Medicine and Health Sciences Commons^™

N-Glycosylation Dictates Proper Processing Of Organic Anion Transporting Polypeptide 1b1, Juan Yao, Weifang Hong, Jiujiu Huang, Kai Zhan, Hong Huang, Mei Hong

School of Information Faculty Publications

Organic anion transporting polypeptides (OATPs) have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion (ADME) of various drugs, xenobiotics and toxins. Putative N-glycosylation sites located in the extracellular loops 2 and 5 is considered a common feature of all OATPs and some members have been demonstrated to be glycosylated proteins. However, experimental evidence is still lacking on how such a post-translational modification affect the transport activity of OATPs and which of the putative glycosylation sites are utilized in these transporter proteins. In the present study, we substituted asparagine residues that are possibly involved in N-glycosylation with …

Missing Drivers With Dementia: Antecedents And Recovery, Meredeth Rowe, Catherine Greenblum, Marie Boltz, James E. Galvin

Nursing Faculty Publications

Objectives: To determine the circumstances under which persons with dementia become lost while driving, how missing drivers are found, and how Silver Alert notifications are instrumental in those discoveries.

Design: A retrospective, descriptive study.

Setting: Retrospective record review.

Participants: Conducted using 156 records from the Florida Silver Alert program for October 2008 through May 2010. These alerts were issued in Florida for missing drivers with dementia.

Measurements: Information derived from the reports on characteristics of the missing driver, antecedents to missing event, and discovery of a missing driver.

Results: The majority of missing drivers were men aged 58 to 94 …

Path Tortuosity In Everyday Movements Of Elderly Persons Increases Fall Prediction Beyond Knowledge Of Fall History, Medication Use, And Standardized Gait And Balance Assessments., William D. Kearns Phd, James L. Fozard Phd, Marion Becker Rn/Phd, Jan M. Jasiewicz Phd, Jeffrey D. Craighead Phd, Lori Holtsclaw Ba, Charles Dion Ma

William D. Kearns, PhD

Abstract Objectives: We hypothesized that variability in voluntary movement paths of assisted living facility (ALF) residents would be greater in the week preceding a fall compared with residents who did not fall. Design: Prospective, observational study using telesurveillance technology. Setting: Two ALFs. Participants: The sample consisted of 69 older ALF residents (53 female) aged 76.9 (SD=11.9 years). Measurement: Daytime movement in ALF common use areas was automatically tracked using a commercially available ultra-wideband radio real-time location sensor network with a spatial resolution of approximately 20 cm. Movement path variability (tortuosity) was gauged using fractal dimension (fractal D). A logistic regressionwas …

Day-To-Day Variability In Nap Duration Predicts Medical Morbidity In Older Adults, Natalie D. Dautovich, Daniel B. Kay, Michael L. Perlis, Joseph M. Dzierzewski, Meredeth Rowe, Christina S. Mccrae

Nursing Faculty Publications

Objective: The objectives for the present study were to (a) examine within-person variability of nap duration and (b) assess how variability in nap duration is related to the number of health conditions in a sample of older adults. For highly variable behaviors such as sleep, it is important to consider fluctuations within the person instead of solely comparing averages of behaviors across persons. Method: Data were drawn from a previous study examining sleep in 103 community-dwelling older adults. Subjective estimates of napping behavior were obtained from sleep diaries and objective estimates of napping behavior were obtained using actigraphy. Both measures …

Relationships Of Heat Stress Levels To Heat-Related Disorders And Acute Injury During Deepwater Horizon Cleanup Operations, Michael H. Hiles

USF Tampa Graduate Theses and Dissertations

Outdoor workers are often subjected to thermal conditions beyond the comfort zone, but to what degree do such conditions affect the health and safety of those workers is still a matter requiring further investigation. The purpose of this study is to examine the relationship between thermal conditions and (1) heat-related disorders and (2) acute injuries using injury and illness data collected during the BP Deepwater Horizon clean-up operations. Over an eleven month period, 5,485 cases were identified as either heat-related or an acute injury (incident type) and further divided by severity. Daily weather data were used to estimate the wet …

Analysis Of Variable Effects On Presence Of Cryptosporidium Oocysts And Giardia Cysts In Effluent Water From Wastewater Treatment Utilities In Florida From 1998 To 2010, Katherine Jane Barkan

USF Tampa Graduate Theses and Dissertations

The concern of a Cryptosporidium or Giardia waterborne outbreak due to treated wastewater has had water treatment utilities using some of the highest water cleansing technologies available. Cryptosporidiosis and Giardiasis are severe diarrheal diseases which can lead to death, thus it is important that appropriate steps are taken to assure these parasites are not present in the effluent of treated wastewater. This study examined the results of 863 assays for Giardia and Cryptosporidium on the effluent of wastewater treatment facilities and found that county of collection, watershed of collection, and laboratory analyzing the sample have the most significant impact on …

Systematic Review Of Core Muscle Electromyographic Activity During Physical Fitness Exercises, Jason Martuscello

USF Tampa Graduate Theses and Dissertations

Activating the core muscles through exercise training programs is believed to be important for athletic performance. Considerable attention has been credited to the lumbar multifidus, transverse abdominis, and quadratus lumborum in designing exercise training programs. Numerous core exercise claims and recommendations abound in the fitness and physical therapy communities touting a superior core challenge for these muscles. The plethora of core activation literature with conflicting outcomes has convoluted the process of choosing exercises for an optimal core training approach. Although an abundance of research studies have quantified the muscle activity, collectively, a consensus on the type of exercise that elicits …

Transformation Of Stimulus Function Through Relational Networks: The Impact Of Derived Stimulus Relations On Stimulus Control Of Behavior, Samantha Rose Florentino

USF Tampa Graduate Theses and Dissertations

Relational Frame Theory research involves either of two protocols utilized to establish relational networks and functions for stimuli in those relational networks. Years of research indicate the most prevalent method involves first establishing a relational frame, conditioning one of the stimuli to acquire a particular function, and then providing a test to see if the function trained to one of the stimuli in the network transferred through the relational network to other stimuli. The less common method involves first training a particular function for a stimulus, entering that stimulus in a relational network with at least two other stimuli, and …

The Effects Of Cognitive Stimulation And Computerized Memory Training Among Older Adults Residing In Indepedent-Living Facilities, Elizabeth M. Hudak

USF Tampa Graduate Theses and Dissertations

Background: With age, older adults experience declines in both short- and long-term memory. One way to counter these age-related declines is through memory interventions which include computerized cognitive training and non-computerized cognitive stimulation. This dissertation examined whether a cognitive training program, Dakim BrainFitness (Dakim Inc., 2002) and a program of cognitive stimulation, Mind Your Mind (Seagull & Seagull, 2007), enhance memory performance among cognitively-intact older adults residing in independent-living retirement communities. Specifically, the following research questions were proposed: (a) How effective is the computerized cognitive training program in improving memory performance relative to the cognitive stimulation program or a no-contact …

Inspiratory Breathing Exercises For Vocal Tremor: A Preliminary Study, Jessica Tayseer Hilo

USF Tampa Graduate Theses and Dissertations

Essential voice tremor (EVT) is a voice disorder that results from dyscoordination within the laryngeal musculature, which negatively impacts the symmetrical motion of the vocal folds. Several investigators have shown that individuals with EVT experience difficulty speaking and a reduced quality of life (QOL; Cohen, Dupont, & Courey, 2006; Verdonck-de Leeuw & Mahieu, 2004). While traditional voice therapy has been ineffective in lessening the severity of vocal tremor, a current approach (Barkmeier- Kraemer, Lato, & Wiley, 2011) designed to lessen the perception of vocal tremor has resulted in reported patient satisfaction with little actual change in voice quality. The present …

Responsiveness Of The Federal Health System To The Needs Of 18-45 Year Old Adults With Physical Disabilities In Islamabad, Pakistan, Shaista Habibullah

USF Tampa Graduate Theses and Dissertations

Abstract

The health system has been defined as all people, institutions and resources that undertake actions with the primary intent of improving health, while responsiveness of the health system refers to its objective of responding to the legitimate expectations of the population it serves. Although responsiveness is a non-health objective of the health system, it affects the health status of the population by influencing treatment compliance, patient-provider communication and health services utilization. Furthermore, responsiveness has a fundamental value as it concerns basic human rights of the individuals being served by the health system.

This study was undertaken to determine how …

Beliefs Of And Attitudes Toward Sexual Violence By A Diverse Group Of Self-Identified Male Collegiate Athletes, Belinda-Rose James

USF Tampa Graduate Theses and Dissertations

The objective of this research was to assess the beliefs of and attitudes towards sexual violence among self-identified male, undergraduate, athletes and non-athletes. Research has shown that there is an association between the subculture of athletics and the beliefs and attitudes towards sexual violence. Male, undergraduate, athletes have disproportionately been reported for sexual violence. This study examined common risk factors attributed to perpetration of sexual violence: rape myth acceptance, lower attitudes toward women, reactive aggression, and physical and verbal sexual coercion. Multiple-level risk factors were studied in order to acquire a comprehensive understanding of what possible associations between male collegiate …

The Relationship Between Self-Reported Cancer Pain And Personality In Black And White Older Adults Receiving Outpatient Cancer Care, Jessica Krok

USF Tampa Graduate Theses and Dissertations

It is well-established that personality not only affects physical health and longevity, but also mental health and coping mechanisms. One area of limited research is the relationship between cancer pain and personality. This study examined how personality traits affect reported cancer pain severity in older patients (N = 150) receiving outpatient treatment at a comprehensive cancer center. Participants were interviewed regarding their pain severity, personality, affect, and self-efficacy for pain management. Symptom data were collected from the Brief Pain Inventory, while personality data were gathered from the Ten Item Personality Inventory and the Positive and Negative Affect Schedule. Self-efficacy for …

Exploring Picture Word Priming Effects In Healthy Aging Adults Using Event Related Potentials, Sasha C. Christopher

USF Tampa Graduate Theses and Dissertations

Objective: The aim of the present study was to investigate the mechanics with which older adults activate and access different subdomains of their mental lexicons during word retrieval for picture naming.

Method: Data were analyzed for 12 aging, native English speakers who performed a picture-word priming task. The auditory probe words were presented in the following conditions in relation to the picture stimuli: Identically related, strongly semantically related, weakly semantically related, strongly phonologically related, weakly phonologically related, semantically related to the strong phonological relative of the target picture label, or phonologically-related to the strong semantic relative of the target picture …

Assessing The Psychometric Properties Of A Self-Efficacy Measure Within A Patient Navigation Research Program, Mariana Arevalo

USF Tampa Graduate Theses and Dissertations

There is a dearth of validated self-efficacy (SE) measures in the field of preventive oncology. The objective of this study is to describe the development and validation of a measure to assess patients' perceived ability to obtain the recommended care following an abnormality suspicious for breast cancer. Guided by a social cognitive theory framework, a 51-item measure was developed to explore perceived capability to obtain follow up care under a number of barriers. A multi-step process was utilized to assess the instrument's psychometric properties. First, cognitive validity assessments with experts were conducted, and these aided in the wording refinement of …

Human Motion Tracking For Assisting Balance Training And Control Of A Humanoid Robot, Ahmad Adli Manasrah

USF Tampa Graduate Theses and Dissertations

Abstract

This project illustrates the use of the human's ability to balance according to his center of gravity as demonstrated in two applications. The center of gravity of a human is explained in detail in order to use it in controlling the Aldebaran NAO robot and in the robot-assisted balance training.

The first application explains how a humanoid robot can mimic a human's movements via a three dimensional depth sensor where the sensor analyzes the position of a user's limbs and how the robot can lift one foot and balance on the other by redistributing the its body mass when …

A Study Of Potential Risk Factors Of Depression Among Latina Breast Cancer Survivors, Claudia Ximena Aguado Loi

USF Tampa Graduate Theses and Dissertations

Women with breast cancer commonly experience depression. However, this condition often goes unrecognized, undertreated, and understudied, especially in ethnic minorities. If left untreated, co-existing depression in women with cancer can complicate cancer treatment, lead to poor treatment adherence for both conditions, and decrease survival. These negative consequences are considerably higher among Latinas. With the growing number of Latinos and diversity within the Latino community, the literature has identified the need to disaggregate Latinos by region of origin. Unfortunately, few studies account for these differences and no study to date has examined risk factors of depression among Latinas diagnosed with breast …

Patient Care Provider Safety: Examining One Intervention To Reduce Hospital Violence, Paul Leslie Ford

USF Tampa Graduate Theses and Dissertations

Abstract

In the summer of 2009, Tampa General care providers met with Hospital Administration to express concern that violence on care units was a growing problem and making it difficult to provide quality care. Nurses stated that such violence was one important reason many of their peers choose to retire. Administration took this situation seriously and formed a committee to gather information and submit suggestions to reduce the violence. The committee consisted of representatives from several nursing units, human resources, risk management, security, and administration. Duties assigned included investigation of the actual number of reports on all units and trends. …

Social Skills Training For Adolescent Youth: Measurement Of Skill Acquisition, Shannon Koehler

USF Tampa Graduate Theses and Dissertations

Abstract

This study evaluated the effectiveness of a classroom based training in teaching social skills to four adolescent females between the ages of 13–17 years old and residing in foster care. The training took place over a three week period, one night a week, for three hours at a time and utilized a Behavioral Skills Training format. The assessments were conducted via role play scenarios; pre- and posttraining. The results show each participant demonstrated an overall increase in skills from pretraining to posttraining indicating that youth in foster care were capable of learning the skills taught.

An Evaluation Of The Implementation Of "The Happiest Toddler On The Block" Parenting Strategies By Young Mothers, Amye Elizabeth Bock

USF Tampa Graduate Theses and Dissertations

Young parents and their children are considered a high-risk population as they are more likely to lack social support networks, have limited access to opportunities to enhance parenting skills, and are often financially dependent. Young children whose mothers have poor parenting skills are more likely to have persistent problem behavior. Three young mothers living in a transitional housing facility participated in this study. The purpose of this study was to determine if these mothers could implement parenting strategies that are a part of a commercially available parenting book and DVD. This study found that: (1) mothers were able to correctly …

Training And Assessment Of Toothbrushing Skills Among Children With Special Needs, Rachel A. Brown

USF Tampa Graduate Theses and Dissertations

The success of applied behavior analysis (ABA) interventions relies heavily on adherence to measures of social importance. One area identified by caregivers, educators, and researchers as having social importance is the area of daily living skills; particularly in populations of children with special needs. A number of studies employed the use of a task analysis to objectively measure toothbrushing, with various training procedures utilized. Behavioral Skills Training (BST) is an effective procedure used to train a variety of skills. Further, research indicates the addition of an in situ assessment promotes generalization of trained skills. The current study examined the use …

Toward A Working Theory Of Neurorhetorics, Jeffrey L. Honnold

USF Tampa Graduate Theses and Dissertations

This piece makes the claim that rhetoric is first philosophy--before philosophy, epistemology, ontology, or any other field--or that rhetoric is, at the least, on equal footing as these fields because:

empathy--and thusly the impulse for communication--is physiologically hardwired into humans; special distinctions between human and animal are largely artificial constructions, as is evidenced by neurosciences; "hard" science, in the form of neurosciences, is providing entrance points & opportunities for rhetoric to raise its status within the academy; and said neurosciences, in addition to empathy studies, have shown strong evidence supporting linguistic and evolutionary links between humans and other species, thereby …

A Cross-National Analysis Of The Human Papillomavirus, Sexually Transmitted Infections, And Sexual Behavior Among Men, Euna Marie August

USF Tampa Graduate Theses and Dissertations

There is a paucity of research on the risk for sexually transmitted infections (STIs) and sexual behavior among general populations of men. Research with male populations predominantly has focused on those subgroups considered to be at high risk of disease transmission, such as gay and bisexual men, injection drug users, and adolescents/young adults. Considerably fewer studies have examined factors among men, in general, and heterosexual men, specifically. Therefore, I conducted analyses with a cross-national sample of adult, sexually active men in Brazil, Mexico, and the United States to investigate sexual behaviors and risk factors associated with the human papillomavirus (HPV) …

Daily Experiences Of Older Adults With Mild Cognitive Impairment, Elizabeth Hahn

USF Tampa Graduate Theses and Dissertations

Rationale and study aims: Persons with mild cognitive impairment (MCI) experience declines in everyday functioning and cognitive performance greater than what is experienced in normal aging but less than that of dementia. Daily stress and daily memory complaints associated with cognitive deficits may contribute to greater psychological distress in the day-to-day experiences of persons with MCI. However, research examining the occurrence of daily stressors, daily memory complaints and psychological distress in MCI is limited, and it is not clear how the daily processes of stress and affect in persons with MCI compare to cognitively healthy older adults. This dissertation examined …

Housing And Housing Services Program Measure – Veterans Version (Hhspm-V), Colleen Clark, M. Scott Young, Sarah R. Moody, Gregory Teague, Rhonda Ort, James Winarski, Kathleen Moore, Minnie Norton, Blake Barrett

Mental Health Law & Policy Faculty Publications

No abstract provided.

The Role Of Hsp70 In Cancer: A Study Of The Hsp70 / Akt Relationship, John Koren

USF Tampa Graduate Theses and Dissertations

The Hsp70 family of molecular chaperones is essential for

protein folding, re-folding misfolded client proteins, clearance

of aberrant client proteins, and can also inhibit programmed

cell death. There are two major cytosolic members of this

family: the constitutive Hsc70, and the inducible Hsp72. Under

stress conditions the Hsp70 family protects the cell from

protein related damage by the induction of Hsp72. Hsc70 and

Hsp72 are highly homologous with minor differences in

substrate binding. In cancers, Hsp72 is commonly induced and

this induction is thought to aid in cancer cell survival. In these

studies we demonstrate the differential regulation of the …

Predator-Based Fear Conditioning: A Novel Approach To The Study Of The Neurobiology Of Memory, Joshua D. Halonen

USF Tampa Graduate Theses and Dissertations

This series of experiments developed novel paradigms involving the integration of conventional and ethologically relevant forms of reinforcement in the study of fear conditioning in rats. Experiment 1 compared the effects of foot shock, immobilization and predator exposure, alone and in combination, on the expression of conditioned fear memory and extinction. The combination of all 3 reinforcers produced a significantly stronger fear memory and greater resistance to extinction, compared to when each reinforcer was administered alone. Furthermore, whereas conditioning with foot shock, alone, resulted in rapid extinction of the fear memory, the combination of immobilization and cat exposure, or all …

Enhancing The Immune Response Through Ikkbeta-Induced Activation Of Nf-Kappab, Emily Hopewell

USF Tampa Graduate Theses and Dissertations

Nuclear factor-κB (NF-κB) is one of the main regulators of inflammatory and immune responses. It is a family of transcription factors composed of five members: RelA, RelB, cRel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Homo- and hetero-dimers of family members are inhibited by inhibitor of &klappaB (IκB) family members and activated by IκB kinase (IKK) family members. The IKK family is comprised of IKKα, IKKΒ, and IKKγ. The focus of my dissertation delves into the role of NF-κB activation by IKKΒ in both an immunotherapy setting and its role in T cell mediated anti-tumor immune responses.

A central focus of immunotherapy …

Regulation Of Natural Killer Cells: Ship-1, 2b4, And Immunomodulation By Lenalidomide, Nicole Renee Fortenbery

USF Tampa Graduate Theses and Dissertations

Natural Killer cells (NK) are critical components of the innate immune system. Often referred to by their morphology, these large granular lymphocytes (LGLs) are bone marrow-derived lymphocytes and can be found throughout the body. NK cells reside in the liver, lymph nodes, spleen, thymus, and mucosal-associated lymphoid tissues (MALT). Importantly, NK cells also circulate throughout the blood where they function as surveyors of the body and are armed to eliminate malignant, infected, damaged, or foreign cells.

NK cells function by a dual receptor system. That is, NK receptors are broadly categorized as inhibitory or activating. It is a fine balance, …

Interrogating Grenadian Masculinities And Violence Against Women: An Evaluation Of The United Nations Partnership For Peace Program, Rohan Dexter Jeremiah

USF Tampa Graduate Theses and Dissertations

This applied anthropology study, guided by a feminist perspective and in particular, Black Feminist Thought is an outgrowth of an evaluation study of the Partnership for Peace Program (PFP) in Grenada, West Indies. The PFP is a Caribbean-specific model that was built into a sixteen-week cycle program by the United Nations Entity for Gender Equality and Empowerment of Women (UNWomen). Since 2005, the PFP has been geared towards Grenadian men, who have used violence against women to express their masculine identities. PFP focuses exclusively on rehabilitating male perpetrators with a goal to protect the human rights of women. This research …