Medicine and Health Sciences Commons^™

Uptake And Toxic Effects Of Surface Modified Nanomaterials In Freshwater Aquatic Organisms, Brandon Seda

All Dissertations

Nanomaterials are a class of materials with unique properties due to their size, and the association of these properties with the toxicity of nanomaterials is poorly understood. The present study assessed the toxic effects of stable aqueous colloidal suspensions of three distinctly different classes of nanomaterials in aquatic organisms. The fullerene, C70, was stabilized through non-covalent surface modification with gallic acid. Toxicity of C70-gallic acid was confirmed to exhibit similar toxic effects as C60-fullerene, including changes in antioxidative processes in Daphnia magna. Daphnia magna fecundity was significantly reduced in 21d bioassays at C70-gallic concentrations below quantifiable limits (0.03 mg/L C70). …

Program Implementers' Evaluation Of The Project P.A.T.H.S.: Findings Based On Different Datasets Over Time, Daniel T. L. Shek, Cecilia M. S. Ma

Pediatrics Faculty Publications

This paper integrates the evaluation findings based on program implementers in nine datasets collected from 2005 to 2009 (244 schools and 7,926 implementers). Using consolidated data with schools as the unit of analysis, results showed that program implementers generally had positive perceptions of the program, themselves, and benefits of the program, with more than four-fifths of the implementers regarding the program as beneficial to the program participants. The subjective outcome evaluation instrument was found to be internally consistent. Multiple regression analyses revealed that perceived qualities of the program and program implementers predicted perceived effectiveness of the program. In conjunction with …

Racemization Of Amino Acids In Teeth For The Determination Of Age, Andrea Lee Toll

Masters Theses & Specialist Projects

Instrumental to forensic investigations is the ability to identify unknown human remains providing key evidence to criminal cases, resolution to missing persons, and assistance in mass or natural disasters. Identification of remains in an effort to determine age is an area of forensics that has received considerable attention. Traditional methods in age determination such as morphology are often biased, antiquated, and frequently result in a large margin of error. Conversely, the emergence of new forensic techniques provide promise to reduce the margin of error in determining age. One such technique has focused on relating the extent of amino acid racemization …

Spatiotemporal Coupling Of The Tongue In Amyotrophic Lateral Sclerosis, Mili S. Kuruvilla, Jordan R. Green, Yana Yunusova, Kathy Hanford

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: The primary aim of the investigation was to identify deficits in spatiotemporal coupling between tongue regions in amyotrophic lateral sclerosis (ALS). The relations between disease-related changes in tongue movement patterns and speech intelligibility were also determined.

Methods: The authors recorded word productions from 11 individuals with ALS with mild, moderate, and severe dysarthria using an x-ray microbeam during word productions. A coupling index based on sliding window covariance was used to determine disease-related changes in the coupling between the tongue regions across each word.

Results: The results indicated decreased spatiotemporal coupling of mid-posterior tongue regions and reduced tongue speed …

Designing An "Information-Experience" Using Creativity Science Theory And Tools, Stephanie Belhomme

Creativity and Change Leadership Graduate Student Master's Projects

An “information-experience” encapsulated by a technological/digital audio-visual tool presents data and potentially meaningful information to prompt actionable knowledge concerning: “unspoken creative process elements;” their profound impacts on both how well our “physiology of creativity” functions; but also on how well foundational creative thinking and behavioral prerequisites (energy, motivation, imagination, and ownership) are leveraged.

The product: 1) introduces the user to one component of the CPS (Creative Problem Solving) Facilitation Process - Exploring the Challenge; 2) features a content specific component which prompts exploration of the many correlations between societal, organizational / community, human physiological / behavioral data, and the direct …

Late Spring 2012, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Late Spring 2012

Native American Health Information Resources On The Internet, Patricia Bradley

Native Health Database project records

Presentation about the Native Health Database.

New Dentist News (May 2012), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Effects Of Moderate Swim Exercise On Adiposity And Metabolic Function In Mice, Roberta L. Pohlman, Ana Carneiro, Vera Farah, Lynn K. Hartzler, Mariana Morris

Biological Sciences Faculty Publications

No abstract provided.

Vital Signs, Summer 2012, Boonshoft School Of Medicine

Vital Signs

A forty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Housing And Housing Services Program Measure – Veterans Version (Hhspm-V), Colleen Clark, M. Scott Young, Sarah R. Moody, Gregory Teague, Rhonda Ort, James Winarski, Kathleen Moore, Minnie Norton, Blake Barrett

Mental Health Law & Policy Faculty Publications

No abstract provided.

Himmelfarb Headlines - May/June 2012, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on data management plans for research, multi-search service, and profiles of Brenda Helen Sheingold, Phd, RN, and Paul Levett.

Fotonovelas: A Parent Resource And Education Guide For Underserved Hispanic Families With Autism In Marin County, Tiffany Chi, Monica Christina Guzman Critchfield, Isaac Xuliang Stahlhut

Dissertations, Masters Theses, Capstones, and Culminating Projects

The current estimated prevalence of autism in the United States is 1 out of 88 children, up from 2006 when the estimated prevalence of autism was 1 out of 110 (Centers for Disease and Prevention, 2012). Increasing numbers are a major concern because there is a greater need for services for individuals with autism. According to Kidsdata (2010), approximately 5.7% of Marin County of California’s population of children has a diagnosis of autism. The Hispanic community forms the largest minority group in Marin County, consisting of 15.5% of the population (US Census Bureau, 2010). This community was the target underserved …

The Role Of Faith And Spirituality In The Work Of End-Of-Life Caregivers, Edward P. Stannard

Master of Arts in Religious Studies (M.A.R.S. Theses)

Nurses, certified nursing assistants and other healthcare workers who care for those who are terminally ill face issues of mortality and even existential questions every day on the job. These professionals, who have intimate contact with their patients daily, must find an inner source of strength and perseverance in order to face people who are at the end of their lives, who may be in pain, and who frequently are alone in their rooms aside from the institution’s staff. This study asks whether an inner sense of religious faith or spirituality helps end-of-life healthcare workers conduct their daily tasks and …

Securing South Africa's Future Grandmothers Against Poverty And Aids As A Model For Social Development Change, Savannah Lynn Eck

Graduate Program in International Studies Theses & Dissertations

Focusing on the role of elder women in South Africa as a lens to understand the central connections among HIV/ AIDS, poverty and Human Security provides a distinct approach to analyze women's contributions to community development and social change. Drawing from the theories of Gender and Development and Human Security, this research aims to highlight HIV/ AIDS as a social and political security issue, while underscoring the vitality of the inclusion of women in the processes of peace building, reconciliation, education and social development. Furthermore, the influential role of elder women in South Africa will serve as a model in …

Functions Of Autophagy In Lipid Homeostasis And Survival In Androgen-Dependent Prostate Cancer Cells, Ramesh Raj Kaini

Biomedical Sciences ETDs

Androgen deprivation therapy, one of the standard treatments for prostate cancer, induces apoptosis as well as autophagy in androgen-responsive PCa cells. As modulation of autophagy is a new paradigm for enhancing the therapeutic efficacy of various cancer therapies, we sought to determine the functions of autophagy during androgen deprivation. In this study, we confirmed that androgen removal or inhibition induces autophagy in two different hormone sensitive prostate cancer cells. Androgen deprivation also caused depletion of lipid droplets which was abrogated on inhibition of autophagy by pharmacological means (3-methyladenine, bafilomycin A1) or using a genetic approach (Atg5 siRNA). In addition, colocalization …

Orientation For Increased Volunteer Effectiveness With Midwives For Haiti, Kelly Toner

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Complications during pregnancy, childbirth, and early infancy claim the lives of millions of mothers and newborn infants across the globe each year. The cause: lack of access to maternal education, medical check-ups, and skilled birth attendants. The unfortunate fact is that death from these complications is largely preventable. Even more astonishingly, maternal infant mortality is only getting worse as time passes. In the country with the highest maternal infant mortality rate in the world, one organization strives to create change from within. Functioning on the premise that “change can occur one person at a time, and through the efforts of …

Novel Mechanisms Of Androgen Receptor Degradation By Alpha-Tocopherylquinone And Curcumin Analog 27, Alexandra Marie Fajardo

Biomedical Sciences ETDs

Defining underlying molecular mechanisms exploited by cancer cells in their development and progression provides a necessary foundation for experimental therapeutics. The androgen receptor (AR) is a known therapeutic target for prostate cancer (CaP) given its well-established role in both the development and progression of CaP. The AR is a ligand activated transcription factor that regulates the expression of many genes involved in proliferation and differentiation. Identifying agents that down-regulate AR expression may elucidate mechanism(s) for selectively targeting the AR. Two related agents of the natural products curcumin and vitamin E, curcumin analog 27 (ca27) and alpha-tocopheryl quinone (TQ), respectively were …

Population Dynamics Of Flaviviruses In The United States, Kendra Pesko

Biomedical Sciences ETDs

The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA viruses have higher mutation rates than DNA viruses, because their virally encoded RNA dependent RNA polymerase has no proofreading activity. These viruses have been shown to exist within and between hosts as swarms of closely related mutant genomes that can be examined through sequence analysis. In the work presented here we focus on the population dynamics of two zoonotic flaviviruses that cause human morbidity and mortality in the United States: tick-borne Powassan virus (POW) and …

Latino/Hispanic Young Men And Health Beliefs, Acculturation, And Emerging Adulthood: An Exploratory Study, Peter Andrew Guarnero

Biomedical Sciences ETDs

The purpose of the study was to identify factors that influenced health promotion behaviors in Latino/Hispanic mens health, including their experiences and health concerns. Acculturation, emerging adulthood and health were the three key ecological variables used in the study. The sample consisted of 16 Latino/Hispanic young men who were students at a Hispanic-serving university in the Southwestern United States. The study consisted of two data collection sessions. Session one consisted of a semi-structured individual interview and completion of a demographic questionnaire, two acculturation scales, a health promoting lifestyle scale, and visual analog scales for overall health perceptions and quality of …

Multifunctional Iron Platinum Stealth Immunomicelles: Targeted Imaging And Therapy Of Prostate Cancer, Robert M. Taylor

Biomedical Sciences ETDs

In the United States, prostate cancer is the second most common reason for cancer death in men. No imaging methods currently exist which are specific for detecting, imaging, and treating extracapsular or metastatic prostate cancer. The goal of this research was to develop novel nanoparticles that would specifically target human prostate cancer cells and simultaneously deliver a chemotherapeutic agent and superior magnetic resonance imaging (MRI) contrast agent to the prostate cancer cells for both therapy and MRI detection. This dissertation describes the synthesis and comprehensive characterization of superparamagnetic iron-platinum nanoparticles (SIPPs) and their subsequent encapsulation with the drug Paclitaxel, using …

Impact Of Structured Meetings On The Learning Of Faculty Members, Ambreen Usmani, Rehana Rehman, Shazia Babar, Azam Afzal

Department of Continuing Professional Education

Objective: To determine impact of structured meetings on learning and faculty development
Methodology: The observational cross sectional study was conducted at Bahria University Medical &
Dental College from October 2010 to March 2011. Feed back of all faculty members of university was
acquired on weekly structured meeting (with alternating theme of journal club and problem based scenario
presentation) by a self reported questionnaire. The responses obtained on a 5-point Likert scale were
divided into two groups; I, senior faculty (professors, associates and assistants) II, junior faculty
(lecturers). Chi square test was applied to compare categorical variables and results considered significant …

Depression And Evangelical Christian Spirituality: Exploring A Theoretical Model, Katheryn Jane Klukow

Masters Theses and Doctoral Dissertations

While religious involvement, particularly intrinsic religiosity or spirituality, has shown a significant inverse relationship with depression, this relationship is complex and multifaceted and several decades of study have yet to reveal a clear pattern. This work is a survey of the current research on the etiology and symptomology of depression and its interaction with spirituality. This work is testing a new model that views the effects of depression on spirituality as a function of an individual’s perceived relationship with God. A survey was distributed to a sample of 135 evangelical Christians. Depressed persons made up approximately 16% of the sample. …

Distribution, Elimination, And Biopersistence To 90 Days Of A Systemically Introduced 30 Nm Ceria-Engineered Nanomaterial In Rats, Robert A. Yokel, Tu C. Au, Robert Macphail, Sarita S. Hardas, D. Allan Butterfield, Rukhsana Sultana, Michael Goodman, Michael T. Tseng, Mo Dan, Hamed Haghnazar, Jason M. Unrine, Uschi M. Graham, Peng Wu, Eric A. Grulke

Pharmaceutical Sciences Faculty Publications

Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture, and is being pursued as an antioxidant therapeutic. Our objective is to extend previous findings showing that there were no reductions of cerium in organs of the mononuclear phagocyte (reticuloendothelial) system up to 30 days after a single nanoscale ceria administration. An ~5% aqueous dispersion of citrate-stabilized 30 nm ceria, synthesized and characterized in-house, or vehicle, was iv infused into rats terminated 1, 7, 30, or 90 days later. Cageside observations were obtained daily, body weight weekly. Daily urinary and fecal cerium outputs were …

Student Experience In Optometry Education In Mozambique: Initial Challenges In An International Collaborative Program, Kajal Shah

Conference Papers

Purpose:

One of the solutions to creating sustainable eye care structures is education of personnel. Mozambique currently has only 17 ophthalmologists for a population of 21 million and 34 trained Ophthalmic Technicians, the only two providers of refraction services within the local health system. There are no optometrists. The Mozambique Eyecare Project is funding the training of the country’s first optometrists at the University of Lurio in Nampula, Mozambique. Their core competencies will be evaluated with a view to creating best practise in education in a developing world environment.

Method:

This is a longitudinal evaluation of the refraction competencies …

Improving Health Care Quality And Safety: The Development And Assessment Of Laparoscopic Surgery Instrumentation, Practices And Procedures, Bernadette Mccrory

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Adverse events due to medical errors are a leading cause of death in the United States exceeding the mortality rates of motor vehicle accidents, breast cancer and AIDS. Improvements can and should be made to reduce the rates of preventable surgical errors since they account for nearly half of all adverse events within hospitals. Although minimally invasive surgery has proven patient benefits such as reduced postoperative pain and hospital stay, its operative environment imposes substantial physical and cognitive strain on the surgeon increasing the risk of error. In order to mitigate errors and protect patients, a multidisciplinary approach was taken …

Occupational Therapy And Sensory Integration For Children With Autism: A Feasibility, Safety, Acceptability And Fidelity Study., Roseann C Schaaf, Teal W. Benevides, Donna Kelly, Zoe Mailloux-Maggio

Department of Occupational Therapy Faculty Papers

Objective: To examine the feasibility, safety, and acceptability of a manualized protocol of occupational therapy using sensory integration principles for children with autism. Methods: Ten children diagnosed with autism spectrum disorder ages 4-8 years received intensive occupational therapy intervention using sensory integration principles following a manualized protocol. Measures of feasibility, acceptability and safety were collected from parents and interveners, and fidelity was measured using a valid and reliable fidelity instrument. Results: The intervention is safe and feasible to implement, acceptable to parents and therapist, and therapists were able to implement protocol with adequate fidelity. These data provide support for implementation …

Ethanol Exposure Impairs Glutamatergic Synaptic Transmission And Plasticity In The Ca1 Hippocampal Region During The Third Trimester-Equivalent Of Human Pregnancy: Implications For Fetal Alcohol Spectrum Disorder, Michael P. Puglia

Biomedical Sciences ETDs

Fetal alcohol spectrum disorder results from developmental exposure to ethanol. Although many organ systems are targeted by this teratogen, the central nervous system is exquisitely sensitive. Children with this disease often present with behavioral disorders as well as impairments in learning and memory. Ethanol exposure affects developmental processes throughout pregnancy; however, the third trimester-equivalent has demonstrated heightened sensitivity. Although the mechanism of action(s) of ethanol remains unknown, studies suggest that impairments in glutamatergic signaling and synaptic plasticity during the third trimester-equivalent period of development lead to alterations in synaptic formation and refinement. However, little is known about the developmental effects …

Moving Toward Culture Change: Defining Skilled Nursing Facility Residents Dining Style Preferences, Katheryn Adams

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Background Public policy fulfillment coupled with skilled nursing facility's desire to increase quality of service to meet changes in residents' expectations and improve marketability warrant a new look at culture change and home like dining as defined by the residents in skilled nursing facilities.

Objective The objectives of this study were to determine residents' home dining practices, define residents' desired dining style practices in the skilled nursing facility and determine the relationship between at home dining and dining preferences in skilled nursing facilities.

Design The quasi-experimental study started with a convenience sample taken from a facility generated potential participant list. …

Oncolog, Volume 57, Number 05, May 2012, Bryan Tutt, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Advances in Gene Mapping Technology May Accelerate Cancer Drug Development: As new technology makes DNA sequencing faster and less expensive, researchers aim to exploit these abilities to develop novel targeted cancer therapies
• Compass: Advanced Renal Cell Carcinoma: Surgery and/or systemic therapy can help manage disease
• HOUSE CALL: Do Nutritional Supplements Help Prevent Cancer ?: For many people, the risks may outweigh the benefits
• INBRIEF: Drug Provides Symptom Reduction and Survival Advantages for Myelofibrosis Patients