Medicine and Health Sciences Commons^™

The Acute Effect Of Endurance Exercise On Lipoproteins Measured By Nuclear Magnetic Resonance (Nmr) In Healthy Men, Hanaa Adnan Shaheen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Cardiovascular disease (CVD) represents a major cause of death in the United States, with abnormal levels of blood lipids and physical inactivity considered as major modifiable risk factors. The conventional lipid profile has been used to assess for CVD risk by directly measuring the concentrations of blood lipids. However, lipoprotein particle size and number obtained from a novel method, Nuclear Magnetic Resonance (NMR) may also asses for CVD risk with greater sensitivity. Exercise and increased physical activity has been shown to produce favorable effects on blood lipids and consequently reduce CVD risk. To understand this effect, it is important …

Improving Evidence Based Asthma Management In An Urban University Student Health Center, Hedian Cho Swanson

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this project was to improve asthma management through focused staff education and training on national asthma guideline recommendations. The Student Health Center (SHC), located in a university in the southwest United States, performed annual reviews of asthma-related electronic medical records (EMR) in an effort to provide quality health care. These reviews used 23 quality improvement (QI) parameters extracted from the 2007 National Asthma Education and Preventive Program Expert Panel Report 3 (NAEPP EPR 3). The SHC QI findings were consistent with current asthma management literature indicating asthma control is often overestimated and undertreated. This project (a) provided …

Use Of Continuous Glucose Monitors In Type-1 Diabetes: An Analysis Of Wave Form Versus Glycemic Values In The Improvement Of Glucose Control And Fear Of Hypoglycemia, Tomas Charles Walker

UNLV Theses, Dissertations, Professional Papers, and Capstones

Type-1 diabetes is a disease of subtle complexities. Patients struggle to understand glucose patterns and their responses to insulin or food intake while maintaining hectic lifestyles. Minor misjudgments in treatments can result in disastrous consequences with significant hypo- or hyperglycemic excursions.

Despite improvements in technologies available for diabetes management, including home monitoring of blood glucose, more predictable insulin therapies, and improved insulin delivery via insulin pump, the average HbA1c has remained relatively unchanged. Poor diabetes control is recognized as contributing to long-term diabetes comorbidities including neuropathy, nephropathy, retinopathy, and micro- and macrovascular disease.

Real-time continuous glucose monitors, such as the …

Chemical Characterization Of Meat Related To Animal Diet, Rossarin Tansawat

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There is currently much interest in increasing health benefits from consuming nutritious food, including beef. Plant secondary compounds (PSC) such as tannins or saponins in various forages have an influence on animal nutrition and health, depending on the type of PSC and the amount consumed. However, relatively little is known about effects of PSC on meat color, flavor, and nutritional value. Thus, additional information is needed to better understand and to develop new animal feeding regimes for optimum animal growth, meat flavor, and meat nutritional quality.

In the first study, grain- vs. pasture-fed beef rib steaks were evaluated. The objective …

Motivating Men Who Have Sex With Men To Get Tested For Hiv, Magaly M. Blas, Luis A. Menacho, Isaac E. Alva, E. Roberto Orellana

School of Social Work Faculty Publications and Presentations

Although men who have sex with men (MSM) have the highest HIV prevalence in Peru, they are underserved by traditional preventive programs. Interestingly, in Peru the Internet and cell-phones have emerged as a convenient tool to reach this population.

Attentional Focus During Balance Training In Idiopathic Parkinson’S Disease (Pd): A Randomized Clinical Trial, Alyssa Davis, Rebecca Hatlevig, Amanda Richards, Leslee Rosenlof

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to compare the effects of various attentional focus strategies on balance in people with PD. Forty-nine adults with idiopathic PD were randomized into one of four groups (internal focus, external focus, no focus, and control). The three intervention groups participated in a month-long balance program. The outcomes measured were the Sensory Organization Test, Berg Balance Scale, self selected gait velocity, Dynamic Gait Index, Activities-specific Balance Confidence Scale and obstacle course completion time. These outcomes were measured at baseline, post intervention, 2-weeks post intervention, and 8-weeks post intervention. Statistical analyses yielded no significant differences among …

Active Recovery And Electro-Muscular Stimulation On Delayed Onset Muscle Soreness After Endurance Running: A Randomized Clinical Trial, Amanda J. Gramly, Kitrick C. Rhodes, Andrea F. Smith

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background/Purpose: Current research on strategies to decrease delayed onset muscle soreness (DOMS) has focused on the effects of active and passive recovery on athletic performance across various sports, but there is little evidence regarding these recoveries at reducing DOMS induced by aerobic activities, such as running. In addition, there is limited research regarding the efficacy of recovery using electro-muscular stimulation (EMS). Therefore, the purpose of this study was to investigate the effects of active and EMS recovery in decreasing DOMS. Subjects: Forty-eight healthy subjects (25 males and 23 females) between the ages of 20 and 40 (25.1 ± 2.9) participated. …

Population-Based Survey Of Lumbar Surgery Beliefs In The United States, Amanda Elyse Mccauley, Zachery Clark Rasmussen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Studies have shown that poor lumbar surgery outcomes may be influenced by a person’s preconceived perceptions of low back surgery (LBS). However, the perceptions of the general population about issues related to lumbar surgery are not known. Therefore, the purpose of this study was to investigate the general population’s perceptions regarding LBS.

Number of Subjects: This study included 262 participants (Average age: 46.1, SD=16.9; 125 Males, 137 Females) who completed the questionnaire from the general population in the Las Vegas area.

Materials/Methods: Questionnaire development involved expert panel feedback from three physical therapists, three spine surgeons, two surgeon assistants/nurses, two …

Therapist Characteristics Influencing Physical Therapy Non-Treatment In The Acute Care Setting, Daniel Mcgarvey, Colby Olsen, Aaron Van Wagoner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background and Purpose: Research has found that participation in physical therapy (PT) services in the acute care setting increases functional outcomes and decreases patient length of stay. Certain physical therapist characteristics could be a potential source of influence on patient non-participation in physical therapy in the acute care setting. The purpose of this study was to determine whether specific characteristics of therapists and patients are predictive of physical therapy non-treatment.

Subjects: Subjects included 16 physical therapists or physical therapist assistants and 1225 patients at a community acute care hospital.

Methods: Characteristics of each therapist and their corresponding patient data were …

Foot Volume Change During Long Distance Running In Healthy Adults, Meghan Boni, Istvan Takacs, Rebecca Wilson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background and purpose: Healthy adults frequently engage in running as a means of cardiovascular exercise. Larger running shoes are often chosen based on common beliefs that feet swell during running, yet many continue to encounter foot injuries, such as blisters, as a result of this activity. Previous research has analyzed the changes in foot volume during short bouts of activity. However, there has been limited research on the effect of long distance running on foot volume, which is where many of these injuries are seen. The purpose of this study was to examine the effects of long distance running, defined …

Supervised Lower Extremity Strengthening Program To Improve Function In Women Over Fifty With Knee Osteoarthritis: A Time Series Design, Janelle Brooke Lemons, Diane Christine Sheesley, Pamela Reagan Sutton

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: Develop a simple, self-paced lower extremity strengthening program incorporating functional activities for women over the age of fifty to reduce limitations associated with knee OA.

Study Design: This was a pilot study utilizing a time series design with 8 women aged 55-65 (M + SD = 60 + 3) meeting the American College of Rheumatology's criteria for clinical diagnosis of knee OA.

Background: Lower extremity weakness in women with knee osteoarthritis is associated with pain and functional limitations.

Methods and Measures: Subjects began the 14-week program with 2 weeks of baseline treadmill walking. The following 12 weeks were divided …

Duration Of The Effects Of Three Static Stretching Conditions With Or Without A Dynamic Warm-Up In College Age Adults, Spencer Blackwell, Andrew Blomberg, Jonathan Griffith

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose. The purpose of this study was to determine the stretching duration (15, 30, 60 seconds) with or without a dynamic warm-up that resulted in the longest lasting acute effects in hamstring flexibility.

Subjects. Forty subjects (17 male, 23 female) (age: 20-35 years) were selected to participate in this study using a sample of convenience from university graduate students.

Methods. This study contained 7 treatment conditions in which each subject completed in random order. Three groups consisted of a 5-minute treadmill warm-up at a self-selected velocity (SSV) followed by one of three stretching durations (15, 30, or 60 sec). …

Biomass Assisted Synthesis Of Antibacterial Gold Nanoparticles And Commentary On Its Future Potential And Applications In Medicine, Chad Willis

Mahurin Honors College Capstone Experience/Thesis Projects

Xylose is a natural monosaccharide found in biomass such as straw, pecan shells, cottonseed hulls, and corncobs. Using this monosaccharide, we report the green synthesis and characterization of biocompatible, biodegradable xylose encapsulated gold nanoparticles (Xyl-GNPs) with potential antibacterial activity. GNPs were synthesized using the bioreduction property of xylose on the chloroaurate anions in an aqueous solution at room temperature and at atmospheric pressure. The characterization of synthesized GNPs was examined by UV-vis spectroscopy; transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS) and fourier transform infrared spectroscopy (FTIR). Results indicate that the particles were stable; near spherical in shape with an …

Interactions Of Nitric Oxide And Superoxide Pathways In Hyperglycemic Endothelial Cells, Steven Clay Rogers

Graduate Theses and Dissertations

Cardiovascular complications arising from diabetic hyperglycemia represents one of the leading causes of death and greatest public health challenges of modern societies. Despite state-of-the-art glucose control, diabetic patients remain at a markedly increased risk of cardiovascular disease. The loss of endothelial function (the development of diabetic endothelial dysfunction) has been implicated in the development of numerous diabetic cardiovascular diseases. The endothelial cell produces many vasoactive substances, hormones and cytoprotective biological factors. Endothelial cells are also involved in and affected by the initiation of inflammatory responses through the release and interaction of cytokines and other immune system molecules. Therefore, regulation of …

Evaluating Complementary And Alternative Medicine (Cam) Utilization In A College Sample: A Multisite Application Of The Sociobehavioral Model Of Healthcare Utilization, Kimberly M. Pratt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The use of complementary and alternative medicine (CAM) among U.S. college students and the general public is substantial and growing; however, research on the characteristics of college students who use CAM and the factors that influence their decision to use CAM is scarce. Even fewer studies have explored such factors within the framework of an empirically supported theory. The college years are seen as an important time for developing long-lasting health behaviors and in many ways college students play an important role in setting the foundation for future healthcare. Thus, it is important for healthcare practitioners to have a clear …

Role Of Endovascular Treatment In Vascular Injuries, Muhammad Misbah Tahir, Tanveer-Ul-Haq

Department of Radiology

OBJECTIVE: To evaluate retrospectively the results, complications and follow-up of patients after endovascular treatment of vascular injuries.

METHODS: Fifty transcatheter embolisation procedures (TCE) were performed in 46 patients between 1999 and 2008 at the Aga Khan University Hospital, Karachi. Injuries in 14 (30.4%) patients were due to road traffic accident; iatrogenic in 13 (28%); accidental in 6 (13%). Firearms, bomb blasts and earthquake contributed to injuries in 8(17%), 4(8.8%) and 1(2.2%) patients respectively. All patients underwent angiography and had evidence of either active haemorrhage, pseudo-aneurysm, abnormal vascularity or arteriovenous fistula. Followup ranged from 1 day to 6 years with mean …

Obstacles To Dieting Behavior, Shahram Heshmat

Journal of Food Law & Policy

Despite documented short term success, dieting has a very low success rates, most dieters regain their weight back within 3-5 years. The question is why do people fail to stick to their goal for eating a healthy diet in order to lose weight? One possible answer is that people have self-control problems in the form of a present-biased preference. From a prior perspective, they want to behave relatively patiently, but as the moment of action approaches, they want to behave relatively impatiently. The essay presents some insights from behavioral economics to explain why people fail to maintain healthy behavior.

European Union Food Law Update, Emilie Majster

Journal of Food Law & Policy

Nutrition is increasingly important in both the European Union (EU) and in global food-related policy making. Governments, which up until recently have focused on regulating food products based on a food safety perspective, are now turning to regulate from a nutritional aspect.

Neurophysiologic Investigation Of The Auditory What And Where Pathways In Young And Middle-Aged Adults, Ann Marie Olson

Theses, Dissertations and Culminating Projects

When a sound is heard, individuals intrinsically attempt to identify the sound and its location. This automatic and parallel processing is known as the auditory “what” and “where” pathways. The present study involved the neurophysiologic investigation of the auditory dual pathways in an attention and working memory task as a function of age. Using identical stimuli, event-related potentials were measured in young and middle-aged adults with normal hearing for both pitch identification (“what” pathway) and location (“where” pathway). Results showed differences in cortical processing of the “what” and “where” pathways as a function of age and task instruction. Although processing …

Role Of Trp Channels In Mediating The Calcium Signaling Response Of Brain Endothelial Cells To Mechanical Stretch, Jonathan Berrout

Dissertations and Theses (Open Access)

Traumatic brain injury (TBI) often results in disruption of the blood brain barrier (BBB), which is an integral component to maintaining the central nervous system homeostasis. Recently cytosolic calcium levels ([Ca²⁺]i), observed to elevate following TBI, have been shown to influence endothelial barrier integrity. However, the mechanism by which TBI-induced calcium signaling alters the endothelial barrier remains unknown. In the present study, an in vitro BBB model was utilized to address this issue. Exposure of cells to biaxial mechanical stretch, in the range expected for TBI, resulted in a rapid cytosolic calcium increase. Modulation of intracellular and extracellular …

Anxiety And Sleep Disorder Comorbidity: Affecting The College Students' Performances, Amanda Rhenee Grimes

Graduate Theses and Dissertations

The purpose of this study is to determine the effects that anxiety disorders and sleep disorders have on students' academic performance. The prevalence of both disorders is rising in the college student population. This study examines those who have been physician diagnosed with the one or both of the disorders and how the students' grade point average (GPA) is affected.

The National College Health Assessment was used for data collection; this survey assesses college students' health habits, behaviors, and perceptions. The sample was comprised of 57 institutions representing every region in the U.S. totaling 34,208 participants. Data was acquired through …

A Role Of Environmental Components In Autoimmune Vitiligo Of Smyth Line Chickens, Lei Dong

Graduate Theses and Dissertations

The Smyth line (SL) of chickens is a well-established animal model for the study of spontaneous autoimmune vitiligo, displaying all the characteristics of human vitiligo. In humans, phenolic derivative 4-tertiary butyl phenol (4-TBP) has been shown to trigger vitiligo in susceptible individuals. In vitiligo-prone SL-chickens, live turkey herpesvirus (HVT) infection at hatch was identified as the most effective trigger of SL-vitiligo expression. This dissertation examined the role of the environmental factors 4-TBP and HVT in the etiology of SL-vitiligo. Specifically, the generation of reactive-oxygen-species by melanocyte-containing feather tissue (MC-FT) and cultured melanocytes in response to 4-TBP exposure in vitro (Study …

Lameness Associated With A Possible Neural Problem In The Lower Spinal Cord Of Chickens, Gallus Gallus, Gurueswar Nagarajan

Graduate Theses and Dissertations

Since the second half of the twentieth century lameness in broiler chickens has been known to be caused by different types of disorders, however the etiology of several type of lameness remain unknown. Because of the intense selection of broilers for rapid growth, some birds are more prone to physiological insults resulting in lameness. This study focuses on possible neural problems in the lower spinal cord associated with lameness in broilers. Broilers were raised in pens with wire floors and provided with food and water ad libitum. Three groups of birds 1) birds displaying a normal gait (Controls), 2) lame …

Cortical Gyrification In Velo-Cardio-Facial (22q11.2 Deletion) Syndrome: A Longitudinal Study, Arun Kunwar, Seethalakshmi Ramanathan, Joshua Nelson, Kevin M. Antshel, Wanda Fremont, Anne Marie Higgins, Robert J. Shprintzen, Wendy R. Kates

Communication Disorders Faculty Publications

Introduction: Velo-cardio-facial syndrome (VCFS) has been identified as an important risk factor for psychoses, with up to 32% of individuals with VCFS developing a psychotic illness. Individuals with VCFS thus form a unique group to identify and explore early symptoms and biological correlates of psychosis. In this study, we examined if cortical gyrification pattern, i.e. gyrification index (GI) can be a potential neurobiological marker for psychosis.

Method: GIs of 91 individuals with VCFS were compared with 29 siblings and 54 controls. Further, 58 participants with VCFS, 21 siblings and 18 normal controls were followed up after 3 years and longitudinal …

Coronary Artery Bypass Grafting After Percutaneous Coronary Intervention, Syed Shahabuddin, Syed Ahmed Sami, Junaid Alam Ansari, Shazia Perveen, Shumaila Furnaz, Saulat H. Fatimi, Hasanat Sharif

Section of Cardiothoracic Surgery

Following percutaneous intervention (PCI), restenosis, progression of disease and multi-vessel involvement may require further intervention in the form of surgical revascularization. Patients with coronary artery bypass grafting (CABG) done after PCI were evaluated to find out the reason for the need of surgical revascularization. Over a period of 12 months, 610 patients underwent CABG. Out of them, 34 patients had previous PCI/stenting. Coronary risk factors including hypertension in 85%, diabetes mellitus in 60%, dyslipidemia in 60%, tobacco use in 50% and a positive family history was present in 53% of the patients. All patients were symptomatic. Multi-vessel disease was present …

The Efficacy Of An Audio Program And Discussion Guide In Promoting Exclusive Breastfeeding In Cameroon, Africa, Kathryn R. Reinsma

Loma Linda University Electronic Theses, Dissertations & Projects

Background: In the Northwest Region of Cameroon, approximately 90% of women initiate breastfeeding; however, only 34% continue exclusive breastfeeding for the recommended six months (Kakute, et al., 2005; WHO, 2008). Entertainment-education is a mass-media communication strategy of placing educational information into media such as television programs, movies, and radio programs (Siegel & Lotenberg, 2007). This form of behavioral change communication has proven effective in addressing health-related issues in developing countries.

Purpose: The aim was to design an audio program and discussion guide to test the hypothesis that an audio program and discussion guide improves exclusive breastfeeding knowledge, beliefs, benefits, self-efficacy, …

Prenatal Alcohol Exposure Effects On Nmda Receptor Subunit Composition And Function In The Mouse Dentate Gyrus, Megan Brady

Biomedical Sciences ETDs

Moderate prenatal alcohol exposure (PAE) in humans leads to learning and memory impairments later in life. The range of physical, behavioral, emotional, and social dysfunctions that are associated with PAE are collectively termed fetal alcohol spectrum disorder (FASD). It is estimated that approximately 12% of women consume alcohol at some time during their pregnancy and as many as 5% of children born in the United States are impacted by PAE. Extensive research has shown that even moderate maternal drinking (1-2 drinks per day) is, in some individuals, associated with cognitive and behavioral deficits. Existing models for PAE have been useful …

Assessment Of Field Effect In The Cancerous Prostate, Christina M. Haaland

Biomedical Sciences ETDs

Prostate cancer is the second leading cause of cancer death in men. Prostate Specific Antigen (PSA) is the current indicator of prostate health, and needle core biopsy of the prostate is the standard of cancer diagnosis. However, PSA is not a specific indicator of cancer, and biopsy may miss actual tumor cells, leading to both false positive and false negative results, respectively. Therefore, better indicators of prostate cancer need to be identified. Field effect is the term used to describe the existence of genetically altered, although histologically normal, cells that surround an area of frank cancer. Better understanding and characterization …

Mechanisms Of Hydrogen Sulfide Induced Vasodilation, Olan Jackson-Weaver

Biomedical Sciences ETDs

Myogenic tone is an important regulator of blood flow and may contribute to peripheral vascular resistance and blood pressure. Myogenic tone is a luminal pressure-induced constriction of the vasculature that is mediated by a vascular smooth muscle cell (VSMC) plasma membrane potential (Em) depolarization and Ca2+ influx. Ca2+ sparks, which are ryanodine receptor (RyR) mediated Ca2+ release events, oppose myogenic tone by activating large-conductance Ca2+-activated K+ channels (BKCa) to hyperpolarize VSMC Em. The gaseous signaling molecules (gasotransmitters) NO and CO activate Ca2+ sparks to cause vasodilation. H2S, a third gasotransmitter produced by cystationine γ-lyase (CSE) in the vasculature, activates several …

Antibody-Mediated Protection Against Pulmonary Infection With Virulent Type A Francisella Tularensis, Gopi Mara-Koosham

Biomedical Sciences ETDs

Respiratory infections with the virulent type A strains of Francisella tularensis (Ft) cause pneumonic tularemia, an illness which results in high case fatalities in the absence of timely antibiotic treatment. Although immunization is an effective countermeasure, vaccines against pulmonary tularemia are currently unavailable. A better understanding of protective immune components is therefore needed to develop licensable vaccines against pulmonary tularemia. While the indispensability of cell-mediated immunity in protection against this gram-negative intracellular bacterium is well-documented, the protective role of antibodies (Abs) is unclear. Hence we examined the role of humoral immunity by developing a passive immunization model of respiratory tularemia …