Medicine and Health Sciences Commons^™

Arab American Adolescents’ Bullying Experiences And Effects On Their Perceived Stress And Health, Maha Albdour

Wayne State University Dissertations

This study is intended to examine the bullying experience among Arab American adolescents and effects on their perceived stress and health. Adolescents who are vulnerable or marginalized might be at higher risk for bullying. Arab American adolescents have not been included in research studies examining bullying and described as the invisible population.

The Neuman System Model, which focuses on wellness of adolescents in relation to environmental stress, guided this study. Bullying is a tension producing stressor, operationally defined as repeated attacks or intimidation that cause fear, distress or harm and perceived power imbalance between bully and victim. Perceived stress is …

Online Health Information Gathering And Health Service Utilization By Emergency Department Patients With Acute, Non-Urgent Illness Symptoms, Joanne Yastik

Wayne State University Dissertations

ABSTRACT

ONLINE HEALTH INFORMATION GATHERING AND HEALTH SERVICE UTILIZATION BY EMERGENCY DEPARTMENT PATIENTS WITH ACUTE, NON-URGENT ILLNESS SYMPTOMS

by

JOANNE M. YASTIK

May 2017

Advisor: Dr. Deborah Schutte

Major: Nursing

Degree: Doctor of Philosophy

Statement of the Problem: The influence of the Internet on our global society cannot be overstated. One of the most utilized areas on the Internet is the quest for health information (Bouche & Migeot, 2008; Goldman & Macpherson, 2006; Warner & Procaccino, 2007, Seckin, 2014). To date, little is known on how this information is being used or whether there is a link between online health …

The Effects Of Bone Marrow Adipocytes On Metabolic Regulation In Metastatic Prostate Cancer, Jonathan Diedrich

Wayne State University Dissertations

Bone is a preferential site of metastasis from prostate cancer (PCa). Although there have been many advances in therapeutic options for patients suffering from metastatic PCa, this disease remains incurable with an estimated five-year survival of 33%. To design effective therapeutic interventions for metastatic PCa, it is essential that we elucidate the molecular mechanisms responsible for tumor cell adaptation to and the ability to thrive within the bone metastatic niche. Age and obesity, conditions that increase adipocyte numbers in bone marrow, are risk factors for skeletal metastases from PCa; therefore, our laboratory is focused on the interactions between marrow adipocytes …

Commissioning And Validation Of Analytical And Monte Carlo Based Dose Calculation Algorithms For Proton Spot Scanning, Jatinder Saini

Wayne State University Dissertations

Purpose: Accurate dose calculation is one of the most necessary components of radiation therapy. While the commercially available photon dose calculation algorithm offerings have improved considerably in last decade, proton dose calculations are still performed using the analytical dose calculation algorithms. The goal of this work is to validate a newly available commercial Monte Carlo (MC) dose calculation algorithm using measurements and simulations in GATE software. A secondary goal is to compare and contrast the performance of analytical algorithm against MC algorithm. Finally, GATE simulations are used to evaluate a newly available ceramic marker for ocular melanoma proton therapy.

Methods: …

Evaluation Of Childhood Exposure To Lead In Community Water Systems In Maine, Nicholas Flavin

Muskie School Capstones and Dissertations

The concentration of lead in Maine’s public drinking water was evaluated from 4,700 first-draw water samples collected from 358 Maine Community Water systems. Samples collected from 2012-2015 were obtained by request from the Maine Center for Disease Control and Prevention’s (MeCDC)’s Drinking Water Program.

Exposure and physiological uptake of lead can be mathematically modelled or predicted based on the amount of lead in “background” sources of contaminated media such as soil, dust, water, air or dietary items; the better the characterization of lead in these media, the better the exposure predictions. To assess childhood lead exposure, EPA recommends using the …

2017-2018 Master Of Science In Allied Health Handbook, Otterbein Office Of Graduate Programs

Graduate School

Master of Science in Allied Health Handbook for Otterbein University Graduate Students in the Department of Health and Sport Sciences.

Myeloperoxidase-Mediated Protein Lysine Oxidation Generates 2- Aminoadipic Acid And Lysine Nitrile In Vivo, Hongqiao Lin, Bruce S. Levison, Jennifer A. Buffa, Ying Huang, Xiaoming Fu, Zeneng Wang, Valentin Gogonea, Joseph A. Didonato, Stanley L. Hazen

Chemistry Faculty Publications

Recent studies reveal 2-aminoadipic acid (2-AAA) is both elevated in subjects at risk for diabetes and mechanistically linked to glucose homeostasis. Prior studies also suggest enrichment of protein-bound 2-AAA as an oxidative post-translational modification of lysyl residues in tissues associated with degenerative diseases of aging. While in vitro studies suggest redox active transition metals or myeloperoxidase (MPO) generated hypochlorous acid (HOCl) may produce protein-bound 2-AAA, the mechanism(s) responsible for generation of 2- AAA during inflammatory diseases are unknown. In initial studies we observed that traditional acid- or basecatalyzed protein hydrolysis methods previously employed to measure tissue 2-AAA can artificially generate …

Using A Social Ecological Model To Explore Upstream And Downstream Solutions To Rural Food Access For The Elderly, Lauri Andress

Faculty & Staff Scholarship

A social ecological model is applied to the secondary analysis of qualitative data to study the impact of place on rural food access for older adults in West Virginia. The use of a social-ecological model to review the senior’s coded narratives provided a clearer picture of higher impact, upstream levers to address food security for older adults in a rural region. The elderly have restricted access to food in rural West Virginia because of an indirect relationship with place that acts through the social ecological domains of the built environment, macrosocial factors, stressors, the natural environment, and social support. The …

The Distinct Metabolic Phenotype Of Lung Squamous Cell Carcinoma Defines Selective Vulnerability To Glycolytic Inhibition, Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford, Jung-Whan Kim

Journal Articles: Eppley Institute

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to individual NSCLC subtypes remain unknown. Here, we perform an integrative analysis of human NSCLC tumour samples, patient-derived xenografts, murine model of NSCLC, NSCLC cell lines and The Cancer Genome Atlas (TCGA) and reveal a markedly elevated expression of the GLUT1 glucose transporter in lung SqCC, which augments glucose uptake and glycolytic flux. We show that a critical reliance on glycolysis renders lung SqCC vulnerable to glycolytic inhibition, …

2016 Refugee Health Needs Assessment In Omaha, Nebraska, Kandy Do, Drissa Toure, Naw Latt Nlam, Dejun Su

Posters and Presentations: College of Public Health

Refugees resettling to Nebraska undeniably have different health needs compared to native Nebraska residents. Capturing those differences is the start to catering local health care to refugees. A health needs assessment of refugees in Omaha, Nebraska seek to assess their perceived needs, barriers, and preferences regarding health care, in order to address them justly. The refugee population in Omaha, Nebraska has exponentially increased over the past decade and will continue to increase, bringing global health matters to our backyard. The data and results from surveying over 290 refugees will guide health care organizations and services to appropriately serve refugees and …

Recent Advances In The Management And Understanding Of Diabetic Retinopathy, Matthew Powers, Margaret Greven, Robert Kleinman, Quan D. Nguyen, Diana V. Do

Journal Articles: Ophthalmology

Despite recent advances in the diagnosis and treatment of diabetic retinopathy, this complication remains a steadfast challenge to patients and physicians. This review summarizes recent progress in the diagnosis and management of diabetic retinopathy, including automated screening, optical coherence tomography, control of systemic risk factors, surgical techniques, laser treatment, and pharmaceutical treatment, including vascular endothelial growth factor inhibitors. Recent advances in pharmaceutical treatments, in particular, hold strong promise of halting and sometimes reversing the disease process. Clinicians nevertheless must remain vigilant in their efforts to diagnose and treat this disease early in its course.

Kiss-And-Run Is A Significant Contributor To Synaptic Exocytosis And Endocytosis In Photoreceptors., Xiangyi Wen, Grant W. Saltzgaber, Wallace B. Thoreson

Journal Articles: Pharmacology & Experimental Neuroscience

Accompanying sustained release in darkness, rod and cone photoreceptors exhibit rapid endocytosis of synaptic vesicles. Membrane capacitance measurements indicated that rapid endocytosis retrieves at least 70% of the exocytotic membrane increase. One mechanism for rapid endocytosis is kiss-and-run fusion where vesicles briefly contact the plasma membrane through a small fusion pore. Release can also occur by full-collapse in which vesicles merge completely with the plasma membrane. We assessed relative contributions of full-collapse and kiss-and-run in salamander photoreceptors using optical techniques to measure endocytosis and exocytosis of large vs. small dye molecules. Incubation with small dyes (SR101, 1 nm; 3-kDa dextran-conjugated …

Proteome Analysis Of Bronchoalveolar Lavage From Calves Infected With Bovine Respiratory Syncytial Virus-Insights In Pathogenesis And Perspectives For New Treatments., Sara Hägglund, Krister Blodörn, Katarina Näslund, Karin Vargmar, Sara Bergström Lind, Jia Mi, Mariluz Araínga, Sabine Riffault, Geraldine Taylor, John Pringle, Jean François Valarcher

Journal Articles: Pharmacology & Experimental Neuroscience

Human and bovine respiratory syncytial viruses (HRSV/BRSV) are major causes of severe lower respiratory tract infections in children and calves, respectively. Shared epidemiological, clinical, pathological and genetic characteristics of these viruses make comparative research highly relevant. To characterise the host response against BRSV infection, bronchoalveolar lavage supernatant (BAL) from i) non-vaccinated, BRSV-infected ii) vaccinated, BRSV-infected and iii) non-infected calves was analysed by tandem mass spectrometry. Proteins were semi-quantified and protein expression was validated by immunoblotting. Correlations between selected proteins and pathology, clinical signs and virus shedding were investigated. Calves with BRSV-induced disease had increased total protein concentrations and a decreased …

Body Mass Index Change In Gastrointestinal Cancer And Chronic Obstructive Pulmonary Disease Is Associated With Dedicator Of Cytokinesis 1, Merry-Lynn Noelle Mcdonald, Sungho Won, Manuel Mattheisen, Peter J. Castaldi, Michael H. Cho, Erica Rutten, Megan Hardin, Wai-Ki Yip, Stephen I. Rennard, David A. Lomas, Emiel F.M. Wouters, Alvar Agusti, Richard Casaburi, Christoph P. Lange, George O'Connor, Craig P. Hersh, Edwin K. Silverman

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (ΔBMI) among cancer and COPD by using GWAS data in the Framingham Heart Study.

METHODS: A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate ΔBMI in participants over 40 years …

Reliability Of Medical Records In Diagnosing Inflammatory Breast Cancer In Egypt, Lynne Le, Catherine Schairer, Ahmed Hablas, Jane L. Meza, Shinobu Watanabe-Galloway, Mohamed Ramadan, Sofia D. Merajver, Ibrahim A. Seifeldin, Amr S. Soliman

Journal Articles: Epidemiology

BACKGROUND: Inflammatory breast cancer (IBC) is a rare, aggressive breast cancer diagnosed clinically by the presence of diffuse erythema, peau d'orange, and edema that arise quickly in the affected breast. This study evaluated the validity of medical records in Gharbiah, Egypt in identifying clinical signs/symptoms of IBC. For 34 IBC cases enrolled in a case-control study at the Gharbiah Cancer Society and Tanta Cancer Center, Egypt (2009-2010), we compared signs/symptoms of IBC noted in medical records to those recorded on a standardized form at the time of IBC diagnosis by clinicians participating in the case-control study. We calculated the sensitivity …

Liver Adiposity And Metabolic Profile In Individuals With Chronic Spinal Cord Injury, Kathleen C. Rankin, Laura C. O’Brien, Liron Segal, M. Rehan Khan, Ashraf S. Gorgey

Physiology and Biophysics Publications and Presentations

Purpose. To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). Materials and Methods. MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants. Intravenous glucose tolerance test was conducted to measure glucose effectiveness (𝑆g) and insulin sensitivity (𝑆i ). Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed. Results. Average hepatic FSF was 3.7% ± 2.1. FSF was positively related to TG, non-HDL-C, fasting glucose, HbA1c, VAT, and …

Transcriptomic And Bioinformatics Analysis Of The Early Time-Course Of The Response To Prostaglandin F2 Alpha In The Bovine Corpus Luteum., Heather Talbott, Xiaoying Hou, Fang Qiu, Pan Zhang, Chittibabu Guda, Fang Yu, Robert A. Cushman, Jennifer R. Wood, Cheng Wang, Andrea S. Cupp, John S. Davis

Journal Articles: Obstetrics & Gynecology

RNA expression analysis was performed on the corpus luteum tissue at five time points after prostaglandin F2 alpha treatment of midcycle cows using an Affymetrix Bovine Gene v1 Array. The normalized linear microarray data was uploaded to the NCBI GEO repository (GSE94069). Subsequent statistical analysis determined differentially expressed transcripts ± 1.5-fold change from saline control with P ≤ 0.05. Gene ontology of differentially expressed transcripts was annotated by DAVID and Panther. Physiological characteristics of the study animals are presented in a figure. Bioinformatic analysis by Ingenuity Pathway Analysis was curated, compiled, and presented in tables. A dataset comparison with similar …

Anaesthesia Error In United States: Reasons For Mismanagement, Abby Wolfe, Anh Nguyen, Ashleigh Galles, Madison Wolfe, Ben Lundberg

Posters and Presentations: College of Public Health

A poster from the UNMC Undergraduate Public Health Workshop

Cyclic-Amp Regulates Postnatal Development Of Neural And Behavioral Responses To Nacl In Rats, Jie Qian, Shobha Mummalaneni, Tam-Hao T. Phan, Gerard L. Heck, John A. Desimone, David West, Sunila Mahavadi, Deanna Hojati, Karnam S. Murthy, Mee-Ra Rhyu, Andrew I. Spielman, Mehmet H. Özdener, Vijay Lyall

Physiology and Biophysics Publications and Presentations

During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently, the intracellular signals that regulate the postnatal development of salt taste have not been identified. We investigated the effect of cAMP, a downstream signal for arginine vasopressin (AVP) action, on the postnatal development of NaCl responses in 19–23 day old rats. ENaC-dependent NaCl CT responses were monitored after lingual application of 8-chlorophenylthio-cAMP (8-CPT-cAMP) under open-circuit conditions and under ±60 mV lingual voltage clamp. Behavioral responses were …

Elucidation Of Molecular Kinetic Schemes From Macroscopic Traces Using System Identification, Miguel Fribourg, Diomedes E. Logothetis, Javier González-Maeso, Stuart C. Sealfon, Belén Galocha-Iragüen, Fernando Las-Heras Andrés, Vladimir Brezina

Physiology and Biophysics Publications and Presentations

Overall cellular responses to biologically-relevant stimuli are mediated by networks of simpler lower-level processes. Although information about some of these processes can now be obtained by visualizing and recording events at the molecular level, this is still possible only in especially favorable cases. Therefore the development of methods to extract the dynamics and relationships between the different lower-level (microscopic) processes from the overall (macroscopic) response remains a crucial challenge in the understanding of many aspects of physiology. Here we have devised a hybrid computational-analytical method to accomplish this task, the SYStems-based MOLecular kinetic scheme Extractor (SYSMOLE). SYSMOLE utilizes system-identification input-output …

Aerobic Fitness Impacts Sympathoadrenal Axis Responses To Concurrent Challenges, Heather E. Webb, Deena A. Rosalky, Matthew J. Mcallister, Edmund O. Acevedo, Gary H. Kamimori

Physiology and Biophysics Publications and Presentations

The combination of mental and physical challenges can elicit exacerbated cardiorespiratory (CR) and catecholamine responses above that of a single challenge alone.

Purpose

This study examined the effects of a combination of acute mental challenges and physical stress on cardiorespiratory and catecholamine responses.

Method

Eight below-average fitness (LF VO2max = 36.58 +/- 3.36 ml(-1) kg(-1) min(-1)) and eight above-average fitness (HF VO2max = 51.18 +/- 2.09 ml(-1) kg(-1) min(-1)) participants completed an exercise-alone condition (EAC) session consisting of moderate-intensity cycling at 60% VO2max for 37 min, and a dual-challenge condition (DCC) that included concurrent participation in mental challenges while cycling. …

Complication Rate And Diagnostic Yield Of Percutaneous Native Kidney Biopsies: A 10-Year Experience At A Tertiary Care Hospital In Pakistan, Sonia Yaqub, Nayla Ahmed, Urooj Fatima, Ayesha Maqbool, Waqar Ashif, Syed A. Hussain

Section of Nephrology

The use of an automated biopsy device, and real-time ultrasound for percutaneous kidney biopsies (PKBs) has improved the likelihood of obtaining adequate tissue for diagnosis and also has reduced the complications associated with the procedure. We aimed to determine the frequency and type of complications associated with PKB and to determine the diagnostic yield. It was a retrospective file-based review of cases who underwent PKB of native kidney between January 2003 and December 2013 at the Aga Khan University Hospital in Karachi, Pakistan. PKBs were performed by trained nephrologists or radiologists using an automated device with a 16/18-gauge needle under …

Quality Assurance Self-Assessment: A Catalyst At Aga Khan University, Tashmin Khamis, Khairunnisa Dhamani

Faculty of Health Sciences, East Africa

This article describes the establishment of the Aga Khan University’s Network of Quality Assurance and Improvement in promoting the principles of quality in its programmes. As an international university, the experiences and lessons learned have the potential to inform quality assurance and improvement in similar contexts. The authors reflect on past attempts to improve the quality of educational offerings, which were primarily traditional quality assurance audits. With the advent of the Inter-University Council for East Africa self-assessment process, the next generation of quality assurance and improvement was launched for the Aga Khan University programmes. They found the self-assessment process effective …

Reflections On An Innovative Mentoring Partnership Facilitators And Inhibitors To Success In Faculty Development, Tashmin Khamis, Marilyn Chapman

Faculty of Health Sciences, East Africa

The need for more interactive, learner-centred pedagogies at Aga Khan University in East Africa led to the development of a partnership with Academics without Borders (AWB). AWB recruited three nursing faculty volunteers to provide mentorship to the nursing faculty at the three Aga Khan University Advanced Nursing Studies campuses in East Africa. As part of the evaluation and as a strategy to improve the quality of the mentoring and the project, the authors developed an action research study to identify facilitators and inhibitors to the success of this inter-cultural initiative. In this article, the authors share their observations and reflections …

Evidence Of Morphological And Functional Variation Among Bluegill Lepomis Macrochirus Populations Across Grand Lake St Mary's Watershed Area, Anthony Bell, Stephen J. Jacquemin

Biological Sciences Faculty Publications

A myriad of factors have been shown to influence the morphology offreshwaterfish. However, studies that parse out where variation is comingfrom (e.g. body size, sex, and habitat) as well as what potential thesechanges have to influence function (e.g. swimming performance) areunderstudied. Therefore, the objectives of this study were to describemorphological variation of BluegillLepomis macrochirusacross the GrandLake St Mary’s watershed area (northwest OH, USA) and test forcovariation of morphology with size, sex, and habitat as well as to assessswimming performance to discern whether any differences in habitat (andmorphology) correspond with functional aspects related to criticalswimming velocity. Geometric morphometric methods were used …

Introduction: Nursing Research Project Posters, Jamela Martin, Janice Evans Hawkins

OUR Journal: ODU Undergraduate Research Journal

Nursing 363, Principles of Practice: Research as Foundation for Practice, is a required course in the undergraduate nursing curriculum at Old Dominion University. This course, offered every spring, focuses on the theories and concepts utilized in the scientific investigation of nursing practice. Students are introduced to scientific inquiry in nursing which forms the basis for nursing practice and theory. To meet course requirements, student groups create professional scientific research posters of their research proposal projects. What follows is a compilation of their research posters which were presented at the College of Health Sciences Interprofessional Poster Presentation day in the spring …

Examining The Attitudes And Knowledge Of Pregnant Teens On The Topic Of Sids, Delani Beilsmith, Emily Garzon, Maurice Jones, Erika Jurist, Catherine Knapp, Nicole Page, Ashley Smith, Courtney Wagner

OUR Journal: ODU Undergraduate Research Journal

Background: Norfolk has the second highest teen pregnancy rate and third highest infant mortality rate in Southeastern Virginia. SIDS is the third leading cause of infant death in Virginia. Providing a group education intervention modeled after centering pregnancy gives teen mothers the opportunity to learn and receive support in a safe space in hopes of making a positive impact on their attitudes and knowledge regarding SIDS.

Hypothesis: Do the attitudes and knowledge of pregnant teens and recent teen mothers change positively after a group education intervention on sudden infant death syndrome (SIDS).

Method: Quasi-experimental non-randomized group trial. …

The Effect Of Prenatal Breastfeeding Classes On The Initiation Rate And Duration Of Breastfeeding, Rebecca Rupnarine, Sarah Hall, Jasmine Harris, Sarah Mariano, Kelley Everhart, Christen Hansel, Arianne Kris Eichas

OUR Journal: ODU Undergraduate Research Journal

Aim: To determine whether an educational prenatal breastfeeding class will increase the initiation rate and duration of breastfeeding among mothers.

Background: Breastfeeding rates continue to be low, particularly among teenage mothers and nonwhite mothers. Some of the factors that contribute to this are social support, education about breastfeeding, social stigmas, and time.

Significance: Breastfeeding can provide many positive benefits to mothers, babies, and communities. Having no breastfeeding education makes women less likely to initiate and maintain breastfeeding.

Methods: Correlational quasi-experimental design. Prenatal breastfeeding class lasting 8 weeks prior to childbirth. Phone interview at 1 week postpartum …

Exploring Community-Based Nutrition Education Programs On Children’S Knowledge Of Effective Budgeting And Nutritional Analysis, Danielle Beard, Katie Harris, Charlotte Harrison, Amanda Hawley, Kerri Healy, Ashley Tuttle

OUR Journal: ODU Undergraduate Research Journal

Children from low-income areas, ages 5-18, are at high risk for obesity and other related nutritional issues, partially due to lack of knowledge about effective budgeting and nutritional content analysis. Little information is known about the education provided by current community programs in Hampton Roads for teaching children to 1) shop smart, 2) read nutrition labels, and 3) the importance of eating healthier. We propose a longitudinal (12-week) observational study to determine what community-based education is provided to children on how and why to shop smart and read nutritional content; and to determine whether or not the education is effective. …

Impact Of After-School Activities On Meeting Cdc Requirements In Virginian Adolescents, Dorcas Bentil, Leah Crouch, Vignette Kaltsas, Christina Luchau, Phoebe Wallen, Lily Zheng

OUR Journal: ODU Undergraduate Research Journal

Aim: To assess the correlation between after-school program attendance and meeting the Center for Disease Control (CDC) requirement of 60 minutes of moderate to vigorous physical activity (MVPA) per day.

Background: Less than 50% of all children meet the CDC required amount of MVPA.1

Methods: Survey provided to 350 students in grades 6-12 describing participation in after-school programs

Analysis: We will analyze how many students participate in the after-school programs and how long those programs dedicate to physical exercise. We will also analyze what type of exercise is performed.

Limitations: We are limited to the …