 And 2 In Traumatic Brain Injury–Induced Neuroinflammation In The Cerebral Cortex Of Rats Exposed To Moderate Fluid Percussion Injury, Hideki Shojo, Cesar V. Borlongan, Tadashi Mabuchi

Neurosurgery and Brain Repair Faculty Publications

After the initial insult in traumatic brain injury (TBI), secondary neurodegeneration occurs that is intimately associated with neuroinflammation. Prostaglandin (PG) synthases and cyclooxygenase (COX) 1 and 2 may contribute to inflammation in the brain. Temporal and spatial expression features of PG and COX1 and 2 following trauma may guide the development of antineuroinflammation strategies. Here, we examined PG synthase signaling and COX1 and 2 gene expression levels and COX-1- and 2-positive cell types and their temporal localization in TBI-induced brain in an effort to reveal their participation in the disease’s evolving neuroinflammation. Using brain samples from the cerebral cortex of …

Racial‐Ethnic Disparities In Acute Stroke Care In The Florida‐Puerto Rico Collaboration To Reduce Stroke Disparities Study, Ralph L. Sacco, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Maria A. Ciliberti-Vargas, Carolina M. Gutierrez, Negar Asdaghi, W. Scott Burgin, Olveen Carrasquillo, Enid J. Garcia-Rivera, Ulises Nobo, Sofia Oluwole, David Z. Rose, Michael F. Waters, Juan Carlos Zevallos, Mary Robichaux, Salina P. Waddy, Jose G. Romano, Tatjana Rundek

Neurology Faculty Publications

Background: Racial‐ethnic disparities in acute stroke care can contribute to inequality in stroke outcomes. We examined race‐ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines‐Stroke hospitals.

Methods and Results: Seventy‐five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010–2014). Logistic regression models examined racial‐ethnic differences in acute stroke performance measures and defect‐free care (intravenous tissue plasminogen activator treatment, in‐hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, appropriate anticoagulation therapy, statin use, smoking cessation counseling) …